Bachmann, Sebastian

[["dc.bibliographiccitation.firstpage","2209"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","Journal of the American Society of Nephrology"],["dc.bibliographiccitation.lastpage","2220"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Theilig, F."],["dc.contributor.author","Bostanjoglo, M."],["dc.contributor.author","Pavenstadt, H."],["dc.contributor.author","Grupp, Clemens"],["dc.contributor.author","Holland, G."],["dc.contributor.author","Slosarek, I."],["dc.contributor.author","Gressner, A. M."],["dc.contributor.author","Russwurm, M."],["dc.contributor.author","Koesling, D."],["dc.contributor.author","Bachmann, Sebastian"],["dc.date.accessioned","2018-11-07T08:29:23Z"],["dc.date.available","2018-11-07T08:29:23Z"],["dc.date.issued","2001"],["dc.description.abstract","Soluble guanylyl cyclase (sGC) catalyzes the biosynthesis of cGMP in response to binding Of L-arginine-derived nitric oxide (NO). Functionally, the NO-sGC-cGMP signaling pathway in kidney and liver has been associated with regional hemodynamics and the regulation of glomerular parameters. The distribution of the ubiquitous sGC isoform alpha1 beta1 sGC was studied with a novel, highly specific antibody against the beta1 subunit. In parallel, the presence of mRNA encoding both subunits was investigated by using in situ hybridization and reverse transcription-PCR assays. The NO-induced, sGC-dependent accumulation of cGMP in cytosolic extracts of tissues and cells was measured in vitro. Renal glomerular arterioles, including the renin-producing granular cells, mesangium, and descending vasa recta, as well as cortical and medullary interstitial fibroblasts, expressed sGC. Stimulation of isolated mesangial cells, renal fibroblasts, and hepatic Ito cells with a NO donor resulted in markedly increased cytosolic cGMP levels. This assessment of sGC expression and activity in vascular and interstitial cells of kidney and liver may have implications for understanding the role of local cGMP signaling cascades."],["dc.identifier.isi","000171857100005"],["dc.identifier.pmid","11675397"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/16638"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.relation.issn","1046-6673"],["dc.title","Cellular distribution and function of soluble guanylyl cyclase in rat kidney and liver"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","8462"],["dc.bibliographiccitation.issue","25"],["dc.bibliographiccitation.journal","Chemistry - A European Journal"],["dc.bibliographiccitation.lastpage","8465"],["dc.bibliographiccitation.volume","22"],["dc.contributor.author","Bachmann, Sebastian"],["dc.contributor.author","Neufeld, Roman"],["dc.contributor.author","Dzemski, Martin"],["dc.contributor.author","Stalke, Dietmar"],["dc.date.accessioned","2018-11-07T10:12:48Z"],["dc.date.available","2018-11-07T10:12:48Z"],["dc.date.issued","2016"],["dc.description.abstract","New external calibration curves (ECCs) for the estimation of aggregation states of small molecules in solution by DOSY NMR spectroscopy for a range of different common NMR solvents ([D-6]DMSO, C6D12, C6D6, CDCl3, and CD2Cl2) are introduced and applied. ECCs are of avail to estimate molecular weights (MWs) from diffusion coefficients of previously unknown aggregates. This enables a straightforward and elaborate examination of (de)aggregation phenomena in solution."],["dc.description.sponsorship","DNRF [DNRF93]"],["dc.identifier.doi","10.1002/chem.201601145"],["dc.identifier.isi","000380270100008"],["dc.identifier.pmid","27061592"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/40307"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-v C H Verlag Gmbh"],["dc.relation.issn","1521-3765"],["dc.relation.issn","0947-6539"],["dc.title","New External Calibration Curves (ECCs) for the Estimation of Molecular Weights in Various Common NMR Solvents"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","13141"],["dc.bibliographiccitation.issue","53"],["dc.bibliographiccitation.journal","Chemistry - A European Journal"],["dc.bibliographiccitation.lastpage","13149"],["dc.bibliographiccitation.volume","23"],["dc.contributor.author","Koehne, Ingo"],["dc.contributor.author","Bachmann, Sebastian"],["dc.contributor.author","Niklas, Thomas"],["dc.contributor.author","Herbst-Irmer, Regine"],["dc.contributor.author","Stalke, Dietmar"],["dc.date.accessioned","2020-12-10T14:05:47Z"],["dc.date.available","2020-12-10T14:05:47Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1002/chem.201702378"],["dc.identifier.issn","0947-6539"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/69653"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","A Novel Bulky Heteroaromatic-Substituted Methanide Mimicking NacNac: Bis(4,6- tert- butylbenzoxazol-2-yl)methanide in s-Block Metal Coordination"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","7752"],["dc.bibliographiccitation.issue","23"],["dc.bibliographiccitation.journal","Chemistry - A European Journal"],["dc.bibliographiccitation.lastpage","7762"],["dc.bibliographiccitation.volume","22"],["dc.contributor.author","Schnegelsberg, Christoph"],["dc.contributor.author","Bachmann, Sebastian"],["dc.contributor.author","Kolter, Marlene"],["dc.contributor.author","Auth, Thomas"],["dc.contributor.author","John, Michael"],["dc.contributor.author","Stalke, Dietmar"],["dc.contributor.author","Koszinowski, Konrad"],["dc.date.accessioned","2018-11-07T10:13:01Z"],["dc.date.available","2018-11-07T10:13:01Z"],["dc.date.issued","2016"],["dc.description.abstract","Grignard reagents RMgCl and their so-called turbo variant, the highly reactive RMgCl center dot LiCl, are of exceptional synthetic utility. Nevertheless, it is still not fully understood which species these compounds form in solution and, in particular, in which way LiCl exerts its reactivity-enhancing effect. A combination of electrospray-ionization mass spectrometry, electrical conductivity measurements, NMR spectroscopy (including diffusion-ordered spectroscopy), and quantum chemical calculations is used to analyze solutions of RMgCl (R=Me, Et, Bu, Hex, Oct, Dec, iPr, tBu, Ph) in tetrahydrofuran and other ethereal solvents in the absence and presence of stoichiometric amounts of LiCl. In tetrahydrofuran, RMgCl forms mononuclear species, which are converted into trinuclear anions as a result of the concentration increase experienced during the electrospray process. These trinuclear anions are theoretically predicted to adopt open cubic geometries, which remarkably resemble structural motifs previously found in the solid state. The molecular constituents of RMgCl and RMgCl center dot LiCl are interrelated via Schlenk equilibria and fast intermolecular exchange processes. A small portion of the Grignard reagent also forms anionic ate complexes in solution. The abundance of these more electron-rich and hence supposedly more nucleophilic ate complexes strongly increases upon the addition of LiCl, thus rationalizing its beneficial effect on the reactivity of Grignard reagents."],["dc.description.sponsorship","Deutsche Forschungsgmeinschaft [KO 2875/4-1]"],["dc.identifier.doi","10.1002/chem.201600699"],["dc.identifier.isi","000380267100015"],["dc.identifier.pmid","27150118"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/40354"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-v C H Verlag Gmbh"],["dc.relation.issn","1521-3765"],["dc.relation.issn","0947-6539"],["dc.title","Association and Dissociation of Grignard Reagents RMgCl and Their Turbo Variant RMgCl center dot LiCl"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","144"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Acta Physiologica"],["dc.bibliographiccitation.lastpage","158"],["dc.bibliographiccitation.volume","215"],["dc.contributor.author","Neymeyer, H."],["dc.contributor.author","Labes, R."],["dc.contributor.author","Reverte, V."],["dc.contributor.author","Saez, F."],["dc.contributor.author","Stroh, T."],["dc.contributor.author","Dathe, C."],["dc.contributor.author","Hohberger, S."],["dc.contributor.author","Zeisberg, Michael"],["dc.contributor.author","Mueller, Georg Anton"],["dc.contributor.author","Salazar, J."],["dc.contributor.author","Bachmann, Sebastian"],["dc.contributor.author","Paliege, A."],["dc.date.accessioned","2018-11-07T09:49:50Z"],["dc.date.available","2018-11-07T09:49:50Z"],["dc.date.issued","2015"],["dc.description.abstract","AimThe anti-inflammatory protein annexin A1 (AnxA1) and its formyl peptide receptor 2 (FPR2) have protective effects in organ fibrosis. Their role in chronic kidney disease (CKD) has not yet been elucidated. Our aim was to characterize the AnxA1/FPR2 system in models of renal fibrosis. MethodsRats were treated with angiotensin receptor antagonist during the nephrogenic period (ARAnp) to induce late-onset hypertensive nephropathy and fibrosis. Localization and regulation of AnxA1 and FPR2 were studied by quantitative real-time PCR and double labelling immunofluorescence. Biological effects of AnxA1 were studied in cultured renal fibroblasts from AnxA1(-/-) and wild-type mice. ResultsAngiotensin receptor antagonist during the nephrogenic period kidneys displayed matrix foci containing CD73(+) fibroblasts, alpha-smooth muscle actin (a-SMA)(+) myofibroblasts and CD68(+) macrophages. TGF- and AnxA1 mRNAs were similar to threefold higher than in controls. AnxA1 was localized to macrophages and fibroblasts; myofibroblasts were negative. FPR2 was localized to fibroblasts, myofibroblasts, macrophages and endothelial cells. AnxA1 and FPR2 immunoreactive signals were increased in the foci, with fibroblasts and macrophages expressing both proteins. AnxA1(-/-) fibroblasts revealed higher -SMA (sevenfold) and collagen 1A1 (Col1A1; 144-fold) mRNA levels than controls. Treatment of murine WT fibroblasts with TGF- (22.5ngmL24h(-1)) increased mRNA levels of -SMA (9.3-fold) and Col1A1 (fourfold). These increases were greatly attenuated upon overexpression of AnxA1 (1.5- and 1.7-fold, respectively; P<0.05). Human fibroblasts reacted similarly when receiving the FPR2 inhibitor WRW4. ConclusionOur results demonstrate that AnxA1 and FPR2 are abundantly expressed in the renal interstitium and modulate fibroblast phenotype and extracellular matrix synthesis activity."],["dc.identifier.doi","10.1111/apha.12586"],["dc.identifier.isi","000362894200007"],["dc.identifier.pmid","26332853"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/35583"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.relation.issn","1748-1716"],["dc.relation.issn","1748-1708"],["dc.title","Activation of annexin A1 signalling in renal fibroblasts exerts antifibrotic effects"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","5689"],["dc.bibliographiccitation.issue","13"],["dc.bibliographiccitation.journal","Dalton Transactions"],["dc.bibliographiccitation.lastpage","5699"],["dc.bibliographiccitation.volume","45"],["dc.contributor.author","Visscher, Arne"],["dc.contributor.author","Bachmann, Sebastian"],["dc.contributor.author","Schnegelsberg, Christoph"],["dc.contributor.author","Teuteberg, Thorsten L."],["dc.contributor.author","Mata, Ricardo A."],["dc.contributor.author","Stalke, Dietmar"],["dc.date.accessioned","2018-11-07T10:20:39Z"],["dc.date.accessioned","2020-05-12T10:21:05Z"],["dc.date.available","2018-11-07T10:20:39Z"],["dc.date.available","2020-05-12T10:21:05Z"],["dc.date.issued","2016"],["dc.description.abstract","Fluorescence spectroscopy investigations of the new acridine derivative bis(N, N-dimethylaminemethylene) acridine (3) show remarkable selectivity and sensitivity towards Zn2+ and Cd2+ ions in methanol and for the latter even in water. Through the chelation of the metal ions the present PET effect is quenched, significantly enhancing the emission intensity of the fluorophore. In solution, the bonding situation is studied by fluorescence and NMR spectroscopy, as well as ESI-TOF mass-spectrometry measurements. The solid state environment is investigated by X-ray diffraction and computational calculations. Here, we can show the complexation of the zinc and cadmium ions by the methylene bridged amine receptors as well as by the nitrogen atom of the acridine system."],["dc.description.sponsorship","Danish National Research Foundation [DNRF93]; Land Niedersachsen"],["dc.identifier.doi","10.1039/C6DT00557H"],["dc.identifier.isi","000372608300032"],["dc.identifier.pmid","26928871"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/12840"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/41933"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/65184"],["dc.language.iso","en"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.relation.eissn","1477-9234"],["dc.relation.issn","1477-9226"],["dc.rights.access","openAccess"],["dc.title","Highly selective and sensitive fluorescence detection of Zn2+ and Cd2+ ions by using an acridine sensor"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","15141"],["dc.bibliographiccitation.issue","47"],["dc.bibliographiccitation.journal","Angewandte Chemie International Edition"],["dc.bibliographiccitation.lastpage","15145"],["dc.bibliographiccitation.volume","56"],["dc.contributor.author","Koehne, Ingo"],["dc.contributor.author","Bachmann, Sebastian"],["dc.contributor.author","Herbst-Irmer, Regine"],["dc.contributor.author","Stalke, Dietmar"],["dc.date.accessioned","2020-12-10T14:08:22Z"],["dc.date.available","2020-12-10T14:08:22Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1002/anie.201706316"],["dc.identifier.issn","1433-7851"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/70438"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","A Water-Containing Organopotassium Compound Based on Bis(4,6- t Bu-benzoxazol-2-yl)methanide and Its Unexpected Stability to Hydrolysis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","371"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Psychological Medicine"],["dc.bibliographiccitation.lastpage","379"],["dc.bibliographiccitation.volume","39"],["dc.contributor.author","Thomann, P. A."],["dc.contributor.author","Wuestenberg, Torsten"],["dc.contributor.author","Dos Santos, V."],["dc.contributor.author","Bachmann, Sebastian"],["dc.contributor.author","Essig, M."],["dc.contributor.author","Schroeder, J."],["dc.date.accessioned","2018-11-07T08:32:29Z"],["dc.date.available","2018-11-07T08:32:29Z"],["dc.date.issued","2009"],["dc.description.abstract","Background. Although minor motor and sensory deficits, or neurological soft signs (NSS), are a well-established finding in schizophrenia, the cerebral changes underlying these signs are only partly understood. We therefore investigated the cerebral correlates of NSS by using magnetic resonance imaging (MRI) in patients with schizophrenia and healthy controls. Method. Forty-two patients, all receiving atypical neuroleptics, with first-episode schizophrenia or schizophreniform disorder and 22 healthy controls matched for age and gender were included. NSS were examined on the Heidelberg Scale after remission of the acute symptoms before discharge and correlated to density values by using optimized voxel-based morphometry (VBM). Results. NSS scores were significantly higher in patients than healthy controls. Within the patient group NSS were significantly associated with reduced grey or white-matter densities in the pre- and post-central gyrus, pre-motor area, middle and inferior frontal gyri, cerebellum, caudate nucleus and thalamus. These associations did not apply for the control group, in whom only the associations between NSS and reduced frontal gyri densities could be confirmed. Conclusions. The pattern of cerebral changes associated with NSS clearly supports the model of 'cognitive dysmetria' with a disrupted cortico-cerebellar-thalamic-cortical circuit in schizophrenia. The variety of sites may correspond with the clinical diversity of NSS, which comprises both motor and sensory signs, and with the putative heterogeneity of the pathogenetic changes involved. That the respective associations did not apply for the healthy control group indicates that NSS in patients and controls refer to different pathogenetic factors."],["dc.description.sponsorship","Stanley Medical Research Institute"],["dc.identifier.doi","10.1017/S0033291708003656"],["dc.identifier.isi","000263810200003"],["dc.identifier.pmid","18578894"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/17350"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Cambridge Univ Press"],["dc.relation.issn","0033-2917"],["dc.title","Neurological soft signs and brain morphology in first-episode schizophrenia"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","6957"],["dc.bibliographiccitation.issue","24"],["dc.bibliographiccitation.journal","ChemistrySelect"],["dc.bibliographiccitation.lastpage","6960"],["dc.bibliographiccitation.volume","2"],["dc.contributor.author","Kreyenschmidt, Anne-Kathrin"],["dc.contributor.author","Bachmann, Sebastian"],["dc.contributor.author","Niklas, Thomas"],["dc.contributor.author","Stalke, Dietmar"],["dc.date.accessioned","2020-12-10T14:07:13Z"],["dc.date.available","2020-12-10T14:07:13Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1002/slct.201701497"],["dc.identifier.issn","2365-6549"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/70149"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Molecular Weight Estimation of Molecules Incorporating Heavier Elements from van-der-Waals Corrected ECC-DOSY"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]