Tietze, Lutz Friedjan

[["dc.bibliographiccitation.firstpage","no"],["dc.bibliographiccitation.issue","26"],["dc.bibliographiccitation.journal","ChemInform"],["dc.bibliographiccitation.lastpage","no"],["dc.bibliographiccitation.volume","33"],["dc.contributor.author","Tietze, Lutz F."],["dc.contributor.author","Ott, Christian"],["dc.contributor.author","Haunert, Frank"],["dc.date.accessioned","2021-12-08T12:28:59Z"],["dc.date.available","2021-12-08T12:28:59Z"],["dc.date.issued","2010"],["dc.identifier.doi","10.1002/chin.200226045"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/95914"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-476"],["dc.relation.eissn","1522-2667"],["dc.relation.issn","0931-7597"],["dc.rights.uri","http://doi.wiley.com/10.1002/tdm_license_1.1"],["dc.title","ChemInform Abstract: Efficient and Regioselective Synthesis of Bridged Ring Systems by Domino Knoevenagel-Hetero-Diels-Alder Reaction."],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","no"],["dc.bibliographiccitation.issue","14"],["dc.bibliographiccitation.journal","ChemInform"],["dc.bibliographiccitation.lastpage","no"],["dc.bibliographiccitation.volume","33"],["dc.contributor.author","Tietze, Lutz F."],["dc.contributor.author","Petersen, Soenke"],["dc.date.accessioned","2021-12-08T12:28:56Z"],["dc.date.available","2021-12-08T12:28:56Z"],["dc.date.issued","2010"],["dc.identifier.doi","10.1002/chin.200214200"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/95892"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-476"],["dc.relation.eissn","1522-2667"],["dc.relation.issn","0931-7597"],["dc.rights.uri","http://doi.wiley.com/10.1002/tdm_license_1.1"],["dc.title","ChemInform Abstract: Stereoselective Synthesis of Novel 19-Nor-Steroids by a Double Heck Reaction."],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","no"],["dc.bibliographiccitation.issue","41"],["dc.bibliographiccitation.journal","ChemInform"],["dc.bibliographiccitation.lastpage","no"],["dc.bibliographiccitation.volume","28"],["dc.contributor.author","TIETZE, L. F."],["dc.contributor.author","BURKHARDT, O."],["dc.contributor.author","HENRICH, M."],["dc.date.accessioned","2021-12-08T12:28:12Z"],["dc.date.available","2021-12-08T12:28:12Z"],["dc.date.issued","2010"],["dc.identifier.doi","10.1002/chin.199741180"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/95594"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-476"],["dc.relation.issn","0931-7597"],["dc.rights.uri","http://doi.wiley.com/10.1002/tdm_license_1.1"],["dc.title","ChemInform Abstract: Diastereo- and Regioselective Intramolecular Heck Reaction of α- Amino Alcohol Derivatives for the Synthesis of Enantiomerically Pure Isoquinolines and Benzazepines at Ambient and High Pressure."],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","cmdc.202100222"],["dc.bibliographiccitation.firstpage","3300"],["dc.bibliographiccitation.issue","21"],["dc.bibliographiccitation.journal","ChemMedChem"],["dc.bibliographiccitation.lastpage","3305"],["dc.bibliographiccitation.volume","16"],["dc.contributor.affiliation","Raad, Farah S.; 1\r\nInstitute of Pharmacology and Toxicology\r\nUniversity Medical Center\r\nGeorg-August-University\r\nGöttingen Germany"],["dc.contributor.affiliation","Khan, Taukeer A.; 2\r\nDZHK (German Center for Cardiovascular Research) – Partner site Göttingen\r\nGöttingen Germany"],["dc.contributor.affiliation","Esser, Tilman U.; 1\r\nInstitute of Pharmacology and Toxicology\r\nUniversity Medical Center\r\nGeorg-August-University\r\nGöttingen Germany"],["dc.contributor.affiliation","Hudson, James E.; 1\r\nInstitute of Pharmacology and Toxicology\r\nUniversity Medical Center\r\nGeorg-August-University\r\nGöttingen Germany"],["dc.contributor.affiliation","Seth, Bhakti Irene; 1\r\nInstitute of Pharmacology and Toxicology\r\nUniversity Medical Center\r\nGeorg-August-University\r\nGöttingen Germany"],["dc.contributor.affiliation","Fujita, Buntaro; 1\r\nInstitute of Pharmacology and Toxicology\r\nUniversity Medical Center\r\nGeorg-August-University\r\nGöttingen Germany"],["dc.contributor.affiliation","Gandamala, Ravi; 3\r\nInstitute of Organic and Biomolecular Chemistry\r\nGeorg-August-University\r\nGöttingen Germany"],["dc.contributor.affiliation","Tietze, Lutz F.; 2\r\nDZHK (German Center for Cardiovascular Research) – Partner site Göttingen\r\nGöttingen Germany"],["dc.contributor.affiliation","Zimmermann, Wolfram-Hubertus; 1\r\nInstitute of Pharmacology and Toxicology\r\nUniversity Medical Center\r\nGeorg-August-University\r\nGöttingen Germany"],["dc.contributor.author","Raad, Farah S."],["dc.contributor.author","Khan, Taukeer A."],["dc.contributor.author","Esser, Tilman U."],["dc.contributor.author","Hudson, James E."],["dc.contributor.author","Seth, Bhakti Irene"],["dc.contributor.author","Fujita, Buntaro"],["dc.contributor.author","Gandamala, Ravi"],["dc.contributor.author","Tietze, Lutz F."],["dc.contributor.author","Zimmermann, Wolfram H."],["dc.date.accessioned","2021-10-01T09:58:46Z"],["dc.date.available","2021-10-01T09:58:46Z"],["dc.date.issued","2021"],["dc.date.updated","2022-03-21T00:45:29Z"],["dc.description.abstract","Abstract Human pluripotent stem cells (hPSCs) hold great promise for applications in cell therapy and drug screening in the cardiovascular field. Bone morphogenetic protein 4 (BMP4) is key for early cardiac mesoderm induction in hPSC and subsequent cardiomyocyte derivation. Small‐molecular BMP4 mimetics may help to standardize cardiomyocyte derivation from hPSCs. Based on observations that chalcones can stimulate BMP4 signaling pathways, we hypothesized their utility in cardiac mesoderm induction. To test this, we set up a two‐tiered screening strategy, (1) for directed differentiation of hPSCs with commercially available chalcones (4’‐hydroxychalcone [4’HC] and Isoliquiritigen) and 24 newly synthesized chalcone derivatives, and (2) a functional screen to assess the propensity of the obtained cardiomyocytes to self‐organize into contractile engineered human myocardium (EHM). We identified 4’HC, 4‐fluoro‐4’‐methoxychalcone, and 4‐fluoro‐4’‐hydroxychalcone as similarly effective in cardiac mesoderm induction, but only 4’HC as an effective replacement for BMP4 in the derivation of contractile EHM‐forming cardiomyocytes."],["dc.description.abstract","Have a little heart: A screen for mesoderm inducing chalcones in human pluripotent stem cell cultures identified 4’‐hydroxychalcone (4’HC) as an effective replacement for bone‐morphogenetic protein 4 (BMP4) in supporting the derivation of engineered heart muscle (EHM)‐formation competent cardiomyocytes. image"],["dc.description.sponsorship","German Center for Cardiovascular Research"],["dc.description.sponsorship","German Federal Ministry for Science and Education"],["dc.description.sponsorship","German Research Foundation http://dx.doi.org/10.13039/501100001659"],["dc.description.sponsorship","Fondation Leducq http://dx.doi.org/10.13039/501100001674"],["dc.identifier.doi","10.1002/cmdc.202100222"],["dc.identifier.pmid","34309224"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/90137"],["dc.identifier.url","https://mbexc.uni-goettingen.de/literature/publications/432"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-469"],["dc.relation","EXC 2067: Multiscale Bioimaging"],["dc.relation.eissn","1860-7187"],["dc.relation.issn","1860-7179"],["dc.relation.workinggroup","RG Zimmermann (Engineered Human Myocardium)"],["dc.rights","This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited."],["dc.title","Chalcone‐Supported Cardiac Mesoderm Induction in Human Pluripotent Stem Cells for Heart Muscle Engineering"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","3286"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","Chemistry - A European Journal"],["dc.bibliographiccitation.lastpage","3291"],["dc.bibliographiccitation.volume","18"],["dc.contributor.author","Tietze, Lutz Friedjan"],["dc.contributor.author","Hungerland, Tim"],["dc.contributor.author","Duefert, Alexander"],["dc.contributor.author","Objartel, Ina"],["dc.contributor.author","Stalke, Dietmar"],["dc.date.accessioned","2018-11-07T09:12:39Z"],["dc.date.available","2018-11-07T09:12:39Z"],["dc.date.issued","2012"],["dc.description.abstract","Helical tetrasubstituted alkenes (7) were obtained in a highly efficient way through a palladium-catalyzed domino-carbopalladation/CH-activation reaction of propargylic alcohols 6 in good to excellent yields. Electron-withdrawing- and electron-donating substituents can be introduced onto the upper and lower aromatic rings. The substrates (6) for the domino process were synthesized by addition of the lithiated alkyne (20) to various aldehydes (19); moreover, the substrates were accessible enantioselectively (in 95?% ee) by reduction of the corresponding ketone using the Noyori procedure."],["dc.identifier.doi","10.1002/chem.201103209"],["dc.identifier.isi","000300972500025"],["dc.identifier.pmid","22259072"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/26989"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-v C H Verlag Gmbh"],["dc.relation.issn","0947-6539"],["dc.title","Synthesis of Tetrasubstituted Alkenes through a Palladium-Catalyzed Domino Carbopalladation/C-H-Activation Reaction"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2007"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Organic Letters"],["dc.bibliographiccitation.lastpage","2010"],["dc.bibliographiccitation.volume","20"],["dc.contributor.author","Khan, Taukeer A."],["dc.contributor.author","Fornefeld, Torsten"],["dc.contributor.author","Hübner, Dennis"],["dc.contributor.author","Vana, Philipp"],["dc.contributor.author","Tietze, Lutz F."],["dc.date.accessioned","2018-08-14T15:26:49Z"],["dc.date.available","2018-08-14T15:26:49Z"],["dc.date.issued","2018"],["dc.description.abstract","A palladium-catalyzed 4-fold domino reaction consisting of two carbopalladation reactions and two C–H activation reactions, followed by the introduction of an acrylate moiety, led to the tetra-substituted helical alkene A2, using the dialkyne A3 as a substrate. The alkene was copolymerized with butyl acrylate by using the reversible addition–fragmentation chain transfer polymerization (RAFT) to give the desired polymeric switch A1."],["dc.identifier.doi","10.1021/acs.orglett.8b00553"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/15296"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.title","Palladium-Catalyzed 4-Fold Domino Reaction for the Synthesis of a Polymeric Double Switch"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1296"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Chemistry - A European Journal"],["dc.bibliographiccitation.lastpage","1302"],["dc.bibliographiccitation.volume","9"],["dc.contributor.author","Tietze, Lutz Friedjan"],["dc.contributor.author","Griesbach, U."],["dc.contributor.author","Schuberth, I."],["dc.contributor.author","Bothe, U."],["dc.contributor.author","Marra, A."],["dc.contributor.author","Dondoni, A."],["dc.date.accessioned","2018-11-07T10:39:58Z"],["dc.date.available","2018-11-07T10:39:58Z"],["dc.date.issued","2003"],["dc.description.abstract","The synthesis of the novel unprotected carboranyl C-glycosides 2 and 20 24 starting from ethynyl C-glycosides 1, 5-8, 10, and 13 is described. The new compounds are highly water-soluble and display only a very low cytotoxicity, which makes them promising candidates for use in boron neutron capture therapy for the treatment of cancer."],["dc.identifier.doi","10.1002/chem.200390148"],["dc.identifier.isi","000181817400005"],["dc.identifier.pmid","12645018"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/46188"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-v C H Verlag Gmbh"],["dc.relation.issn","0947-6539"],["dc.title","Novel carboranyl C-glycosides for the treatment of cancer by boron neutron capture therapy"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","517"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Antimicrobial Agents and Chemotherapy"],["dc.bibliographiccitation.lastpage","521"],["dc.bibliographiccitation.volume","54"],["dc.contributor.author","Bajohr, Lara Liv"],["dc.contributor.author","Ma, Ling"],["dc.contributor.author","Platte, Christian"],["dc.contributor.author","Liesenfeld, Oliver"],["dc.contributor.author","Tietze, Lutz Friedjan"],["dc.contributor.author","Gross, Uwe"],["dc.contributor.author","Bohne, Wolfgang"],["dc.date.accessioned","2018-11-07T08:47:00Z"],["dc.date.available","2018-11-07T08:47:00Z"],["dc.date.issued","2010"],["dc.description.abstract","1-Hydroxy-2-dodecyl-4(1H) quinolone (HDQ) was recently identified as a Toxoplasma gondii inhibitor. We describe here two novel 1-hydroxyquinolones, which displayed 50% inhibitory concentrations 10- and 5-fold lower than that of HDQ. In a mouse model of acute toxoplasmosis, these two compounds and HDQ reduced the percentages of infected peritoneal cells and decreased the parasite loads in lungs and livers. Compound B showed a tendency toward lowering parasite loads in brains in a mouse model of toxoplasmic encephalitis."],["dc.identifier.doi","10.1128/AAC.01001-09"],["dc.identifier.isi","000272931200069"],["dc.identifier.pmid","19884369"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/20837"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Soc Microbiology"],["dc.relation.issn","0066-4804"],["dc.title","In Vitro and In Vivo Activities of 1-Hydroxy-2-Alkyl-4(1H)Quinolone Derivatives against Toxoplasma gondii"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","no"],["dc.bibliographiccitation.issue","31"],["dc.bibliographiccitation.journal","ChemInform"],["dc.bibliographiccitation.lastpage","no"],["dc.bibliographiccitation.volume","31"],["dc.contributor.author","Tietze, Lutz F."],["dc.contributor.author","Thede, Kai"],["dc.contributor.author","Schimpf, Ralph"],["dc.contributor.author","Sannicolo, Franco"],["dc.date.accessioned","2021-12-08T12:28:40Z"],["dc.date.available","2021-12-08T12:28:40Z"],["dc.date.issued","2010"],["dc.identifier.doi","10.1002/chin.200031031"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/95785"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-476"],["dc.relation.eissn","1522-2667"],["dc.relation.issn","0931-7597"],["dc.rights.uri","http://doi.wiley.com/10.1002/tdm_license_1.1"],["dc.title","ChemInform Abstract: Enantioselective Synthesis of Tetrahydroisoquinolines and Benzazepines by Silane Terminated Heck Reactions with the Chiral Ligands (+)-TMBTP and (R)-BITIANP."],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","no"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","ChemInform"],["dc.bibliographiccitation.lastpage","no"],["dc.bibliographiccitation.volume","32"],["dc.contributor.author","Tietze, Lutz F."],["dc.contributor.author","Schirok, Hartmut"],["dc.contributor.author","Woehrmann, Michael"],["dc.contributor.author","Schrader, Klaus"],["dc.date.accessioned","2021-12-08T12:28:45Z"],["dc.date.available","2021-12-08T12:28:45Z"],["dc.date.issued","2001"],["dc.identifier.doi","10.1002/chin.200104218"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/95823"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-476"],["dc.relation.eissn","1522-2667"],["dc.relation.issn","0931-7597"],["dc.rights.uri","http://doi.wiley.com/10.1002/tdm_license_1.1"],["dc.title","ChemInform Abstract: Efficient Synthesis of Six-Membered Ring D Analogues of the Pentacyclic Alkaloid Cephalotaxine by Two Palladium-Catalyzed Reactions."],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]