Laskawi, Raíner

[["dc.bibliographiccitation.firstpage","556"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","NERVENHEILKUNDE"],["dc.bibliographiccitation.lastpage","559"],["dc.bibliographiccitation.volume","29"],["dc.contributor.author","Olthoff, Arno"],["dc.contributor.author","Laskawi, Rainer"],["dc.date.accessioned","2018-11-07T08:48:12Z"],["dc.date.available","2018-11-07T08:48:12Z"],["dc.date.issued","2010"],["dc.description.abstract","A focal laryngeal dystonia might cause dysphonia, dysphagia or dyspnea. These dysorders can appear discrete or combined. The treatment with botulinum toxin is a symptomatic off-label-use that has to be repetitive every three to six months to conserve a positive outcome. In case of dysphonia and dyspnea the laryngeal muscles and in case of dysphagia the cricopharyngeal muscle and the salivary glands are injected. For a selective indication an interdisciplinary diagnostic is essential."],["dc.identifier.isi","000282799000008"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/21153"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Schattauer Gmbh-verlag Medizin Naturwissenschaften"],["dc.relation.issn","0722-1541"],["dc.title","Treatment of dysphonia, dysphagia and dyspnea with botulinum toxin"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","654"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","HNO"],["dc.bibliographiccitation.lastpage","657"],["dc.bibliographiccitation.volume","51"],["dc.contributor.author","Fierek, O."],["dc.contributor.author","Laskawi, Raíner"],["dc.contributor.author","Bönnemann, C."],["dc.contributor.author","Hanefeld, Folker"],["dc.date.accessioned","2018-11-07T10:37:18Z"],["dc.date.available","2018-11-07T10:37:18Z"],["dc.date.issued","2003"],["dc.description.abstract","The Levy-Hollister syndrome is characterized by a highly variable expression of dysplasia in different organ systems. Autosomal-dominant inheritance is recognised, but most cases are sporadic. In the field of otorhinolaryngology, xerostomia can be found due to aplasia of the major salivary glands, as well as congenital sensorineural, conductive or combined hearing loss and dysplasia of the auricles, mostly appearing as cup-shaped ears. Here we report on a 2-year-old boy with severe xerostomia. The disease v as found to be caused by bilateral aplasia of the parotid and submandibular glands.-There were also slight dysplasias of both auricles and a bilateral inner ear malformation as the origin of sensorineural hearing loss. Due to its highly variable expression, Levy-Hollister syndrome is often difficult to distinguish from other diseases and syndromes, so that the cooperation of different departments is necessary for an accurate diagnosis. Because of its dominant inheritance,a genetic consultation should be recommended to the patient. Auricular dysplasia and conductive hearing loss can possibly be treated surgically."],["dc.identifier.doi","10.1007/s00106-002-0779-5"],["dc.identifier.isi","000184858600008"],["dc.identifier.pmid","12942181"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/45529"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0017-6192"],["dc.title","The Levy-Hollister syndrome: a syndrome of dysplasias with ENT-manifestations"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","170"],["dc.bibliographiccitation.lastpage","177"],["dc.contributor.author","Laskawi, R."],["dc.contributor.author","Rohrbach, S."],["dc.contributor.editor","Kreyden, O.P."],["dc.contributor.editor","Böni, R."],["dc.contributor.editor","Burg, G."],["dc.date.accessioned","2021-06-02T10:44:19Z"],["dc.date.available","2021-06-02T10:44:19Z"],["dc.date.issued","2002"],["dc.identifier.doi","10.1159/000060675"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/87001"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.publisher","KARGER"],["dc.publisher.place","Basel"],["dc.relation.isbn","3-8055-7306-5"],["dc.relation.ispartof","Current Problems in Dermatology"],["dc.relation.ispartof","Hyperhidrosis and Botulinum Toxin in Dermatology"],["dc.title","Frey's Syndrome"],["dc.type","book_chapter"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","121"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","HNO"],["dc.bibliographiccitation.lastpage","123"],["dc.bibliographiccitation.volume","62"],["dc.contributor.author","Winterhoff, J."],["dc.contributor.author","Gehrt, A."],["dc.contributor.author","Matthias, C."],["dc.contributor.author","Laskawi, R."],["dc.date.accessioned","2021-06-01T10:49:04Z"],["dc.date.available","2021-06-01T10:49:04Z"],["dc.date.issued","2013"],["dc.identifier.doi","10.1007/s00106-013-2717-0"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/86155"],["dc.language.iso","de"],["dc.notes.intern","DOI-Import GROB-425"],["dc.relation.eissn","1433-0458"],["dc.relation.issn","0017-6192"],["dc.title","Rhinorrhoe nach Laryngektomie Behandlung mit Botulinumtoxin Typ A"],["dc.title.translated","Rhinorrhea following laryngectomy"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","397"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Journal of Oral and Maxillofacial Surgery"],["dc.bibliographiccitation.lastpage","401"],["dc.bibliographiccitation.volume","64"],["dc.contributor.author","Ellies, M."],["dc.contributor.author","Schutz, S."],["dc.contributor.author","Quondamatteo, T."],["dc.contributor.author","Laskawi, Rainer"],["dc.date.accessioned","2018-11-07T10:13:53Z"],["dc.date.available","2018-11-07T10:13:53Z"],["dc.date.issued","2006"],["dc.description.abstract","Purpose: We wanted to prove the hypothesis that local injections of botulinum toxin A have an influence on the immunoreactivity of neuronal nitric oxide synthase (nNOS) in parotid glands of adult rats. Materials and Methods: Our group carried out immunohistochemical reaction of neuronal nitric oxide synthase (nNOS) in the parotid gland of female adult Wistar rats, in native (untreated) glands and after intraglandular injection of botulinum toxin A under general anesthesia. The immunoreactivity of nNOS was investigated on different times after injection. Results: Compared with the untreated glands, there was a significant decrease of nNOS in the treated organs that became stronger with extended toxin exposure time. After our laboratory in a pilot study had already shown in general a decrease of nNOS immunoreactivity after injection of botulinum toxin A into the cephalic salivary glands of the rat, the present study shows more explicit data on the effect of botulinum toxin A injection on a higher number of examined parotid glands and analyzes a time course of the effect duration. Conclusions: in our study, it was shown that botulinum toxin A had an influence on the immunoreactivity of neuronal nitric oxide synthase (nNOS) in parotid glands. Participation of nitric oxide (NO) in the regulation of secretion from the parotid gland of the rat seems to be likely. It might be assumed that the influence of botulinum. toxin A on nNOS in the parotid gland of the rat is able to explain the sometimes longer duration of toxin effect at the neuroglandular junction than at the motor endplate. (c) 2006 American Association of Oral and Maxillofacial Surgeons."],["dc.identifier.doi","10.1016/j.joms.2005.11.029"],["dc.identifier.isi","000235786800008"],["dc.identifier.pmid","16487800"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/40513"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","W B Saunders Co-elsevier Inc"],["dc.relation.issn","0278-2391"],["dc.title","Immunohistochemical investigations of the influence of botulinum toxin A on the immunoreactivity of nNOS in the parotid gland of the rat"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","S142"],["dc.bibliographiccitation.journal","Laryngo-Rhino-Otologie"],["dc.bibliographiccitation.lastpage","S155"],["dc.bibliographiccitation.volume","84"],["dc.contributor.author","Laskawi, Rainer"],["dc.contributor.author","Rohrbach, S."],["dc.date.accessioned","2018-11-07T11:04:47Z"],["dc.date.available","2018-11-07T11:04:47Z"],["dc.date.issued","2005"],["dc.identifier.doi","10.1055/s-2005-861153"],["dc.identifier.isi","000228718100011"],["dc.identifier.pmid","15846548"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/51915"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Georg Thieme Verlag Kg"],["dc.publisher.place","Stuttgart"],["dc.relation.conference","76th Annual Meeting of the Deutschen-Gesellschaft-fur-Hals-Nasen-Ohren-Heilkunde-Kopf-und-Hals-Chir urgie"],["dc.relation.eventlocation","GERMANY"],["dc.relation.issn","0935-8943"],["dc.title","Impaired motor functions - Operative and conservative processes for the restoration of motor functions in the Nervus facialis, Nervus accessorius, Nervus hypoglossus"],["dc.type","conference_paper"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","327"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Neuropediatrics"],["dc.bibliographiccitation.lastpage","330"],["dc.bibliographiccitation.volume","33"],["dc.contributor.author","Ellies, M."],["dc.contributor.author","Rohrbach-Volland, S."],["dc.contributor.author","Arglebe, C."],["dc.contributor.author","Wilken, Barbara"],["dc.contributor.author","Laskawi, Rainer"],["dc.contributor.author","Hanefeld, Folker"],["dc.date.accessioned","2018-11-07T09:46:56Z"],["dc.date.available","2018-11-07T09:46:56Z"],["dc.date.issued","2002"],["dc.description.abstract","Objectives: The present study investigates the effect of topical injections of botulinum toxin A into the cephalic salivary glands of children with chronic hypersalivation due to neurodegenerative diseases. Methods: Five children with hypersalivation due to severe neurological diseases received, under ultrasound guidance, a total of 50 - 65 units of botulinum toxin A (Botox((R))) into the parotid and submandibular glands on both sides. All injections were tolerated without local anaesthesia. Before and 1, 2, 4, 8 and 12 weeks after toxin injection, salivary flow rates and the concentrations of total protein, alpha-amylase, acid phosphatase, kallikrein, and immunoglobulin A were measured in the secretions; simultaneously, the patients were clinically examined with regard to severity of symptoms, and their salivary glands were subjected to ultrasound study. Results: A distinct improvement of symptoms within the first 2 weeks following toxin administration were reported by the parents. Sialometry revealed considerably reduced flow rates but sialochemistry showed an increase of amylase activity. Ultrasound examination did not reveal any changes of the salivary parenchyma, and side-effects were absent. Conclusions: Treatment of drooling by topical injection of botulinum toxin A into the salivary glands is a reliable and also side-effect-free therapeutic option for children with neurological disorders. All children involved in our study experienced a distinct improvement of their quality of life."],["dc.identifier.doi","10.1055/s-2002-37084"],["dc.identifier.isi","000181014100011"],["dc.identifier.pmid","12571790"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/34997"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Georg Thieme Verlag Kg"],["dc.relation.issn","0174-304X"],["dc.title","Successful management of drooling with botulinum toxin A in neurologically disabled children"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","450"],["dc.bibliographiccitation.issue","08"],["dc.bibliographiccitation.journal","Fortschritte der Neurologie · Psychiatrie"],["dc.bibliographiccitation.lastpage","462"],["dc.bibliographiccitation.volume","85"],["dc.contributor.author","Olthoff, Arno"],["dc.contributor.author","Grosheva, Maria"],["dc.contributor.author","Reichel, Gerhard"],["dc.contributor.author","Volk, Gerd Fabian"],["dc.contributor.author","Laskawi, Rainer"],["dc.date.accessioned","2020-12-10T18:12:26Z"],["dc.date.available","2020-12-10T18:12:26Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1055/s-0043-115644"],["dc.identifier.eissn","1439-3522"],["dc.identifier.issn","0720-4299"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/74374"],["dc.language.iso","de"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Die Behandlung der laryngealen Dystonie mit Botulinumtoxin"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","251"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Journal of Neural Transmission"],["dc.bibliographiccitation.lastpage","258"],["dc.bibliographiccitation.volume","123"],["dc.contributor.author","Dressler, Dirk"],["dc.contributor.author","Altenmueller, Eckart"],["dc.contributor.author","Bhidayasiri, Roongroj"],["dc.contributor.author","Bohlega, Saeed"],["dc.contributor.author","Chana, Pedro"],["dc.contributor.author","Chung, Tae Mo"],["dc.contributor.author","Frucht, Steven"],["dc.contributor.author","Garcia-Ruiz, Pedro J."],["dc.contributor.author","Kaelin, Alain"],["dc.contributor.author","Kaji, Ryuji"],["dc.contributor.author","Kanovsky, Petr"],["dc.contributor.author","Laskawi, Rainer"],["dc.contributor.author","Micheli, Federico"],["dc.contributor.author","Orlova, Olga"],["dc.contributor.author","Relja, Maja"],["dc.contributor.author","Rosales, Raymond"],["dc.contributor.author","Slawek, Jaroslaw"],["dc.contributor.author","Timerbaeva, Sofia"],["dc.contributor.author","Warner, Thomas T."],["dc.contributor.author","Saberi, Fereshte Adib"],["dc.date.accessioned","2018-11-07T10:17:22Z"],["dc.date.available","2018-11-07T10:17:22Z"],["dc.date.issued","2016"],["dc.description.abstract","Treatment of dystonias is generally symptomatic. To produce sufficient therapy effects, therefore, frequently a multimodal and interdisciplinary therapeutic approach becomes necessary, combining botulinum toxin therapy, deep brain stimulation, oral antidystonic drugs, adjuvant drugs and rehabilitation therapy including physiotherapy, occupational therapy, re-training, speech therapy, psychotherapy and sociotherapy. This review presents the recommendations of the IAB-Interdisciplinary Working Group for Movement Disorders Special Task Force on Interdisciplinary Treatment of Dystonia. It reviews the different therapeutic modalities and outlines a strategy to adapt them to the dystonia localisation and severity of the individual patient. Hints to emerging and future therapies will be given."],["dc.identifier.doi","10.1007/s00702-015-1453-x"],["dc.identifier.isi","000373162900011"],["dc.identifier.pmid","26370676"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/41214"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","Wien"],["dc.relation.issn","1435-1463"],["dc.relation.issn","0300-9564"],["dc.title","Strategies for treatment of dystonia"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","71"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Annals of Otology Rhinology & Laryngology"],["dc.bibliographiccitation.lastpage","76"],["dc.bibliographiccitation.volume","112"],["dc.contributor.author","Rodel, RMW"],["dc.contributor.author","Laskawi, Rainer"],["dc.contributor.author","Markus, H."],["dc.date.accessioned","2018-11-07T10:41:55Z"],["dc.date.available","2018-11-07T10:41:55Z"],["dc.date.issued","2003"],["dc.description.abstract","Motor evoked potentials (MEPs) of the lingual muscles elicited by focal cortical transcranial magnetic stimulation (TMS) with a figure 8-shaped coil were investigated in 17 healthy subjects with special regard to amplitude and onset latency as a function of the coil position on the head surface. Bilateral reproducible responses could be observed at coil positions mostly varying from approximately 6 to 13 cm lateral to the vertex. During moderate muscle activation, maximum responses were obtained at a mean stimulus position of about I I cm lateral and 3 cm anterior to the vertex with similar onset latencies, but with significantly higher amplitudes on the contralateral side (3.5 +/- 1.9 mV, 9.5 +/- 1.1 ms contralateral; 2.6 +/- 1.5 mV, 9.7 +/- 1.0 ms ipsilateral). Comparing our data on the orbicularis oculi muscle with the results obtained on lower lip muscles, we found a considerable overlap of those coil positions from which reproducible MEPs could be elicited in both groups of target muscles, but the lingual area was placed more laterally. Thus, a statistically significant separation of the cortical representation areas of lingual and lower lip mimetic muscles is possible by focal cortical TMS, reflecting somatotopic organization of the face-associated motor cortex."],["dc.identifier.isi","000180442300014"],["dc.identifier.pmid","12537062"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/46654"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Annals Publ Co"],["dc.relation.issn","0003-4894"],["dc.title","Tongue representation in the lateral cortical motor region of the human brain as assessed by transcranial magnetic stimulation"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]