Lakemeier, Stefan

[["dc.bibliographiccitation.firstpage","585"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Archives of Orthopaedic and Trauma Surgery"],["dc.bibliographiccitation.lastpage","592"],["dc.bibliographiccitation.volume","136"],["dc.contributor.author","Foelsch, Christian"],["dc.contributor.author","Federmann, Maike"],["dc.contributor.author","Lakemeier, Stefan"],["dc.contributor.author","Kuehn, Klaus D."],["dc.contributor.author","Kittinger, Clemens"],["dc.contributor.author","Kerwat, Martina"],["dc.contributor.author","Fuchs-Winkelmann, Susanne"],["dc.contributor.author","Paletta, Juergen R. J."],["dc.contributor.author","Roessler, Philip P."],["dc.date.accessioned","2018-11-07T10:16:24Z"],["dc.date.available","2018-11-07T10:16:24Z"],["dc.date.issued","2016"],["dc.description.abstract","Treatment of implant-associated osteomyelitis regularly involves the use of systemic antibiotics in addition to surgical intervention. However, it remains unclear if perioperative systemic application of bactericide substances can improve overall outcome in models of severe intramedullary infection. The present study investigated the use of systemic gentamicin in addition to a controlled local release from a highly lipophilic gentamicinpalmitate compound while the previous study showed efficacy of sole antibiotic implant-coating. Forty male Sprague-Dawley rats were divided into two groups receiving an intramedullary femoral injection of 10(2) CFU of a common methicillin susceptible Staphylococcus aureus strain (MSSA Rosenbach). Group I received an uncoated implant whereas group II received a coated implant. All animals received a single shot intraperitoneal application of gentamicinsulfate directly after wound closure while the historical control group III (n = 20) had no antibiotic treatment at all. Animals were observed for 28 and 42 days. Serum haptoglobin and relative weight gain were assessed as well as roll over cultures of explanted femur nails and histological scores of periprosthetic infection in dissected femora. Systemic application of gentamicin combined with antibiotic-coated implant did not further reduce bacterial growth significantly compared with systemic or local antibiotic application alone. Combined local and systemic therapy reduced serum haptoglobin significantly after day 7, 28 and 42 whereas systemic application alone did not compare to controls. Systemic perioperative and implant-associated application of antibiotics were both comparably effective to treat implant-associated infections whereas the combined antibiotic therapy further reduced systemic signs of infection time dependent."],["dc.description.sponsorship","Synthes GmbH, Umkirch, Germany"],["dc.identifier.doi","10.1007/s00402-016-2419-7"],["dc.identifier.isi","000373179000020"],["dc.identifier.pmid","26873243"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/41032"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","1434-3916"],["dc.relation.issn","0936-8051"],["dc.title","Systemic antibiotic therapy does not significantly improve outcome in a rat model of implant-associated osteomyelitis induced by Methicillin susceptible Staphylococcus aureus"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","228"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Anesthesia & Analgesia"],["dc.bibliographiccitation.lastpage","235"],["dc.bibliographiccitation.volume","117"],["dc.contributor.author","Lakemeier, Stefan"],["dc.contributor.author","Lind, Marcel"],["dc.contributor.author","Schultz, Wolfgang"],["dc.contributor.author","Fuchs-Winkelmann, Susanne"],["dc.contributor.author","Timmesfeld, Nina"],["dc.contributor.author","Foelsch, Christian"],["dc.contributor.author","Peterlein, Christian D."],["dc.date.accessioned","2018-11-07T09:22:37Z"],["dc.date.available","2018-11-07T09:22:37Z"],["dc.date.issued","2013"],["dc.description.abstract","BACKGROUND: Lumbar facet joint degeneration is a source of chronic low back pain, with an incidence of 15% to 45% among patients with low back pain. Various therapeutic techniques in the treatment of facet-related pain have been described in the literature, including intraarticular lumbar facet joint steroid injections and radiofrequency denervation. In this study, we compared the effectiveness of intraarticular facet joint steroid injections and radiofrequency denervation. METHODS: Our randomized, double-blind, controlled study included patients who received intraarticular steroid infiltrations in the lumbar facet joints (L3/L4-L5/S1) and patients who underwent radiofrequency denervation of L3/L4-L5/S1 segments. The inclusion criteria were based first on magnetic resonance imaging findings showing hypertrophy of the facet joints L3/L4-L5/S1 and a positive response to an intraarticular test infiltration of the facet joints L3/L4-L5/S1 with local anesthetics. The primary end point was the Roland-Morris Questionnaire. Secondary end points were the visual analog scale and the Oswestry Disability Index. All outcome assessments were performed at baseline and at 6 months. RESULTS: Fifty-six patients were randomized; 24 of 29 patients in the steroid injection group and 26 of 27 patients in the denervation group completed the 6-month follow-up. Pain relief and functional improvement were observed in both groups. There were no significant differences between the 2 groups for the primary end point (95% confidence interval [CI], -3 to 4) and for both secondary end points (95% CI for visual analog scale, -2 to 1; 95% CI for Oswestry Disability Index, -18 to 0). CONCLUSIONS: Intraarticular steroid infiltration or radiofrequency denervation appear to be a managing option for chronic function-limiting low back pain of facet origin with favorable short- and midterm results in terms of pain relief and function improvement, but improvements were similar in both groups."],["dc.identifier.doi","10.1213/ANE.0b013e3182910c4d"],["dc.identifier.isi","000326512300034"],["dc.identifier.pmid","23632051"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/29390"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.relation.issn","1526-7598"],["dc.relation.issn","0003-2999"],["dc.title","A Comparison of Intraarticular Lumbar Facet Joint Steroid Injections and Lumbar Facet Joint Radiofrequency Denervation in the Treatment of Low Back Pain: A Randomized, Controlled, Double-Blind Trial"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","400"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Journal of Spinal Disorders & Techniques"],["dc.bibliographiccitation.lastpage","406"],["dc.bibliographiccitation.volume","26"],["dc.contributor.author","Lakemeier, Stefan"],["dc.contributor.author","Schofer, Markus D."],["dc.contributor.author","Foltz, Lisa"],["dc.contributor.author","Schmid, Raphael"],["dc.contributor.author","Efe, Turgay"],["dc.contributor.author","Rohlfs, Jochen"],["dc.contributor.author","Fuchs-Winkelmann, Susanne"],["dc.contributor.author","El-Zayat, Bilal F."],["dc.contributor.author","Paletta, Juergen R. J."],["dc.contributor.author","Foelsch, Christian"],["dc.date.accessioned","2018-11-07T09:19:12Z"],["dc.date.available","2018-11-07T09:19:12Z"],["dc.date.issued","2013"],["dc.description.abstract","Study Design:Immunohistological study.Objective:To elucidate the role of matrix metalloproteinases (MMPs), hypoxia-inducible factor-1 (HIF), and vascular endothelial growth factor (VEGF) in the hypertrophied ligamentum flavum (LF) obtained from patients with lumbar spinal stenosis (LSS).Summary of Background Data:The most common spinal disorder in the elderly is LSS, which results in part from LF hypertrophy. Although prior histologic and immunochemical studies have been performed in this area, the pathophysiology of loss of elasticity and hypertrophy is not completely understood.Methods:LF samples of 38 patients with LSS were harvested during spinal decompression. Twelve LF samples obtained from patients with disk herniation and no visible degeneration on preoperative magnetic resonance imaging were obtained as controls. Samples were dehydrated and paraffin embedded. For immunohistochemical determination of VEGF, HIF, and MMPs 1, 3, and 9 expression, slices were stained with VEGF, HIF, and MMP antibody dilution. Neovessel density and number of elastic fibers were counted after Masson-Goldner staining. LF hypertrophy and cross-sectional area (CSA) were measured on T1-weighted magnetic resonance imaging.Results:MMPs 1, 3, 9 and VEGF expression were significantly increased in the hypertrophy group (P<0.05). HIF expression was negative in both groups. Vessel density was increased in the hypertrophy group, although this was not statistically significant. The number of elastic fibres was significantly higher in the control group. In the hypertrophy group, LF thickness was significantly increased, whereas CSA was significantly decreased. There was a statistical correlation between LF thickness, CSA, MMP, and VEGF expression in the hypertrophy group (P<0.05).Conclusions:LF hypertrophy is accompanied by increased MMPs 1, 3, 9 and VEGF expression. Neovessel density is increased in hypertrophied LF. HIF is not expressed in hypertrophied LF."],["dc.identifier.doi","10.1097/BSD.0b013e3182495b88"],["dc.identifier.isi","000326398500015"],["dc.identifier.pmid","22323068"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/28585"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.relation.issn","1539-2465"],["dc.relation.issn","1536-0652"],["dc.title","Expression of Hypoxia-inducible Factor-1 alpha, Vascular Endothelial Growth Factor, and Matrix Metalloproteinases 1, 3, and 9 in Hypertrophied Ligamentum Flavum"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]