Lakemeier, Stefan

[["dc.bibliographiccitation.firstpage","473"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Biomedical Engineering / Biomedizinische Technik"],["dc.bibliographiccitation.lastpage","480"],["dc.bibliographiccitation.volume","57"],["dc.contributor.author","Foelsch, Christian"],["dc.contributor.author","Goost, Hans"],["dc.contributor.author","Figiel, Jens"],["dc.contributor.author","Paletta, Juergen R. J."],["dc.contributor.author","Schultz, Wolfgang"],["dc.contributor.author","Lakemeier, Stefan"],["dc.date.accessioned","2018-11-07T09:02:38Z"],["dc.date.available","2018-11-07T09:02:38Z"],["dc.date.issued","2012"],["dc.description.abstract","Background: Cement augmentation of pedicle screws increases fixation strength in an osteoporotic spine. This study was designed to determine the cement distribution and the correlation between the pull-out strength of the augmented screw and the cement volume within polyurethane (PU) foam. Methods: Twenty-eight cannulated pedicle screws (6 x 45 mm) (Peter Brehm, Erlangen, Germany) with four holes at the distal end of the screw were augmented with the acrylic Stabilit ER Bone Cement Vertebral Augmentation System (DFine Inc., San Jose, CA, USA) and implanted into open-cell rigid PU foam (Pacific Research Laboratories, Vashon Island, WA, USA) with a density of 0.12 g/cm(3), resembling severe osteoporosis. Volumetric measurement of the cement with consideration of the distribution around the screws was done with multislice computed tomography scan (Somatom Definition, Siemens, Erlangen, Germany). Pull-out strength was tested with a servohydraulic system (MTS System Corporation, Eden Prairie, MN, USA), and nonaugmented screws served as control. Pearson ' s correlation coefficient with significance level a = 0.05 and one-way analysis of variance test were used. Results: We found a high (r = 0.88) and significant (p < 0.01) correlation between the cement volume and the pull-out strength, which increased by more than 5-fold with a volume of 3 ml. The correlation appeared linear at least up to 4 ml cement volume and failure always occurred at the cement-bone interface. The cement distribution was symmetric and circular around the most proximal hole, with a distance of 14 mm from the tip, and nearly 90% of the cement was found 6 mm distal and cranial to it. The 95% confidence interval for the relative amount of cement was 37% -41% within 2 mm of the most proximal hole. Conclusion: Compared with the control, a cement volume between 2.0 and 3.0 ml increased the pull-out strength significantly and is relevant for clinical purposes, whereas a volume of 0.5 ml did not. A cement volume beyond 3.0 ml should further increase the pull-out strength because the correlation was linear at least up to 4.0 ml, but the possibility of in vivo cement leakage with increasing volume has to be considered. Pressure-controlled cement application might be a tool to avoid this complication. The cement almost completely penetrated the most proximal perforation."],["dc.identifier.doi","10.1515/bmt-2012-0012"],["dc.identifier.isi","000312707900007"],["dc.identifier.pmid","23152399"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/10598"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/24730"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Walter De Gruyter & Co"],["dc.relation.issn","0013-5585"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Correlation of pull-out strength of cement-augmented pedicle screws with CT-volumetric measurement of cement"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","292"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Journal of Medical Case Reports"],["dc.bibliographiccitation.volume","9"],["dc.contributor.author","Hammad, Ahmed"],["dc.contributor.author","Leute, Philip J F"],["dc.contributor.author","Hoffmann, Isabel"],["dc.contributor.author","Hoppe, Sebastian"],["dc.contributor.author","Lakemeier, Stefan"],["dc.contributor.author","Klinger, Hans-Michael"],["dc.date.accessioned","2019-07-09T11:42:01Z"],["dc.date.available","2019-07-09T11:42:01Z"],["dc.date.issued","2015"],["dc.description.abstract","Abstract Background Brodie’s abscess is an uncommon form of subacute osteomyelitis where the main presenting symptom is mild to moderate pain of insidious onset for several months’ duration. We report a case of a patient presenting with acute leg pain resembling that of a deep vein thrombosis, and a beginning leg compartment syndrome following a suspected ruptured Baker’s cyst. Our case is unusual because of the acute presentation of the Brodie’s abscess with acute leg pain and acute swelling without any preceding trauma; to the best of our knowledge, this presentation has not been reported before. Case presentation A 17-year-old white boy presented to our out-patient clinic with a 6-month history of pain in his left knee joint of insidious onset. There was no history of trauma to the extremity. After performing physical and radiological (X-ray) examinations, we initially diagnosed medial meniscus damage. One week later he presented to our emergency department with acute sudden increase in the pain and swelling of his left knee, and pain and swelling of his left leg, without any trauma. Deep vein thrombosis and beginning leg compartment syndrome from ruptured Baker’s cyst were initially diagnosed. Magnetic resonance imaging was performed and Brodie’s abscess was the most probable diagnosis. We performed open surgical debridement and curettage with drainage of the abscess and administered postoperative antibiotics. He presented to our out-patient clinic 3 months postoperatively, where he was pain-free with no residual local tenderness. Conclusions In cases of sudden acute increase in joint or extremity pain or swelling that has been insidiously present for months, Brodie’s abscess should be considered as one of the differential diagnoses, as it may present acutely in cases with accompanying fasciitis and myositis and be clinically mistaken for deep vein thrombosis or limb compartment. Magnetic resonance imaging remains the gold standard imaging study, and surgical treatment followed by postoperative antibiotics remains the standard treatment."],["dc.identifier.doi","10.1186/s13256-015-0770-x"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/12658"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/58565"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Acute leg pain with suspected beginning leg compartment syndrome and deep vein thrombosis as differential diagnoses in an unusual presentation of Brodie’s abscess: a case report"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1752"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","Biomolecules"],["dc.bibliographiccitation.volume","11"],["dc.contributor.author","Westhoff, Christina C."],["dc.contributor.author","Peterlein, Christian-Dominik"],["dc.contributor.author","Daniel, Hanna"],["dc.contributor.author","Paletta, Juergen R."],["dc.contributor.author","Moll, Roland"],["dc.contributor.author","Ramaswamy, Annette"],["dc.contributor.author","Lakemeier, Stefan"],["dc.date.accessioned","2022-02-01T10:31:43Z"],["dc.date.available","2022-02-01T10:31:43Z"],["dc.date.issued","2021"],["dc.description.abstract","The most common spinal disorder in elderly is lumbar spinal stenosis (LSS), resulting partly from ligamentum flavum (LF) hypertrophy. Its pathophysiology is not completely understood. The present study wants to elucidate the role of estrogen receptor α (ER α) in fibroblasts of hypertrophied LF. LF samples of 38 patients with LSS were obtained during spinal decompression. Twelve LF samples from patients with disk herniation served as controls. Hematoxylin & Eosin (H&E) and Elastica stains and immunohistochemistry for ER α were performed. The proportions of fibrosis, loss and/or degeneration of elastic fibers and proliferation of collagen fibers were assessed according to the scores of Sairyo and Okuda. Group differences in the ER α and Sairyo and Okuda scores between patients and controls, male and female sex and absence and presence of additional orthopedic diagnoses were assessed with the Mann–Whitney U test. There was a tendency towards higher expression of ER α in LF fibroblasts in the hypertrophy group (p = 0.065). The Sairyo and Okuda scores were more severe for the hypertrophy group but, in general, not statistically relevant. There was no statistically relevant correlation between the expression of ER α and sex (p = 0.326). ER α expression was higher in patients with osteochondrosis but not statistically significant (p = 0.113). In patients with scoliosis, ER α expression was significantly lower (p = 0.044). LF hypertrophy may be accompanied by a higher expression of ER α in fibroblasts. No difference in ER α expression was observed regarding sex. Further studies are needed to clarify the biological and clinical significance of these findings."],["dc.description.abstract","The most common spinal disorder in elderly is lumbar spinal stenosis (LSS), resulting partly from ligamentum flavum (LF) hypertrophy. Its pathophysiology is not completely understood. The present study wants to elucidate the role of estrogen receptor α (ER α) in fibroblasts of hypertrophied LF. LF samples of 38 patients with LSS were obtained during spinal decompression. Twelve LF samples from patients with disk herniation served as controls. Hematoxylin & Eosin (H&E) and Elastica stains and immunohistochemistry for ER α were performed. The proportions of fibrosis, loss and/or degeneration of elastic fibers and proliferation of collagen fibers were assessed according to the scores of Sairyo and Okuda. Group differences in the ER α and Sairyo and Okuda scores between patients and controls, male and female sex and absence and presence of additional orthopedic diagnoses were assessed with the Mann–Whitney U test. There was a tendency towards higher expression of ER α in LF fibroblasts in the hypertrophy group (p = 0.065). The Sairyo and Okuda scores were more severe for the hypertrophy group but, in general, not statistically relevant. There was no statistically relevant correlation between the expression of ER α and sex (p = 0.326). ER α expression was higher in patients with osteochondrosis but not statistically significant (p = 0.113). In patients with scoliosis, ER α expression was significantly lower (p = 0.044). LF hypertrophy may be accompanied by a higher expression of ER α in fibroblasts. No difference in ER α expression was observed regarding sex. Further studies are needed to clarify the biological and clinical significance of these findings."],["dc.identifier.doi","10.3390/biom11121752"],["dc.identifier.pii","biom11121752"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/98931"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-517"],["dc.relation.eissn","2218-273X"],["dc.title","Expression of Estrogen Receptor Alpha and Evaluation of Histological Degeneration Scores in Fibroblasts of Hypertrophied Ligamentum Flavum: A Qualitative Study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1663"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","International Orthopaedics"],["dc.bibliographiccitation.lastpage","1668"],["dc.bibliographiccitation.volume","40"],["dc.contributor.author","Braatz, Frank"],["dc.contributor.author","Staude, Daniel"],["dc.contributor.author","Klotz, Matthias C."],["dc.contributor.author","Wolf, Sebastian I."],["dc.contributor.author","Dreher, Thomas"],["dc.contributor.author","Lakemeier, Stefan"],["dc.date.accessioned","2018-11-07T10:11:07Z"],["dc.date.available","2018-11-07T10:11:07Z"],["dc.date.issued","2016"],["dc.description.abstract","Introduction Neurogenic hip dislocation is quite common in children with cerebral palsy (CP). The purpose of this study was to evaluate the long-term outcome of single-event multilevel surgery (SEMLS) in combination with hip reconstruction by using a periacetabular osteotomy as described by Dega concerning post-operative remodeling and plasticity of the femoral head post-operatively. Methods A total of 72 patients with CP as the primary disease and in whom a complex surgical hip reconstruction was performed during SEMLS between 1998 and 2004 were included in the study. There were 45 men and 27 women, with a median age of 7.6 (4.7-16.3) years at the time SEMLS was performed. The mean follow-up time was 7.7 years (4.9-11.8). X-rays were taken before and after surgery, and Rippstein 1 and 2 were used for follow-up. As the most reliable value for decentration, migration percentage (MP) as described by Reimers was used. To measure hip-joint cover at follow-up, the centre-edge angle was used. The hip was divided into four different categories according to sphericity and congruity. Using this approach, we could evaluate joint remodeling. Results Pre-operatively, the mean MP measured by X-ray was 68 %. Directly after surgery, this value decreased on average by 12 % and at the long-term follow-up was 16.0 % on average. A high rate of incongruence was observed on X-rays taken directly after surgery: 66 hip joints were classified as incongruent. The number of aspherical and incongruent joints decreased to 54 at the follow-up examination. Conclusion Data of our study with high plasticity of the hip joint suggest that even if the femoral head is deformed and a persistent incongruency after surgery is expected, hip reconstruction can be recommended."],["dc.identifier.doi","10.1007/s00264-015-3013-2"],["dc.identifier.isi","000380690500015"],["dc.identifier.pmid","26454662"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/39985"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","1432-5195"],["dc.relation.issn","0341-2695"],["dc.title","Hip-joint congruity after Dega osteotomy in patients with cerebral palsy: long-term results"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","111"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology"],["dc.bibliographiccitation.lastpage","120"],["dc.bibliographiccitation.volume","18"],["dc.contributor.author","Leute, Philip J. F."],["dc.contributor.author","Hoffmann, Isabel"],["dc.contributor.author","Hammad, Ahmed"],["dc.contributor.author","Lakemeier, Stefan"],["dc.contributor.author","Klinger, Hans-Michael"],["dc.contributor.author","Baums, Mike H."],["dc.date.accessioned","2019-02-14T16:50:32Z"],["dc.date.available","2019-02-14T16:50:32Z"],["dc.date.issued","2017"],["dc.description.abstract","Aseptic loosening after total hip arthroplasty is likely related to nicotine ingestion. However, aseptic loosening as a direct consequence of smoking habits has not been described with regard to proximal mega-prosthetic femoral replacement. The aim of the present study was to evaluate the association between nicotine consumption and aseptic loosening rates after proximal mega-prosthetic femoral replacement."],["dc.identifier.doi","10.1007/s10195-016-0426-7"],["dc.identifier.pmid","27535061"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14192"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/57566"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","final"],["dc.relation.eissn","1590-9999"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Nicotine consumption may lead to aseptic loosening in proximal mega-prosthetic femoral replacement"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","359"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Acta Neurochirurgica"],["dc.bibliographiccitation.lastpage","365"],["dc.bibliographiccitation.volume","154"],["dc.contributor.author","Lakemeier, Stefan"],["dc.contributor.author","Schmid, Raphael"],["dc.contributor.author","Foltz, Lisa"],["dc.contributor.author","Rohlfs, Jochen"],["dc.contributor.author","Fuchs-Winkelmann, Susanne"],["dc.contributor.author","Efe, Turgay"],["dc.contributor.author","Foelsch, Christian"],["dc.contributor.author","Paletta, Jürgen R. J."],["dc.date.accessioned","2019-07-09T11:54:37Z"],["dc.date.available","2019-07-09T11:54:37Z"],["dc.date.issued","2011"],["dc.description.abstract","Background The most common spinal disorder in the elderly is lumbar spinal stenosis (LSS), which results in part from ligamentum flavum (LF) hypertrophy. Although prior histologic and immunochemical studies have been performed in this area, the pathophysiology of loss of elasticity and hypertrophy is not completely understood. The purpose of this immunohistological study is to elucidate the role of CD44 and its splice variants CD44v5 and CD44v6 in the hypertrophied LF obtained from patients with lumbar spinal stenosis (LSS). Materials and methods LF samples of 38 patients with LSS were harvested during spinal decompression. Twelve LF samples obtained from patients with disc herniation and no visible degeneration on preoperative MRI were obtained as controls. Samples were dehydrated and embedded in paraffin. For immunohistochemical determination, slices were stained with antibodies against CD44, Cd44v4, and CD44v6 stained with DAB. LF hypertrophy and cross-sectional area (CSA) were measured with T1-weighted MRI. Results CD44 and CD44v5 expression were significantly increased in the hypertrophy group (p<0.05). CD44v6 expression was not significantly increased. The number of elastic fibers was significantly higher in the hypertrophy group. In the hypertrophy group, LF thickness was significantly increased while CSA was significantly decreased. There was a statistical correlation between LF thickness, CSA, CD44, and CD44v5 expression in the hypertrophy group (p<0.05). Conclusions LF hypertrophy is accompanied by increased CD44 and CD44v5 expression. CD44v6 expression is not enhanced in LF hypertrophy."],["dc.format.extent","7"],["dc.identifier.doi","10.1007/s00701-011-1206-z"],["dc.identifier.fs","593532"],["dc.identifier.pmid","22052472"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/9467"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/60696"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","0942-0940"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Increased expression of CD44 in hypertrophied ligamentum flavum and relevance of splice variants CD44v5 and CD44v6"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","111"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Archives of Orthopaedic and Trauma Surgery"],["dc.bibliographiccitation.lastpage","118"],["dc.bibliographiccitation.volume","135"],["dc.contributor.author","Baums, M. H."],["dc.contributor.author","Schminke, B."],["dc.contributor.author","Posmyk, A."],["dc.contributor.author","Miosge, N."],["dc.contributor.author","Klinger, H.-M."],["dc.contributor.author","Lakemeier, S."],["dc.date.accessioned","2018-08-20T12:33:19Z"],["dc.date.available","2018-08-20T12:33:19Z"],["dc.date.issued","2015"],["dc.description.abstract","The clinical superiority of the double-row technique is still a subject of controversial debate in rotator cuff repair. We hypothesised that the expression of different collagen types will differ between double-row and single-row rotator cuff repair indicating a faster healing response by the double-row technique."],["dc.identifier.doi","10.1007/s00402-014-2118-1"],["dc.identifier.pmid","25416099"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/15438"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation.eissn","1434-3916"],["dc.relation.eissn","0936-8051"],["dc.title","Effect of single- and double-row rotator cuff repair at the tendon-to-bone interface"],["dc.title.subtitle","Preliminary results using an in vivo sheep model"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","335"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","PM&R"],["dc.bibliographiccitation.lastpage","341"],["dc.bibliographiccitation.volume","4"],["dc.contributor.author","Foelsch, Christian"],["dc.contributor.author","Schloegel, Stefanie"],["dc.contributor.author","Lakemeier, Stefan"],["dc.contributor.author","Wolf, Udo"],["dc.contributor.author","Timmesfeld, Nina"],["dc.contributor.author","Skwara, Adrian"],["dc.date.accessioned","2018-11-07T09:10:33Z"],["dc.date.available","2018-11-07T09:10:33Z"],["dc.date.issued","2012"],["dc.description.abstract","Objective: To explore the reliability of the Zebris CMS 20 ultrasound analysis system with pointer application for measuring end-range flexion, end-range extension, and neutral kyphosis angle of the thoracic spine. Setting: The study was performed within the School of Physiotherapy in cooperation with the Orthopedic Department at a University Hospital. Participants: The thoracic spines of 28 healthy subjects were measured. Methods: Measurements for neutral kyphosis angle, end-range flexion, and end-range extension were taken once at each time point. The bone landmarks were palpated by one examiner and marked with a pointer containing 2 transmitters using a frequency of 40 kHz. A third transmitter was fixed to the pelvis, and 3 microphones were used as receiver. The real angle was calculated by the software. Bland-Altman plots with 95% limits of agreement, intraclass correlations (ICC), standard deviations of mean measurements, and standard error of measurements were used for statistical analyses. The test-retest reliability in this study was measured within a 24-hour interval. Main Outcome Measurements: Statistical parameters were used to judge reliability. Results: The mean kyphosis angle was 44.8 degrees with a standard deviation of 17.3 degrees at the first measurement and a mean of 45.8 degrees with a standard deviation of 16.2 degrees the following day. The ICC was high at 0.95 for the neutral kyphosis angle, and the Bland-Altman 95% limits of agreement were within clinical acceptable margins. The ICC was 0.71 for end-range flexion and 0.34 for end-range extension, whereas the Bland-Altman 95% limits of agreement were wider than with the static measurement of kyphosis. Compared with static measurements, the analysis of motion with 3-dimensional ultrasound showed an increased standard deviation for test-retest measurements. Conclusions: The test-retest reliability of ultrasound measuring of the neutral kyphosis angle of the thoracic spine was demonstrated within 24 hours. Bland-Altman 95% limits of agreement and the standard deviation of differences did not appear to be clinically acceptable for measuring flexion and extension. PM R 2012;4:335-341"],["dc.identifier.doi","10.1016/j.pmrj.2012.01.009"],["dc.identifier.isi","000305872800003"],["dc.identifier.pmid","22464951"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/26518"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Inc"],["dc.relation.issn","1934-1482"],["dc.title","Test-Retest Reliability of 3D Ultrasound Measurements of the Thoracic Spine"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","22"],["dc.bibliographiccitation.journal","Journal of medical case reports"],["dc.bibliographiccitation.volume","9"],["dc.contributor.author","Leute, Philip Johannes Felix"],["dc.contributor.author","Hammad, Ahmed"],["dc.contributor.author","Hoffmann, Isabel"],["dc.contributor.author","Hoppe, Sebastian"],["dc.contributor.author","Klinger, Hans-Michael"],["dc.contributor.author","Lakemeier, Stefan"],["dc.date.accessioned","2019-07-09T11:42:26Z"],["dc.date.available","2019-07-09T11:42:26Z"],["dc.date.issued","2015"],["dc.description.abstract","INTRODUCTION: Transforaminal lumbar interbody fusion is a popular procedure used to achieve spondylodesis in patients with degenerative lumbar spinal diseases. We present a rare case of a patient with a set screw fracture with cage dislocation after an open transforaminal lumbar interbody fusion procedure. To the best of our knowledge, this case is the first of its kind to be reported. CASE PRESENTATION: A 44-year-old Caucasian woman attended a follow-up appointment at our hospital 3 months after treatment for second-degree lumbar spondylolisthesis (L4/L5) and osteochondrosis (L5/S1) with transforaminal lumbar interbody fusion and dorsal spondylodesis. She complained of severe leg pain on the left side. Her physical examination revealed a normal neurological status, except for paresthesia of the entire left lower limb and at the ball of the left foot. Radiological imaging showed breaking of the set screws with cage dislocation. Surgical revision was then performed with exchange of the whole dorsal instrumentation and the dislocated cage. Six weeks post-operatively, the patient was seen again at our clinic without neurological complaints, except for decreased sensitivity on the dorsum of her left foot. The wound healing and radiological follow-up were uneventful. CONCLUSIONS: Hardware-related complications are rarely seen in patients with open transforaminal lumbar interbody fusion, but must be kept in mind and can potentially cause severe neurological deficits."],["dc.format.extent","6"],["dc.identifier.doi","10.1186/1752-1947-9-22"],["dc.identifier.pmid","25609204"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/13451"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/58669"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","1752-1947"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.subject.mesh","Adult"],["dc.subject.mesh","Bone Screws"],["dc.subject.mesh","Female"],["dc.subject.mesh","Foreign-Body Migration"],["dc.subject.mesh","Humans"],["dc.subject.mesh","Lumbar Vertebrae"],["dc.subject.mesh","Reoperation"],["dc.subject.mesh","Spinal Fusion"],["dc.subject.mesh","Spondylolisthesis"],["dc.subject.mesh","Treatment Outcome"],["dc.title","Set screw fracture with cage dislocation after two-level transforaminal lumbar interbody fusion (TLIF): a case report."],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","585"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Archives of Orthopaedic and Trauma Surgery"],["dc.bibliographiccitation.lastpage","592"],["dc.bibliographiccitation.volume","136"],["dc.contributor.author","Foelsch, Christian"],["dc.contributor.author","Federmann, Maike"],["dc.contributor.author","Lakemeier, Stefan"],["dc.contributor.author","Kuehn, Klaus D."],["dc.contributor.author","Kittinger, Clemens"],["dc.contributor.author","Kerwat, Martina"],["dc.contributor.author","Fuchs-Winkelmann, Susanne"],["dc.contributor.author","Paletta, Juergen R. J."],["dc.contributor.author","Roessler, Philip P."],["dc.date.accessioned","2018-11-07T10:16:24Z"],["dc.date.available","2018-11-07T10:16:24Z"],["dc.date.issued","2016"],["dc.description.abstract","Treatment of implant-associated osteomyelitis regularly involves the use of systemic antibiotics in addition to surgical intervention. However, it remains unclear if perioperative systemic application of bactericide substances can improve overall outcome in models of severe intramedullary infection. The present study investigated the use of systemic gentamicin in addition to a controlled local release from a highly lipophilic gentamicinpalmitate compound while the previous study showed efficacy of sole antibiotic implant-coating. Forty male Sprague-Dawley rats were divided into two groups receiving an intramedullary femoral injection of 10(2) CFU of a common methicillin susceptible Staphylococcus aureus strain (MSSA Rosenbach). Group I received an uncoated implant whereas group II received a coated implant. All animals received a single shot intraperitoneal application of gentamicinsulfate directly after wound closure while the historical control group III (n = 20) had no antibiotic treatment at all. Animals were observed for 28 and 42 days. Serum haptoglobin and relative weight gain were assessed as well as roll over cultures of explanted femur nails and histological scores of periprosthetic infection in dissected femora. Systemic application of gentamicin combined with antibiotic-coated implant did not further reduce bacterial growth significantly compared with systemic or local antibiotic application alone. Combined local and systemic therapy reduced serum haptoglobin significantly after day 7, 28 and 42 whereas systemic application alone did not compare to controls. Systemic perioperative and implant-associated application of antibiotics were both comparably effective to treat implant-associated infections whereas the combined antibiotic therapy further reduced systemic signs of infection time dependent."],["dc.description.sponsorship","Synthes GmbH, Umkirch, Germany"],["dc.identifier.doi","10.1007/s00402-016-2419-7"],["dc.identifier.isi","000373179000020"],["dc.identifier.pmid","26873243"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/41032"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","1434-3916"],["dc.relation.issn","0936-8051"],["dc.title","Systemic antibiotic therapy does not significantly improve outcome in a rat model of implant-associated osteomyelitis induced by Methicillin susceptible Staphylococcus aureus"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]