Kuo, Hsiao-I

[["dc.bibliographiccitation.firstpage","1273"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","The Journal of Physiology"],["dc.bibliographiccitation.lastpage","1288"],["dc.bibliographiccitation.volume","595"],["dc.contributor.author","Jamil, Asif"],["dc.contributor.author","Batsikadze, Giorgi"],["dc.contributor.author","Kuo, Hsiao-I."],["dc.contributor.author","Labruna, Ludovica"],["dc.contributor.author","Hasan, Alkomiet"],["dc.contributor.author","Paulus, Walter"],["dc.contributor.author","Nitsche, Michael A."],["dc.date.accessioned","2020-12-10T18:36:34Z"],["dc.date.available","2020-12-10T18:36:34Z"],["dc.date.issued","2017"],["dc.description.abstract","Contemporary non-invasive neuromodulatory techniques, such as transcranial direct current stimulation (tDCS), have shown promising potential in both restituting impairments in cortical physiology in clinical settings, as well as modulating cognitive abilities in the healthy population. However, neuroplastic after-effects of tDCS are highly dependent on stimulation parameters, relatively short lasting, and not expectedly uniform between individuals. The present study systematically investigates the full range of current intensity between 0.5 and 2.0mA on left primary motor cortex (M1) plasticity, as well as the impact of individual-level covariates on explaining inter-individual variability. Thirty-eight healthy subjects were divided into groups of anodal and cathodal tDCS. Five DC intensities (sham, 0.5, 1.0, 1.5 and 2.0mA) were investigated in separate sessions. Using transcranial magnetic stimulation (TMS), 25 motor-evoked potentials (MEPs) were recorded before, and 10 time points up to 2h following 15min of tDCS. Repeated-measures ANOVAs indicated a main effect of intensity for both anodal and cathodal tDCS. With anodal tDCS, all active intensities resulted in equivalent facilitatory effects relative to sham while for cathodal tDCS, only 1.0mA resulted in sustained excitability diminution. An additional experiment conducted to assess intra-individual variability revealed generally good reliability of 1.0mA anodal tDCS (ICC(2,1)=0.74 over the first 30min). A post hoc analysis to discern sources of inter-individual variability confirmed a previous finding in which individual TMS SI1mV (stimulus intensity for 1mV MEP amplitude) sensitivity correlated negatively with 1.0mA anodal tDCS effects on excitability. Our study thus provides further insights on the extent of non-linear intensity-dependent neuroplastic after-effects of anodal and cathodal tDCS."],["dc.identifier.doi","10.1113/JP272738"],["dc.identifier.isi","000394581400030"],["dc.identifier.issn","0022-3751"],["dc.identifier.pmid","27723104"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/76672"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Wiley"],["dc.relation.issn","1469-7793"],["dc.relation.issn","0022-3751"],["dc.title","Systematic evaluation of the impact of stimulation intensity on neuroplastic after-effects induced by transcranial direct current stimulation"],["dc.title.alternative","Effects of DC intensity on cortical excitability"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","644"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Brain Stimulation"],["dc.bibliographiccitation.lastpage","648"],["dc.bibliographiccitation.volume","6"],["dc.contributor.author","Kuo, Hsiao-I."],["dc.contributor.author","Bikson, Marom"],["dc.contributor.author","Datta, Abhishek"],["dc.contributor.author","Minhas, Preet"],["dc.contributor.author","Paulus, Walter J."],["dc.contributor.author","Kuo, Mm-Fang"],["dc.contributor.author","Nitsche, Michael A."],["dc.date.accessioned","2018-11-07T09:22:54Z"],["dc.date.available","2018-11-07T09:22:54Z"],["dc.date.issued","2013"],["dc.description.abstract","Background: Transcranial direct current stimulation (tDCS) induces long-lasting NMDA receptor-dependent cortical plasticity via persistent subthreshold polarization of neuronal membranes. Conventional bipolar tDCS is applied with two large (35 cm(2)) rectangular electrodes, resulting in directional modulation of neuronal excitability. Recently a newly designed 4 x 1 high-definition (HD) tDCS protocol was proposed for more focal stimulation according to the results of computational modeling. HD tDCS utilizes small disc electrodes deployed in 4 x 1 ring configuration whereby the physiological effects of the induced electric field are thought to be grossly constrained to the cortical area circumscribed by the ring. Objective: We aim to compare the physiological effects of both tDCS electrode arrangements on motor cortex excitability. Methods: tDCS was applied with 2 mA for 10 min. Fourteen healthy subjects participated, and motor cortex excitability was monitored by transcranial magnetic stimulation (TMS) before and after tDCS. Results: Excitability enhancement following anodal and a respective reduction after cathodal stimulation occurred in both, conventional and HD tDCS. However, the plastic changes showed a more delayed peak at 30 min and longer lasting after-effects for more than 2 h after HD tDCS for both polarities, as compared to conventional tDCS. Conclusion: The results show that this new electrode arrangement is efficient for the induction of neuroplasticity in the primary motor cortex. The pattern of aftereffects might be compatible with the concept of GABA-mediated surround inhibition, which should be explored in future studies directly. (C) 2013 Elsevier Inc. All rights reserved."],["dc.identifier.doi","10.1016/j.brs.2012.09.010"],["dc.identifier.isi","000322292600025"],["dc.identifier.pmid","23149292"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/29449"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Inc"],["dc.relation.issn","1935-861X"],["dc.title","Comparing Cortical Plasticity Induced by Conventional and High-Definition 4 x 1 Ring tDCS: A Neurophysiological Study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1223"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Neuropsychopharmacology"],["dc.bibliographiccitation.lastpage","1230"],["dc.bibliographiccitation.volume","41"],["dc.contributor.author","Kuo, Hsiao-I"],["dc.contributor.author","Paulus, Walter"],["dc.contributor.author","Batsikadze, Giorgi"],["dc.contributor.author","Jamil, Asif"],["dc.contributor.author","Kuo, Min-Fang"],["dc.contributor.author","Nitsche, Michael A."],["dc.date.accessioned","2018-10-10T11:05:50Z"],["dc.date.available","2018-10-10T11:05:50Z"],["dc.date.issued","2016"],["dc.description.abstract","Serotonin affects memory formation via modulating long-term potentiation (LTP) and depression (LTD). Accordingly, acute selective serotonin reuptake inhibitor (SSRI) administration enhanced LTP-like plasticity induced by transcranial direct current stimulation (tDCS) in humans. However, it usually takes some time for SSRI to reduce clinical symptoms such as anxiety, negative mood, and related symptoms of depression and anxiety disorders. This might be related to an at least partially different effect of chronic serotonergic enhancement on plasticity, as compared with single-dose medication. Here we explored the impact of chronic application of the SSRI citalopram (CIT) on plasticity induced by tDCS in healthy humans in a partially double-blinded, placebo (PLC)-controlled, randomized crossover study. Furthermore, we explored the dependency of plasticity induction from the glutamatergic system via N-methyl-D-aspartate receptor antagonism. Twelve healthy subjects received PLC medication, combined with anodal or cathodal tDCS of the primary motor cortex. Afterwards, the same subjects took CIT (20 mg/day) consecutively for 35 days. During this period, four additional interventions were performed (CIT and PLC medication with anodal/cathodal tDCS, CIT and dextromethorphan (150 mg) with anodal/cathodal tDCS). Plasticity was monitored by motor-evoked potential amplitudes elicited by transcranial magnetic stimulation. Chronic application of CIT increased and prolonged the LTP-like plasticity induced by anodal tDCS for over 24 h, and converted cathodal tDCS-induced LTD-like plasticity into facilitation. These effects were abolished by dextromethorphan. Chronic serotonergic enhancement results in a strengthening of LTP-like glutamatergic plasticity, which might partially explain the therapeutic impact of SSRIs in depression and other neuropsychiatric diseases."],["dc.identifier.doi","10.1038/npp.2015.270"],["dc.identifier.pmid","26329381"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/15950"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation.issn","1740-634X"],["dc.title","Chronic Enhancement of Serotonin Facilitates Excitatory Transcranial Direct Current Stimulation-Induced Neuroplasticity"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1305"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","The Journal of Physiology"],["dc.bibliographiccitation.lastpage","1314"],["dc.bibliographiccitation.volume","595"],["dc.contributor.author","Kuo, Hsiao-I."],["dc.contributor.author","Paulus, Walter"],["dc.contributor.author","Batsikadze, Giorgi"],["dc.contributor.author","Jamil, Asif"],["dc.contributor.author","Kuo, Min-Fang"],["dc.contributor.author","Nitsche, Michael A."],["dc.date.accessioned","2020-12-10T18:36:34Z"],["dc.date.available","2020-12-10T18:36:34Z"],["dc.date.issued","2017"],["dc.description.abstract","Chronic administration of the selective noradrenaline reuptake inhibitor (NRI) reboxetine (RBX) increased and prolonged the long-term potentiation-like plasticity induced by anodal transcranial direct current stimulation (tDCS) for over 24 h. Chronic administration of RBX converted cathodal tDCS-induced long-term depression-like plasticity into facilitation for 120 min. Chronic noradrenergic activity enhancement on plasticity of the human brain might partially explain the delayed therapeutic impact of selective NRIs in depression and other neuropsychiatric diseases."],["dc.identifier.doi","10.1113/JP273137"],["dc.identifier.issn","0022-3751"],["dc.identifier.pmid","27925214"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/76673"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.status","final"],["dc.relation.issn","1469-7793"],["dc.title","Acute and chronic effects of noradrenergic enhancement on transcranial direct current stimulation-induced neuroplasticity in humans"],["dc.title.alternative","Long-term impact of noradrenaline on neuroplasticity"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1644"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Human Brain Mapping"],["dc.bibliographiccitation.lastpage","1666"],["dc.bibliographiccitation.volume","41"],["dc.contributor.author","Jamil, Asif"],["dc.contributor.author","Batsikadze, Giorgi"],["dc.contributor.author","Kuo, Hsiao‐I."],["dc.contributor.author","Meesen, Raf L. J."],["dc.contributor.author","Dechent, Peter"],["dc.contributor.author","Paulus, Walter"],["dc.contributor.author","Nitsche, Michael A."],["dc.date.accessioned","2021-04-14T08:26:55Z"],["dc.date.available","2021-04-14T08:26:55Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1002/hbm.24901"],["dc.identifier.eissn","1097-0193"],["dc.identifier.issn","1065-9471"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/82112"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","1097-0193"],["dc.relation.issn","1065-9471"],["dc.title","Current intensity‐ and polarity‐specific online and aftereffects of transcranial direct current stimulation: An fMRI study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","634"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","The International Journal of Neuropsychopharmacology"],["dc.bibliographiccitation.lastpage","643"],["dc.bibliographiccitation.volume","20"],["dc.contributor.author","Kuo, Hsiao-I."],["dc.contributor.author","Paulus, Walter"],["dc.contributor.author","Batsikadze, Giorgi"],["dc.contributor.author","Jamil, Asif"],["dc.contributor.author","Kuo, Min-Fang"],["dc.contributor.author","Nitsche, Michael A."],["dc.date.accessioned","2019-07-09T11:43:50Z"],["dc.date.available","2019-07-09T11:43:50Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1093/ijnp/pyx026"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14694"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/58979"],["dc.notes.intern","Merged from goescholar"],["dc.rights","CC BY-ND 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nd/4.0"],["dc.title","Acute and Chronic Noradrenergic Effects on Cortical Excitability in Healthy Humans"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","490"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","International Journal of Neuropsychopharmacology"],["dc.bibliographiccitation.lastpage","498"],["dc.bibliographiccitation.volume","24"],["dc.contributor.author","Kuo, Hsiao-I"],["dc.contributor.author","Qi, Feng-Xue"],["dc.contributor.author","Paulus, Walter"],["dc.contributor.author","Kuo, Min-Fang"],["dc.contributor.author","Nitsche, Michael A"],["dc.date.accessioned","2021-09-01T06:42:10Z"],["dc.date.available","2021-09-01T06:42:10Z"],["dc.date.issued","2021"],["dc.description.abstract","Abstract Background Noradrenaline has an important role as a neuromodulator of the central nervous system. Noradrenergic enhancement was recently shown to enhance glutamate-dependent cortical facilitation and long term potentiation-like plasticity. As cortical excitability and plasticity are closely linked to various cognitive processes, here we aimed to explore whether these alterations are associated with respective cognitive performance changes. Specifically, we assessed the impact of noradrenergic enhancement on motor learning (serial reaction time task), attentional processes (Stroop interference task), and working memory performance (n-back letter task). Methods The study was conducted in a cross-over design. Twenty-five healthy humans performed the respective cognitive tasks after a single dose of the noradrenaline reuptake inhibitor reboxetine or placebo administration. Results The results show that motor learning, attentional processes, and working memory performance in healthy participants were improved by reboxetine application compared with placebo. Conclusions The results of the present study thus suggest that noradrenergic enhancement can improve memory formation and executive functions in healthy humans. The respective changes are in line with related effects of noradrenaline on cortical excitability and plasticity."],["dc.description.abstract","Abstract Background Noradrenaline has an important role as a neuromodulator of the central nervous system. Noradrenergic enhancement was recently shown to enhance glutamate-dependent cortical facilitation and long term potentiation-like plasticity. As cortical excitability and plasticity are closely linked to various cognitive processes, here we aimed to explore whether these alterations are associated with respective cognitive performance changes. Specifically, we assessed the impact of noradrenergic enhancement on motor learning (serial reaction time task), attentional processes (Stroop interference task), and working memory performance (n-back letter task). Methods The study was conducted in a cross-over design. Twenty-five healthy humans performed the respective cognitive tasks after a single dose of the noradrenaline reuptake inhibitor reboxetine or placebo administration. Results The results show that motor learning, attentional processes, and working memory performance in healthy participants were improved by reboxetine application compared with placebo. Conclusions The results of the present study thus suggest that noradrenergic enhancement can improve memory formation and executive functions in healthy humans. The respective changes are in line with related effects of noradrenaline on cortical excitability and plasticity."],["dc.identifier.doi","10.1093/ijnp/pyab006"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/88995"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-455"],["dc.relation.eissn","1469-5111"],["dc.relation.issn","1461-1457"],["dc.title","Noradrenergic Enhancement of Motor Learning, Attention, and Working Memory in Humans"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]