Ghosh, Sajal Kumar

[["dc.bibliographiccitation.artnumber","041014"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Physical Review X"],["dc.bibliographiccitation.volume","6"],["dc.contributor.author","Abbott, B. P."],["dc.contributor.author","Abbott, R."],["dc.contributor.author","Abbott, T. D."],["dc.contributor.author","Abernathy, M. R."],["dc.contributor.author","Acernese, F."],["dc.contributor.author","Ackley, K."],["dc.contributor.author","Adams, C."],["dc.contributor.author","Adams, T."],["dc.contributor.author","Addesso, P."],["dc.contributor.author","Adhikari, R. X."],["dc.contributor.author","Chao, S."],["dc.contributor.author","Chen, Y."],["dc.contributor.author","Chung, S."],["dc.contributor.author","Dent, T."],["dc.contributor.author","Ghosh, S."],["dc.contributor.author","Gras, S."],["dc.contributor.author","Huang, S."],["dc.contributor.author","Karki, S."],["dc.contributor.author","Khan, S."],["dc.contributor.author","Munch, J."],["dc.contributor.author","Nguyen, T. T."],["dc.contributor.author","Oliver, M."],["dc.contributor.author","Qin, J."],["dc.contributor.author","Schmidt, J."],["dc.contributor.author","Singh, A."],["dc.contributor.author","Thomas, M."],["dc.contributor.author","Thomas, P."],["dc.contributor.author","Wang, H."],["dc.contributor.author","Wang, Y."],["dc.contributor.author","Westphal, T."],["dc.contributor.author","Zhang, M."],["dc.contributor.author","Zhang, Y."],["dc.contributor.author","Röver, C."],["dc.contributor.author","De, S."],["dc.date.accessioned","2016-11-04T09:18:28Z"],["dc.date.accessioned","2021-10-27T13:20:48Z"],["dc.date.available","2016-11-04T09:18:28Z"],["dc.date.available","2021-10-27T13:20:48Z"],["dc.date.issued","2016"],["dc.identifier.doi","10.1103/PhysRevX.6.041014"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/13828"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/91981"],["dc.language.iso","en"],["dc.notes.intern","Migrated from goescholar"],["dc.relation.issn","2160-3308"],["dc.relation.orgunit","Universitätsmedizin Göttingen"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Improved analysis of GW150914 using a fully spin-precessing waveform model"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2633"],["dc.bibliographiccitation.issue","14"],["dc.bibliographiccitation.journal","ChemPhysChem"],["dc.bibliographiccitation.lastpage","2640"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Ghosh, Sajal Kumar"],["dc.contributor.author","Aeffner, Sebastian"],["dc.contributor.author","Salditt, Tim"],["dc.date.accessioned","2017-09-07T11:43:23Z"],["dc.date.available","2017-09-07T11:43:23Z"],["dc.date.issued","2011"],["dc.description.abstract","Phosphatidylinositol 4,5-bis-phosphate (PIP2) is an important lipid in regulation of several cellular processes, particularly membrane fusion. We use X-ray diffraction from solid-supported multilamellar 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC)/PIP2 samples to study changes in bilayer structure and the lyotropic phase behavior induced by physiologically relevant concentrations of PIP2. Electron-density profiles reconstructed from X-ray reflectivity measurements indicate that PIP2 strongly affects structural parameters such as lipid head-group width, bilayer thickness, and lamellar repeat spacing of DOPC bilayer stacks. In addition, at lower degrees of hydration, a few molar per cent of PIP2 facilitates stalk-phase formation and also leads to formation of a hexagonal phase, which is not observed in pure DOPC. These results indicate that the role of PIP2 in membrane fusion could be, in part, due to its effect on the properties of the lipid bilayer matrix. Furthermore, coexistence of two lamellar phases with different lattice constants is observed in single-component PIP2 samples."],["dc.identifier.doi","10.1002/cphc.201100154"],["dc.identifier.gro","3142652"],["dc.identifier.isi","000295252900021"],["dc.identifier.pmid","21826776"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/79"],["dc.language.iso","en"],["dc.notes.intern","WoS Import 2017-03-10"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation.issn","1439-4235"],["dc.relation.orgunit","Institut für Röntgenphysik"],["dc.relation.workinggroup","RG Salditt (Structure of Biomolecular Assemblies and X-Ray Physics)"],["dc.subject.gro","x-ray scattering"],["dc.subject.gro","membrane biophysics"],["dc.title","Effect of PIP2 on Bilayer Structure and Phase Behavior of DOPC: An X-ray Scattering Study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","012015"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Journal of Physics: Conference Series"],["dc.bibliographiccitation.volume","247"],["dc.contributor.affiliation","S Castorph, ; 1Institut für Röntgenphysik, Georg-August-Universität Göttingen, Göttingen, D"],["dc.contributor.affiliation","L Arleth, ; 2Biophysics, Faculty of Life Sciences, University of Copenhagen, Frederiksberg, DK"],["dc.contributor.affiliation","M Sztucki, ; 3European Synchrotron Radiation Facility, Grenoble, F"],["dc.contributor.affiliation","U Vainio, ; 4Hamburger Synchrotronstrahlungslabor at Deutsches Elektronen-Synchrotron, Hamburg, D"],["dc.contributor.affiliation","S K Ghosh, ; 1Institut für Röntgenphysik, Georg-August-Universität Göttingen, Göttingen, D"],["dc.contributor.affiliation","M Holt, ; 5Max Planck Institut für Biophysikalische Chemie, Department of Neurobiology, Göttingen, D"],["dc.contributor.affiliation","R Jahn, ; 5Max Planck Institut für Biophysikalische Chemie, Department of Neurobiology, Göttingen, D"],["dc.contributor.affiliation","T Salditt, ; 1Institut für Röntgenphysik, Georg-August-Universität Göttingen, Göttingen, D"],["dc.contributor.author","Castorph, Simon"],["dc.contributor.author","Arleth, Lise"],["dc.contributor.author","Sztucki, Michael"],["dc.contributor.author","Vainio, Ulla"],["dc.contributor.author","Ghosh, S. K."],["dc.contributor.author","Holt, M."],["dc.contributor.author","Jahn, Reinhard"],["dc.contributor.author","Salditt, Tim"],["dc.date.accessioned","2017-09-07T11:54:07Z"],["dc.date.available","2017-09-07T11:54:07Z"],["dc.date.issued","2010"],["dc.date.updated","2022-02-18T08:56:36Z"],["dc.description.abstract","We discuss different spherically symmetric and anisotropic form factor models and test them against high resolution synchrotron based small-angle x-ray scattering (SAXS) data from synaptic vesicles (SVs), isolated from rat brain. Anisotropy of the model form factors is found to be a key ingredient for the description of the native synaptic vesicle structure. We describe changes in structural parameters due to protease digestion of SVs, and present SAXS data of SVs recorded under different pH conditions."],["dc.identifier.doi","10.1088/1742-6596/247/1/012015"],["dc.identifier.fs","581310"],["dc.identifier.gro","3145120"],["dc.identifier.issn","1742-6596"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/7197"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/2821"],["dc.language.iso","en"],["dc.notes.intern","Crossref Import"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.relation.issn","1742-6596"],["dc.relation.orgunit","Institut für Röntgenphysik"],["dc.relation.orgunit","Fakultät für Physik"],["dc.relation.workinggroup","RG Salditt (Structure of Biomolecular Assemblies and X-Ray Physics)"],["dc.rights.uri","https://publishingsupport.iopscience.iop.org/open_access/"],["dc.subject.gro","x-ray scattering"],["dc.subject.gro","neuro biophysics"],["dc.title","Synaptic Vesicles Studied by SAXS: Derivation and Validation of a Model Form Factor"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","no"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","241102"],["dc.bibliographiccitation.issue","24"],["dc.bibliographiccitation.journal","Physical Review Letters"],["dc.bibliographiccitation.volume","116"],["dc.contributor.author","Abbott, B. P."],["dc.contributor.author","Abbott, R."],["dc.contributor.author","Abbott, T. D."],["dc.contributor.author","Abernathy, M. R."],["dc.contributor.author","Acernese, F."],["dc.contributor.author","Ackley, K."],["dc.contributor.author","Adams, C."],["dc.contributor.author","Adams, T."],["dc.contributor.author","Addesso, P."],["dc.contributor.author","Adhikari, R. X."],["dc.contributor.author","Chao, S."],["dc.contributor.author","Chen, Y."],["dc.contributor.author","Chung, S."],["dc.contributor.author","Dent, T."],["dc.contributor.author","Franco, S."],["dc.contributor.author","Fricke, T. T."],["dc.contributor.author","Ghosh, S."],["dc.contributor.author","Gras, S."],["dc.contributor.author","Huang, S."],["dc.contributor.author","Karki, S."],["dc.contributor.author","Khan, S."],["dc.contributor.author","Kim, C."],["dc.contributor.author","Munch, J."],["dc.contributor.author","Nguyen, T. T."],["dc.contributor.author","Oliver, M."],["dc.contributor.author","Qin, J."],["dc.contributor.author","Röver, C."],["dc.contributor.author","Schmidt, J."],["dc.contributor.author","Shah, S."],["dc.contributor.author","Singh, A."],["dc.contributor.author","Thomas, M."],["dc.contributor.author","Thomas, P."],["dc.contributor.author","Wang, H."],["dc.contributor.author","Wang, Y."],["dc.contributor.author","Westphal, T."],["dc.contributor.author","Zhang, M."],["dc.contributor.author","Zhang, Y."],["dc.date.accessioned","2016-06-16T20:22:30Z"],["dc.date.accessioned","2021-10-27T13:20:31Z"],["dc.date.available","2016-06-16T20:22:30Z"],["dc.date.available","2021-10-27T13:20:31Z"],["dc.date.issued","2016"],["dc.identifier.doi","10.1103/PhysRevLett.116.241102"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/13362"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/91969"],["dc.language.iso","en"],["dc.notes.intern","Migrated from goescholar"],["dc.relation.issn","1079-7114"],["dc.relation.issn","0031-9007"],["dc.relation.orgunit","Universitätsmedizin Göttingen"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Properties of the Binary Black Hole Merger GW150914"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","105004"],["dc.bibliographiccitation.journal","New Journal of Physics"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Ghosh, S. K."],["dc.contributor.author","Castorph, S."],["dc.contributor.author","Konovalov, O."],["dc.contributor.author","Jahn, R."],["dc.contributor.author","Holt, M."],["dc.contributor.author","Salditt, T."],["dc.date.accessioned","2017-09-07T11:45:15Z"],["dc.date.available","2017-09-07T11:45:15Z"],["dc.date.issued","2010"],["dc.description.abstract","The fusion of synaptic vesicles (SVs) with the plasma membrane in neurons is a crucial step in the release of neurotransmitters, which are responsible for carrying signals between nerve cells. While many of the molecular players involved in this fusion process have been identified, a precise molecular description of their roles in the process is still lacking. A case in point is the plasma membrane lipid phosphatidylinositol 4,5-bisphosphate (PIP2). Although PIP2 is known to be essential for vesicle fusion, its precise role in the process remains unclear. We have re-investigated the role of this lipid in membrane structure and function using the complementary experimental techniques of x-ray reflectivity, both on lipid monolayers at an air-water interface and bilayers on a solid support, and grazing incidence x-ray diffraction on lipid monolayers. These techniques provide unprecedented access to structural information at the molecular level, and detail the profound structural changes that occur in a membrane following PIP2 incorporation. Further, we also confirm and extend previous findings that the association of SVs with membranes is enhanced by PIP2 incorporation, and reveal the structural changes that underpin this phenomenon. Further, the association is further intensified by a physiologically relevant amount of Ca2+ ions in the subphase of the monolayer, as revealed by the increase in interfacial pressure seen with the lipid monolayer system. Finally, a theoretical calculation concerning the products arising from the fusion of these SVs with proteoliposomes is presented, with which we aim to illustrate the potential future uses of this system."],["dc.identifier.doi","10.1088/1367-2630/12/10/105004"],["dc.identifier.fs","572802"],["dc.identifier.gro","3142842"],["dc.identifier.isi","000284768300002"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/7194"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/290"],["dc.language.iso","en"],["dc.notes.intern","WoS Import 2017-03-10"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation.issn","1367-2630"],["dc.relation.orgunit","Institut für Röntgenphysik"],["dc.relation.orgunit","Fakultät für Physik"],["dc.relation.workinggroup","RG Salditt (Structure of Biomolecular Assemblies and X-Ray Physics)"],["dc.subject.gro","membrane biophysics"],["dc.subject.gro","neuro biophysics"],["dc.title","In vitro study of interaction of synaptic vesicles with lipid membranes"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1394"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Biophysical Journal"],["dc.bibliographiccitation.lastpage","1402"],["dc.bibliographiccitation.volume","102"],["dc.contributor.author","Ghosh, Sajal Kumar"],["dc.contributor.author","Castorph, Simon"],["dc.contributor.author","Konovalov, Oleg"],["dc.contributor.author","Salditt, Tim"],["dc.contributor.author","Jahn, Reinhard"],["dc.contributor.author","Holt, Matthew"],["dc.date.accessioned","2017-09-07T11:48:56Z"],["dc.date.available","2017-09-07T11:48:56Z"],["dc.date.issued","2012"],["dc.description.abstract","Synaptic vesicles (SVs) are small, membrane-bound organelles that are found in the synaptic terminal of neurons. Although tremendous progress has been made in understanding the protein machinery that drives fusion of SVs with the presynaptic membrane, little progress has been made in understanding changes in the membrane structure that accompany this process. We used lipid monolayers of defined composition to mimic biological membranes, which were probed by x-ray reflectivity and grazing incidence x-ray diffraction. These techniques allowed us to successfully monitor structural changes in the membranes at molecular level, both in response to injection of SVs in the subphase below the monolayer, as well as to physiological cues involved in neurotransmitter release, such as increases in the concentration of the membrane lipid PIP2, or addition of physiological levels of Ca2+. Such structural changes may well modulate vesicle fusion in vivo."],["dc.identifier.doi","10.1016/j.bpj.2012.01.006"],["dc.identifier.gro","3142562"],["dc.identifier.isi","000301907400018"],["dc.identifier.pmid","22455922"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/8926"],["dc.language.iso","en"],["dc.notes.intern","WoS Import 2017-03-10"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation.issn","0006-3495"],["dc.relation.orgunit","Institut für Röntgenphysik"],["dc.relation.workinggroup","RG Salditt (Structure of Biomolecular Assemblies and X-Ray Physics)"],["dc.subject.gro","membrane biophysics"],["dc.subject.gro","neuro biophysics"],["dc.title","Measuring Ca2+-Induced Structural Changes in Lipid Monolayers: Implications for Synaptic Vesicle Exocytosis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","815"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Langmuir"],["dc.bibliographiccitation.lastpage","824"],["dc.bibliographiccitation.volume","29"],["dc.contributor.author","Ghosh, S. K."],["dc.contributor.author","Salgin, B."],["dc.contributor.author","Pontoni, D."],["dc.contributor.author","Reusch, Tobias"],["dc.contributor.author","Keil, P."],["dc.contributor.author","Vogel, D."],["dc.contributor.author","Rohwerder, M."],["dc.contributor.author","Reichert, H."],["dc.contributor.author","Salditt, Tim"],["dc.date.accessioned","2017-09-07T11:48:18Z"],["dc.date.available","2017-09-07T11:48:18Z"],["dc.date.issued","2013"],["dc.description.abstract","The effect of hard X-ray radiation on the structure and electrostatics of solid-supported lipid multilayer membranes is investigated using a scanning Kelvin probe (SKP) integrated with a high-energy synchrotron beamline to enable in situ measurements of the membranes' local Volta g potential (V-p) during X-ray structural characterization. The :a undulator radiation employed does not induce any detectable structural damage, but the V-p of both bare and lipid-modified substrates is found to undergo strong radiation-induced shifts, almost immediately after X-ray exposure. Sample regions that are macroscopically distant (similar to cm) from the irradiated region experience an exponential V-p growth with a characteristic time constant of several minutes. The V-p variations occurring upon periodic on/off X-ray beam switching are fully or partially reversible depending on the location and time-scale of the SKP measurement. The general relevance of these findings for synchrotron-based characterization of biomolecular thin films is critically reviewed."],["dc.identifier.doi","10.1021/la304139w"],["dc.identifier.gro","3142405"],["dc.identifier.isi","000313667300035"],["dc.identifier.pmid","23231362"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/7919"],["dc.language.iso","en"],["dc.notes.intern","WoS Import 2017-03-10"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation.issn","0743-7463"],["dc.relation.orgunit","Institut für Röntgenphysik"],["dc.relation.workinggroup","RG Salditt (Structure of Biomolecular Assemblies and X-Ray Physics)"],["dc.subject.gro","membrane biophysics"],["dc.title","Structure and Volta Potential of Lipid Multilayers: Effect of X-ray Irradiation"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]