Schuster, Andreas

[["dc.bibliographiccitation.journal","Frontiers in Physiology"],["dc.bibliographiccitation.volume","9"],["dc.contributor.author","Wagenhäuser, Markus U."],["dc.contributor.author","Schellinger, Isabel N."],["dc.contributor.author","Yoshino, Takuya"],["dc.contributor.author","Toyama, Kensuke"],["dc.contributor.author","Kayama, Yosuke"],["dc.contributor.author","Deng, Alicia"],["dc.contributor.author","Guenther, Sabina P."],["dc.contributor.author","Petzold, Anne"],["dc.contributor.author","Mulorz, Joscha"],["dc.contributor.author","Mulorz, Pireyatharsheny"],["dc.contributor.author","Hasenfuß, Gerd"],["dc.contributor.author","Ibing, Wiebke"],["dc.contributor.author","Elvers, Margitta"],["dc.contributor.author","Schuster, Andreas"],["dc.contributor.author","Ramasubramanian, Anand K."],["dc.contributor.author","Adam, Matti"],["dc.contributor.author","Schelzig, Hubert"],["dc.contributor.author","Spin, Joshua M."],["dc.contributor.author","Raaz, Uwe"],["dc.contributor.author","Tsao, Philip S."],["dc.date.accessioned","2020-12-10T18:44:37Z"],["dc.date.available","2020-12-10T18:44:37Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.3389/fphys.2018.01459"],["dc.identifier.eissn","1664-042X"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/78531"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Chronic Nicotine Exposure Induces Murine Aortic Remodeling and Stiffness Segmentation—Implications for Abdominal Aortic Aneurysm Susceptibility"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","566"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Clinical Research in Cardiology"],["dc.bibliographiccitation.lastpage","573"],["dc.bibliographiccitation.volume","104"],["dc.contributor.author","Schuster, Andreas"],["dc.contributor.author","Faulkner, Maggie"],["dc.contributor.author","Zeymer, Uwe"],["dc.contributor.author","Ouarrak, Taoufik"],["dc.contributor.author","Eitel, Ingo"],["dc.contributor.author","Desch, Steffen"],["dc.contributor.author","Hasenfuß, Gerd"],["dc.contributor.author","Thiele, Holger"],["dc.date.accessioned","2017-09-07T11:43:44Z"],["dc.date.available","2017-09-07T11:43:44Z"],["dc.date.issued","2015"],["dc.description.abstract","The Intra-aortic Balloon Pump in Cardiogenic Shock II (IABP-SHOCK II) trial has demonstrated the safety of intra-aortic balloon (IABP) support in patients with acute myocardial infarction (AMI) complicated by cardiogenic shock, but no beneficial effect on mortality. Currently, intra-aortic balloon pumping is still the most widely used support device. However, little is known about the economic implications associated with this device. Data of 600 patients included in the IABP-SHOCK II trial (registered at ClinicalTrials.gov, NCT00491036) with follow-up at 30 days, 6 and 12 months were subjected to an economic analysis. Patients with cardiogenic shock complicating AMI were randomly assigned to IABP additionally to optimal medical therapy (OMT; n = 301) or OMT alone (n = 299) before early revascularization. Costs were calculated from the perspective of a German healthcare payer. Cost-effectiveness and cost-utility analyses were performed using quality-adjusted life years (QALY) and reduction in New York Heart Association (NYHA) and Canadian Cardiac Society (CCS) class as effectiveness measures. There was a statistically significant difference in overall costs between the IABP (33,155 +/- A 14,593 a,not sign) and the control group (32,538 +/- A 14,031 a,not sign, p < 0.00001). This was predominantly attributed to the IABP costs in the IABP (760 +/- A 174 a,not sign) versus control group (64 +/- A 218 a,not sign, p < 0.0001) whilst the intensive care unit costs did not differ between the groups (29,177 +/- A 12,013 a,not sign and 29,401 +/- A 12,063 a,not sign, p = 0.82). There was no significant difference in QALY or NYHA and CCS reduction, respectively (p = n.s.). IABP support is associated with higher healthcare costs as compared to conservative treatment regimens. Clinically, IABP support cannot generally be recommended in AMI complicated by cardiogenic shock in the absence of a mortality benefit. However, economically considering the relatively little contribution to overall costs generated by IABP therapy it may still be considered if clinical scenarios with an IABP-induced benefit may be identified in the future."],["dc.identifier.doi","10.1007/s00392-015-0819-2"],["dc.identifier.gro","3141878"],["dc.identifier.isi","000356814200004"],["dc.identifier.pmid","25637294"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/2078"],["dc.notes.intern","WoS Import 2017-03-10"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Springer"],["dc.publisher.place","Heidelberg"],["dc.relation.eissn","1861-0692"],["dc.relation.issn","1861-0684"],["dc.title","Economic implications of intra-aortic balloon support for myocardial infarction with cardiogenic shock: an analysis from the IABP-SHOCK II-trial"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","e006785"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Circulation: Cardiovascular Imaging"],["dc.bibliographiccitation.volume","10"],["dc.contributor.author","von Roeder, Maximilian"],["dc.contributor.author","Rommel, Karl-Philipp"],["dc.contributor.author","Kowallick, Johannes Tammo"],["dc.contributor.author","Blazek, Stephan"],["dc.contributor.author","Besler, Christian"],["dc.contributor.author","Fengler, Karl"],["dc.contributor.author","Lotz, Joachim"],["dc.contributor.author","Hasenfuß, Gerd"],["dc.contributor.author","Lücke, Christian"],["dc.contributor.author","Gutberlet, Matthias"],["dc.contributor.author","Schuler, Gerhard"],["dc.contributor.author","Schuster, Andreas"],["dc.contributor.author","Lurz, Philipp"],["dc.date.accessioned","2018-04-23T11:48:10Z"],["dc.date.available","2018-04-23T11:48:10Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1161/circimaging.117.006785"],["dc.identifier.gro","3142332"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/13467"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/110017"],["dc.language.iso","en"],["dc.notes.intern","lifescience updates Crossref Import"],["dc.notes.status","final"],["dc.relation.eissn","1942-0080"],["dc.relation.issn","1941-9651"],["dc.title","Response by von Roeder et al to Letter Regarding Article, “Influence of Left Atrial Function on Exercise Capacity and Left Ventricular Function in Patients With Heart Failure and Preserved Ejection Fraction”"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.peerReviewed","no"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","54"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Clinical Research in Cardiology"],["dc.bibliographiccitation.lastpage","66"],["dc.bibliographiccitation.volume","109"],["dc.contributor.author","von Roeder, Maximilian"],["dc.contributor.author","Kowallick, Johannes Tammo"],["dc.contributor.author","Rommel, Karl-Philipp"],["dc.contributor.author","Blazek, Stephan"],["dc.contributor.author","Besler, Christian"],["dc.contributor.author","Fengler, Karl"],["dc.contributor.author","Lotz, Joachim"],["dc.contributor.author","Hasenfuß, Gerd"],["dc.contributor.author","Lücke, Christian"],["dc.contributor.author","Gutberlet, Matthias"],["dc.contributor.author","Thiele, Holger"],["dc.contributor.author","Schuster, Andreas"],["dc.contributor.author","Lurz, Philipp"],["dc.date.accessioned","2020-12-10T14:10:23Z"],["dc.date.available","2020-12-10T14:10:23Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1007/s00392-019-01484-0"],["dc.identifier.eissn","1861-0692"],["dc.identifier.issn","1861-0684"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/70742"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Right atrial–right ventricular coupling in heart failure with preserved ejection fraction"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","International Journal of Cardiology"],["dc.contributor.author","Backhaus, Sören J."],["dc.contributor.author","Kowallick, Johannes T."],["dc.contributor.author","Stiermaier, Thomas"],["dc.contributor.author","Lange, Torben"],["dc.contributor.author","Koschalka, Alexander"],["dc.contributor.author","Navarra, Jenny-Lou"],["dc.contributor.author","Uhlig, Johannes"],["dc.contributor.author","Lotz, Joachim"],["dc.contributor.author","Kutty, Shelby"],["dc.contributor.author","Bigalke, Boris"],["dc.contributor.author","Gutberlet, Matthias"],["dc.contributor.author","Hasenfuß, Gerd"],["dc.contributor.author","Thiele, Holger"],["dc.contributor.author","Eitel, Ingo"],["dc.contributor.author","Schuster, Andreas"],["dc.date.accessioned","2019-08-06T12:07:43Z"],["dc.date.available","2019-08-06T12:07:43Z"],["dc.date.issued","2019"],["dc.description.abstract","Sex-specific outcome data following myocardial infarction (MI) are inconclusive with some evidence suggesting association of female sex and increased major adverse cardiac events (MACE). Since mechanistic principles remain elusive, we aimed to quantify the underlying phenotype using cardiovascular magnetic resonance (CMR) quantitative deformation imaging and tissue characterisation."],["dc.identifier.doi","10.1016/j.ijcard.2019.06.036"],["dc.identifier.pmid","31300172"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/62311"],["dc.language.iso","en"],["dc.notes.status","zu prüfen"],["dc.relation.eissn","1874-1754"],["dc.relation.issn","0167-5273"],["dc.title","Atrioventricular mechanical coupling and major adverse cardiac events in female patients following acute ST elevation myocardial infarction"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","e109164"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","PLoS ONE"],["dc.bibliographiccitation.volume","9"],["dc.contributor.author","Kowallick, Johannes Tammo"],["dc.contributor.author","Lamata, Pablo"],["dc.contributor.author","Hussain, Shazia T."],["dc.contributor.author","Kutty, Shelby"],["dc.contributor.author","Steinmetz, Michael"],["dc.contributor.author","Sohns, Jan Martin"],["dc.contributor.author","Fasshauer, Martin"],["dc.contributor.author","Staab, Wieland"],["dc.contributor.author","Unterberg-Buchwald, Christina"],["dc.contributor.author","Bigalke, Boris"],["dc.contributor.author","Lotz, Joachim"],["dc.contributor.author","Hasenfuß, Gerd"],["dc.contributor.author","Schuster, Andreas"],["dc.date.accessioned","2017-09-07T11:45:27Z"],["dc.date.available","2017-09-07T11:45:27Z"],["dc.date.issued","2014"],["dc.description.abstract","Objectives: Cardiovascular magnetic resonance feature tracking (CMR-FT) offers quantification of myocardial deformation from routine cine images. However, data using CMR-FT to quantify left ventricular (LV) torsion and diastolic recoil are not yet available. We therefore sought to evaluate the feasibility and reproducibility of CMR-FT to quantify LV torsion and peak recoil rate using an optimal anatomical approach. Methods: Short-axis cine stacks were acquired at rest and during dobutamine stimulation (10 and 20 mu g.kg(-1).min(-1)) in 10 healthy volunteers. Rotational displacement was analysed for all slices. A complete 3D-LV rotational model was developed using linear interpolation between adjacent slices. Torsion was defined as the difference between apical and basal rotation, divided by slice distance. Depending on the distance between the most apical (defined as 0% LV distance) and basal (defined as 100% LV distance) slices, four different models for the calculation of torsion were examined: Model-1 (25-75%), Model-2 (0-100%), Model-3 (25-100%) and Model-4 (0-75%). Analysis included subendocardial, subepicardial and global torsion and recoil rate (mean of subendocardial and subepicardial values). Results: Quantification of torsion and recoil rate was feasible in all subjects. There was no significant difference between the different models at rest. However, only Model-1 (25-75%) discriminated between rest and stress (Global Torsion: 2.7 +/- 1.5 degrees cm(-1), 3.6 +/- 2.0 degrees cm(-1), 5.1 +/- 2.2 degrees cm(-1), p<0.01; Global Recoil Rate: -30.1 +/- 11.1 degrees cm(-1) s (-1), -469 +/- 15.0 degrees cm (-1) s (-1), -68.9 +/- 32.3 degrees cm(-1) s(-1), p<0.01; for rest, 10 and 20 mu g.kg(-1).min(-1) of dobutamine, respectively). Reproducibility was sufficient for all parameters as determined by Bland-Altman analysis, intraclass correlation coefficients and coefficient of variation. Conclusions: CMR-FT based derivation of myocardial torsion and recoil rate is feasible and reproducible at rest and with dobutamine stress. Using an optimal anatomical approach measuring rotation at 25% and 75% apical and basal LV locations allows effective quantification of torsion and recoil dynamics. Application of these new measures of deformation by CMR-FT should next be explored in disease states."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2014"],["dc.identifier.doi","10.1371/journal.pone.0109164"],["dc.identifier.gro","3142035"],["dc.identifier.isi","000345743700050"],["dc.identifier.pmid","25285656"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/10994"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/3823"],["dc.notes.intern","WoS Import 2017-03-10"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Public Library Science"],["dc.relation.issn","1932-6203"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Quantification of Left Ventricular Torsion and Diastolic Recoil Using Cardiovascular Magnetic Resonance Myocardial Feature Tracking"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","e0202146"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","PLoS One"],["dc.bibliographiccitation.volume","13"],["dc.contributor.author","Stiermaier, Thomas"],["dc.contributor.author","Lange, Torben"],["dc.contributor.author","Chiribiri, Amedeo"],["dc.contributor.author","Möller, Christian"],["dc.contributor.author","Graf, Tobias"],["dc.contributor.author","Raaz, Uwe"],["dc.contributor.author","Villa, Adriana"],["dc.contributor.author","Kowallick, Johannes T."],["dc.contributor.author","Lotz, Joachim"],["dc.contributor.author","Hasenfuß, Gerd"],["dc.contributor.author","Thiele, Holger"],["dc.contributor.author","Schuster, Andreas"],["dc.contributor.author","Eitel, Ingo"],["dc.contributor.editor","Novo, Giuseppina"],["dc.date.accessioned","2020-12-10T18:42:08Z"],["dc.date.available","2020-12-10T18:42:08Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1371/journal.pone.0202146"],["dc.identifier.eissn","1932-6203"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/15691"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/77819"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.intern","Merged from goescholar"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Right ventricular strain assessment by cardiovascular magnetic resonance myocardial feature tracking allows optimized risk stratification in Takotsubo syndrome"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1262"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","European Heart Journal - Cardiovascular Imaging"],["dc.bibliographiccitation.lastpage","1270"],["dc.bibliographiccitation.volume","20"],["dc.contributor.author","Schuster, Andreas"],["dc.contributor.author","Backhaus, Sören J"],["dc.contributor.author","Stiermaier, Thomas"],["dc.contributor.author","Kowallick, Johannes T."],["dc.contributor.author","Stulle, Alina"],["dc.contributor.author","Koschalka, Alexander"],["dc.contributor.author","Lotz, Joachim"],["dc.contributor.author","Kutty, Shelby"],["dc.contributor.author","Bigalke, Boris"],["dc.contributor.author","Gutberlet, Matthias"],["dc.contributor.author","Hasenfuß, Gerd"],["dc.contributor.author","Thiele, Holger"],["dc.contributor.author","Eitel, Ingo"],["dc.date.accessioned","2020-04-03T13:12:22Z"],["dc.date.available","2020-04-03T13:12:22Z"],["dc.date.issued","2019-11-01"],["dc.description.abstract","Cardiovascular magnetic resonance feature tracking (CMR-FT) global longitudinal strain (GLS) provides incremental prognostic value following acute myocardial infarction (AMI) but requires substantial post-processing. Alternatively, manual global long-axis strain (LAS) can be easily assessed from standard steady state free precession images. We aimed to define the prognostic value of LAS in a large multicentre study in patients following AMI."],["dc.identifier.doi","10.1093/ehjci/jez077"],["dc.identifier.pmid","31329854"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/63616"],["dc.language.iso","en"],["dc.relation.eissn","2047-2412"],["dc.relation.issn","2047-2404"],["dc.relation.issn","2047-2412"],["dc.title","Fast manual long-axis strain assessment provides optimized cardiovascular event prediction following myocardial infarction"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Circulation"],["dc.contributor.author","Backhaus, Sören J"],["dc.contributor.author","Lange, Torben"],["dc.contributor.author","George, Elisabeth F"],["dc.contributor.author","Hellenkamp, Kristian"],["dc.contributor.author","Gertz, Roman J"],["dc.contributor.author","Billing, Marcus"],["dc.contributor.author","Wachter, Rolf"],["dc.contributor.author","Steinmetz, Michael"],["dc.contributor.author","Kutty, Shelby"],["dc.contributor.author","Raaz, Uwe"],["dc.contributor.author","Lotz, Joachim"],["dc.contributor.author","Friede, Tim"],["dc.contributor.author","Uecker, Martin"],["dc.contributor.author","Hasenfuß, Gerd P."],["dc.contributor.author","Seidler, Tim"],["dc.contributor.author","Schuster, Andreas"],["dc.date.accessioned","2021-03-08T07:13:50Z"],["dc.date.available","2021-03-08T07:13:50Z"],["dc.date.issued","2021-01-21"],["dc.description.abstract","Background: Right heart catheterisation (RHC) using exercise-stress is the reference standard for the diagnosis of heart failure with preserved ejection fraction (HFpEF) but carries the risk of the invasive procedure. We hypothesized that real-time cardiovascular magnetic resonance (RT-CMR) exercise imaging with pathophysiologic data at excellent temporal and spatial resolution may represent a contemporary non-invasive alternative for diagnosing HFpEF. Methods: The HFpEF stress trial (DZHK-17, NCT03260621) prospectively recruited 75 patients with echocardiographic signs of diastolic dysfunction and dyspnea on exertion (E/e'>8, New York Heart Association (NYHA) class ≥II) to undergo echocardiography, RHC and RT-CMR at rest and during exercise-stress. HFpEF was defined according to pulmonary capillary wedge pressure (PCWP ≥15mmHg at rest or ≥25mmHg during exercise stress). RT-CMR functional assessments included time-volume curves for total and early (1/3) diastolic left ventricular (LV) filling, left atrial (LA) emptying and LV/LA long axis strain (LAS). Results: HFpEF patients (n=34, median PCWP rest 13mmHg, stress 27mmHg) had higher E/e' (12.5 vs. 9.15), NT-proBNP (255 vs. 75ng/l) and LA volume index (43.8 vs. 36.2ml/m2) compared to non-cardiac dyspnea patients (n=34, rest 8mmHg, stress 18mmHg, p≤0.001 for all). Seven patients were excluded due to the presence of non HFpEF cardiac disease causing dyspnea on imaging. There were no differences in RT-CMR LV total and early diastolic filling at rest and during exercise-stress (p≥0.164) between HFpEF and non-cardiac dyspnea. RT-CMR revealed significantly impaired LA total and early (p<0.001) diastolic emptying in HFpEF during exercise-stress. RT-CMR exercise-stress LA LAS was independently associated with HFpEF (adjusted odds ratio 0.657, 95% confidence interval [0.516; 0.838], p=0.001) after adjustment for clinical and imaging parameters and emerged as the best predictor for HFpEF (area under the curve rest 0.82 vs. exercise-stress 0.93, p=0.029). Conclusions: RT-CMR allows highly accurate identification of HFpEF during physiological exercise and qualifies as a suitable non-invasive diagnostic alternative. These results will need to be confirmed in multi-centre prospective research studies to establish widespread routine clinical use. Clinical Trial Registration: URL: https://www.clinicaltrials.gov Unique Identifier: NCT03260621."],["dc.identifier.doi","10.1161/CIRCULATIONAHA.120.051542"],["dc.identifier.pmid","33472397"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/80476"],["dc.identifier.url","https://mbexc.uni-goettingen.de/literature/publications/302"],["dc.language.iso","en"],["dc.relation","EXC 2067: Multiscale Bioimaging"],["dc.relation.issn","0009-7322"],["dc.relation.issn","1524-4539"],["dc.relation.workinggroup","RG Hasenfuß"],["dc.relation.workinggroup","RG Uecker"],["dc.title","Exercise-Stress Real-time Cardiac Magnetic Resonance Imaging for Non-Invasive Characterisation of Heart Failure with Preserved Ejection Fraction: The HFpEF Stress Trial"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","965512"],["dc.bibliographiccitation.journal","Frontiers in Cardiovascular Medicine"],["dc.bibliographiccitation.volume","9"],["dc.contributor.author","Evertz, Ruben"],["dc.contributor.author","Schulz, Alexander"],["dc.contributor.author","Lange, Torben"],["dc.contributor.author","Backhaus, Sören J."],["dc.contributor.author","Vollmann, Dirk"],["dc.contributor.author","Kowallick, Johannes T."],["dc.contributor.author","von Haehling, Stephan"],["dc.contributor.author","Hasenfuß, Gerd"],["dc.contributor.author","Schuster, Andreas"],["dc.date.accessioned","2022-10-04T10:21:43Z"],["dc.date.available","2022-10-04T10:21:43Z"],["dc.date.issued","2022"],["dc.description.abstract","Background\r\n The risk of myocarditis after mRNA vaccination against COVID-19 has emerged recently. Current evidence suggests that young male patients are predominantly affected. In the majority of the cases, only mild symptoms were observed. However, little is known about cardiac magnetic resonance (CMR) imaging patterns in mRNA-related myocarditis and their differences when compared to classical viral myocarditis in the acute phase of inflammation.\r\n \r\n \r\n Methods and results\r\n \r\n In total, 10 mRNA vaccination-associated patients with myocarditis were retrospectively enrolled in this study and compared to 10 patients suffering from viral myocarditis, who were matched for age, sex, comorbidities, and laboratory markers. All patients (\r\n n\r\n = 20) were hospitalized and underwent a standardized clinical examination, as well as an echocardiography and a CMR. Both, clinical and imaging findings and, in particular, functional and volumetric CMR assessments, as well as detailed tissue characterization using late gadolinium enhancement and T1 + T2-weighted sequences, were compared between both groups. The median age of the overall cohort was 26 years (group 1: 25.5; group 2: 27.5;\r\n p\r\n = 0.57). All patients described chest pain as the leading reason for their initial presentation. CMR volumetric and functional parameters did not differ significantly between both groups. In all cases, the lateral left ventricular wall showed late gadolinium enhancement without significant differences in terms of the localization or in-depth tissue characterization (late gadolinium enhancement [LGE] enlargement: group 1: 5.4%; group 2: 6.5%;\r\n p\r\n = 0.14; T2 global/maximum value: group 1: 38.9/52 ms; group 2: 37.8/54.5 ms;\r\n p\r\n = 0.79 and\r\n p\r\n = 0.80).\r\n \r\n \r\n \r\n Conclusion\r\n This study yielded the first evidence that COVID-19 mRNA vaccine-associated myocarditis does not show specific CMR patterns during the very acute stage in the most affected patient group of young male patients. The observed imaging markers were closely related to regular viral myocarditis in our cohort. Additionally, we could not find any markers implying adverse outcomes in this relatively little number of patients; however, this has to be confirmed by future studies that will include larger sample sizes."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2022"],["dc.identifier.doi","10.3389/fcvm.2022.965512"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/114481"],["dc.notes.intern","DOI-Import GROB-600"],["dc.relation.eissn","2297-055X"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0/"],["dc.title","Cardiovascular magnetic resonance imaging patterns of acute COVID-19 mRNA vaccine-associated myocarditis in young male patients: A first single-center experience"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]