Lohse, Nils

[["dc.bibliographiccitation.firstpage","201"],["dc.bibliographiccitation.issue","Pt A"],["dc.bibliographiccitation.journal","Journal of controlled release : official journal of the Controlled Release Society"],["dc.bibliographiccitation.lastpage","209"],["dc.bibliographiccitation.volume","220"],["dc.contributor.author","Lohse, N."],["dc.contributor.author","Moser, N."],["dc.contributor.author","Backhaus, S."],["dc.contributor.author","Annen, T."],["dc.contributor.author","Epple, M."],["dc.contributor.author","Schliephake, H."],["dc.date.accessioned","2018-06-25T07:52:25Z"],["dc.date.available","2018-06-25T07:52:25Z"],["dc.date.issued","2015"],["dc.description.abstract","The aim of the present study was to test the hypothesis that different amounts of vascular endothelial growth factor and bone morphogenic protein differentially affect bone formation when applied for repair of non-healing defects in the rat mandible. Porous composite PDLLA/CaCO3 carriers were fabricated as slow release carriers and loaded with rhBMP2 and rhVEGF165 in 10 different dosage combinations using gas foaming with supercritical carbon dioxide. They were implanted in non-healing defects of the mandibles of 132 adult Wistar rats with additional lateral augmentation. Bone formation was assessed both radiographically (bone volume) and by histomorphometry (bone density). The use of carriers with a ratio of delivery of VEGF/BMP between 0.7 and 1.2 was significantly related to the occurrence of significant increases in radiographic bone volume and/or histologic bone density compared to the use of carriers with a ratio of delivery of ≤ 0.5 when all intervals and all outcome parameters were considered. Moreover, simultaneous delivery at this ratio helped to \"save\" rhBMP2 as both bone volume and bone density after 13 weeks were reached/surpassed using half the dosage required for rhBMP2 alone. It is concluded, that the combined delivery of rhVEGF165 and rhBMP2 for repair of critical size mandibular defects can significantly enhance volume and density of bone formation over delivery of rhBMP2 alone. It appears from the present results that continuous simultaneous delivery of rhVEGF165 and rhBMP2 at a ratio of approximately 1 is favourable for the enhancement of bone formation."],["dc.identifier.doi","10.1016/j.jconrel.2015.10.032"],["dc.identifier.pmid","26485046"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/15136"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation.eissn","1873-4995"],["dc.title","Continuous delivery of rhBMP2 and rhVEGF165 at a certain ratio enhances bone formation in mandibular defects over the delivery of rhBMP2 alone--An experimental study in rats"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","351"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","QUINTESSENCE INTERNATIONAL"],["dc.bibliographiccitation.lastpage","361"],["dc.bibliographiccitation.volume","46"],["dc.contributor.author","Troeltzsch, Markus"],["dc.contributor.author","Lohse, Nils"],["dc.contributor.author","Moser, Norman"],["dc.contributor.author","Kauffmann, Philipp"],["dc.contributor.author","Cordesmeyer, Robert"],["dc.contributor.author","Aung, Thiha"],["dc.contributor.author","Brodine, Brian"],["dc.contributor.author","Troeltzsch, Matthias"],["dc.date.accessioned","2018-11-07T09:59:18Z"],["dc.date.available","2018-11-07T09:59:18Z"],["dc.date.issued","2015"],["dc.description.abstract","Odontogenic infections are common in the dental practice and their treatment should be a standard procedure for every dentist. For optimal management of septic intraoral problems, the practitioner must understand the underlying causes and etiologies of odontogenic infections. Therefore, the purpose of this article is to outline basic inflammatory processes involved in the development of odontogenic and intraoral infections including relevant pathogens, biochemical processes mediated by pro-inflammatory molecules, the basics of abscess formation, the host response, and the clinical appearance of intraoral septic processes. Furthermore, treatment modalities of odontogenic infections and associated lesions are discussed and a brief explanation of possible complications and their management is provided."],["dc.identifier.doi","10.3290/j.qi.a33448"],["dc.identifier.isi","000351715500009"],["dc.identifier.pmid","25692182"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/37561"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.relation.issn","1936-7163"],["dc.relation.issn","0033-6572"],["dc.title","A review of pathogenesis, diagnosis, treatment options, and differential diagnosis of odontogenic infections: A rather mundane pathology?"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]