Lohse, Nils

[["dc.bibliographiccitation.firstpage","201"],["dc.bibliographiccitation.issue","Pt A"],["dc.bibliographiccitation.journal","Journal of controlled release : official journal of the Controlled Release Society"],["dc.bibliographiccitation.lastpage","209"],["dc.bibliographiccitation.volume","220"],["dc.contributor.author","Lohse, N."],["dc.contributor.author","Moser, N."],["dc.contributor.author","Backhaus, S."],["dc.contributor.author","Annen, T."],["dc.contributor.author","Epple, M."],["dc.contributor.author","Schliephake, H."],["dc.date.accessioned","2018-06-25T07:52:25Z"],["dc.date.available","2018-06-25T07:52:25Z"],["dc.date.issued","2015"],["dc.description.abstract","The aim of the present study was to test the hypothesis that different amounts of vascular endothelial growth factor and bone morphogenic protein differentially affect bone formation when applied for repair of non-healing defects in the rat mandible. Porous composite PDLLA/CaCO3 carriers were fabricated as slow release carriers and loaded with rhBMP2 and rhVEGF165 in 10 different dosage combinations using gas foaming with supercritical carbon dioxide. They were implanted in non-healing defects of the mandibles of 132 adult Wistar rats with additional lateral augmentation. Bone formation was assessed both radiographically (bone volume) and by histomorphometry (bone density). The use of carriers with a ratio of delivery of VEGF/BMP between 0.7 and 1.2 was significantly related to the occurrence of significant increases in radiographic bone volume and/or histologic bone density compared to the use of carriers with a ratio of delivery of ≤ 0.5 when all intervals and all outcome parameters were considered. Moreover, simultaneous delivery at this ratio helped to \"save\" rhBMP2 as both bone volume and bone density after 13 weeks were reached/surpassed using half the dosage required for rhBMP2 alone. It is concluded, that the combined delivery of rhVEGF165 and rhBMP2 for repair of critical size mandibular defects can significantly enhance volume and density of bone formation over delivery of rhBMP2 alone. It appears from the present results that continuous simultaneous delivery of rhVEGF165 and rhBMP2 at a ratio of approximately 1 is favourable for the enhancement of bone formation."],["dc.identifier.doi","10.1016/j.jconrel.2015.10.032"],["dc.identifier.pmid","26485046"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/15136"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation.eissn","1873-4995"],["dc.title","Continuous delivery of rhBMP2 and rhVEGF165 at a certain ratio enhances bone formation in mandibular defects over the delivery of rhBMP2 alone--An experimental study in rats"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","162"],["dc.bibliographiccitation.journal","European Cells and Materials"],["dc.bibliographiccitation.lastpage","179"],["dc.bibliographiccitation.volume","34"],["dc.contributor.author","Moser, N"],["dc.contributor.author","Lohse, N"],["dc.contributor.author","Goldstein, J"],["dc.contributor.author","Kauffmann, P"],["dc.contributor.author","Sven, B"],["dc.contributor.author","Epple, M"],["dc.contributor.author","Schliephake, H"],["dc.contributor.authorgroup","Department of Oral and Maxillofacial Surgery, George-Augusta-University, Robert-Koch-Str. 40, 37075 Göttingen, Germany"],["dc.date.accessioned","2021-06-01T10:48:39Z"],["dc.date.available","2021-06-01T10:48:39Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.22203/eCM.v034a11"],["dc.identifier.pmid","28980278"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/17007"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/86006"],["dc.notes.intern","DOI-Import GROB-425"],["dc.notes.intern","Merged from goescholar"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Do we need retarded delivery of bone growth factors in facial bone repair? An experimental study in rats"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","413"],["dc.bibliographiccitation.journal","European Cells and Materials"],["dc.bibliographiccitation.lastpage","424"],["dc.bibliographiccitation.volume","23"],["dc.contributor.author","Lohse, Nils"],["dc.contributor.author","Schulz, Jutta"],["dc.contributor.author","Schliephake, Henning"],["dc.contributor.authorgroup","Department of Oral and Maxillofacial Surgery, George-Augusta-University, Robert-Koch-Str. 40, 37075 Goettingen, Germany"],["dc.date.accessioned","2021-06-01T10:48:38Z"],["dc.date.available","2021-06-01T10:48:38Z"],["dc.date.issued","2012"],["dc.description.abstract","The aim of the present study was to test the hypothesis that a fibrin matrix enhances the osteogenic differentiation and expression of vascular endothelial growth factor (VEGF) by human bone marrow stromal cells (hBMSCs) seeded into mineralised scaffolds. Porous calcium carbonate scaffolds were droplet seeded with hBMSCs using a matrix containing 3 % fibrinogen and cultured for 3 weeks. Seeded scaffolds without the fibrin matrix served as controls. The scaffolds were evaluated, using undecalcified thick sections, for fluorescence staining for nuclei, osteocalcin (OC) and VEGF. The sections were systematically scanned using optical sectioning and three dimensional distributions of cells and positive staining indicating expression of OC and VEGF were reconstructed from the z-stacks. The fibrin matrix maintained a significantly higher level of cell numbers after 2 d and 1 week and delayed the onset of osteogenic differentiation while sustaining a significantly higher level of OC and VEGF expression after 2 and 3 weeks, starting from the periphery of the scaffolds. There was a decrease in cell density from the periphery to the centre of the scaffolds in both groups The percentage of cells expressing OC and VEGF was significantly different between the centre and the periphery of the scaffolds in the fibrin(+) group but not in the controls. It is concluded that the fibrin matrix used appears to be a useful adjunct for supporting and sustaining osteogenic and angiogenic activity of hBMSCs in tissue engineered constructs. This could help to improve their performance in a clinical setting."],["dc.identifier.doi","10.22203/eCM.v023a32"],["dc.identifier.fs","586089"],["dc.identifier.pmid","22665163"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/9550"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/86004"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","1473-2262"],["dc.relation.orgunit","Universitätsmedizin Göttingen"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.subject.ddc","610"],["dc.title","Effect of fibrin on osteogenic differentiation and VEGF expression of bone marrow stromal cells in mineralised scaffolds: a three-dimensional analysis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","351"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","QUINTESSENCE INTERNATIONAL"],["dc.bibliographiccitation.lastpage","361"],["dc.bibliographiccitation.volume","46"],["dc.contributor.author","Troeltzsch, Markus"],["dc.contributor.author","Lohse, Nils"],["dc.contributor.author","Moser, Norman"],["dc.contributor.author","Kauffmann, Philipp"],["dc.contributor.author","Cordesmeyer, Robert"],["dc.contributor.author","Aung, Thiha"],["dc.contributor.author","Brodine, Brian"],["dc.contributor.author","Troeltzsch, Matthias"],["dc.date.accessioned","2018-11-07T09:59:18Z"],["dc.date.available","2018-11-07T09:59:18Z"],["dc.date.issued","2015"],["dc.description.abstract","Odontogenic infections are common in the dental practice and their treatment should be a standard procedure for every dentist. For optimal management of septic intraoral problems, the practitioner must understand the underlying causes and etiologies of odontogenic infections. Therefore, the purpose of this article is to outline basic inflammatory processes involved in the development of odontogenic and intraoral infections including relevant pathogens, biochemical processes mediated by pro-inflammatory molecules, the basics of abscess formation, the host response, and the clinical appearance of intraoral septic processes. Furthermore, treatment modalities of odontogenic infections and associated lesions are discussed and a brief explanation of possible complications and their management is provided."],["dc.identifier.doi","10.3290/j.qi.a33448"],["dc.identifier.isi","000351715500009"],["dc.identifier.pmid","25692182"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/37561"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.relation.issn","1936-7163"],["dc.relation.issn","0033-6572"],["dc.title","A review of pathogenesis, diagnosis, treatment options, and differential diagnosis of odontogenic infections: A rather mundane pathology?"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]