Witte, Mirko

[["dc.bibliographiccitation.firstpage","347"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Nature Medicine"],["dc.bibliographiccitation.lastpage","354"],["dc.bibliographiccitation.volume","23"],["dc.contributor.author","Koukouli, Fani"],["dc.contributor.author","Rooy, Marie"],["dc.contributor.author","Tziotis, Dimitrios"],["dc.contributor.author","Sailor, Kurt A."],["dc.contributor.author","O'Neill, Heidi C."],["dc.contributor.author","Levenga, Josien"],["dc.contributor.author","Witte, Mirko"],["dc.contributor.author","Nilges, Michael"],["dc.contributor.author","Changeux, Jean-Pierre"],["dc.contributor.author","Hoeffer, Charles A."],["dc.contributor.author","Stitzel, Jerry A."],["dc.contributor.author","Gutkin, Boris S."],["dc.contributor.author","DiGregorio, David A."],["dc.contributor.author","Maskos, Uwe"],["dc.date.accessioned","2018-11-07T10:27:06Z"],["dc.date.available","2018-11-07T10:27:06Z"],["dc.date.issued","2017"],["dc.description.abstract","The prefrontal cortex (PFC) underlies higher cognitive processes(1) that are modulated by nicotinic acetylcholine receptor (nAChR) activation by cholinergic inputs(2). PFC spontaneous default activity(3) is altered in neuropsychiatric disorders(4), including schizophrenia(5) a disorder that can be accompanied by heavy smoking(6). Recently, genome-wide association studies (GWAS) identified single-nucleotide polymorphisms (SNPs) in the human CHRNA5 gene, encoding the alpha 5 nAChR subunit, that increase the risks for both smoking and schizophrenia(7'8). Mice with altered nAChR gene function exhibit PFC-dependent behavioral deficits(9-11), but it is unknown how the corresponding human polymorphisms alter the cellular and circuit mechanisms underlying behavior. Here we show that mice expressing a human 5 SNP exhibit neurocognitive behavioral deficits in social interaction and sensorimotor gating tasks. Two-photon calcium imaging in awake mouse models showed that nicotine can differentially influence PFC pyramidal cell activity by nAChR modulation of layer II/III hierarchical inhibitory circuits. In 5-SNP-expressing and 5-knockout mice, lower activity of vasoactive intestinal polypeptide (VIP) interneurons resulted in an increased somatostatin (SOM) interneuron inhibitory drive over layer II/III pyramidal neurons. The decreased activity observed in 5-SNP-expressing mice resembles the hypofrontality observed in patients with psychiatric disorders, including schizophrenia and addiction(5,12).Chronic nicotine administration reversed this hypofrontality, suggesting that administration of nicotine may represent a therapeutic strategy for the treatment of schizophrenia, and a physiological basis for the tendency of patients with schizophrenia to self-medicate by smoking(13)."],["dc.identifier.doi","10.1038/nm.4274"],["dc.identifier.isi","000395848400015"],["dc.identifier.pmid","28112735"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/43182"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Nature Publishing Group"],["dc.relation.issn","1546-170X"],["dc.relation.issn","1078-8956"],["dc.title","Nicotine reverses hypofrontality in animal models of addiction and schizophrenia"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","no"],["dc.bibliographiccitation.issue","23"],["dc.bibliographiccitation.journal","ChemInform"],["dc.bibliographiccitation.lastpage","no"],["dc.bibliographiccitation.volume","31"],["dc.contributor.author","Witt, M."],["dc.contributor.author","Roesky, H. W."],["dc.date.accessioned","2021-12-08T12:28:38Z"],["dc.date.available","2021-12-08T12:28:38Z"],["dc.date.issued","2010"],["dc.identifier.doi","10.1002/chin.200023284"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/95774"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-476"],["dc.relation.eissn","1522-2667"],["dc.relation.issn","0931-7597"],["dc.rights.uri","http://doi.wiley.com/10.1002/tdm_license_1.1"],["dc.title","ChemInform Abstract: Organoaluminum Chemistry at the Forefront of Research and Development"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Frontiers in Neuroanatomy"],["dc.bibliographiccitation.volume","13"],["dc.contributor.author","Almási, Zsuzsanna"],["dc.contributor.author","Dávid, Csaba"],["dc.contributor.author","Witte, Mirko"],["dc.contributor.author","Staiger, Jochen F."],["dc.date.accessioned","2020-12-10T18:44:30Z"],["dc.date.available","2020-12-10T18:44:30Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.3389/fnana.2019.00045"],["dc.identifier.eissn","1662-5129"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/78478"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Distribution Patterns of Three Molecularly Defined Classes of GABAergic Neurons Across Columnar Compartments in Mouse Barrel Cortex"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Cerebral Cortex"],["dc.contributor.author","Prönneke, Alvar"],["dc.contributor.author","Witte, Mirko"],["dc.contributor.author","Möck, Martin"],["dc.contributor.author","Staiger, Jochen F"],["dc.date.accessioned","2020-12-10T18:18:41Z"],["dc.date.available","2020-12-10T18:18:41Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1093/cercor/bhz102"],["dc.identifier.eissn","1460-2199"],["dc.identifier.issn","1047-3211"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/75092"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Neuromodulation Leads to a Burst-Tonic Switch in a Subset of VIP Neurons in Mouse Primary Somatosensory (Barrel) Cortex"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1427"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Cerebral Cortex"],["dc.bibliographiccitation.lastpage","1443"],["dc.bibliographiccitation.volume","31"],["dc.contributor.author","Hafner, Georg"],["dc.contributor.author","Guy, Julien"],["dc.contributor.author","Witte, Mirko"],["dc.contributor.author","Truschow, Pavel"],["dc.contributor.author","Rüppel, Alina"],["dc.contributor.author","Sirmpilatze, Nikoloz"],["dc.contributor.author","Dadarwal, Rakshit"],["dc.contributor.author","Boretius, Susann"],["dc.contributor.author","Staiger, Jochen F"],["dc.date.accessioned","2021-06-01T09:41:52Z"],["dc.date.available","2021-06-01T09:41:52Z"],["dc.date.issued","2020"],["dc.description.abstract","Abstract The neocortex is composed of layers. Whether layers constitute an essential framework for the formation of functional circuits is not well understood. We investigated the brain-wide input connectivity of vasoactive intestinal polypeptide (VIP) expressing neurons in the reeler mouse. This mutant is characterized by a migration deficit of cortical neurons so that no layers are formed. Still, neurons retain their properties and reeler mice show little cognitive impairment. We focused on VIP neurons because they are known to receive strong long-range inputs and have a typical laminar bias toward upper layers. In reeler, these neurons are more dispersed across the cortex. We mapped the brain-wide inputs of VIP neurons in barrel cortex of wild-type and reeler mice with rabies virus tracing. Innervation by subcortical inputs was not altered in reeler, in contrast to the cortical circuitry. Numbers of long-range ipsilateral cortical inputs were reduced in reeler, while contralateral inputs were strongly increased. Reeler mice had more callosal projection neurons. Hence, the corpus callosum was larger in reeler as shown by structural imaging. We argue that, in the absence of cortical layers, circuits with subcortical structures are maintained but cortical neurons establish a different network that largely preserves cognitive functions."],["dc.identifier.doi","10.1093/cercor/bhaa280"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/85068"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.relation.eissn","1460-2199"],["dc.relation.issn","1047-3211"],["dc.title","Increased Callosal Connectivity in Reeler Mice Revealed by Brain-Wide Input Mapping of VIP Neurons in Barrel Cortex"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Cerebral Cortex"],["dc.contributor.author","Guy, Julien"],["dc.contributor.author","Sachkova, Alexandra"],["dc.contributor.author","Möck, Martin"],["dc.contributor.author","Witte, Mirko"],["dc.contributor.author","Wagener, Robin J."],["dc.contributor.author","Staiger, Jochen F."],["dc.date.accessioned","2020-12-10T18:18:32Z"],["dc.date.available","2020-12-10T18:18:32Z"],["dc.date.issued","2016"],["dc.identifier.doi","10.1093/cercor/bhw281"],["dc.identifier.eissn","1460-2199"],["dc.identifier.issn","1047-3211"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/75088"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Intracortical Network Effects Preserve Thalamocortical Input Efficacy in a Cortex Without Layers"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]