Liesegang, Heiko

[["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Genome Announcements"],["dc.bibliographiccitation.volume","6"],["dc.contributor.author","Wemheuer, Franziska"],["dc.contributor.author","Hollensteiner, Jacqueline"],["dc.contributor.author","Poehlein, Anja"],["dc.contributor.author","Liesegang, Heiko"],["dc.contributor.author","Daniel, Rolf"],["dc.contributor.author","Wemheuer, Bernd"],["dc.date.accessioned","2020-04-28T12:41:35Z"],["dc.date.available","2020-04-28T12:41:35Z"],["dc.date.issued","2018"],["dc.description.abstract","Bacillus mycoides GM6LP is an endophyte isolated from plant tissues of Lolium perenne L. Here, we report its draft genome sequence (6.2 Mb), which contains 96 contigs and 6,129 protein-coding genes. Knowledge about its genome will enable us to evaluate the potential use of GM6LP as a plant growth-promoting bacterium."],["dc.identifier.doi","10.1128/genomeA.00011-18"],["dc.identifier.eissn","2169-8287"],["dc.identifier.pmid","29437086"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/64449"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.relation.issn","2169-8287"],["dc.title","Draft Genome Sequence of the Endophyte Bacillus mycoides Strain GM6LP Isolated from Lolium perenne"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","324"],["dc.bibliographiccitation.journal","BMC Genomics"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Kalhoefer, Daniela"],["dc.contributor.author","Thole, Sebastian"],["dc.contributor.author","Voget, Sonja"],["dc.contributor.author","Lehmann, Ruediger"],["dc.contributor.author","Liesegang, Heiko"],["dc.contributor.author","Wollher, Antje"],["dc.contributor.author","Daniel, Rolf"],["dc.contributor.author","Simon, Meinhard"],["dc.contributor.author","Brinkhoff, Thorsten"],["dc.date.accessioned","2018-11-07T08:54:59Z"],["dc.date.available","2018-11-07T08:54:59Z"],["dc.date.issued","2011"],["dc.description.abstract","Background: Roseobacter litoralis OCh149, the type species of the genus, and Roseobacter denitrificans OCh114 were the first described organisms of the Roseobacter clade, an ecologically important group of marine bacteria. Both species were isolated from seaweed and are able to perform aerobic anoxygenic photosynthesis. Results: The genome of R. litoralis OCh149 contains one circular chromosome of 4,505,211 bp and three plasmids of 93,578 bp (pRLO149_94), 83,129 bp (pRLO149_83) and 63,532 bp (pRLO149_63). Of the 4537 genes predicted for R. litoralis, 1122 (24.7%) are not present in the genome of R. denitrificans. Many of the unique genes of R. litoralis are located in genomic islands and on plasmids. On pRLO149_83 several potential heavy metal resistance genes are encoded which are not present in the genome of R. denitrificans. The comparison of the heavy metal tolerance of the two organisms showed an increased zinc tolerance of R. litoralis. In contrast to R. denitrificans, the photosynthesis genes of R. litoralis are plasmid encoded. The activity of the photosynthetic apparatus was confirmed by respiration rate measurements, indicating a growth-phase dependent response to light. Comparative genomics with other members of the Roseobacter clade revealed several genomic regions that were only conserved in the two Roseobacter species. One of those regions encodes a variety of genes that might play a role in host association of the organisms. The catabolism of different carbon and nitrogen sources was predicted from the genome and combined with experimental data. In several cases, e. g. the degradation of some algal osmolytes and sugars, the genome-derived predictions of the metabolic pathways in R. litoralis differed from the phenotype. Conclusions: The genomic differences between the two Roseobacter species are mainly due to lateral gene transfer and genomic rearrangements. Plasmid pRLO149_83 contains predominantly recently acquired genetic material whereas pRLO149_94 was probably translocated from the chromosome. Plasmid pRLO149_63 and one plasmid of R. denitrifcans (pTB2) seem to have a common ancestor and are important for cell envelope biosynthesis. Several new mechanisms of substrate degradation were indicated from the combination of experimental and genomic data. The photosynthetic activity of R. litoralis is probably regulated by nutrient availability."],["dc.identifier.doi","10.1186/1471-2164-12-324"],["dc.identifier.isi","000292985100001"],["dc.identifier.pmid","21693016"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/6835"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/22799"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Biomed Central Ltd"],["dc.relation.issn","1471-2164"],["dc.rights","CC BY 2.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/2.0"],["dc.title","Comparative genome analysis and genome-guided physiological analysis of Roseobacter litoralis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Genome Announcements"],["dc.bibliographiccitation.volume","6"],["dc.contributor.author","Hollensteiner, Jacqueline"],["dc.contributor.author","Poehlein, Anja"],["dc.contributor.author","Granzow, Sandra"],["dc.contributor.author","Liesegang, Heiko"],["dc.contributor.author","Daniel, Rolf"],["dc.contributor.author","Vidal, Stefan"],["dc.contributor.author","Wemheuer, Franziska"],["dc.date.accessioned","2020-12-10T18:37:01Z"],["dc.date.available","2020-12-10T18:37:01Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1128/genomeA.01517-17"],["dc.identifier.eissn","2169-8287"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/76814"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Draft Genome Sequence of the Endophyte Bacillus mycoides Strain GM5LP Isolated from Lolium perenne"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","365"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Journal of Biotechnology"],["dc.bibliographiccitation.lastpage","369"],["dc.bibliographiccitation.volume","167"],["dc.contributor.author","Rachinger, Michael"],["dc.contributor.author","Bauch, Melanie"],["dc.contributor.author","Strittmatter, Axel W."],["dc.contributor.author","Bongaerts, Johannes"],["dc.contributor.author","Evers, Stefan"],["dc.contributor.author","Maurer, Karl-Heinz"],["dc.contributor.author","Daniel, Rolf"],["dc.contributor.author","Liebl, Wolfgang"],["dc.contributor.author","Liesegang, Heiko"],["dc.contributor.author","Ehrenreich, Armin"],["dc.date.accessioned","2018-11-07T09:19:50Z"],["dc.date.available","2018-11-07T09:19:50Z"],["dc.date.issued","2013"],["dc.description.abstract","Conjugative shuttle vectors of the pKVM series, based on an IncP transfer origin and the pMAD vector with a temperature sensitive replication were constructed to establish a markerless gene deletion protocol for Bacilli without natural competence such as the exoenzyme producer Bacillus licheniformis. The pKVM plasmids can be conjugated to strains of B. licheniformis and B. subtilis. For chromosomal gene deletion, regions flanking the target gene are fused and cloned in a pKVM vector prior to conjugative transfer from Escherichia coli to B. licheniformis. Appropriate markers on the vector backbone allow for the identification of the integration at the target locus and thereafter the vector excision, both events taking place via homologous recombination. The functionality of the deletion system was demonstrated with B. licheniformis by a markerless 939 bp in-frame deletion of the yqfD gene and the deletion of a 31 kbp genomic segment carrying a PBSX-like prophage. (c) 2013 Elsevier B.V. All rights reserved."],["dc.description.sponsorship","BMBF GenoMik-Plus program [0313751A]; GenoMik Design program [0313917D]"],["dc.identifier.doi","10.1016/j.jbiotec.2013.07.026"],["dc.identifier.isi","000324737900002"],["dc.identifier.pmid","23916947"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/28734"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Bv"],["dc.relation.issn","1873-4863"],["dc.relation.issn","0168-1656"],["dc.title","Size unlimited markerless deletions by a transconjugative plasmid-system in Bacillus licheniformis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","766"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","The ISME Journal"],["dc.bibliographiccitation.lastpage","776"],["dc.bibliographiccitation.volume","6"],["dc.contributor.author","Gardebrecht, Antje"],["dc.contributor.author","Markert, Stephanie"],["dc.contributor.author","Sievert, Stefan M."],["dc.contributor.author","Felbeck, Horst"],["dc.contributor.author","Thuermer, Andrea"],["dc.contributor.author","Albrecht, Dirk"],["dc.contributor.author","Wollherr, Antje"],["dc.contributor.author","Kabisch, Johannes"],["dc.contributor.author","Le Bris, Nadine"],["dc.contributor.author","Lehmann, Ruediger"],["dc.contributor.author","Daniel, Rolf"],["dc.contributor.author","Liesegang, Heiko"],["dc.contributor.author","Hecker, Michael"],["dc.contributor.author","Schweder, Thomas"],["dc.date.accessioned","2018-11-07T09:11:51Z"],["dc.date.available","2018-11-07T09:11:51Z"],["dc.date.issued","2012"],["dc.description.abstract","The two closely related deep-sea tubeworms Riftia pachyptila and Tevnia jerichonana both rely exclusively on a single species of sulfide-oxidizing endosymbiotic bacteria for their nutrition. They do, however, thrive in markedly different geochemical conditions. A detailed proteogenomic comparison of the endosymbionts coupled with an in situ characterization of the geochemical environment was performed to investigate their roles and expression profiles in the two respective hosts. The metagenomes indicated that the endosymbionts are genotypically highly homogeneous. Gene sequences coding for enzymes of selected key metabolic functions were found to be 99.9% identical. On the proteomic level, the symbionts showed very consistent metabolic profiles, despite distinctly different geochemical conditions at the plume level of the respective hosts. Only a few minor variations were observed in the expression of symbiont enzymes involved in sulfur metabolism, carbon fixation and in the response to oxidative stress. Although these changes correspond to the prevailing environmental situation experienced by each host, our data strongly suggest that the two tubeworm species are able to effectively attenuate differences in habitat conditions, and thus to provide their symbionts with similar micro-environments. The ISME Journal (2012) 6, 766-776; doi: 10.1038/ismej.2011.137; published online 20 October 2011"],["dc.identifier.doi","10.1038/ismej.2011.137"],["dc.identifier.isi","000301945500007"],["dc.identifier.pmid","22011719"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/26816"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Nature Publishing Group"],["dc.relation.issn","1751-7362"],["dc.title","Physiological homogeneity among the endosymbionts of Riftia pachyptila and Tevnia jerichonana revealed by proteogenomics"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","760"],["dc.bibliographiccitation.journal","Microbiology"],["dc.bibliographiccitation.lastpage","773"],["dc.bibliographiccitation.volume","157"],["dc.contributor.author","Rechnitzer, Hagai"],["dc.contributor.author","Brzuszkiewicz, Elzbieta B."],["dc.contributor.author","Strittmatter, Axel W."],["dc.contributor.author","Liesegang, Heiko"],["dc.contributor.author","Lysnyansky, Inna"],["dc.contributor.author","Daniel, Rolf"],["dc.contributor.author","Gottschalk, Gerhard"],["dc.contributor.author","Rottem, Shlomo"],["dc.date.accessioned","2018-11-07T08:58:29Z"],["dc.date.available","2018-11-07T08:58:29Z"],["dc.date.issued","2011"],["dc.description.abstract","We present the complete genomic sequence of Mycoplasma fermentans, an organism suggested to be associated with the pathogenesis of rheumatoid arthritis in humans. The genome is composed of 977 524 bp and has a mean G + C content of 26.95 mol%. There are 835 predicted protein-coding sequences and a mean coding density of 87.6%. Functions have been assigned to 58.8% of the predicted protein-coding sequences, while 18.4% of the proteins are conserved hypothetical proteins and 22.8% are hypothetical proteins. In addition, there are two complete rRNA operons and 36 tRNA coding sequences. The largest gene families are the ABC transporter family (42 members), and the functionally heterogeneous group of lipoproteins (28 members), which encode the characteristic prokaryotic cysteine 'lipobox'. Protein secretion occurs through a pathway consisting of SecA, SecD, SecE, SecG, SecY and YidC. Some highly conserved eubacterial proteins, such as GroEL and GroES, are notably absent. The genes encoding DnaK-DnaJ-GrpE and Tig, forming the putative complex of chaperones, are intact, providing the only known control over protein folding. Eighteen nucleases and 17 proteases and peptidases were detected as well as three genes for the thioredoxin-thioreductase system. Overall, this study presents insights into the physiology of M. fermentans, and provides several examples of the genetic basis of systems that might function as virulence factors in this organism."],["dc.description.sponsorship","FEMS; Niedersachsisches Ministerium fur Wissenschaft und Kultur"],["dc.identifier.doi","10.1099/mic.0.043208-0"],["dc.identifier.isi","000288833000015"],["dc.identifier.pmid","21109561"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/23653"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Soc General Microbiology"],["dc.relation.issn","1350-0872"],["dc.title","Genomic features and insights into the biology of Mycoplasma fermentans"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","883"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","Archives of Microbiology"],["dc.bibliographiccitation.lastpage","891"],["dc.bibliographiccitation.volume","193"],["dc.contributor.author","Brzuszkiewicz, Elzbieta B."],["dc.contributor.author","Thuermer, Andrea"],["dc.contributor.author","Schuldes, Joerg"],["dc.contributor.author","Leimbach, Andreas"],["dc.contributor.author","Liesegang, Heiko"],["dc.contributor.author","Meyer, Frauke-Dorothee"],["dc.contributor.author","Boelter, Juergen"],["dc.contributor.author","Petersen, Heiko"],["dc.contributor.author","Gottschalk, Gerhard"],["dc.contributor.author","Daniel, Rolf"],["dc.date.accessioned","2018-11-07T08:49:30Z"],["dc.date.available","2018-11-07T08:49:30Z"],["dc.date.issued","2011"],["dc.description.abstract","The genome sequences of two Escherichia coli O104:H4 strains derived from two different patients of the 2011 German E. coli outbreak were determined. The two analyzed strains were designated E. coli GOS1 and GOS2 (German outbreak strain). Both isolates comprise one chromosome of approximately 5.31 Mbp and two putative plasmids. Comparisons of the 5,217 (GOS1) and 5,224 (GOS2) predicted protein-encoding genes with various E. coli strains, and a multilocus sequence typing analysis revealed that the isolates were most similar to the entero-aggregative E. coli (EAEC) strain 55989. In addition, one of the putative plasmids of the outbreak strain is similar to pAA-type plasmids of EAEC strains, which contain aggregative adhesion fimbrial operons. The second putative plasmid harbors genes for extended-spectrum beta-lactamases. This type of plasmid is widely distributed in pathogenic E. coli strains. A significant difference of the E. coli GOS1 and GOS2 genomes to those of EAEC strains is the presence of a prophage encoding the Shiga toxin, which is characteristic for enterohemorrhagic E. coli (EHEC) strains. The unique combination of genomic features of the German outbreak strain, containing characteristics from pathotypes EAEC and EHEC, suggested that it represents a new pathotype Entero-Aggregative-Haemorrhagic Escherichia coli (EAHEC)."],["dc.identifier.doi","10.1007/s00203-011-0725-6"],["dc.identifier.isi","000297223500005"],["dc.identifier.pmid","21713444"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/7515"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/21476"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0302-8933"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Genome sequence analyses of two isolates from the recent Escherichia coli outbreak in Germany reveal the emergence of a new pathotype: Entero-Aggregative-Haemorrhagic Escherichia coli (EAHEC)"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","BMC Genomics"],["dc.bibliographiccitation.lastpage","14"],["dc.bibliographiccitation.volume","19"],["dc.contributor.author","Groß, Uwe"],["dc.contributor.author","Brzuszkiewicz, Elzbieta B."],["dc.contributor.author","Gunka, Katrin"],["dc.contributor.author","Starke, Jessica"],["dc.contributor.author","Riedel, Thomas"],["dc.contributor.author","Bunk, Boyke"],["dc.contributor.author","Spröer, Cathrin"],["dc.contributor.author","Wetzel, Daniela"],["dc.contributor.author","Poehlein, Anja"],["dc.contributor.author","Chibani, Cynthia"],["dc.contributor.author","Bohne, Wolfgang"],["dc.contributor.author","Overmann, Jörg"],["dc.contributor.author","Zimmermann, Ortrud"],["dc.contributor.author","Daniel, Rolf"],["dc.contributor.author","Liesegang, Heiko"],["dc.date.accessioned","2019-07-09T11:45:11Z"],["dc.date.available","2019-07-09T11:45:11Z"],["dc.date.issued","2018"],["dc.description.abstract","BACKGROUND: Clostridioides difficile infections (CDI) have emerged over the past decade causing symptoms that range from mild, antibiotic-associated diarrhea (AAD) to life-threatening toxic megacolon. In this study, we describe a multiple and isochronal (mixed) CDI caused by the isolates DSM 27638, DSM 27639 and DSM 27640 that already initially showed different morphotypes on solid media. RESULTS: The three isolates belonging to the ribotypes (RT) 012 (DSM 27639) and 027 (DSM 27638 and DSM 27640) were phenotypically characterized and high quality closed genome sequences were generated. The genomes were compared with seven reference strains including three strains of the RT 027, two of the RT 017, and one of the RT 078 as well as a multi-resistant RT 012 strain. The analysis of horizontal gene transfer events revealed gene acquisition incidents that sort the strains within the time line of the spread of their RTs within Germany. We could show as well that horizontal gene transfer between the members of different RTs occurred within this multiple infection. In addition, acquisition and exchange of virulence-related features including antibiotic resistance genes were observed. Analysis of the two genomes assigned to RT 027 revealed three single nucleotide polymorphisms (SNPs) and apparently a regional genome modification within the flagellar switch that regulates the fli operon. CONCLUSION: Our findings show that (i) evolutionary events based on horizontal gene transfer occur within an ongoing CDI and contribute to the adaptation of the species by the introduction of new genes into the genomes, (ii) within a multiple infection of a single patient the exchange of genetic material was responsible for a much higher genome variation than the observed SNPs."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2018"],["dc.identifier.doi","10.1186/s12864-017-4368-0"],["dc.identifier.pmid","29291715"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/15054"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/59178"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.notes.intern","In goescholar not merged with http://resolver.sub.uni-goettingen.de/purl?gs-1/15123 but duplicate"],["dc.notes.status","final"],["dc.relation.issn","1471-2164"],["dc.rights","CC BY 4.0"],["dc.rights.access","openAccess"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.subject.ddc","570"],["dc.title","Comparative genome and phenotypic analysis of three Clostridioides difficile strains isolated from a single patient provide insight into multiple infection of C. difficile."],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","e1001078"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","PLoS Pathogens"],["dc.bibliographiccitation.volume","6"],["dc.contributor.author","Zdziarski, Jaroslaw"],["dc.contributor.author","Brzuszkiewicz, Elzbieta B."],["dc.contributor.author","Wullt, Bjorn"],["dc.contributor.author","Liesegang, Heiko"],["dc.contributor.author","Biran, Dvora"],["dc.contributor.author","Voigt, Birgit"],["dc.contributor.author","Gronberg-Hernandez, Jenny"],["dc.contributor.author","Ragnarsdottir, Bryndis"],["dc.contributor.author","Hecker, Michael"],["dc.contributor.author","Ron, Eliora Z."],["dc.contributor.author","Daniel, Rolf"],["dc.contributor.author","Gottschalk, Gerhard"],["dc.contributor.author","Hacker, Joerg"],["dc.contributor.author","Svanborg, Catharina"],["dc.contributor.author","Dobrindt, Ulrich"],["dc.date.accessioned","2018-11-07T08:41:04Z"],["dc.date.available","2018-11-07T08:41:04Z"],["dc.date.issued","2010"],["dc.description.abstract","Bacteria lose or gain genetic material and through selection, new variants become fixed in the population. Here we provide the first, genome-wide example of a single bacterial strain's evolution in different deliberately colonized patients and the surprising insight that hosts appear to personalize their microflora. By first obtaining the complete genome sequence of the prototype asymptomatic bacteriuria strain E. coli 83972 and then resequencing its descendants after therapeutic bladder colonization of different patients, we identified 34 mutations, which affected metabolic and virulence-related genes. Further transcriptome and proteome analysis proved that these genome changes altered bacterial gene expression resulting in unique adaptation patterns in each patient. Our results provide evidence that, in addition to stochastic events, adaptive bacterial evolution is driven by individual host environments. Ongoing loss of gene function supports the hypothesis that evolution towards commensalism rather than virulence is favored during asymptomatic bladder colonization."],["dc.identifier.doi","10.1371/journal.ppat.1001078"],["dc.identifier.isi","000281399900048"],["dc.identifier.pmid","20865122"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/7263"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/19388"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Public Library Science"],["dc.relation.issn","1553-7366"],["dc.rights","CC BY 2.5"],["dc.rights.uri","https://creativecommons.org/licenses/by/2.5"],["dc.title","Host Imprints on Bacterial Genomes-Rapid, Divergent Evolution in Individual Patients"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","61"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","The ISME Journal"],["dc.bibliographiccitation.lastpage","77"],["dc.bibliographiccitation.volume","4"],["dc.contributor.author","Wagner-Doebler, Irene"],["dc.contributor.author","Ballhausen, Britta"],["dc.contributor.author","Berger, Martine"],["dc.contributor.author","Brinkhoff, Thorsten"],["dc.contributor.author","Buchholz, Ina"],["dc.contributor.author","Bunk, Boyke"],["dc.contributor.author","Cypionka, Heribert"],["dc.contributor.author","Daniel, Rolf"],["dc.contributor.author","Drepper, Thomas"],["dc.contributor.author","Gerdts, Gunnar"],["dc.contributor.author","Hahnke, Sarah"],["dc.contributor.author","Han, Cliff"],["dc.contributor.author","Jahn, Dieter"],["dc.contributor.author","Kalhoefer, Daniela"],["dc.contributor.author","Kiss, Hajnalka"],["dc.contributor.author","Klenk, Hans-Peter"],["dc.contributor.author","Kyrpides, Nikos C."],["dc.contributor.author","Liebl, Wolfgang"],["dc.contributor.author","Liesegang, Heiko"],["dc.contributor.author","Meincke, Linda"],["dc.contributor.author","Pati, Amrita"],["dc.contributor.author","Petersen, Joern"],["dc.contributor.author","Piekarski, Tanja"],["dc.contributor.author","Pommerenke, Claudia"],["dc.contributor.author","Pradella, Silke"],["dc.contributor.author","Pukall, Ruediger"],["dc.contributor.author","Rabus, Ralf"],["dc.contributor.author","Stackebrandt, Erko"],["dc.contributor.author","Thole, Sebastian"],["dc.contributor.author","Thompson, Linda"],["dc.contributor.author","Tielen, Petra"],["dc.contributor.author","Tomasch, Juergen"],["dc.contributor.author","von Jan, Mathias"],["dc.contributor.author","Wanphrut, Nittaya"],["dc.contributor.author","Wichels, Antje"],["dc.contributor.author","Zech, Hajo"],["dc.contributor.author","Simon, Meinhard"],["dc.date.accessioned","2018-11-07T08:47:51Z"],["dc.date.available","2018-11-07T08:47:51Z"],["dc.date.issued","2010"],["dc.description.abstract","Dinoroseobacter shibae DFL12(T), a member of the globally important marine Roseobacter clade, comprises symbionts of cosmopolitan marine microalgae, including toxic dinoflagellates. Its annotated 4 417 868 bp genome sequence revealed a possible advantage of this symbiosis for the algal host. D. shibae DFL12(T) is able to synthesize the vitamins B(1) and B(12) for which its host is auxotrophic. Two pathways for the de novo synthesis of vitamin B12 are present, one requiring oxygen and the other an oxygen-independent pathway. The de novo synthesis of vitamin B(12) was confirmed to be functional, and D. shibae DFL12(T) was shown to provide the growth-limiting vitamins B(1) and B(12) to its dinoflagellate host. The Roseobacter clade has been considered to comprise obligate aerobic bacteria. However, D. shibae DFL12(T) is able to grow anaerobically using the alternative electron acceptors nitrate and dimethylsulfoxide; it has the arginine deiminase survival fermentation pathway and a complex oxygen-dependent Fnr (fumarate and nitrate reduction) regulon. Many of these traits are shared with other members of the Roseobacter clade. D. shibae DFL12(T) has five plasmids, showing examples for vertical recruitment of chromosomal genes (thiC) and horizontal gene transfer (cox genes, gene cluster of 47 kb) possibly by conjugation (vir gene cluster). The long-range (80%) synteny between two sister plasmids provides insights into the emergence of novel plasmids. D. shibae DFL12(T) shows the most complex viral defense system of all Rhodobacterales sequenced to date. The ISME Journal (2010) 4, 61-77; doi:10.1038/ismej.2009.94; published online 10 September 2009"],["dc.description.sponsorship","Marine Biotechnology [ZN1225, ZN2235]; Moore Foundation, USA"],["dc.identifier.doi","10.1038/ismej.2009.94"],["dc.identifier.isi","000273350200006"],["dc.identifier.pmid","19741735"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/21066"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Nature Publishing Group"],["dc.relation.issn","1751-7362"],["dc.title","The complete genome sequence of the algal symbiont Dinoroseobacter shibae: a hitchhiker's guide to life in the sea"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]