Now showing 1 - 10 of 71
  • 2018Journal Article
    [["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Genome Announcements"],["dc.bibliographiccitation.volume","6"],["dc.contributor.author","Wemheuer, Franziska"],["dc.contributor.author","Hollensteiner, Jacqueline"],["dc.contributor.author","Poehlein, Anja"],["dc.contributor.author","Liesegang, Heiko"],["dc.contributor.author","Daniel, Rolf"],["dc.contributor.author","Wemheuer, Bernd"],["dc.date.accessioned","2020-04-28T12:41:35Z"],["dc.date.available","2020-04-28T12:41:35Z"],["dc.date.issued","2018"],["dc.description.abstract","Bacillus mycoides GM6LP is an endophyte isolated from plant tissues of Lolium perenne L. Here, we report its draft genome sequence (6.2 Mb), which contains 96 contigs and 6,129 protein-coding genes. Knowledge about its genome will enable us to evaluate the potential use of GM6LP as a plant growth-promoting bacterium."],["dc.identifier.doi","10.1128/genomeA.00011-18"],["dc.identifier.eissn","2169-8287"],["dc.identifier.pmid","29437086"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/64449"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.relation.issn","2169-8287"],["dc.title","Draft Genome Sequence of the Endophyte Bacillus mycoides Strain GM6LP Isolated from Lolium perenne"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]
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  • 2011Journal Article
    [["dc.bibliographiccitation.artnumber","324"],["dc.bibliographiccitation.journal","BMC Genomics"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Kalhoefer, Daniela"],["dc.contributor.author","Thole, Sebastian"],["dc.contributor.author","Voget, Sonja"],["dc.contributor.author","Lehmann, Ruediger"],["dc.contributor.author","Liesegang, Heiko"],["dc.contributor.author","Wollher, Antje"],["dc.contributor.author","Daniel, Rolf"],["dc.contributor.author","Simon, Meinhard"],["dc.contributor.author","Brinkhoff, Thorsten"],["dc.date.accessioned","2018-11-07T08:54:59Z"],["dc.date.available","2018-11-07T08:54:59Z"],["dc.date.issued","2011"],["dc.description.abstract","Background: Roseobacter litoralis OCh149, the type species of the genus, and Roseobacter denitrificans OCh114 were the first described organisms of the Roseobacter clade, an ecologically important group of marine bacteria. Both species were isolated from seaweed and are able to perform aerobic anoxygenic photosynthesis. Results: The genome of R. litoralis OCh149 contains one circular chromosome of 4,505,211 bp and three plasmids of 93,578 bp (pRLO149_94), 83,129 bp (pRLO149_83) and 63,532 bp (pRLO149_63). Of the 4537 genes predicted for R. litoralis, 1122 (24.7%) are not present in the genome of R. denitrificans. Many of the unique genes of R. litoralis are located in genomic islands and on plasmids. On pRLO149_83 several potential heavy metal resistance genes are encoded which are not present in the genome of R. denitrificans. The comparison of the heavy metal tolerance of the two organisms showed an increased zinc tolerance of R. litoralis. In contrast to R. denitrificans, the photosynthesis genes of R. litoralis are plasmid encoded. The activity of the photosynthetic apparatus was confirmed by respiration rate measurements, indicating a growth-phase dependent response to light. Comparative genomics with other members of the Roseobacter clade revealed several genomic regions that were only conserved in the two Roseobacter species. One of those regions encodes a variety of genes that might play a role in host association of the organisms. The catabolism of different carbon and nitrogen sources was predicted from the genome and combined with experimental data. In several cases, e. g. the degradation of some algal osmolytes and sugars, the genome-derived predictions of the metabolic pathways in R. litoralis differed from the phenotype. Conclusions: The genomic differences between the two Roseobacter species are mainly due to lateral gene transfer and genomic rearrangements. Plasmid pRLO149_83 contains predominantly recently acquired genetic material whereas pRLO149_94 was probably translocated from the chromosome. Plasmid pRLO149_63 and one plasmid of R. denitrifcans (pTB2) seem to have a common ancestor and are important for cell envelope biosynthesis. Several new mechanisms of substrate degradation were indicated from the combination of experimental and genomic data. The photosynthetic activity of R. litoralis is probably regulated by nutrient availability."],["dc.identifier.doi","10.1186/1471-2164-12-324"],["dc.identifier.isi","000292985100001"],["dc.identifier.pmid","21693016"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/6835"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/22799"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Biomed Central Ltd"],["dc.relation.issn","1471-2164"],["dc.rights","CC BY 2.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/2.0"],["dc.title","Comparative genome analysis and genome-guided physiological analysis of Roseobacter litoralis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]
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  • 2003Journal Article
    [["dc.bibliographiccitation.firstpage","1316"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"],["dc.bibliographiccitation.lastpage","1321"],["dc.bibliographiccitation.volume","100"],["dc.contributor.author","Bruggemann, H."],["dc.contributor.author","Baumer, S."],["dc.contributor.author","Fricke, Wolfgang Florian"],["dc.contributor.author","Wiezer, A."],["dc.contributor.author","Liesegang, Heiko"],["dc.contributor.author","Decker, I."],["dc.contributor.author","Herzberg, C."],["dc.contributor.author","Martinez-Arias, R."],["dc.contributor.author","Merkl, R."],["dc.contributor.author","Henne, A."],["dc.contributor.author","Gottschalk, G."],["dc.date.accessioned","2018-11-07T10:40:58Z"],["dc.date.available","2018-11-07T10:40:58Z"],["dc.date.issued","2003"],["dc.description.abstract","Tetanus disease is one of the most dramatic and globally prevalent diseases of humans and vertebrate animals, and has been reported for over 24 centuries. The manifestation of the disease, spastic paralysis, is caused by the second most poisonous substance known, the tetanus toxin, with a human lethal dose of approximate to1 ng/kg. Fortunately, this disease is successfully controlled through immunization with tetanus toxoid; nevertheless, according to the World Health Organization, an estimated 400,000 cases still occur each year, mainly of neonatal tetanus. The causative agent of tetanus disease is Clostridium tetani, an anaerobic spore-forming bacterium, whose natural habitat is soil, dust, and intestinal tracts of various animals. Here we report the complete genome sequence of toxigenic C. tetani E88, a variant of strain Massachusetts. The genome consists of a 2,799,250-bp chromosome encoding 2,372 ORFs. The tetanus toxin and a collagenase are encoded on a 74,082-bp plasmid, containing 61 ORFs. Additional virulence-related factors could be identified, such as an array of surface-layer and adhesion proteins (35 ORFs), some of them unique to C. tetani. Comparative genomics with the genomes of Clostridium perfringens, the causative agent of gas gangrene, and Clostridium acetobutylicum, a nonpathogenic solvent producer, revealed a remarkable capacity of C. tetani: The organism can rely on an extensive sodium ion bioenergetics. Additional candidate genes involved in the establishment and maintenance of a pathogenic lifestyle of C. tetani are presented."],["dc.identifier.doi","10.1073/pnas.0335853100"],["dc.identifier.isi","000180838100098"],["dc.identifier.pmid","12552129"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/46432"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Natl Acad Sciences"],["dc.relation.issn","0027-8424"],["dc.title","The genome sequence of Clostridium tetani, the causative agent of tetanus disease"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]
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  • 2015Journal Article
    [["dc.bibliographiccitation.firstpage","2255"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Applied Microbiology and Biotechnology"],["dc.bibliographiccitation.lastpage","2266"],["dc.bibliographiccitation.volume","99"],["dc.contributor.author","Jakobs, Mareike"],["dc.contributor.author","Hoffmann, Kerstin"],["dc.contributor.author","Liesegang, Heiko"],["dc.contributor.author","Volland, Sonja"],["dc.contributor.author","Meinhardt, Friedhelm"],["dc.date.accessioned","2018-11-07T10:00:29Z"],["dc.date.available","2018-11-07T10:00:29Z"],["dc.date.issued","2015"],["dc.description.abstract","In Bacillus subtilis, natural genetic competence is subject to complex genetic regulation and quorum sensing dependent. Upon extracellular accumulation of the peptide-pheromone ComX, the membrane-bound sensor histidine kinase ComP initiates diverse signaling pathways by activating-among others-DegQ and ComS. While DegQ favors the expression of extracellular enzymes rather than competence development, ComS is crucial for competence development as it prevents proteolytic degradation of ComK, the key transcriptional activator of all genes required for the uptake and integration of DNA. In Bacillus licheniformis, ComX/ComP sensed cell density negatively influences competence development, suggesting differences from the quorum-sensing-dependent control mechanism in Bacillus subtilis. Here, we show that each of six investigated strains possesses both of two different, recently identified putative comS genes. When expressed from an inducible promoter, none of the comS candidate genes displayed an impact on competence development neither in B. subtilis nor in B. licheniformis. Moreover, disruption of the genes did not reduce transformation efficiency. While the putative comS homologs do not contribute to competence development, we provide evidence that the degQ gene as for B. subtilis negatively influences genetic competency in B. licheniformis."],["dc.identifier.doi","10.1007/s00253-014-6291-5"],["dc.identifier.isi","000350029000019"],["dc.identifier.pmid","25520171"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/37819"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","1432-0614"],["dc.relation.issn","0175-7598"],["dc.title","The two putative comS homologs of the biotechnologically important Bacillus licheniformis do not contribute to competence development"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]
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  • 2017Journal Article
    [["dc.bibliographiccitation.issue","48"],["dc.bibliographiccitation.journal","Genome Announcements"],["dc.bibliographiccitation.volume","5"],["dc.contributor.author","Chibani, Cynthia Maria"],["dc.contributor.author","Poehlein, Anja"],["dc.contributor.author","Roth, Olivia"],["dc.contributor.author","Liesegang, Heiko"],["dc.contributor.author","Wendling, Carolin Charlotte"],["dc.date.accessioned","2020-12-10T18:36:58Z"],["dc.date.available","2020-12-10T18:36:58Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1128/genomeA.01368-17"],["dc.identifier.eissn","2169-8287"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/76806"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Draft Genome Sequence of Vibrio splendidus DSM 19640"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]
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  • 2022Journal Article
    [["dc.bibliographiccitation.artnumber","20221070"],["dc.bibliographiccitation.issue","1984"],["dc.bibliographiccitation.journal","Proceedings of the Royal Society B: Biological Sciences"],["dc.bibliographiccitation.volume","289"],["dc.contributor.author","Wendling, Carolin C."],["dc.contributor.author","Lange, Janina"],["dc.contributor.author","Liesegang, Heiko"],["dc.contributor.author","Sieber, Michael"],["dc.contributor.author","Poehlein, Anja"],["dc.contributor.author","Bunk, Boyke"],["dc.contributor.author","Rajkov, Jelena"],["dc.contributor.author","Goehlich, Henry"],["dc.contributor.author","Roth, Olivia"],["dc.contributor.author","Brockhurst, Michael A."],["dc.date.accessioned","2022-11-01T10:16:57Z"],["dc.date.available","2022-11-01T10:16:57Z"],["dc.date.issued","2022"],["dc.description.abstract","Pathogens vary strikingly in their virulence and the selection they impose on their hosts. While the evolution of different virulence levels is well studied, the evolution of host resistance in response to different virulence levels is less understood and, at present, mainly based on observations and theoretical predictions with few experimental tests. Increased virulence can increase selection for host resistance evolution if the benefits of avoiding infection outweigh resistance costs. To test this, we experimentally evolved the bacterium\n Vibrio alginolyticus\n in the presence of two variants of a filamentous phage that differ in their virulence. The bacterial host exhibited two alternative defence strategies: (1) super infection exclusion (SIE), whereby phage-infected cells were immune to subsequent infection at the cost of reduced growth, and (2) surface receptor mutations (SRM), providing resistance to infection by preventing phage attachment. While SIE emerged rapidly against both phages, SRM evolved faster against the high- than the low-virulence phage. Using a mathematical model of our system, we show that increasing virulence strengthens selection for SRM owing to the higher costs of infection suffered by SIE immune hosts. Thus, by accelerating the evolution of host resistance, more virulent phages caused shorter epidemics."],["dc.description.sponsorship"," Deutsche Forschungsgemeinschaft http://dx.doi.org/10.13039/501100001659"],["dc.identifier.doi","10.1098/rspb.2022.1070"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/116697"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-605"],["dc.relation.eissn","1471-2954"],["dc.relation.issn","0962-8452"],["dc.rights.uri","https://royalsociety.org/journals/ethics-policies/data-sharing-mining/"],["dc.title","Higher phage virulence accelerates the evolution of host resistance"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]
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  • 2003Journal Article
    [["dc.bibliographiccitation.firstpage","7298"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","Applied and Environmental Microbiology"],["dc.bibliographiccitation.lastpage","7309"],["dc.bibliographiccitation.volume","69"],["dc.contributor.author","Schmeisser, C."],["dc.contributor.author","Stockigt, C."],["dc.contributor.author","Raasch, C."],["dc.contributor.author","Wingender, J."],["dc.contributor.author","Timmis, K. N."],["dc.contributor.author","Wenderoth, D. F."],["dc.contributor.author","Flemming, H. C."],["dc.contributor.author","Liesegang, Heiko"],["dc.contributor.author","Schmitz, Ruth A."],["dc.contributor.author","Jaeger, K. E."],["dc.contributor.author","Streit, Wolfgang R."],["dc.date.accessioned","2018-11-07T10:34:13Z"],["dc.date.available","2018-11-07T10:34:13Z"],["dc.date.issued","2003"],["dc.description.abstract","Most naturally occurring biofilms contain a vast majority of microorganisms which have not yet been cultured, and therefore we have little information on the genetic information content of these communities. Therefore, we initiated work to characterize the complex metagenome of model drinking water biofilms grown on rubber-coated valves by employing three different strategies. First, a sequence analysis of 650 16S rRNA clones indicated a high diversity within the biofilm communities, with the majority of the microbes being closely related to the Proteobacteria. Only a small fraction of the 16S rRNA sequences were highly similar to rRNA sequences from Actinobacteria, low-G+C gram-positives and the Cytophaga-Flavobacterium-Bacteroides group. Our second strategy included a snapshot genome sequencing approach. Homology searches in public databases with 5,000 random sequence clones from a small insert library resulted in the identification of 2,200 putative protein-coding sequences, of which 1,026 could be classified into functional groups. Similarity analyses indicated that significant fractions of the genes and proteins identified were highly similar to known proteins observed in the genera Rhizobium, Pseudomonas, and Escherichia. Finally, we report 144 kb of DNA sequence information from four selected cosmid clones, of which two formed a 75-kb overlapping contig. The majority of the proteins identified by whole-cosmid sequencing probably originated from microbes closely related to the alpha-, beta-, and gamma-Proteobacteria. The sequence information was used to set up a database containing the phylogenetic and genomic information on this model microbial community. Concerning the potential health risk of the microbial community studied, no DNA or protein sequences directly linked to pathogenic traits were identified."],["dc.identifier.doi","10.1128/AEM.69.12.7298-7309.2003"],["dc.identifier.isi","000187234000043"],["dc.identifier.pmid","14660379"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/44807"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Soc Microbiology"],["dc.relation.issn","0099-2240"],["dc.title","Metagenome survey of biofilms in drinking-water networks"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]
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  • 2011Conference Paper
    [["dc.bibliographiccitation.artnumber","S6"],["dc.bibliographiccitation.journal","Microbial Cell Factories"],["dc.bibliographiccitation.volume","10"],["dc.contributor.author","Vogel, Rudi F."],["dc.contributor.author","Pavlovic, Melanie"],["dc.contributor.author","Ehrmann, Matthias A."],["dc.contributor.author","Wiezer, Arnim"],["dc.contributor.author","Liesegang, Heiko"],["dc.contributor.author","Offschanka, Stefanie"],["dc.contributor.author","Voget, Sonja"],["dc.contributor.author","Angelov, Angel"],["dc.contributor.author","Boecker, Georg"],["dc.contributor.author","Liebl, Wolfgang"],["dc.date.accessioned","2018-11-07T08:53:04Z"],["dc.date.available","2018-11-07T08:53:04Z"],["dc.date.issued","2011"],["dc.description.abstract","Sourdough has played a significant role in human nutrition and culture for thousands of years and is still of eminent importance for human diet and the bakery industry. Lactobacillus sanfranciscensis is the predominant key bacterium in traditionally fermented sourdoughs. The genome of L. sanfranciscensis TMW 1.1304 isolated from an industrial sourdough fermentation was sequenced with a combined Sanger/454-pyrosequencing approach followed by gap closing by walking on fosmids. The sequencing data revealed a circular chromosomal sequence of 1,298,316 bp and two additional plasmids, pLS1 and pLS2, with sizes of 58,739 bp and 18,715 bp, which are predicted to encode 1,437, 63 and 19 orfs, respectively. The overall GC content of the chromosome is 34.71%. Several specific features appear to contribute to the ability of L. sanfranciscensis to outcompete other bacteria in the fermentation. L. sanfranciscensis contains the smallest genome within the lactobacilli and the highest density of ribosomal RNA operons per Mbp genome among all known genomes of free-living bacteria, which is important for the rapid growth characteristics of the organism. A high frequency of gene inactivation and elimination indicates a process of reductive evolution. The biosynthetic capacity for amino acids scarcely availably in cereals and exopolysaccharides reveal the molecular basis for an autochtonous sourdough organism with potential for further exploitation in functional foods. The presence of two CRISPR/cas loci versus a high number of transposable elements suggests recalcitrance to gene intrusion and high intrinsic genome plasticity."],["dc.identifier.doi","10.1186/1475-2859-10-S1-S6"],["dc.identifier.isi","000303913600006"],["dc.identifier.pmid","21995419"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/7586"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/22318"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Biomed Central Ltd"],["dc.publisher.place","London"],["dc.relation.conference","10th Symposium on Lactic Acid Bacterium (LAB)"],["dc.relation.eventlocation","Egmond aan Zee, NETHERLANDS"],["dc.relation.issn","1475-2859"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Genomic analysis reveals Lactobacillus sanfranciscensis as stable element in traditional sourdoughs"],["dc.type","conference_paper"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]
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  • 2018Journal Article
    [["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Genome Announcements"],["dc.bibliographiccitation.volume","6"],["dc.contributor.author","Hollensteiner, Jacqueline"],["dc.contributor.author","Poehlein, Anja"],["dc.contributor.author","Granzow, Sandra"],["dc.contributor.author","Liesegang, Heiko"],["dc.contributor.author","Daniel, Rolf"],["dc.contributor.author","Vidal, Stefan"],["dc.contributor.author","Wemheuer, Franziska"],["dc.date.accessioned","2020-12-10T18:37:01Z"],["dc.date.available","2020-12-10T18:37:01Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1128/genomeA.01517-17"],["dc.identifier.eissn","2169-8287"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/76814"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Draft Genome Sequence of the Endophyte Bacillus mycoides Strain GM5LP Isolated from Lolium perenne"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]
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  • 2006Journal Article
    [["dc.bibliographiccitation.firstpage","1257"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","Nature Biotechnology"],["dc.bibliographiccitation.lastpage","1262"],["dc.bibliographiccitation.volume","24"],["dc.contributor.author","Pohlmann, Anne"],["dc.contributor.author","Fricke, Wolfgang Florian"],["dc.contributor.author","Reinecke, Frank"],["dc.contributor.author","Kusian, Bernhard"],["dc.contributor.author","Liesegang, Heiko"],["dc.contributor.author","Cramm, Rainer"],["dc.contributor.author","Eitinger, Thomas"],["dc.contributor.author","Ewering, Christian"],["dc.contributor.author","Poetter, Markus"],["dc.contributor.author","Schwartz, Edward"],["dc.contributor.author","Strittmatter, Axel W."],["dc.contributor.author","Voss, Ingo"],["dc.contributor.author","Gottschalk, Gerhard"],["dc.contributor.author","Steinbuechel, Alexander"],["dc.contributor.author","Friedrich, Baerbel"],["dc.contributor.author","Bowien, Botho"],["dc.date.accessioned","2018-11-07T09:12:07Z"],["dc.date.available","2018-11-07T09:12:07Z"],["dc.date.issued","2006"],["dc.description.abstract","sThe H-2-oxidizing lithoautotrophic bacterium Ralstonia eutropha H16 is a metabolically versatile organism capable of subsisting, in the absence of organic growth substrates, on H-2 and CO2 as its sole sources of energy and carbon. R. eutropha H16 first attracted biotechnological interest nearly 50 years ago with the realization that the organism's ability to produce and store large amounts of poly[R-(-)-3-hydroxybutyrate] and other polyesters could be harnessed to make biodegradable plastics. Here we report the complete genome sequence of the two chromosomes of R. eutropha H16. Together, chromosome 1 (4,052,032 base pairs (bp)) and chromosome 2 (2,912,490 bp) encode 6,116 putative genes. Analysis of the genome sequence offers the genetic basis for exploiting the biotechnological potential of this organism and provides insights into its remarkable metabolic versatility."],["dc.identifier.doi","10.1038/nbt1244"],["dc.identifier.isi","000241191700029"],["dc.identifier.pmid","16964242"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/26879"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Nature Publishing Group"],["dc.relation.issn","1087-0156"],["dc.title","Genome sequence of the bioplastic-producing \"Knallgas\" bacterium Ralstonia eutropha H16"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]
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