Liesegang, Heiko

[["dc.bibliographiccitation.firstpage","1316"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"],["dc.bibliographiccitation.lastpage","1321"],["dc.bibliographiccitation.volume","100"],["dc.contributor.author","Bruggemann, H."],["dc.contributor.author","Baumer, S."],["dc.contributor.author","Fricke, Wolfgang Florian"],["dc.contributor.author","Wiezer, A."],["dc.contributor.author","Liesegang, Heiko"],["dc.contributor.author","Decker, I."],["dc.contributor.author","Herzberg, C."],["dc.contributor.author","Martinez-Arias, R."],["dc.contributor.author","Merkl, R."],["dc.contributor.author","Henne, A."],["dc.contributor.author","Gottschalk, G."],["dc.date.accessioned","2018-11-07T10:40:58Z"],["dc.date.available","2018-11-07T10:40:58Z"],["dc.date.issued","2003"],["dc.description.abstract","Tetanus disease is one of the most dramatic and globally prevalent diseases of humans and vertebrate animals, and has been reported for over 24 centuries. The manifestation of the disease, spastic paralysis, is caused by the second most poisonous substance known, the tetanus toxin, with a human lethal dose of approximate to1 ng/kg. Fortunately, this disease is successfully controlled through immunization with tetanus toxoid; nevertheless, according to the World Health Organization, an estimated 400,000 cases still occur each year, mainly of neonatal tetanus. The causative agent of tetanus disease is Clostridium tetani, an anaerobic spore-forming bacterium, whose natural habitat is soil, dust, and intestinal tracts of various animals. Here we report the complete genome sequence of toxigenic C. tetani E88, a variant of strain Massachusetts. The genome consists of a 2,799,250-bp chromosome encoding 2,372 ORFs. The tetanus toxin and a collagenase are encoded on a 74,082-bp plasmid, containing 61 ORFs. Additional virulence-related factors could be identified, such as an array of surface-layer and adhesion proteins (35 ORFs), some of them unique to C. tetani. Comparative genomics with the genomes of Clostridium perfringens, the causative agent of gas gangrene, and Clostridium acetobutylicum, a nonpathogenic solvent producer, revealed a remarkable capacity of C. tetani: The organism can rely on an extensive sodium ion bioenergetics. Additional candidate genes involved in the establishment and maintenance of a pathogenic lifestyle of C. tetani are presented."],["dc.identifier.doi","10.1073/pnas.0335853100"],["dc.identifier.isi","000180838100098"],["dc.identifier.pmid","12552129"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/46432"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Natl Acad Sciences"],["dc.relation.issn","0027-8424"],["dc.title","The genome sequence of Clostridium tetani, the causative agent of tetanus disease"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1257"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","Nature Biotechnology"],["dc.bibliographiccitation.lastpage","1262"],["dc.bibliographiccitation.volume","24"],["dc.contributor.author","Pohlmann, Anne"],["dc.contributor.author","Fricke, Wolfgang Florian"],["dc.contributor.author","Reinecke, Frank"],["dc.contributor.author","Kusian, Bernhard"],["dc.contributor.author","Liesegang, Heiko"],["dc.contributor.author","Cramm, Rainer"],["dc.contributor.author","Eitinger, Thomas"],["dc.contributor.author","Ewering, Christian"],["dc.contributor.author","Poetter, Markus"],["dc.contributor.author","Schwartz, Edward"],["dc.contributor.author","Strittmatter, Axel W."],["dc.contributor.author","Voss, Ingo"],["dc.contributor.author","Gottschalk, Gerhard"],["dc.contributor.author","Steinbuechel, Alexander"],["dc.contributor.author","Friedrich, Baerbel"],["dc.contributor.author","Bowien, Botho"],["dc.date.accessioned","2018-11-07T09:12:07Z"],["dc.date.available","2018-11-07T09:12:07Z"],["dc.date.issued","2006"],["dc.description.abstract","sThe H-2-oxidizing lithoautotrophic bacterium Ralstonia eutropha H16 is a metabolically versatile organism capable of subsisting, in the absence of organic growth substrates, on H-2 and CO2 as its sole sources of energy and carbon. R. eutropha H16 first attracted biotechnological interest nearly 50 years ago with the realization that the organism's ability to produce and store large amounts of poly[R-(-)-3-hydroxybutyrate] and other polyesters could be harnessed to make biodegradable plastics. Here we report the complete genome sequence of the two chromosomes of R. eutropha H16. Together, chromosome 1 (4,052,032 base pairs (bp)) and chromosome 2 (2,912,490 bp) encode 6,116 putative genes. Analysis of the genome sequence offers the genetic basis for exploiting the biotechnological potential of this organism and provides insights into its remarkable metabolic versatility."],["dc.identifier.doi","10.1038/nbt1244"],["dc.identifier.isi","000241191700029"],["dc.identifier.pmid","16964242"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/26879"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Nature Publishing Group"],["dc.relation.issn","1087-0156"],["dc.title","Genome sequence of the bioplastic-producing \"Knallgas\" bacterium Ralstonia eutropha H16"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","547"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Nature Biotechnology"],["dc.bibliographiccitation.lastpage","553"],["dc.bibliographiccitation.volume","22"],["dc.contributor.author","Henne, A."],["dc.contributor.author","Bruggemann, H."],["dc.contributor.author","Raasch, C."],["dc.contributor.author","Wiezer, A."],["dc.contributor.author","Hartsch, T."],["dc.contributor.author","Liesegang, Heiko"],["dc.contributor.author","Johann, A."],["dc.contributor.author","Lienard, T."],["dc.contributor.author","Gohl, O."],["dc.contributor.author","Martinez-Arias, R."],["dc.contributor.author","Jacobi, C."],["dc.contributor.author","Starkuviene, V."],["dc.contributor.author","Schlenczeck, S."],["dc.contributor.author","Dencker, S."],["dc.contributor.author","Huber, R."],["dc.contributor.author","Klenk, H. P."],["dc.contributor.author","Kramer, W."],["dc.contributor.author","Merkl, R."],["dc.contributor.author","Gottschalk, G."],["dc.contributor.author","Fritz, Hans-Joachim"],["dc.date.accessioned","2018-11-07T10:49:25Z"],["dc.date.available","2018-11-07T10:49:25Z"],["dc.date.issued","2004"],["dc.description.abstract","Thermus thermophilus HB27 is an extremely thermophilic, halotolerant bacterium, which was originally isolated from a natural thermal environment in Japan. This organism has considerable biotechnological potential; many thermostable proteins isolated from members of the genus Thermus are indispensable in research and in industrial applications. We present here the complete genome sequence of T. thermophilus HB27, the first for the genus Thermus. The genome consists of a 1,894,877 base pair chromosome and a 232,605 base pair megaplasmid, designated pTT27. The 2,218 identified putative genes were compared to those of the closest relative sequenced so far, the mesophilic bacterium Deinococcus radiodurans. Both organisms share a similar set of proteins, although their genomes lack extensive synteny. Many new genes of potential interest for biotechnological applications were found in T. thermophilus HB27. Candidates include various proteases and key enzymes of other fundamental biological processes such as DNA replication, DNA repair and RNA maturation."],["dc.identifier.doi","10.1038/nbt956"],["dc.identifier.isi","000221159700022"],["dc.identifier.pmid","15064768"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/48423"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Nature Publishing Group"],["dc.relation.issn","1087-0156"],["dc.title","The genome sequence of the extreme thermophile Thermus thermophilus"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","760"],["dc.bibliographiccitation.journal","Microbiology"],["dc.bibliographiccitation.lastpage","773"],["dc.bibliographiccitation.volume","157"],["dc.contributor.author","Rechnitzer, Hagai"],["dc.contributor.author","Brzuszkiewicz, Elzbieta B."],["dc.contributor.author","Strittmatter, Axel W."],["dc.contributor.author","Liesegang, Heiko"],["dc.contributor.author","Lysnyansky, Inna"],["dc.contributor.author","Daniel, Rolf"],["dc.contributor.author","Gottschalk, Gerhard"],["dc.contributor.author","Rottem, Shlomo"],["dc.date.accessioned","2018-11-07T08:58:29Z"],["dc.date.available","2018-11-07T08:58:29Z"],["dc.date.issued","2011"],["dc.description.abstract","We present the complete genomic sequence of Mycoplasma fermentans, an organism suggested to be associated with the pathogenesis of rheumatoid arthritis in humans. The genome is composed of 977 524 bp and has a mean G + C content of 26.95 mol%. There are 835 predicted protein-coding sequences and a mean coding density of 87.6%. Functions have been assigned to 58.8% of the predicted protein-coding sequences, while 18.4% of the proteins are conserved hypothetical proteins and 22.8% are hypothetical proteins. In addition, there are two complete rRNA operons and 36 tRNA coding sequences. The largest gene families are the ABC transporter family (42 members), and the functionally heterogeneous group of lipoproteins (28 members), which encode the characteristic prokaryotic cysteine 'lipobox'. Protein secretion occurs through a pathway consisting of SecA, SecD, SecE, SecG, SecY and YidC. Some highly conserved eubacterial proteins, such as GroEL and GroES, are notably absent. The genes encoding DnaK-DnaJ-GrpE and Tig, forming the putative complex of chaperones, are intact, providing the only known control over protein folding. Eighteen nucleases and 17 proteases and peptidases were detected as well as three genes for the thioredoxin-thioreductase system. Overall, this study presents insights into the physiology of M. fermentans, and provides several examples of the genetic basis of systems that might function as virulence factors in this organism."],["dc.description.sponsorship","FEMS; Niedersachsisches Ministerium fur Wissenschaft und Kultur"],["dc.identifier.doi","10.1099/mic.0.043208-0"],["dc.identifier.isi","000288833000015"],["dc.identifier.pmid","21109561"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/23653"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Soc General Microbiology"],["dc.relation.issn","1350-0872"],["dc.title","Genomic features and insights into the biology of Mycoplasma fermentans"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","883"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","Archives of Microbiology"],["dc.bibliographiccitation.lastpage","891"],["dc.bibliographiccitation.volume","193"],["dc.contributor.author","Brzuszkiewicz, Elzbieta B."],["dc.contributor.author","Thuermer, Andrea"],["dc.contributor.author","Schuldes, Joerg"],["dc.contributor.author","Leimbach, Andreas"],["dc.contributor.author","Liesegang, Heiko"],["dc.contributor.author","Meyer, Frauke-Dorothee"],["dc.contributor.author","Boelter, Juergen"],["dc.contributor.author","Petersen, Heiko"],["dc.contributor.author","Gottschalk, Gerhard"],["dc.contributor.author","Daniel, Rolf"],["dc.date.accessioned","2018-11-07T08:49:30Z"],["dc.date.available","2018-11-07T08:49:30Z"],["dc.date.issued","2011"],["dc.description.abstract","The genome sequences of two Escherichia coli O104:H4 strains derived from two different patients of the 2011 German E. coli outbreak were determined. The two analyzed strains were designated E. coli GOS1 and GOS2 (German outbreak strain). Both isolates comprise one chromosome of approximately 5.31 Mbp and two putative plasmids. Comparisons of the 5,217 (GOS1) and 5,224 (GOS2) predicted protein-encoding genes with various E. coli strains, and a multilocus sequence typing analysis revealed that the isolates were most similar to the entero-aggregative E. coli (EAEC) strain 55989. In addition, one of the putative plasmids of the outbreak strain is similar to pAA-type plasmids of EAEC strains, which contain aggregative adhesion fimbrial operons. The second putative plasmid harbors genes for extended-spectrum beta-lactamases. This type of plasmid is widely distributed in pathogenic E. coli strains. A significant difference of the E. coli GOS1 and GOS2 genomes to those of EAEC strains is the presence of a prophage encoding the Shiga toxin, which is characteristic for enterohemorrhagic E. coli (EHEC) strains. The unique combination of genomic features of the German outbreak strain, containing characteristics from pathotypes EAEC and EHEC, suggested that it represents a new pathotype Entero-Aggregative-Haemorrhagic Escherichia coli (EAHEC)."],["dc.identifier.doi","10.1007/s00203-011-0725-6"],["dc.identifier.isi","000297223500005"],["dc.identifier.pmid","21713444"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/7515"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/21476"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0302-8933"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Genome sequence analyses of two isolates from the recent Escherichia coli outbreak in Germany reveal the emergence of a new pathotype: Entero-Aggregative-Haemorrhagic Escherichia coli (EAHEC)"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","e1001078"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","PLoS Pathogens"],["dc.bibliographiccitation.volume","6"],["dc.contributor.author","Zdziarski, Jaroslaw"],["dc.contributor.author","Brzuszkiewicz, Elzbieta B."],["dc.contributor.author","Wullt, Bjorn"],["dc.contributor.author","Liesegang, Heiko"],["dc.contributor.author","Biran, Dvora"],["dc.contributor.author","Voigt, Birgit"],["dc.contributor.author","Gronberg-Hernandez, Jenny"],["dc.contributor.author","Ragnarsdottir, Bryndis"],["dc.contributor.author","Hecker, Michael"],["dc.contributor.author","Ron, Eliora Z."],["dc.contributor.author","Daniel, Rolf"],["dc.contributor.author","Gottschalk, Gerhard"],["dc.contributor.author","Hacker, Joerg"],["dc.contributor.author","Svanborg, Catharina"],["dc.contributor.author","Dobrindt, Ulrich"],["dc.date.accessioned","2018-11-07T08:41:04Z"],["dc.date.available","2018-11-07T08:41:04Z"],["dc.date.issued","2010"],["dc.description.abstract","Bacteria lose or gain genetic material and through selection, new variants become fixed in the population. Here we provide the first, genome-wide example of a single bacterial strain's evolution in different deliberately colonized patients and the surprising insight that hosts appear to personalize their microflora. By first obtaining the complete genome sequence of the prototype asymptomatic bacteriuria strain E. coli 83972 and then resequencing its descendants after therapeutic bladder colonization of different patients, we identified 34 mutations, which affected metabolic and virulence-related genes. Further transcriptome and proteome analysis proved that these genome changes altered bacterial gene expression resulting in unique adaptation patterns in each patient. Our results provide evidence that, in addition to stochastic events, adaptive bacterial evolution is driven by individual host environments. Ongoing loss of gene function supports the hypothesis that evolution towards commensalism rather than virulence is favored during asymptomatic bladder colonization."],["dc.identifier.doi","10.1371/journal.ppat.1001078"],["dc.identifier.isi","000281399900048"],["dc.identifier.pmid","20865122"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/7263"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/19388"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Public Library Science"],["dc.relation.issn","1553-7366"],["dc.rights","CC BY 2.5"],["dc.rights.uri","https://creativecommons.org/licenses/by/2.5"],["dc.title","Host Imprints on Bacterial Genomes-Rapid, Divergent Evolution in Individual Patients"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1007"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Nature Biotechnology"],["dc.bibliographiccitation.lastpage","1014"],["dc.bibliographiccitation.volume","25"],["dc.contributor.author","Chen, Xiao Hua"],["dc.contributor.author","Koumoutsi, Alexandra"],["dc.contributor.author","Scholz, Romy"],["dc.contributor.author","Eisenreich, Andreas"],["dc.contributor.author","Schneider, Kathrin"],["dc.contributor.author","Heinemeyer, Isabelle"],["dc.contributor.author","Morgenstern, Burkhard"],["dc.contributor.author","Voss, Bjoern"],["dc.contributor.author","Hess, Wolfgang R."],["dc.contributor.author","Reva, Oleg"],["dc.contributor.author","Junge, Helmut"],["dc.contributor.author","Voigt, Birgit"],["dc.contributor.author","Jungblut, Peter R."],["dc.contributor.author","Vater, Joachim"],["dc.contributor.author","Suessmuth, Roderich D."],["dc.contributor.author","Liesegang, Heiko"],["dc.contributor.author","Strittmatter, Axel W."],["dc.contributor.author","Gottschalk, Gerhard"],["dc.contributor.author","Borriss, Rainer"],["dc.date.accessioned","2018-11-07T10:59:15Z"],["dc.date.available","2018-11-07T10:59:15Z"],["dc.date.issued","2007"],["dc.description.abstract","Bacillus amyloliquefaciens FZB42 is a Gram-positive, plant-associated bacterium, which stimulates plant growth and produces secondary metabolites that suppress soil-borne plant pathogens. Its 3,918-kb genome, containing an estimated 3,693 protein-coding sequences, lacks extended phage insertions, which occur ubiquitously in the closely related Bacillus subtilis 168 genome. The B. amyloliquefaciens FZB42 genome reveals an unexpected potential to produce secondary metabolites, including the polyketides bacillaene and difficidin. More than 8.5% of the genome is devoted to synthesizing antibiotics and siderophores by pathways not involving ribosomes. Besides five gene clusters, known from B. subtilis to mediate nonribosomal synthesis of secondary metabolites, we identified four giant gene clusters absent in B. subtilis 168. The pks2 gene cluster encodes the components to synthesize the macrolactin core skeleton."],["dc.identifier.doi","10.1038/nbt1325"],["dc.identifier.isi","000249444200024"],["dc.identifier.pmid","17704766"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/50657"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Nature Publishing Group"],["dc.relation.issn","1087-0156"],["dc.title","Comparative analysis of the complete genome sequence of the plant growth-promoting bacterium Bacillus amyloliquefaciens FZB42"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","5850"],["dc.bibliographiccitation.issue","21"],["dc.bibliographiccitation.journal","Journal of Bacteriology"],["dc.bibliographiccitation.lastpage","5851"],["dc.bibliographiccitation.volume","192"],["dc.contributor.author","Liesegang, Heiko"],["dc.contributor.author","Kaster, Anne-Kristin"],["dc.contributor.author","Wiezer, Arnim"],["dc.contributor.author","Goenrich, Meike"],["dc.contributor.author","Wollherr, Antje"],["dc.contributor.author","Seedorf, Henning"],["dc.contributor.author","Gottschalk, Gerhard"],["dc.contributor.author","Thauer, Rudolf K."],["dc.date.accessioned","2018-11-07T08:37:35Z"],["dc.date.available","2018-11-07T08:37:35Z"],["dc.date.issued","2010"],["dc.description.abstract","The circular genome sequence of the chemolithoautotrophic euryarchaeon Methanothermobacter marburgensis, with 1,639,135 bp, was determined and compared with that of Methanothermobacter thermautotrophicus. The genomes of the two model methanogens differ substantially in protein coding sequences, in insertion sequence (IS)-like elements, and in clustered regularly interspaced short palindromic repeats (CRISPR) loci."],["dc.identifier.doi","10.1128/JB.00844-10"],["dc.identifier.isi","000282807900036"],["dc.identifier.pmid","20802048"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/18572"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Soc Microbiology"],["dc.relation.issn","0021-9193"],["dc.title","Complete Genome Sequence of Methanothermobacter marburgensis, a Methanoarchaeon Model Organism"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","204"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Journal of Molecular Microbiology and Biotechnology"],["dc.bibliographiccitation.lastpage","211"],["dc.bibliographiccitation.volume","7"],["dc.contributor.author","Veith, B."],["dc.contributor.author","Herzberg, C."],["dc.contributor.author","Steckel, S."],["dc.contributor.author","Feesche, J."],["dc.contributor.author","Maurer, K. H."],["dc.contributor.author","Ehrenreich, P."],["dc.contributor.author","Baumer, S."],["dc.contributor.author","Henne, A."],["dc.contributor.author","Liesegang, Heiko"],["dc.contributor.author","Merkl, R."],["dc.contributor.author","Ehrenreich, Armin"],["dc.contributor.author","Gottschalk, Gerhard"],["dc.date.accessioned","2018-11-07T10:52:49Z"],["dc.date.available","2018-11-07T10:52:49Z"],["dc.date.issued","2004"],["dc.description.abstract","The genome of Bacillus licheniformis DSM13 consists of a single chromosome that has a size of 4,222,748 base pairs. The average G+C ratio is 46.2%. 4,286 open reading frames, 72 tRNA genes, 7 rRNA operons and 20 transposase genes were identified. The genome shows a marked co-linearity with Bacillus subtilis but contains defined inserted regions that can be identified at the sequence as well as at the functional level. B. licheniformis DSM13 has a well-conserved secretory system, no polyketide biosynthesis, but is able to form the lipopeptide lichenysin. From the further analysis of the genome sequence, we identified conserved regulatory DNA motives, the occurrence of the glyoxylate bypass and the presence of anaerobic ribonucleotide reductase explaining that B. licheniformis is able to grow on acetate and 2,3-butanediol as well as anaerobically on glucose. Many new genes of potential interest for biotechnological applications were found in B. licheniformis; candidates include proteases, pectate lyases, lipases and various polysaccharide degrading enzymes. Copyright (C) 2004 S. Karger AG, Basel."],["dc.identifier.doi","10.1159/000079829"],["dc.identifier.isi","000226021300005"],["dc.identifier.pmid","15383718"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/49200"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Karger"],["dc.relation.issn","1464-1801"],["dc.title","The complete genome sequence of Bacillus licheniformis DSM13, an organism with great industrial potential"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1"],["dc.bibliographiccitation.journal","Archaea"],["dc.bibliographiccitation.lastpage","23"],["dc.bibliographiccitation.volume","2011"],["dc.contributor.author","Kaster, Anne-Kristin"],["dc.contributor.author","Goenrich, Meike"],["dc.contributor.author","Seedorf, Henning"],["dc.contributor.author","Liesegang, Heiko"],["dc.contributor.author","Wollherr, Antje"],["dc.contributor.author","Gottschalk, Gerhard"],["dc.contributor.author","Thauer, Rudolf K."],["dc.date.accessioned","2019-07-09T11:53:35Z"],["dc.date.available","2019-07-09T11:53:35Z"],["dc.date.issued","2011"],["dc.description.abstract","The hydrogenotrophic methanogens Methanothermobacter marburgensis and Methanothermobacter thermautotrophicus can easily be mass cultured. They have therefore been used almost exclusively to study the biochemistry of methanogenesis from H2 and CO2, and the genomes of these two model organisms have been sequenced. The close relationship of the two organisms is reflected in their genomic architecture and coding potential. Within the 1,607 protein coding sequences (CDS) in common, we identified approximately 200 CDS required for the synthesis of the enzymes, coenzymes, and prosthetic groups involved in CO2 reduction to methane and in coupling this process with the phosphorylation of ADP. Approximately 20 additional genes, such as those for the biosynthesis of F430 and methanofuran and for the posttranslationalmodifications of the two methyl-coenzyme M reductases, remain to be identified."],["dc.identifier.doi","10.1155/2011/973848"],["dc.identifier.fs","590271"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/7732"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/60457"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","More Than 200 Genes Required for Methane Formation from H2 and CO2 and Energy Conservation Are Present in Methanothermobacter marburgensis and Methanothermobacter thermautotrophicus"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]