Liesegang, Heiko

[["dc.bibliographiccitation.artnumber","324"],["dc.bibliographiccitation.journal","BMC Genomics"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Kalhoefer, Daniela"],["dc.contributor.author","Thole, Sebastian"],["dc.contributor.author","Voget, Sonja"],["dc.contributor.author","Lehmann, Ruediger"],["dc.contributor.author","Liesegang, Heiko"],["dc.contributor.author","Wollher, Antje"],["dc.contributor.author","Daniel, Rolf"],["dc.contributor.author","Simon, Meinhard"],["dc.contributor.author","Brinkhoff, Thorsten"],["dc.date.accessioned","2018-11-07T08:54:59Z"],["dc.date.available","2018-11-07T08:54:59Z"],["dc.date.issued","2011"],["dc.description.abstract","Background: Roseobacter litoralis OCh149, the type species of the genus, and Roseobacter denitrificans OCh114 were the first described organisms of the Roseobacter clade, an ecologically important group of marine bacteria. Both species were isolated from seaweed and are able to perform aerobic anoxygenic photosynthesis. Results: The genome of R. litoralis OCh149 contains one circular chromosome of 4,505,211 bp and three plasmids of 93,578 bp (pRLO149_94), 83,129 bp (pRLO149_83) and 63,532 bp (pRLO149_63). Of the 4537 genes predicted for R. litoralis, 1122 (24.7%) are not present in the genome of R. denitrificans. Many of the unique genes of R. litoralis are located in genomic islands and on plasmids. On pRLO149_83 several potential heavy metal resistance genes are encoded which are not present in the genome of R. denitrificans. The comparison of the heavy metal tolerance of the two organisms showed an increased zinc tolerance of R. litoralis. In contrast to R. denitrificans, the photosynthesis genes of R. litoralis are plasmid encoded. The activity of the photosynthetic apparatus was confirmed by respiration rate measurements, indicating a growth-phase dependent response to light. Comparative genomics with other members of the Roseobacter clade revealed several genomic regions that were only conserved in the two Roseobacter species. One of those regions encodes a variety of genes that might play a role in host association of the organisms. The catabolism of different carbon and nitrogen sources was predicted from the genome and combined with experimental data. In several cases, e. g. the degradation of some algal osmolytes and sugars, the genome-derived predictions of the metabolic pathways in R. litoralis differed from the phenotype. Conclusions: The genomic differences between the two Roseobacter species are mainly due to lateral gene transfer and genomic rearrangements. Plasmid pRLO149_83 contains predominantly recently acquired genetic material whereas pRLO149_94 was probably translocated from the chromosome. Plasmid pRLO149_63 and one plasmid of R. denitrifcans (pTB2) seem to have a common ancestor and are important for cell envelope biosynthesis. Several new mechanisms of substrate degradation were indicated from the combination of experimental and genomic data. The photosynthetic activity of R. litoralis is probably regulated by nutrient availability."],["dc.identifier.doi","10.1186/1471-2164-12-324"],["dc.identifier.isi","000292985100001"],["dc.identifier.pmid","21693016"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/6835"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/22799"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Biomed Central Ltd"],["dc.relation.issn","1471-2164"],["dc.rights","CC BY 2.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/2.0"],["dc.title","Comparative genome analysis and genome-guided physiological analysis of Roseobacter litoralis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","S6"],["dc.bibliographiccitation.journal","Microbial Cell Factories"],["dc.bibliographiccitation.volume","10"],["dc.contributor.author","Vogel, Rudi F."],["dc.contributor.author","Pavlovic, Melanie"],["dc.contributor.author","Ehrmann, Matthias A."],["dc.contributor.author","Wiezer, Arnim"],["dc.contributor.author","Liesegang, Heiko"],["dc.contributor.author","Offschanka, Stefanie"],["dc.contributor.author","Voget, Sonja"],["dc.contributor.author","Angelov, Angel"],["dc.contributor.author","Boecker, Georg"],["dc.contributor.author","Liebl, Wolfgang"],["dc.date.accessioned","2018-11-07T08:53:04Z"],["dc.date.available","2018-11-07T08:53:04Z"],["dc.date.issued","2011"],["dc.description.abstract","Sourdough has played a significant role in human nutrition and culture for thousands of years and is still of eminent importance for human diet and the bakery industry. Lactobacillus sanfranciscensis is the predominant key bacterium in traditionally fermented sourdoughs. The genome of L. sanfranciscensis TMW 1.1304 isolated from an industrial sourdough fermentation was sequenced with a combined Sanger/454-pyrosequencing approach followed by gap closing by walking on fosmids. The sequencing data revealed a circular chromosomal sequence of 1,298,316 bp and two additional plasmids, pLS1 and pLS2, with sizes of 58,739 bp and 18,715 bp, which are predicted to encode 1,437, 63 and 19 orfs, respectively. The overall GC content of the chromosome is 34.71%. Several specific features appear to contribute to the ability of L. sanfranciscensis to outcompete other bacteria in the fermentation. L. sanfranciscensis contains the smallest genome within the lactobacilli and the highest density of ribosomal RNA operons per Mbp genome among all known genomes of free-living bacteria, which is important for the rapid growth characteristics of the organism. A high frequency of gene inactivation and elimination indicates a process of reductive evolution. The biosynthetic capacity for amino acids scarcely availably in cereals and exopolysaccharides reveal the molecular basis for an autochtonous sourdough organism with potential for further exploitation in functional foods. The presence of two CRISPR/cas loci versus a high number of transposable elements suggests recalcitrance to gene intrusion and high intrinsic genome plasticity."],["dc.identifier.doi","10.1186/1475-2859-10-S1-S6"],["dc.identifier.isi","000303913600006"],["dc.identifier.pmid","21995419"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/7586"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/22318"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Biomed Central Ltd"],["dc.publisher.place","London"],["dc.relation.conference","10th Symposium on Lactic Acid Bacterium (LAB)"],["dc.relation.eventlocation","Egmond aan Zee, NETHERLANDS"],["dc.relation.issn","1475-2859"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Genomic analysis reveals Lactobacillus sanfranciscensis as stable element in traditional sourdoughs"],["dc.type","conference_paper"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","883"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","Archives of Microbiology"],["dc.bibliographiccitation.lastpage","891"],["dc.bibliographiccitation.volume","193"],["dc.contributor.author","Brzuszkiewicz, Elzbieta B."],["dc.contributor.author","Thuermer, Andrea"],["dc.contributor.author","Schuldes, Joerg"],["dc.contributor.author","Leimbach, Andreas"],["dc.contributor.author","Liesegang, Heiko"],["dc.contributor.author","Meyer, Frauke-Dorothee"],["dc.contributor.author","Boelter, Juergen"],["dc.contributor.author","Petersen, Heiko"],["dc.contributor.author","Gottschalk, Gerhard"],["dc.contributor.author","Daniel, Rolf"],["dc.date.accessioned","2018-11-07T08:49:30Z"],["dc.date.available","2018-11-07T08:49:30Z"],["dc.date.issued","2011"],["dc.description.abstract","The genome sequences of two Escherichia coli O104:H4 strains derived from two different patients of the 2011 German E. coli outbreak were determined. The two analyzed strains were designated E. coli GOS1 and GOS2 (German outbreak strain). Both isolates comprise one chromosome of approximately 5.31 Mbp and two putative plasmids. Comparisons of the 5,217 (GOS1) and 5,224 (GOS2) predicted protein-encoding genes with various E. coli strains, and a multilocus sequence typing analysis revealed that the isolates were most similar to the entero-aggregative E. coli (EAEC) strain 55989. In addition, one of the putative plasmids of the outbreak strain is similar to pAA-type plasmids of EAEC strains, which contain aggregative adhesion fimbrial operons. The second putative plasmid harbors genes for extended-spectrum beta-lactamases. This type of plasmid is widely distributed in pathogenic E. coli strains. A significant difference of the E. coli GOS1 and GOS2 genomes to those of EAEC strains is the presence of a prophage encoding the Shiga toxin, which is characteristic for enterohemorrhagic E. coli (EHEC) strains. The unique combination of genomic features of the German outbreak strain, containing characteristics from pathotypes EAEC and EHEC, suggested that it represents a new pathotype Entero-Aggregative-Haemorrhagic Escherichia coli (EAHEC)."],["dc.identifier.doi","10.1007/s00203-011-0725-6"],["dc.identifier.isi","000297223500005"],["dc.identifier.pmid","21713444"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/7515"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/21476"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0302-8933"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Genome sequence analyses of two isolates from the recent Escherichia coli outbreak in Germany reveal the emergence of a new pathotype: Entero-Aggregative-Haemorrhagic Escherichia coli (EAHEC)"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","BMC Genomics"],["dc.bibliographiccitation.lastpage","14"],["dc.bibliographiccitation.volume","19"],["dc.contributor.author","Groß, Uwe"],["dc.contributor.author","Brzuszkiewicz, Elzbieta B."],["dc.contributor.author","Gunka, Katrin"],["dc.contributor.author","Starke, Jessica"],["dc.contributor.author","Riedel, Thomas"],["dc.contributor.author","Bunk, Boyke"],["dc.contributor.author","Spröer, Cathrin"],["dc.contributor.author","Wetzel, Daniela"],["dc.contributor.author","Poehlein, Anja"],["dc.contributor.author","Chibani, Cynthia"],["dc.contributor.author","Bohne, Wolfgang"],["dc.contributor.author","Overmann, Jörg"],["dc.contributor.author","Zimmermann, Ortrud"],["dc.contributor.author","Daniel, Rolf"],["dc.contributor.author","Liesegang, Heiko"],["dc.date.accessioned","2019-07-09T11:45:11Z"],["dc.date.available","2019-07-09T11:45:11Z"],["dc.date.issued","2018"],["dc.description.abstract","BACKGROUND: Clostridioides difficile infections (CDI) have emerged over the past decade causing symptoms that range from mild, antibiotic-associated diarrhea (AAD) to life-threatening toxic megacolon. In this study, we describe a multiple and isochronal (mixed) CDI caused by the isolates DSM 27638, DSM 27639 and DSM 27640 that already initially showed different morphotypes on solid media. RESULTS: The three isolates belonging to the ribotypes (RT) 012 (DSM 27639) and 027 (DSM 27638 and DSM 27640) were phenotypically characterized and high quality closed genome sequences were generated. The genomes were compared with seven reference strains including three strains of the RT 027, two of the RT 017, and one of the RT 078 as well as a multi-resistant RT 012 strain. The analysis of horizontal gene transfer events revealed gene acquisition incidents that sort the strains within the time line of the spread of their RTs within Germany. We could show as well that horizontal gene transfer between the members of different RTs occurred within this multiple infection. In addition, acquisition and exchange of virulence-related features including antibiotic resistance genes were observed. Analysis of the two genomes assigned to RT 027 revealed three single nucleotide polymorphisms (SNPs) and apparently a regional genome modification within the flagellar switch that regulates the fli operon. CONCLUSION: Our findings show that (i) evolutionary events based on horizontal gene transfer occur within an ongoing CDI and contribute to the adaptation of the species by the introduction of new genes into the genomes, (ii) within a multiple infection of a single patient the exchange of genetic material was responsible for a much higher genome variation than the observed SNPs."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2018"],["dc.identifier.doi","10.1186/s12864-017-4368-0"],["dc.identifier.pmid","29291715"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/15054"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/59178"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.notes.intern","In goescholar not merged with http://resolver.sub.uni-goettingen.de/purl?gs-1/15123 but duplicate"],["dc.notes.status","final"],["dc.relation.issn","1471-2164"],["dc.rights","CC BY 4.0"],["dc.rights.access","openAccess"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.subject.ddc","570"],["dc.title","Comparative genome and phenotypic analysis of three Clostridioides difficile strains isolated from a single patient provide insight into multiple infection of C. difficile."],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","e1001078"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","PLoS Pathogens"],["dc.bibliographiccitation.volume","6"],["dc.contributor.author","Zdziarski, Jaroslaw"],["dc.contributor.author","Brzuszkiewicz, Elzbieta B."],["dc.contributor.author","Wullt, Bjorn"],["dc.contributor.author","Liesegang, Heiko"],["dc.contributor.author","Biran, Dvora"],["dc.contributor.author","Voigt, Birgit"],["dc.contributor.author","Gronberg-Hernandez, Jenny"],["dc.contributor.author","Ragnarsdottir, Bryndis"],["dc.contributor.author","Hecker, Michael"],["dc.contributor.author","Ron, Eliora Z."],["dc.contributor.author","Daniel, Rolf"],["dc.contributor.author","Gottschalk, Gerhard"],["dc.contributor.author","Hacker, Joerg"],["dc.contributor.author","Svanborg, Catharina"],["dc.contributor.author","Dobrindt, Ulrich"],["dc.date.accessioned","2018-11-07T08:41:04Z"],["dc.date.available","2018-11-07T08:41:04Z"],["dc.date.issued","2010"],["dc.description.abstract","Bacteria lose or gain genetic material and through selection, new variants become fixed in the population. Here we provide the first, genome-wide example of a single bacterial strain's evolution in different deliberately colonized patients and the surprising insight that hosts appear to personalize their microflora. By first obtaining the complete genome sequence of the prototype asymptomatic bacteriuria strain E. coli 83972 and then resequencing its descendants after therapeutic bladder colonization of different patients, we identified 34 mutations, which affected metabolic and virulence-related genes. Further transcriptome and proteome analysis proved that these genome changes altered bacterial gene expression resulting in unique adaptation patterns in each patient. Our results provide evidence that, in addition to stochastic events, adaptive bacterial evolution is driven by individual host environments. Ongoing loss of gene function supports the hypothesis that evolution towards commensalism rather than virulence is favored during asymptomatic bladder colonization."],["dc.identifier.doi","10.1371/journal.ppat.1001078"],["dc.identifier.isi","000281399900048"],["dc.identifier.pmid","20865122"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/7263"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/19388"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Public Library Science"],["dc.relation.issn","1553-7366"],["dc.rights","CC BY 2.5"],["dc.rights.uri","https://creativecommons.org/licenses/by/2.5"],["dc.title","Host Imprints on Bacterial Genomes-Rapid, Divergent Evolution in Individual Patients"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","195"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Viruses"],["dc.bibliographiccitation.volume","11"],["dc.contributor.author","Chibani, Cynthia Maria"],["dc.contributor.author","Farr, Anton"],["dc.contributor.author","Klama, Sandra"],["dc.contributor.author","Dietrich, Sascha"],["dc.contributor.author","Liesegang, Heiko"],["dc.date.accessioned","2019-07-09T11:50:13Z"],["dc.date.available","2019-07-09T11:50:13Z"],["dc.date.issued","2019"],["dc.description.abstract","This work reports the method ClassiPhage to classify phage genomes using sequence derived taxonomic features. ClassiPhage uses a set of phage specific Hidden Markov Models (HMMs) generated from clusters of related proteins. The method was validated on all publicly available genomes of phages that are known to infect Vibrionaceae. The phages belong to the well-described phage families of Myoviridae, Podoviridae, Siphoviridae, and Inoviridae. The achieved classification is consistent with the assignments of the International Committee on Taxonomy of Viruses (ICTV), all tested phages were assigned to the corresponding group of the ICTV-database. In addition, 44 out of 58 genomes of Vibrio phages not yet classified could be assigned to a phage family. The remaining 14 genomes may represent phages of new families or subfamilies. Comparative genomics indicates that the ability of the approach to identify and classify phages is correlated to the conserved genomic organization. ClassiPhage classifies phages exclusively based on genome sequence data and can be applied on distinct phage genomes as well as on prophage regions within host genomes. Possible applications include (a) classifying phages from assembled metagenomes; and (b) the identification and classification of integrated prophages and the splitting of phage families into subfamilies."],["dc.description.sponsorship","Deutsche Forschungsgemeinschaft"],["dc.identifier.doi","10.3390/v11020195"],["dc.identifier.pmid","30813498"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/15883"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/59724"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.publisher","MDPI"],["dc.relation.eissn","1999-4915"],["dc.relation.issn","1999-4915"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.subject.ddc","570"],["dc.title","Classifying the Unclassified: A Phage Classification Method."],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1"],["dc.bibliographiccitation.journal","Archaea"],["dc.bibliographiccitation.lastpage","23"],["dc.bibliographiccitation.volume","2011"],["dc.contributor.author","Kaster, Anne-Kristin"],["dc.contributor.author","Goenrich, Meike"],["dc.contributor.author","Seedorf, Henning"],["dc.contributor.author","Liesegang, Heiko"],["dc.contributor.author","Wollherr, Antje"],["dc.contributor.author","Gottschalk, Gerhard"],["dc.contributor.author","Thauer, Rudolf K."],["dc.date.accessioned","2019-07-09T11:53:35Z"],["dc.date.available","2019-07-09T11:53:35Z"],["dc.date.issued","2011"],["dc.description.abstract","The hydrogenotrophic methanogens Methanothermobacter marburgensis and Methanothermobacter thermautotrophicus can easily be mass cultured. They have therefore been used almost exclusively to study the biochemistry of methanogenesis from H2 and CO2, and the genomes of these two model organisms have been sequenced. The close relationship of the two organisms is reflected in their genomic architecture and coding potential. Within the 1,607 protein coding sequences (CDS) in common, we identified approximately 200 CDS required for the synthesis of the enzymes, coenzymes, and prosthetic groups involved in CO2 reduction to methane and in coupling this process with the phosphorylation of ADP. Approximately 20 additional genes, such as those for the biosynthesis of F430 and methanofuran and for the posttranslationalmodifications of the two methyl-coenzyme M reductases, remain to be identified."],["dc.identifier.doi","10.1155/2011/973848"],["dc.identifier.fs","590271"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/7732"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/60457"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","More Than 200 Genes Required for Methane Formation from H2 and CO2 and Energy Conservation Are Present in Methanothermobacter marburgensis and Methanothermobacter thermautotrophicus"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","577"],["dc.bibliographiccitation.journal","BMC Genomics"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Gounder, Kamini"],["dc.contributor.author","Brzuszkiewicz, Elzbieta B."],["dc.contributor.author","Liesegang, Heiko"],["dc.contributor.author","Wollherr, Antje"],["dc.contributor.author","Daniel, Rolf"],["dc.contributor.author","Gottschalk, Gerhard"],["dc.contributor.author","Reva, Oleg"],["dc.contributor.author","Kumwenda, Benjamin"],["dc.contributor.author","Srivastava, Malay"],["dc.contributor.author","Bricio, Carlos"],["dc.contributor.author","Berenguer, Jose"],["dc.contributor.author","van Heerden, Esta"],["dc.contributor.author","Litthauer, Derek"],["dc.date.accessioned","2018-11-07T08:49:39Z"],["dc.date.available","2018-11-07T08:49:39Z"],["dc.date.issued","2011"],["dc.description.abstract","Background: Many strains of Thermus have been isolated from hot environments around the world. Thermus scotoductus SA-01 was isolated from fissure water collected 3.2 km below surface in a South African gold mine. The isolate is capable of dissimilatory iron reduction, growth with oxygen and nitrate as terminal electron acceptors and the ability to reduce a variety of metal ions, including gold, chromate and uranium, was demonstrated. The genomes from two different Thermus thermophilus strains have been completed. This paper represents the completed genome from a second Thermus species - T. scotoductus. Results: The genome of Thermus scotoductus SA-01 consists of a chromosome of 2,346,803 bp and a small plasmid which, together are about 11% larger than the Thermus thermophilus genomes. The T. thermophilus megaplasmid genes are part of the T. scotoductus chromosome and extensive rearrangement, deletion of nonessential genes and acquisition of gene islands have occurred, leading to a loss of synteny between the chromosomes of T. scotoductus and T. thermophilus. At least nine large inserts of which seven were identified as alien, were found, the most remarkable being a denitrification cluster and two operons relating to the metabolism of phenolics which appear to have been acquired from Meiothermus ruber. The majority of acquired genes are from closely related species of the Deinococcus-Thermus group, and many of the remaining genes are from microorganisms with a thermophilic or hyperthermophilic lifestyle. The natural competence of Thermus scotoductus was confirmed experimentally as expected as most of the proteins of the natural transformation system of Thermus thermophilus are present. Analysis of the metabolic capabilities revealed an extensive energy metabolism with many aerobic and anaerobic respiratory options. An abundance of sensor histidine kinases, response regulators and transporters for a wide variety of compounds are indicative of an oligotrophic lifestyle. Conclusions: The genome of Thermus scotoductus SA-01 shows remarkable plasticity with the loss, acquisition and rearrangement of large portions of its genome compared to Thermus thermophilus. Its ability to naturally take up foreign DNA has helped it adapt rapidly to a subsurface lifestyle in the presence of a dense and diverse population which acted as source of nutrients. The genome of Thermus scotoductus illustrates how rapid adaptation can be achieved by a highly dynamic and plastic genome."],["dc.identifier.doi","10.1186/1471-2164-12-577"],["dc.identifier.isi","000297856200002"],["dc.identifier.pmid","22115438"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/7032"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/21516"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Biomed Central Ltd"],["dc.relation.issn","1471-2164"],["dc.rights","CC BY 2.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/2.0"],["dc.title","Sequence of the hyperplastic genome of the naturally competent Thermus scotoductus SA-01"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","e00525-13"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Genome Announcements"],["dc.bibliographiccitation.volume","1"],["dc.contributor.author","Volland, Sonja"],["dc.contributor.author","Daniel, Rolf"],["dc.contributor.author","Liesegang, Heiko"],["dc.date.accessioned","2014-08-27T09:57:34Z"],["dc.date.accessioned","2021-10-27T13:11:16Z"],["dc.date.available","2014-08-27T09:57:34Z"],["dc.date.available","2021-10-27T13:11:16Z"],["dc.date.issued","2013"],["dc.description.abstract","Strains of the species Bacillus licheniformis are widely used in biotechnology for the production of enzymes and antibiotics (M. Schallmey, A. Singh, and O. P. Ward, Can. J. Microbiol. 50:1–17, 2004). However, research and application of B. licheniformis strains are adversely affected by poor genetic accessibility. Thus, for a closer inspection of natural competence in B. licheniformis, the genome of strain 9945A, of which derivatives are known to be naturally competent (C. B. Thorne and H. B. Stull, J. Bacteriol. 91:1012–1020, 1966), was completely sequenced and manually annotated."],["dc.identifier.doi","10.1128/genomeA.00525-13"],["dc.identifier.fs","601764"],["dc.identifier.pmid","23908277"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/10706"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/91577"],["dc.language.iso","en"],["dc.notes.intern","Migrated from goescholar"],["dc.relation.issn","2169-8287"],["dc.relation.orgunit","Fakultät für Biologie und Psychologie"],["dc.rights","CC BY 3.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/3.0"],["dc.title","First Insights into the Completely Annotated Genome Sequence of Bacillus licheniformis Strain 9945A"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","BMC Genomics"],["dc.bibliographiccitation.volume","21"],["dc.contributor.author","Chibani, Cynthia Maria"],["dc.contributor.author","Roth, Olivia"],["dc.contributor.author","Liesegang, Heiko"],["dc.contributor.author","Wendling, Carolin Charlotte"],["dc.date.accessioned","2020-12-10T18:38:51Z"],["dc.date.available","2020-12-10T18:38:51Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1186/s12864-020-6735-5"],["dc.identifier.eissn","1471-2164"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/17313"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/77459"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.intern","Merged from goescholar"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Genomic variation among closely related Vibrio alginolyticus strains is located on mobile genetic elements"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]