Chaieb, Leila

[["dc.bibliographiccitation.firstpage","1"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Neurogenetics"],["dc.bibliographiccitation.lastpage","11"],["dc.bibliographiccitation.volume","15"],["dc.contributor.author","Chaieb, Leila"],["dc.contributor.author","Antal, Andrea"],["dc.contributor.author","Ambrus, Geza Gergely"],["dc.contributor.author","Paulus, Walter J."],["dc.date.accessioned","2018-11-07T09:43:05Z"],["dc.date.available","2018-11-07T09:43:05Z"],["dc.date.issued","2014"],["dc.description.abstract","Val66Met (rs6265) is a gene variation, a single nucleotide polymorphism (SNP) in the brain-derived neurotrophic factor (BDNF) gene that codes for the protein BDNF. The substitution of Met for Val occurs at position 66 in the pro-region of the BDNF gene and is responsible for altered activity-dependent release and recruitment of BDNF in neurons. This is believed to manifest itself in an altered ability in neuroplasticity induction and an increased predisposition toward a number of neurological disorders. Many studies using neuroplasticity-inducing protocols have investigated the impact of the BDNF polymorphism on cortical modulation and plasticity; however, the results are partly contradictory and dependent on the paradigm used in a given study. The aim of this review is to summarize recent knowledge on the relationship of this BDNF SNP and neuroplasticity."],["dc.identifier.doi","10.1007/s10048-014-0393-1"],["dc.identifier.isi","000333707900001"],["dc.identifier.pmid","24567226"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/34100"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","1364-6753"],["dc.relation.issn","1364-6745"],["dc.title","Brain-derived neurotrophic factor: its impact upon neuroplasticity and neuroplasticity inducing transcranial brain stimulation protocols"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","642"],["dc.bibliographiccitation.journal","Frontiers in Psychology"],["dc.bibliographiccitation.volume","5"],["dc.contributor.author","Antal, Andrea"],["dc.contributor.author","Ambrus, Geza Gergely"],["dc.contributor.author","Chaieb, Leila"],["dc.date.accessioned","2018-11-07T09:38:51Z"],["dc.date.available","2018-11-07T09:38:51Z"],["dc.date.issued","2014"],["dc.description.abstract","Stimulation using weak electrical direct currents has shown to be capable of inducing polarity-dependent diminutions or elevations in motor and visual cortical excitability. The aim of the present study was to test if reading during transcranial direct current stimulation (tDCS) is able to modify stimulation-induced plasticity in the visual cortex. Phosphene thresholds (PTs) in 12 healthy subjects were recorded before and after 10 min of anodal, cathodal, and sham tDCS in combination with reading. Reading alone decreased PTs significantly, compared to the sham tDCS condition without reading. Interestingly, after both anodal and cathodal stimulation there was a tendency toward smaller PTs. Our results support the observation that tDCS-induced plasticity is highly dependent on the cognitive state of the subject during stimulation, not only in the case of motor cortex but also in the case of visual cortex stimulation."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2014"],["dc.identifier.doi","10.3389/fpsyg.2014.00642"],["dc.identifier.isi","000338686500001"],["dc.identifier.pmid","24999339"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/10461"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/33151"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Frontiers Media S.A."],["dc.relation.eissn","1664-1078"],["dc.relation.issn","1664-1078"],["dc.rights","CC BY 3.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/3.0"],["dc.title","Toward unraveling reading-related modulations of tDCS-induced neuroplasticity in the human visual cortex"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","92"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Brain Stimulation"],["dc.bibliographiccitation.lastpage","96"],["dc.bibliographiccitation.volume","7"],["dc.contributor.author","Chaieb, Leila"],["dc.contributor.author","Antal, Andrea"],["dc.contributor.author","Pisoni, Alberto"],["dc.contributor.author","Saiote, Catarina"],["dc.contributor.author","Opitz, Alexander"],["dc.contributor.author","Ambrus, Geza Gergely"],["dc.contributor.author","Focke, Niels K."],["dc.contributor.author","Paulus, Walter J."],["dc.date.accessioned","2018-11-07T09:46:49Z"],["dc.date.available","2018-11-07T09:46:49Z"],["dc.date.issued","2014"],["dc.description.abstract","Background: Sinusoidal transcranial alternating current stimulation (tACS) at 5 kHz applied for 10 min at 1 mA intensity over the hand area of the primary motor cortex (M1) results in sustained changes in cortical excitability as previously demonstrated. Objective: Here we have assessed safety aspects of this stimulation method by measuring neuron-specific enolase (NSE) levels, examining electroencephalogram (EEG) traces and analyzing anatomical data by using magnetic resonance imaging (MRI). Methods: Altogether 18 healthy volunteers participated in the study. tACS was applied at 5 kHz for a duration of 10 min over the left M1 at an intensity of 1 mA. Results: After stimulation no significant changes were detected in NSE levels, no structural alterations were observed in the anatomical scans and no pathological changes were found in the EEG recordings. Conclusions: Our data imply that the application of tACS is safe at least within these parameters and with these applied protocols. (C) 2014 Elsevier Inc. All rights reserved."],["dc.identifier.doi","10.1016/j.brs.2013.08.004"],["dc.identifier.isi","000329947300014"],["dc.identifier.pmid","24064065"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/34974"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Inc"],["dc.relation.issn","1876-4754"],["dc.relation.issn","1935-861X"],["dc.title","Safety of 5 kHz tACS"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","499"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Brain Stimulation"],["dc.bibliographiccitation.lastpage","504"],["dc.bibliographiccitation.volume","5"],["dc.contributor.author","Ambrus, Geza Gergely"],["dc.contributor.author","Al-Moyed, Hanan"],["dc.contributor.author","Chaieb, Leila"],["dc.contributor.author","Sarp, Lena"],["dc.contributor.author","Antal, Andrea"],["dc.contributor.author","Paulus, Walter J."],["dc.date.accessioned","2018-11-07T09:04:52Z"],["dc.date.available","2018-11-07T09:04:52Z"],["dc.date.issued","2012"],["dc.description.abstract","Objective: Slowly ramping down initial current intensity after a minimal interval of stimulation is the de facto standard for sham stimulation in transcranial electrical stimulation research. The aim of this study is to further investigate the effectiveness of this method of blinding. Methods: We have investigated the time course of the cutaneous perception during 10 min of anodal, cathodal, and sham transcranial direct current stimulation, probing the perceived strength and site of the perceived sensation. We have also utilized post-stimulation assessment and measurements of sleepiness prior to and after the intervention. Previous exposure to tDCS has also been taken into account: the experiment has been repeated in naive and experienced subject groups, and a group consisting of investigators who use tDCS as a research tool. Results: Although we have observed a general reduction in the perceived strength of the stimulation with time, we have not found the complete disappearance of the cutaneous perception during either the verum or the sham conditions. Experienced subjects were more likely to be able to differentiate between trials with stimulation and non-stimulation trials and to correctly identify sham and verum stimulation conditions. Conclusion: When taking only naive and experienced subjects into account, there was no significant difference between the strength of the perceived stimulation in the verum and sham conditions. The fade-in - short stimulation - fade-out sham stimulation can be indistinguishable from verum stimulation, but not because it mimics the disappearance of the cutaneous sensations associated with the verum stimulation, but because these sensations persist also in the sham stimulation. The significance of this finding with potential confounding factors and limitations are discussed. (C) 2012 Elsevier Inc. All rights reserved."],["dc.identifier.doi","10.1016/j.brs.2011.12.001"],["dc.identifier.isi","000311532200008"],["dc.identifier.pmid","22405745"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/25193"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Inc"],["dc.relation.issn","1935-861X"],["dc.title","The fade-in - Short stimulation - Fade out approach to sham tDCS - Reliable at 1 mA for naive and experienced subjects, but not investigators"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","98"],["dc.bibliographiccitation.journal","Neuroscience Letters"],["dc.bibliographiccitation.lastpage","104"],["dc.bibliographiccitation.volume","616"],["dc.contributor.author","Ambrus, Geza Gergely"],["dc.contributor.author","Chaieb, Leila"],["dc.contributor.author","Stilling, Roman"],["dc.contributor.author","Rothkegel, Holger"],["dc.contributor.author","Antal, Andrea"],["dc.contributor.author","Paulus, Walter J."],["dc.date.accessioned","2018-11-07T10:16:52Z"],["dc.date.available","2018-11-07T10:16:52Z"],["dc.date.issued","2016"],["dc.description.abstract","The measurement of the motor evoked potential (MEP) amplitudes using single pulse transcranial magnetic stimulation (TMS) is a common method to observe changes in motor cortical excitability. The level of cortical excitability has been shown to change during motor learning. Conversely, motor learning can be improved by using anodal transcranial direct current stimulation (tDCS). In the present study, we aimed to monitor cortical excitability changes during an implicit motor learning paradigm, a version of the serial reaction time task (SRTT). Responses from the first dorsal interosseous (FDI) and forearm flexor (FLEX) muscles were recorded before, during and after the performance of the SRTT. Online measurements were combined with anodal, cathodal or sham tDCS for the duration of the SRTT. Negative correlations between the amplitude of online FDI MEPs and SRTT reaction times (RTs) were observed across the learning blocks in the cathodal condition (higher average MEP amplitudes associated with lower RTs) but no significant differences in the anodal and sham conditions. tDCS did not have an impact on SRTT performance, as would be predicted based on previous studies. The offline before after SRTT MEP amplitudes showed an increase after anodal and a tendency to decrease after cathodal stimulation, but these changes were not significant. The combination of different interventions during tDCS might result in reduced efficacy of the stimulation that in future studies need further attention. (C) 2016 Elsevier Ireland Ltd. All rights reserved."],["dc.identifier.doi","10.1016/j.neulet.2016.01.039"],["dc.identifier.isi","000373553900017"],["dc.identifier.pmid","26826607"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/41121"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Ireland Ltd"],["dc.relation.issn","1872-7972"],["dc.relation.issn","0304-3940"],["dc.title","Monitoring transcranial direct current stimulation induced changes in cortical excitability during the serial reaction time task"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","649"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Wiley Interdisciplinary Reviews Cognitive Science"],["dc.bibliographiccitation.lastpage","659"],["dc.bibliographiccitation.volume","5"],["dc.contributor.author","Antal, Andrea"],["dc.contributor.author","Ambrus, Geza Gergely"],["dc.contributor.author","Chaieb, Leila"],["dc.date.accessioned","2018-11-07T09:33:12Z"],["dc.date.available","2018-11-07T09:33:12Z"],["dc.date.issued","2014"],["dc.description.abstract","Low-intensity transcranial electrical stimulation (tES) methods are a group of noninvasive brain stimulation techniques, whereby currents are applied with intensities typically ranging between 1 and 2mA, through the human scalp. These techniques have been shown to induce changes in cortical excitability and activity during and after the stimulation in a reversible manner. They include transcranial direct current simulation (tDCS), transcranial alternating current simulation (tACS), and transcranial random noise stimulation (tRNS). Currently, an increasing number of studies have been published regarding the effects of tES on cognitive performance and behavior. Processes of learning and increases in cognitive performance are accompanied by changes in cortical plasticity. tES can impact upon these processes and is able to affect task execution. Many studies have been based on the accepted idea that by increasing cortical excitability (e.g., by applying anodal tDCS) or coherence of oscillatory activity (e.g., by applying tACS) an increase in performance should be detected; however, a number of studies now suggest that the basic knowledge of the mechanisms of action is insufficient to predict the outcome of applied stimulation on the execution of a cognitive or behavioral task, and so far no standard paradigms for increasing cortical plasticity changes during learning or cognitive tasks have been established. The aim of this review is to summarize recent findings with regard to the effects of tES on behavior concentrating on the motor and visual areas. WIREs Cogn Sci 2014, 5:649-659. doi: 10.1002/wcs.1319 For further resources related to this article, please visit the . Conflict of interest: The authors have declared no conflicts of interest for this article."],["dc.identifier.doi","10.1002/wcs.1319"],["dc.identifier.isi","000344354200004"],["dc.identifier.pmid","26308871"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/31914"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","1939-5086"],["dc.relation.issn","1939-5078"],["dc.title","The impact of electrical stimulation techniques on behavior"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]