Koebernick, Katja

[["dc.bibliographiccitation.firstpage","16148"],["dc.bibliographiccitation.issue","37"],["dc.bibliographiccitation.journal","PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"],["dc.bibliographiccitation.lastpage","16153"],["dc.bibliographiccitation.volume","107"],["dc.contributor.author","Koebernick, Katja"],["dc.contributor.author","Loeber, Jana"],["dc.contributor.author","Arthur, Patrick Kobina"],["dc.contributor.author","Tarbashevich, Katsiaryna"],["dc.contributor.author","Pieler, Tomas"],["dc.date.accessioned","2018-11-07T08:39:12Z"],["dc.date.available","2018-11-07T08:39:12Z"],["dc.date.issued","2010"],["dc.description.abstract","Segregation of the future germline defines a crucial cell fate decision during animal development. In Xenopus, germ cells are specified by inheritance of vegetally localized maternal determinants, including a group of specific mRNAs. Here, we show that the vegetal localization elements (LE) of Xenopus Dead end (XDE) and of several other germ-line-specific, vegetally localized transcripts mediate germ cell-specific stabilization and somatic clearance of microinjected reporter mRNA in Xenopus embryos. The part of XDE-LE critical for somatic RNA clearance exhibits homology to zebrafish nanos1 and appears to be targeted by Xenopus miR-18 for somatic mRNA clearance. Xenopus Elr-type proteins of the vegetal localization complex can alleviate somatic RNA clearance of microinjected XDE-LE and endogenous XDE mRNA. ElrB1 synergizes with Xenopus Dead end protein in the stabilization of XDE-LE mRNA. Taken together, our findings unveil a functional link of vegetal mRNA localization and the protection of germ-line mRNAs from somatic clearance."],["dc.description.sponsorship","Deutsche Forschungsgemeinschaft [Pi159/9-1]"],["dc.identifier.doi","10.1073/pnas.1004401107"],["dc.identifier.isi","000281799000033"],["dc.identifier.pmid","20805475"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/6118"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/18939"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Natl Acad Sciences"],["dc.relation.issn","0027-8424"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Elr-type proteins protect Xenopus Dead end mRNA from miR-18-mediated clearance in the soma"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","554"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Developmental Biology"],["dc.bibliographiccitation.lastpage","565"],["dc.bibliographiccitation.volume","311"],["dc.contributor.author","Tarbashevich, Katsiaryna"],["dc.contributor.author","Koebemick, Katja"],["dc.contributor.author","Pieler, Tomas"],["dc.date.accessioned","2018-11-07T10:53:19Z"],["dc.date.available","2018-11-07T10:53:19Z"],["dc.date.issued","2007"],["dc.description.abstract","The Xenopus germ line is derived from a specialized region in the vegetal hemisphere of the oocyte, the germ plasm. Several maternal transcripts harboured in this region have been connected to the process of germ cell specification. We identified and functionally characterized a novel vegetally localizing mRNA encoding a glutamate receptor interacting protein (GRIP) family member in Xenopus, termed XGRIP2.1. XGRIP2.1 is specifically associated with the germ plasm and PGCs throughout Xenopus embryogenesis. Morpholino-mediated knockdown and overexpression of a putative dominant negative XGRIP2.1 protein fragment reduced average PGC numbers and interfered with the proper anteroposterior positioning of PGCs at tailbud stages. Thus, our results suggest that XGRIP2.1 is required for normal PGC development and migration in Xenopus. (c) 2007 Elsevier Inc. All rights reserved."],["dc.identifier.doi","10.1016/j.ydbio.2007.09.012"],["dc.identifier.isi","251123900023"],["dc.identifier.pmid","17936745"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/49334"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Academic Press Inc Elsevier Science"],["dc.relation.issn","0012-1606"],["dc.title","XGRIP2.1 is encoded by a vegetally localizing, matemal mRNA and functions in germ cell development and anteroposterior PGC positioning in Xenopus laevis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]