Koebernick, Katja

[["dc.bibliographiccitation.firstpage","69"],["dc.bibliographiccitation.issue","2-3"],["dc.bibliographiccitation.journal","Differentiation"],["dc.bibliographiccitation.lastpage","76"],["dc.bibliographiccitation.volume","70"],["dc.contributor.author","Koebernick, K."],["dc.contributor.author","Pieler, T."],["dc.date.accessioned","2018-11-07T10:30:07Z"],["dc.date.available","2018-11-07T10:30:07Z"],["dc.date.issued","2002"],["dc.description.abstract","Secreted proteins of the Hedgehog (Hh) family direct the development of diverse organs and tissues of vertebrates and invertebrates. Gli-type zinc finger proteins function as transcriptional mediators of the Hh signaling cascade and were implicated both in the activation and repression of Hh target genes. The differential activity of Gli-type zinc finger proteins is regulated on the level of proteolytic processing and subcellular localization as a complex concert of Hh-responsive, intracellular determinants. Here, we provide a survey of recent studies on the characterization of molecular mechanisms involved in the interpretation of Hh signals by Gli-type zinc finger proteins."],["dc.identifier.doi","10.1046/j.1432-0436.2002.700201.x"],["dc.identifier.isi","000175553900001"],["dc.identifier.pmid","12076333"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/43793"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Blackwell Verlag Gmbh"],["dc.relation.issn","0301-4681"],["dc.title","Gli-type zinc finger proteins as bipotential transducers of Hedgehog signaling"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","312"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Developmental Biology"],["dc.bibliographiccitation.lastpage","326"],["dc.bibliographiccitation.volume","298"],["dc.contributor.author","Koebernick, Katja"],["dc.contributor.author","Kashef, Jubin"],["dc.contributor.author","Pieler, Tomas"],["dc.contributor.author","Wedlich, Doris"],["dc.date.accessioned","2018-11-07T09:09:43Z"],["dc.date.available","2018-11-07T09:09:43Z"],["dc.date.issued","2006"],["dc.description.abstract","We have isolated two related Xenopus homologues of the homeotic zinc finger protein Teashirt1 (Tsh1), XTsh1a and XTsh1b. While Drosophila teashirt specifies trunk identity in the fly, the developmental relevance of vertebrate Tsh homologues is unknown. XTsh1a/b are expressed in prospective trunk CNS throughout early neurula stages and later in the migrating cranial neural crest (CNC) of the third arch. In postmigratory CNC, XTsh1a/b is uniformly activated in the posterior arches. Gain- and loss-of-function experiments reveal that reduction or increase of XTsh1 levels selectively inhibits specification of the hindbrain and mid/hindbrain boundary in Xenopus embryos. In addition, both overexpression and depletion of XTsh1 interfere with the determination of CNC segment identity. In transplantation assays, ectopic XTsh1a inhibits the routing of posterior, but not of mandibular CNC streams. The loss of function phenotype could be rescued with low amounts either of XTsh1a or murine Tsh3. Our results demonstrate that proper expression of XTsh1 is essential for segmentally restricted gene expression in the posterior brain and CNC and suggest for the first time that teashirt genes act as positional factors also in vertebrate development. (c) 2006 Elsevier Inc. All rights reserved."],["dc.identifier.doi","10.1016/j.ydbio.2006.06.041"],["dc.identifier.isi","241071100027"],["dc.identifier.pmid","16916510"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/26324"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Academic Press Inc Elsevier Science"],["dc.relation.issn","0012-1606"],["dc.title","Xenopus Teashirt1 regulates posterior identity in brain and cranial neural crest"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","325"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Developmental Biology"],["dc.bibliographiccitation.lastpage","338"],["dc.bibliographiccitation.volume","260"],["dc.contributor.author","Koebernick, K."],["dc.contributor.author","Hollemann, T."],["dc.contributor.author","Pieler, T."],["dc.date.accessioned","2018-11-07T10:36:57Z"],["dc.date.available","2018-11-07T10:36:57Z"],["dc.date.issued","2003"],["dc.description.abstract","Vertebrate inner ear development is initiated by the specification of the otic placode, an ectodermal structure induced by signals from neighboring tissue. Although several signaling molecules have been identified as candidate otic inducers, many details of the process of inner ear induction remain elusive. Here, we report that otic induction is responsive to the level of Hedgehog (Hh) signaling activity in Xenopus, making use of both gain- and loss-of-function approaches. Ectopic activation of Hedgehog signaling resulted in the development of ectopic vesicular structures expressing the otic marker genes XPax-2, Xdll-3, and Xwnt-3A, thus revealing otic identity. Induction of ectopic otic vesicles was also achieved by misexpression of two different inhibitors of Hh signaling: the putative Hh antagonist mHIP and XPtc lDeltaLoop2, a dominant-negative form of the Hh receptor Patched. In addition, misexpression of XPtc I DeltaLoop2 as well as treatment of Xenopus embryos with the specific Hh signaling antagonist cyclopamine resulted in the formation of enlarged otic vesicles. In summary, our observations suggest that a defined level of Hh signaling provides a restrictive environment for otic fate in Xenopus embryos. (C) 2003 Elsevier Science (USA). All rights reserved."],["dc.identifier.doi","10.1016/S0012-1606(03)00242-2"],["dc.identifier.isi","000184946000004"],["dc.identifier.pmid","12921735"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/45447"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Academic Press Inc Elsevier Science"],["dc.relation.issn","0012-1606"],["dc.title","A restrictive role for Hedgehog signalling during otic specification in Xenopus"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","European Journal of Cell Biology"],["dc.bibliographiccitation.volume","82"],["dc.contributor.author","Koebernick, K."],["dc.contributor.author","Pieler, T."],["dc.contributor.author","Wedlich, D."],["dc.date.accessioned","2018-11-07T10:40:18Z"],["dc.date.available","2018-11-07T10:40:18Z"],["dc.date.issued","2003"],["dc.format.extent","28"],["dc.identifier.isi","000182016200020"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/46273"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Urban & Fischer Verlag"],["dc.publisher.place","Jena"],["dc.relation.conference","Annual Meeting of the Deutschen-Gesellschaft-fur-Zellbiologie/Gesellschaft-fur-Entwicklungsbio logie"],["dc.relation.eventlocation","BONN, GERMANY"],["dc.relation.issn","0171-9335"],["dc.title","The function of Xenopus Teashirt1 during CNS and neural crest differentiation"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","303"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Mechanisms of Development"],["dc.bibliographiccitation.lastpage","308"],["dc.bibliographiccitation.volume","100"],["dc.contributor.author","Koebernick, K."],["dc.contributor.author","Hollemann, T."],["dc.contributor.author","Pieler, T."],["dc.date.accessioned","2018-11-07T09:25:21Z"],["dc.date.available","2018-11-07T09:25:21Z"],["dc.date.issued","2001"],["dc.description.abstract","Inductive signaling mediated by secreted factors of the Hedgehog (Hh) gene family regulates cellular proliferation and differentiation in many embryonic tissues. Two transmembrane proteins associated in a complex, Patched (Ptc) and Smoothened (Smo), are indispensable for the reception of Hh signals (Cell 86 (1996) 221; Nature 382 (1996) 547; Nature 384 (1996) 176; Nature 384 (1996) 129). Here, we report on the identification of Pre and Smo homologues from Xenopus and analyze their spatio-temporal expression during embryogenesis. The intracellular response to Hh signals involves upregulation of Ptc transcription (Genes Dev. 10 (1996) 301; J. Biol. Chem. 271 (1996) 12125). In accordance with its putative function as Shh target gene, XPtc1 expression during early stages of Xenopus embryogenesis is detected in mesodermal and neuroectodermal tissues proximal to the notochord, a known expression domain of Shh. Although the expression pattern of XPtc1 was similar to that of other vertebrates, expression domains specific to Xenopus could be detected in the hypochord, dorsal mesencephalon, otic vesicles and pituitary anlage. Unlike other vertebrate Ptc1 homologues, semitic expression of XPtc1 is confined to a central cell layer. In contrast to the tissue-specific expression characteristics of XPtc1, XSmo expression appears to be ubiquitously activated in early embryonic stages but condenses in the terminal regions of the embryo at tailbud stage. In many tissues and organs of the adult, XPtc1 and XSmo are found to display similar expression levels. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved."],["dc.identifier.doi","10.1016/S0925-4773(00)00526-8"],["dc.identifier.isi","000166837600013"],["dc.identifier.pmid","11165486"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/30042"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Bv"],["dc.relation.issn","1872-6356"],["dc.relation.issn","0925-4773"],["dc.title","Molecular cloning and expression analysis of the Hedgehog receptors XPtc1 and XSmo in Xenopus laevis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","16148"],["dc.bibliographiccitation.issue","37"],["dc.bibliographiccitation.journal","PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"],["dc.bibliographiccitation.lastpage","16153"],["dc.bibliographiccitation.volume","107"],["dc.contributor.author","Koebernick, Katja"],["dc.contributor.author","Loeber, Jana"],["dc.contributor.author","Arthur, Patrick Kobina"],["dc.contributor.author","Tarbashevich, Katsiaryna"],["dc.contributor.author","Pieler, Tomas"],["dc.date.accessioned","2018-11-07T08:39:12Z"],["dc.date.available","2018-11-07T08:39:12Z"],["dc.date.issued","2010"],["dc.description.abstract","Segregation of the future germline defines a crucial cell fate decision during animal development. In Xenopus, germ cells are specified by inheritance of vegetally localized maternal determinants, including a group of specific mRNAs. Here, we show that the vegetal localization elements (LE) of Xenopus Dead end (XDE) and of several other germ-line-specific, vegetally localized transcripts mediate germ cell-specific stabilization and somatic clearance of microinjected reporter mRNA in Xenopus embryos. The part of XDE-LE critical for somatic RNA clearance exhibits homology to zebrafish nanos1 and appears to be targeted by Xenopus miR-18 for somatic mRNA clearance. Xenopus Elr-type proteins of the vegetal localization complex can alleviate somatic RNA clearance of microinjected XDE-LE and endogenous XDE mRNA. ElrB1 synergizes with Xenopus Dead end protein in the stabilization of XDE-LE mRNA. Taken together, our findings unveil a functional link of vegetal mRNA localization and the protection of germ-line mRNAs from somatic clearance."],["dc.description.sponsorship","Deutsche Forschungsgemeinschaft [Pi159/9-1]"],["dc.identifier.doi","10.1073/pnas.1004401107"],["dc.identifier.isi","000281799000033"],["dc.identifier.pmid","20805475"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/6118"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/18939"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Natl Acad Sciences"],["dc.relation.issn","0027-8424"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Elr-type proteins protect Xenopus Dead end mRNA from miR-18-mediated clearance in the soma"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","554"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Developmental Biology"],["dc.bibliographiccitation.lastpage","565"],["dc.bibliographiccitation.volume","311"],["dc.contributor.author","Tarbashevich, Katsiaryna"],["dc.contributor.author","Koebemick, Katja"],["dc.contributor.author","Pieler, Tomas"],["dc.date.accessioned","2018-11-07T10:53:19Z"],["dc.date.available","2018-11-07T10:53:19Z"],["dc.date.issued","2007"],["dc.description.abstract","The Xenopus germ line is derived from a specialized region in the vegetal hemisphere of the oocyte, the germ plasm. Several maternal transcripts harboured in this region have been connected to the process of germ cell specification. We identified and functionally characterized a novel vegetally localizing mRNA encoding a glutamate receptor interacting protein (GRIP) family member in Xenopus, termed XGRIP2.1. XGRIP2.1 is specifically associated with the germ plasm and PGCs throughout Xenopus embryogenesis. Morpholino-mediated knockdown and overexpression of a putative dominant negative XGRIP2.1 protein fragment reduced average PGC numbers and interfered with the proper anteroposterior positioning of PGCs at tailbud stages. Thus, our results suggest that XGRIP2.1 is required for normal PGC development and migration in Xenopus. (c) 2007 Elsevier Inc. All rights reserved."],["dc.identifier.doi","10.1016/j.ydbio.2007.09.012"],["dc.identifier.isi","251123900023"],["dc.identifier.pmid","17936745"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/49334"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Academic Press Inc Elsevier Science"],["dc.relation.issn","0012-1606"],["dc.title","XGRIP2.1 is encoded by a vegetally localizing, matemal mRNA and functions in germ cell development and anteroposterior PGC positioning in Xenopus laevis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]