Koebernick, Katja

[["dc.bibliographiccitation.firstpage","16148"],["dc.bibliographiccitation.issue","37"],["dc.bibliographiccitation.journal","PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"],["dc.bibliographiccitation.lastpage","16153"],["dc.bibliographiccitation.volume","107"],["dc.contributor.author","Koebernick, Katja"],["dc.contributor.author","Loeber, Jana"],["dc.contributor.author","Arthur, Patrick Kobina"],["dc.contributor.author","Tarbashevich, Katsiaryna"],["dc.contributor.author","Pieler, Tomas"],["dc.date.accessioned","2018-11-07T08:39:12Z"],["dc.date.available","2018-11-07T08:39:12Z"],["dc.date.issued","2010"],["dc.description.abstract","Segregation of the future germline defines a crucial cell fate decision during animal development. In Xenopus, germ cells are specified by inheritance of vegetally localized maternal determinants, including a group of specific mRNAs. Here, we show that the vegetal localization elements (LE) of Xenopus Dead end (XDE) and of several other germ-line-specific, vegetally localized transcripts mediate germ cell-specific stabilization and somatic clearance of microinjected reporter mRNA in Xenopus embryos. The part of XDE-LE critical for somatic RNA clearance exhibits homology to zebrafish nanos1 and appears to be targeted by Xenopus miR-18 for somatic mRNA clearance. Xenopus Elr-type proteins of the vegetal localization complex can alleviate somatic RNA clearance of microinjected XDE-LE and endogenous XDE mRNA. ElrB1 synergizes with Xenopus Dead end protein in the stabilization of XDE-LE mRNA. Taken together, our findings unveil a functional link of vegetal mRNA localization and the protection of germ-line mRNAs from somatic clearance."],["dc.description.sponsorship","Deutsche Forschungsgemeinschaft [Pi159/9-1]"],["dc.identifier.doi","10.1073/pnas.1004401107"],["dc.identifier.isi","000281799000033"],["dc.identifier.pmid","20805475"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/6118"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/18939"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Natl Acad Sciences"],["dc.relation.issn","0027-8424"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Elr-type proteins protect Xenopus Dead end mRNA from miR-18-mediated clearance in the soma"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]