Fuchs, Thomas

[["dc.bibliographiccitation.firstpage","450"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","LaboratoriumsMedizin"],["dc.bibliographiccitation.lastpage","455"],["dc.bibliographiccitation.volume","32"],["dc.contributor.author","Przybilla, Bernhard"],["dc.contributor.author","Aberer, Werner"],["dc.contributor.author","Bircher, Andreas J."],["dc.contributor.author","Brehler, Randolph"],["dc.contributor.author","Brockow, Knut"],["dc.contributor.author","Dickel, Heinrich"],["dc.contributor.author","Fuchs, Thomas"],["dc.contributor.author","Hertl, Michael"],["dc.contributor.author","Mockenhaupt, Maja"],["dc.contributor.author","Pfaar, Oliver"],["dc.contributor.author","Ring, Johannes"],["dc.contributor.author","Sachs, Bernhardt"],["dc.contributor.author","Vieluf, Dieter"],["dc.contributor.author","Wedi, Bettina"],["dc.contributor.author","Worm, Margitta"],["dc.contributor.author","Zuberbier, Torsten"],["dc.contributor.author","Merk, Hans F."],["dc.date.accessioned","2018-11-07T11:09:37Z"],["dc.date.available","2018-11-07T11:09:37Z"],["dc.date.issued","2008"],["dc.description.abstract","Drug hypersensitivity reactions have to be tested to identify the culprit substance. The history includes the general information and specific data concerning used drugs, the classification and circumstances of the reaction. Skin tests are performed in all hypersensitivity reactions with allergic symptoms. Tests should be done between four weeks and six months after clearance of the symptoms by performing skin prick test, intradermal test, patch test or photopatch test. Validated tests for the detection of specific IgE antibodies in the serum are available for only few drugs, especially betalactam antibiotics. Other laboratory tests, e.g., the basophil activation test are done only in special cases. Provocation tests are indicated, if the culprit drug cannot be identified by the above mentioned tests. If possible, the evaluation of provocation tests should rely on objective parameters. The concluding assessment will be discussed with the patient and will be documented in an allergy pass."],["dc.identifier.doi","10.1515/JLM.2008.056"],["dc.identifier.isi","000261453700009"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/53047"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Walter De Gruyter Gmbh"],["dc.relation.issn","1439-0477"],["dc.relation.issn","0342-3026"],["dc.title","Allergological approach to drug hypersensitivity reactions"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","373"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Contact Dermatitis"],["dc.bibliographiccitation.lastpage","385"],["dc.bibliographiccitation.volume","78"],["dc.contributor.author","Dittmar, Daan"],["dc.contributor.author","Uter, Wolfgang"],["dc.contributor.author","Bauer, Andrea"],["dc.contributor.author","Fortina, Ana B."],["dc.contributor.author","Bircher, Andreas J."],["dc.contributor.author","Czarnecka‐Operacz, Magdalena"],["dc.contributor.author","Dugonik, Aleksandra"],["dc.contributor.author","Elsner, Peter"],["dc.contributor.author","Gallo, Rosella"],["dc.contributor.author","Ghaffar, Sharizan A."],["dc.contributor.author","Giménez‐Arnau, Anna"],["dc.contributor.author","Johnston, Graham A."],["dc.contributor.author","Kręcisz, Beata"],["dc.contributor.author","Filon, Francesca L."],["dc.contributor.author","Rustemeyer, Thomas"],["dc.contributor.author","Sadowska‐Przytocka, Anna"],["dc.contributor.author","Sánchez‐Pérez, Javier"],["dc.contributor.author","Schnuch, Axel"],["dc.contributor.author","Simon, Dagmar"],["dc.contributor.author","Spiewak, Radoslaw"],["dc.contributor.author","Spring, Philipp"],["dc.contributor.author","Corradin, Maria T."],["dc.contributor.author","Valiukevičienė, Skaidra"],["dc.contributor.author","Vok, Marko"],["dc.contributor.author","Weisshaar, Elke"],["dc.contributor.author","Wilkinson, Mark"],["dc.contributor.author","Schuttelaar, Marie L."],["dc.contributor.author","Aberer, Werner"],["dc.contributor.author","Ballmer‐Weber, Barbara"],["dc.contributor.author","Grabbe, Jürgen"],["dc.contributor.author","Beiteke, Ulrike"],["dc.contributor.author","Brasch, Jochen"],["dc.contributor.author","Fuchs, Thomas"],["dc.contributor.author","John, Swen Malte"],["dc.contributor.author","Mahler, Vera"],["dc.contributor.author","Pesonen, Maria"],["dc.contributor.author","Jolanki, Riitta"],["dc.contributor.author","Rantanen, Tapio"],["dc.contributor.author","Armario‐Hita, José Carlos"],["dc.contributor.author","Fernández‐Redondo, Virginia"],["dc.contributor.author","García‐Gavín, Juan"],["dc.contributor.author","Mercader, Pedro"],["dc.contributor.author","Ruiz, Inmaculada"],["dc.contributor.author","Silvestre, Juan Fco."],["dc.contributor.author","Balato, Anna"],["dc.contributor.author","Ayala, Fabio"],["dc.contributor.author","Peserico, Andrea"],["dc.contributor.author","Sliuziaviciene, Gondinga"],["dc.contributor.author","Kieć‐Świerczyńska, Marta"],["dc.contributor.author","Kmecl, Tanja"],["dc.contributor.author","Pandurovic, Maja Kalac"],["dc.contributor.author","Kecelj, Nada"],["dc.contributor.author","Lunder, Tomaž"],["dc.contributor.author","Simončič Godnič, Mojca"],["dc.contributor.author","Chowdhury, Mahbub M. U."],["dc.contributor.author","Cooper, Susan M."],["dc.contributor.author","English, John S. C."],["dc.contributor.author","Cousen, Philippa"],["dc.contributor.author","Horne, Helen L."],["dc.contributor.author","Gawkrodger, David J."],["dc.contributor.author","Holden, Catherine"],["dc.contributor.author","Sabroe, Ruth"],["dc.contributor.author","Green, Cathy M."],["dc.contributor.author","King, Codagh M."],["dc.contributor.author","Ormerod, Anthony D."],["dc.contributor.author","Samson, Jane E."],["dc.contributor.author","Statham, Barry"],["dc.contributor.author","Stone, Natalie"],["dc.contributor.author","White, Ian"],["dc.date.accessioned","2020-12-10T18:27:11Z"],["dc.date.available","2020-12-10T18:27:11Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1111/cod.12966"],["dc.identifier.eissn","1600-0536"],["dc.identifier.issn","0105-1873"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/76269"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","European Surveillance System on Contact Allergies (ESSCA): polysensitization, 2009–2014"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","199"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Contact Dermatitis"],["dc.bibliographiccitation.lastpage","202"],["dc.bibliographiccitation.volume","60"],["dc.contributor.author","Geier, Johannes"],["dc.contributor.author","Lessmann, Holger"],["dc.contributor.author","Hellweg, Brigitte"],["dc.contributor.author","Jappe, Uta"],["dc.contributor.author","Spornraft-Ragaller, Petra"],["dc.contributor.author","Fuchs, Thomas"],["dc.contributor.author","Aberer, Werner"],["dc.contributor.author","Frosch, Peter J."],["dc.contributor.author","Weisshaar, Elke"],["dc.contributor.author","Mahler, Vera"],["dc.contributor.author","Loeffler, Harald"],["dc.contributor.author","Skudlik, Christoph"],["dc.contributor.author","Szliska, Christiane"],["dc.contributor.author","Koch, Patrick"],["dc.contributor.author","Pfoehler, Claudia"],["dc.contributor.author","Lilie, Martina"],["dc.contributor.author","Becker, Detlef"],["dc.contributor.author","Trcka, Jiri"],["dc.contributor.author","Meyer, Jochen"],["dc.contributor.author","Hahn, Jens-Uwe"],["dc.contributor.author","Adam, Monika"],["dc.date.accessioned","2018-11-07T08:34:16Z"],["dc.date.available","2018-11-07T08:34:16Z"],["dc.date.issued","2009"],["dc.description.abstract","Background: Hidden allergen exposure may contribute to persistence and relapse of chromate dermatitis. According to case reports, chromated metal products, such as screws, fittings, etc., may be relevant allergen sources for patients sensitized to chromate. Objectives: To examine concomitant patch test reactivity to potassium dichromate 0.5% petrolatum ( pet.) and three different types of chromated metal rings. Patients/Methods: Patients with proven or suspected chromate allergy were patch tested with potassium dichromate 0.5% pet. and three different types of chromated metal rings ( yellow, olive, and black). Hexavalent chromium Cr(VI) release from the patch tested rings was chemically analysed. Results: Ninety-five patients were tested: 49/95 (52%) reacted to potassium dichromate and 25/95 (26%) reacted to black chromated rings. Reactions to chromated rings exclusively occurred in patients reacting to potassium dichromate. Of 20 patients with a strong reaction to potassium dichromate, 14 reacted to black chromated rings. These were shown to have a high Cr(VI) release. Only two patients reacted to the other chromated rings, which had a very low Cr(VI) release. Conclusions: Handling chromated metal products must be regarded a hazard to chromate-sensitive patients, in particular those with a strong sensitization."],["dc.identifier.isi","000264609700003"],["dc.identifier.pmid","19338587"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/17772"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell Publishing, Inc"],["dc.relation.issn","0105-1873"],["dc.title","Chromated metal products may be hazardous to patients with chromate allergy"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","770"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","JDDG Journal der Deutschen Dermatologischen Gesellschaft"],["dc.bibliographiccitation.lastpage","775"],["dc.bibliographiccitation.volume","6"],["dc.contributor.author","Schnuch, Axel"],["dc.contributor.author","Aberer, Werner"],["dc.contributor.author","Agathos, Monika"],["dc.contributor.author","Becker, Detlef"],["dc.contributor.author","Brasch, Jochen"],["dc.contributor.author","Elsner, Peter"],["dc.contributor.author","Frosch, Peter J."],["dc.contributor.author","Fuchs, Thomas"],["dc.contributor.author","Geier, Johannes"],["dc.contributor.author","Hillen, Uwe"],["dc.contributor.author","Loeffler, Harald"],["dc.contributor.author","Mahler, Vera"],["dc.contributor.author","Richter, Gerhard"],["dc.contributor.author","Szliska, Christiane"],["dc.date.accessioned","2018-11-07T11:11:34Z"],["dc.date.available","2018-11-07T11:11:34Z"],["dc.date.issued","2008"],["dc.identifier.doi","10.1111/j.1610-0387.2008.06787.x"],["dc.identifier.isi","000259375300012"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/53463"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.relation.issn","1610-0379"],["dc.title","Performing patch testing with contact allergens"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","563"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","Allergologie"],["dc.bibliographiccitation.lastpage","589"],["dc.bibliographiccitation.volume","35"],["dc.contributor.author","Przybilla, Bernhard"],["dc.contributor.author","Rueff, Franziska"],["dc.contributor.author","Walker, A."],["dc.contributor.author","Rawer, H.-C."],["dc.contributor.author","Aberer, Werner"],["dc.contributor.author","Bauer, C. P."],["dc.contributor.author","Berdel, D."],["dc.contributor.author","Biedermann, Tilo"],["dc.contributor.author","Brockow, Knut"],["dc.contributor.author","Forster, J."],["dc.contributor.author","Fuchs, Thomas"],["dc.contributor.author","Hamelmann, E."],["dc.contributor.author","Jakob, Thilo"],["dc.contributor.author","Jarisch, R."],["dc.contributor.author","Merk, Hans F"],["dc.contributor.author","Mueller, U."],["dc.contributor.author","Ott, H."],["dc.contributor.author","Sitter, W."],["dc.contributor.author","Urbanek, R."],["dc.contributor.author","Wedi, Bettina"],["dc.date.accessioned","2018-11-07T09:03:49Z"],["dc.date.available","2018-11-07T09:03:49Z"],["dc.date.issued","2012"],["dc.description.abstract","Diagnosis and therapy of bee and wasp venom allergy Allergic reactions caused by stings of honey bees (Apis mellifera) or social wasps (particularly Vespula vulgaris, V germanica) nearly always present as large local reactions (in up to 25% of the population) or as systemic reactions with symptoms of immediate type allergy (anaphylaxis; in up to 3.5% of the population). Systemic sting reactions are induced by IgE antibodies interacting with venom components. Other clinical presentations of allergic reactions (\"unusual sting reactions\") and toxic reactions after numerous stings are very rare. Particularly severe anaphylactic reactions may be fatal or result in disability. Acute reactions are managed by symptomatic treatment. Patients with allergic reactions profit from long-term treatment comprising education to avoid further stings, and from training to be prepared for self-management including the use of emergency medication in case of further stings. Adrenaline for self-administration is part of the emergency kit in those patients presenting with systemic immediate type reactions. Specific immunotherapy (SIT) is the main treatment option to prevent subsequent systemic reactions. Diagnostics in patients with systemic immediate type reactions are based on history, skin tests, and assessment of specific IgE antibodies to whole venom. Sometimes, these tests may not yield a venom sensitization which corresponds with the patient's history. In such cases, it is recommended to determine concentrations of specific serum IgE antibodies to relevant single venom allergens (currently Api m 1 and Ves v 5 are available) and to perform cellular tests, if appropriate. The results of diagnostic procedures, however, are sensitive to a variety of interferences. Therefore, \"false-negative\" or \"false-positive\" reactions may occur in any system. Patients with an elevated serum concentration of baseline tryptase (95th percentile 11.4 mu g/l) and/or with mastocytosis frequently suffer from very severe anaphylactic sting reactions. To recognize these risks, baseline serum tryptase concentration should be determined and the skin should be inspected for the presence of cutaneous mastocytosis. SIT with bee or wasp venom is mandatory for patients who have experienced sting reactions with respiratory or cardiovascular symptoms. For patients with mild systemic sting reactions limited to the skin and with individual risk factors, SIT is also urgently recommended. Beyond that, SIT is advisable to all adult patients with systemic immediate type sting reactions independently of the severity grade. Only for children with systemic immediate type reactions confined to the skin data are available showing that SIT is not mandatory. There are numerous protocols for dose increase during the initial phase of venom SIT: The maintenance dose may be reached within one day (ultrarush), alter 3 5 days (rush) or within weeks or months (conventional SIT). The frequency of adverse effects is related to the speed of dose increase. The standard maintenance dose is 100 mu g. Bee venom SIT is less effective than wasp venom SIT. Therefore, high-risk patients suffering from bee venom-allergy may receive an increased maintenance dose of 200 mu g right from the start; this strategy may be also indicated in selected high-risk patients with wasp venom allergy. Systemic anaphylactic reactions and subjective complaints are the most important adverse effects of venom SIT, occurring particularly during the incremental phase. Mostly, these reactions are mild. Rarely, there are repeated anaphylactic reactions which substantially hamper treatment or even necessitate its termination. In such cases, co-treatment and/or pre-treatment with the anti-IgE antibody omalizumab appears to be the best option currently available to achieve tolerance of SIT; it has to be considered, however, that using omalizumab for this indication would be an off-label use. Also, these patients are treated with an increased maintenance dose (>= 200 mu g). There are no laboratory tests to determine the efficacy of SIT. A sting challenge test using a living insect should be performed about 6 18 months alter the maintenance dose has been reached to identify treatment failure. If necessary, this interval may be shortened in high-risk patients. Sting challenge tests need to be performed with utmost caution providing emergency room conditions. If a patient continues to develop a systemic reaction despite SIT, administration of an increased maintenance dose nearly always provides protection (usually 200 mu g are sufficient). In most patients, SIT can be stopped after 3 5 years, if SIT and a re-sting were tolerated without systemic reactions. If there is no tolerance or if a patient presents with individual risks, a decision has to be made as to whether SIT should be continued or not. This decision largely depends on the patient's individual risk profile, and usually prolonged treatment is necessary. Life-long SIT is indicated for some patients, e.g. for those with mastocytosis or in case of a prior sting reaction requiring cardiopulmonary resuscitation."],["dc.identifier.doi","10.5414/ALX01447"],["dc.identifier.isi","000311766500004"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/24976"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.relation.issn","0344-5062"],["dc.title","Diagnosis and therapy of bee and wasp venom allergy"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","31"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Contact Dermatitis"],["dc.bibliographiccitation.lastpage","38"],["dc.bibliographiccitation.volume","61"],["dc.contributor.author","Uter, Wolfgang"],["dc.contributor.author","Raemsch, Christiane"],["dc.contributor.author","Aberer, Werner"],["dc.contributor.author","Ayala, Fabio"],["dc.contributor.author","Balato, Anna"],["dc.contributor.author","Beliauskiene, Aiste"],["dc.contributor.author","Fortina, Anna Belloni"],["dc.contributor.author","Bircher, Andreas J."],["dc.contributor.author","Brasch, Jochen"],["dc.contributor.author","Chowdhury, Mahbub M. U."],["dc.contributor.author","Coenraads, Pieter-Jan"],["dc.contributor.author","Schuttelaar, Marie-Louise"],["dc.contributor.author","Cooper, Sue"],["dc.contributor.author","Corradin, Maria Teresa"],["dc.contributor.author","Elsner, Peter"],["dc.contributor.author","English, John S. C."],["dc.contributor.author","Fartasch, Manige"],["dc.contributor.author","Mahler, Vera"],["dc.contributor.author","Frosch, Peter J."],["dc.contributor.author","Fuchs, Thomas"],["dc.contributor.author","Gawkrodger, David J."],["dc.contributor.author","Gimenez-Arnau, Ana-Maria"],["dc.contributor.author","Green, Cathy M."],["dc.contributor.author","Horne, Helen L."],["dc.contributor.author","Jolanki, Riitta"],["dc.contributor.author","King, Codagh M."],["dc.contributor.author","Krecisz, Beata"],["dc.contributor.author","Kiec-Swierczynska, Marta"],["dc.contributor.author","Ormerod, Anthony D."],["dc.contributor.author","Orton, David I."],["dc.contributor.author","Peserico, Andrea"],["dc.contributor.author","Rantanen, Tapio"],["dc.contributor.author","Rustemeyer, Thomas"],["dc.contributor.author","Sansom, Jane E."],["dc.contributor.author","Simon, Dagmar"],["dc.contributor.author","Statham, Barry N."],["dc.contributor.author","Wilkinson, Mark"],["dc.contributor.author","Schnuch, Axel"],["dc.date.accessioned","2018-11-07T08:34:13Z"],["dc.date.available","2018-11-07T08:34:13Z"],["dc.date.issued","2009"],["dc.description.abstract","Background Continual surveillance based on patch test results has proved useful for the identification of contact allergy. Objectives To provide a current view on the spectrum of contact allergy to important sensitizers across Europe. Patients/Methods Clinical and patch test data of 19 793 patients patch tested in 2005/2006 in the 31 participating departments from 10 European countries (the European Surveillance System on Contact Allergies' (ESSCA) www.essca-dc.org) were descriptively analysed, aggregated to four European regions. Results Nickel sulfate remains the most common allergen with standardized prevalences ranging from 19.7% (central Europe) to 24.4% (southern Europe). While a number of allergens shows limited variation across the four regions, such as Myroxylon pereirae (5.3-6.8%), cobalt chloride (6.2-8.8%) or thiuram mix (1.7-2.4%), the differences observed with other allergens may hint on underlying differences in exposures, for example: dichromate 2.4% in the UK (west) versus 4.5-5.9% in the remaining EU regions, methylchloroisothiazolinone/methylisothiazolinone 4.1% in the South versus 2.1-2.7% in the remaining regions. Conclusions Notwithstanding residual methodological variation (affecting at least some 'difficult' allergens) tackled by ongoing efforts for standardization, a comparative analysis as presented provides (i) a broad overview on contact allergy frequencies and (ii) interesting starting points for further, in-depth investigation."],["dc.identifier.isi","000268052000004"],["dc.identifier.pmid","19659962"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/17766"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.relation.issn","0105-1873"],["dc.title","The European baseline series in 10 European Countries, 2005/2006-Results of the European Surveillance System on Contact Allergies (ESSCA)"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]