Now showing 1 - 10 of 32
  • 2021Journal Article Research Paper
    [["dc.bibliographiccitation.journal","Facial Plastic Surgery & Aesthetic Medicine"],["dc.contributor.author","Hawellek, Thelonius"],["dc.contributor.author","Beil, Frank Timo"],["dc.contributor.author","Hischke, Sandra"],["dc.contributor.author","Saul, Dominik"],["dc.contributor.author","Hoffmann, Daniel Bernd"],["dc.contributor.author","Kleiss, Sebastian"],["dc.contributor.author","Rolvien, Tim"],["dc.contributor.author","Ries, Christian"],["dc.contributor.author","PĂĽschel, Klaus"],["dc.contributor.author","Frosch, Stephan"],["dc.contributor.author","Hubert, Jan"],["dc.date.accessioned","2021-12-01T09:23:50Z"],["dc.date.available","2021-12-01T09:23:50Z"],["dc.date.issued","2021"],["dc.identifier.doi","10.1089/fpsam.2021.0063"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/94768"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-478"],["dc.relation.eissn","2689-3622"],["dc.relation.issn","2689-3614"],["dc.rights.uri","https://www.liebertpub.com/nv/resources-tools/text-and-data-mining-policy/121/"],["dc.title","Costal Cartilage Calcification: Prevalence, Amount, and Structural Pattern in the General Population and Its Association with Age: A Cadaveric Study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]
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  • 2018Journal Article
    [["dc.bibliographiccitation.firstpage","935"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Foot & Ankle International"],["dc.bibliographiccitation.lastpage","941"],["dc.bibliographiccitation.volume","39"],["dc.contributor.author","Hubert, Jan"],["dc.contributor.author","Hawellek, Thelonius"],["dc.contributor.author","Beil, Frank Timo"],["dc.contributor.author","Saul, Dominik"],["dc.contributor.author","Kling, Jens Henning"],["dc.contributor.author","Viebahn, Christoph"],["dc.contributor.author","Jungesblut, Oliver Dirk"],["dc.contributor.author","Stücker, Ralf"],["dc.contributor.author","Rupprecht, Martin"],["dc.date.accessioned","2020-06-09T07:11:04Z"],["dc.date.available","2020-06-09T07:11:04Z"],["dc.date.issued","2018"],["dc.description.abstract","Background: The purpose of the study was to present a novel operative technique in the management of medial talocalcaneal coalition (TC) and to report our clinical and radiologic results after interposition of a pediculated flap (PF) of the tibialis posterior tendon sheath. Methods: Twelve feet of 10 patients with a medial TC were treated with the interposition of PF of the tibialis posterior tendon sheath following resection. Pre- and postoperative clinical examinations were performed to evaluate the range of motion and the function of the tibialis posterior muscle of the affected foot. Pain was registered by visual analog scale (VAS) and the function of the foot by the American Orthopaedic Foot & Ankle Society (AOFAS) hindfoot score. The mean follow-up duration was 57.2 months (SD ±37.2 range 12-128) after surgery. Magnetic resonance imaging (MRI) was carried out to assess the outcome. Results: All patients reported a significant reduction of pain (P = .002) at the final follow-up. The activity level had improved since the operation, and the subtalar joint motion was increased, but no weakness of the tibialis posterior muscle could be observed. The AOFAS hindfoot score was significantly improved (P = .002). MRI did not reveal any migration of the tibialis posterior tendon sheath, and the interposed PF was confirmed at the resection zone. Furthermore, no TC relapse or ruptures of the functional anatomical structures could be observed. Conclusion: The resection combined with the interposition of a PF of the tendon sheath seems to avoid relapse of TC and improves symptoms and the function of the foot."],["dc.identifier.doi","10.1177/1071100718768257"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/66213"],["dc.language.iso","en"],["dc.relation.issn","1071-1007"],["dc.title","Resection of Medial Talocalcaneal Coalition With Interposition of a Pediculated Flap of Tibialis Posterior Tendon Sheath"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]
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  • 2017Journal Article Research Paper
    [["dc.bibliographiccitation.firstpage","705"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Calcified Tissue International"],["dc.bibliographiccitation.lastpage","719"],["dc.bibliographiccitation.volume","102"],["dc.contributor.author","Saul, D."],["dc.contributor.author","Harlas, B."],["dc.contributor.author","Ahrabi, A."],["dc.contributor.author","Kosinsky, R. L."],["dc.contributor.author","Hoffmann, D. B."],["dc.contributor.author","Wassmann, M."],["dc.contributor.author","Wigger, R."],["dc.contributor.author","Böker, K. O."],["dc.contributor.author","Sehmisch, S."],["dc.contributor.author","Komrakova, M."],["dc.date.accessioned","2020-06-10T14:22:48Z"],["dc.date.available","2020-06-10T14:22:48Z"],["dc.date.issued","2017"],["dc.description.abstract","Osteoporosis is often accompanied by sarcopenia. The effect of strontium ranelate (SR) on muscle tissue has not been investigated sufficiently. In this study, the effect of different SR treatments on muscle was studied. Additionally, the lumbar vertebrae were analyzed. Three-month-old female rats were divided into five groups (n = 12): Group 1: untreated (NON-OVX); Group 2: ovariectomized and left untreated (OVX); Group 3: SR after OVX until the study ended (13 weeks, SR prophylaxis and therapy = pr+th); Group 4: OVX and SR for 8 weeks (SR prophylaxis = pr); Group 5: SR for 5 weeks from the 8 week after OVX (SR therapy = SR th). SR was applied in food (630 mg/kg body weight). The size of muscle fibers, capillary density, metabolic enzymes, and mRNA expression were assessed in soleus, gastrocnemius, and longissimus muscles. The vertebral bodies underwent micro-CT, biomechanical, and ashing analyses. In general, SR did not alter the muscle histological parameters. The changes in fiber size and capillary ratio were related to the body weight. Myostatin mRNA was decreased in Sr pr+th; protein expression was not changed. SR th led to increase in mRNA expression of vascular endothelial growth factor (Vegf-B). In lumbar spine, SR pr+th enhanced biomechanical properties, bone mineral density, trabecular area, density, and thickness and cortical density. The reduced calcium/phosphate ratio in the SR pr+th group indicates the replacement of calcium by strontium ions. SR has no adverse effects on muscle tissue and it shows a favorable time-dependent effect on vertebrae. A functional analysis of muscles could verify these findings."],["dc.identifier.doi","10.1007/s00223-017-0374-0"],["dc.identifier.pmid","29242963"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/66222"],["dc.language.iso","en"],["dc.relation.eissn","1432-0827"],["dc.relation.issn","0171-967X"],["dc.title","Effect of Strontium Ranelate on the Muscle and Vertebrae of Ovariectomized Rats"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]
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  • 2021Journal Article
    [["dc.bibliographiccitation.journal","Clinical Biochemistry"],["dc.contributor.author","Saul, D."],["dc.contributor.author","Hünicke, P."],["dc.contributor.author","Böker, K.O."],["dc.contributor.author","Spering, C."],["dc.contributor.author","Maheshwari, A.K."],["dc.contributor.author","Acharya, M."],["dc.contributor.author","Lehmann, W."],["dc.date.accessioned","2021-06-01T10:49:30Z"],["dc.date.available","2021-06-01T10:49:30Z"],["dc.date.issued","2021"],["dc.identifier.doi","10.1016/j.clinbiochem.2021.04.020"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/86310"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.relation.issn","0009-9120"],["dc.title","Predicting the disaster – The role of CRP in acetabular surgery"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]
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  • 2018Journal Article
    [["dc.bibliographiccitation.firstpage","243"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Journal of Bone and Mineral Metabolism"],["dc.bibliographiccitation.lastpage","255"],["dc.bibliographiccitation.volume","37"],["dc.contributor.author","Hoffmann, D. B."],["dc.contributor.author","Komrakova, M."],["dc.contributor.author","Pflug, S."],["dc.contributor.author","Oertzen, M. von"],["dc.contributor.author","Saul, D."],["dc.contributor.author","Weiser, L."],["dc.contributor.author","Walde, T. A."],["dc.contributor.author","Wassmann, M."],["dc.contributor.author","Schilling, A. F."],["dc.contributor.author","Lehmann, W."],["dc.contributor.author","Sehmisch, S."],["dc.date.accessioned","2020-06-15T13:52:01Z"],["dc.date.available","2020-06-15T13:52:01Z"],["dc.date.issued","2018"],["dc.description.abstract","We investigated the combinatorial effects of whole-body vertical vibration (WBVV) with the primarily osteoanabolic parathyroid hormone (PTH) and the mainly antiresorptive strontium ranelate (SR) in a rat model of osteoporosis. Ovariectomies were performed on 76 three-month-old Sprague-Dawley rats (OVX, n = 76; NON-OVX, n = 12). After 8 weeks, the ovariectomized rats were divided into 6 groups. One group (OVX + PTH) received daily injections of PTH (40 µg/kg body weight/day) for 6 weeks. Another group (OVX + SR) was fed SR-supplemented chow (600 mg/kg body weight/day). Three groups (OVX + VIB, OVX + PTH + VIB, and OVX + SR + VIB) were treated with WBVV twice a day at 70 Hz for 15 min. Two groups (OVX + PTH + VIB, OVX + SR + VIB) were treated additionally with PTH and SR, respectively. The rats were killed at 14 weeks post-ovariectomy. The lumbar vertebrae and femora were removed for biomechanical and morphological assessment. PTH produced statistically significant improvements in biomechanical and structural properties, including bone mineral density (BMD) and trabecular bone quality. In contrast, SR treatment exerted mild effects, with significant effects in cortical thickness only. SR produced no significant improvement in biomechanical properties. WBVV as a single or an adjunctive therapy produced no significant improvements. In conclusion, vibration therapy administered as a single or dual treatment had no significant impact on bones affected by osteoporosis. PTH considerably improved bone quality in osteoporosis cases and is superior to treatment with SR."],["dc.identifier.doi","10.1007/s00774-018-0929-9"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/66263"],["dc.language.iso","en"],["dc.relation.issn","0914-8779"],["dc.title","Evaluation of Ostarine as a Selective Androgen Receptor Modulator in a Rat Model of Postmenopausal Osteoporosis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]
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  • 2016Journal Article
    [["dc.bibliographiccitation.firstpage","252"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Der Unfallchirurg"],["dc.bibliographiccitation.lastpage","256"],["dc.bibliographiccitation.volume","120"],["dc.contributor.author","Saul, D."],["dc.contributor.author","Ammon, J. C."],["dc.contributor.author","August, F."],["dc.date.accessioned","2018-11-07T10:26:50Z"],["dc.date.accessioned","2020-06-15T06:47:12Z"],["dc.date.available","2018-11-07T10:26:50Z"],["dc.date.available","2020-06-15T06:47:12Z"],["dc.date.issued","2016"],["dc.description.abstract","We report the case of a 15-year-old boy with combined fractures of the scaphoid, capitate, and hamate that represents a rare variation of the well-known Fenton's syndrome. Fixation was performed for the unstable fractures of the scaphoid and capitate with the use of cannulated Herbert screws and KaEurowires respectively. KaEurowires were removed after 6 months, with subsequent physiotherapy. After 6 months, CT confirmed complete consolidation of the two surgically treated carpal fractures and the conservatively treated fracture of the hamate. Regarding function, the patient is able to incorporate the hand into his school-related activities and has a good range of motion, with strong closure of the fist."],["dc.description.abstract","Wir berichten über einen 15-jährigen Jungen mit Skaphoidfraktur, Kapitatumfraktur und Hamatumfraktur als seltene Variation des bekannten Fenton-Syndroms. Die operative Versorgung der instabilen Frakturen von Skaphoid und Kapitatum erfolgte jeweils mit einer Herbertschraube und einem K‑Draht, Letztere wurden nach sechs Monaten entfernt, gefolgt von physiotherapeutischer Beübung. Nach sechs Monaten zeigte sich im CT eine vollständige Verheilung der beiden operativ versorgten Handwurzelfrakturen und der konservativ therapierten Hamatumfraktur. Funktionell kann der Patient seine Hand in den schulischen Alltag integrieren und zeigt ein gutes Bewegungsausmaß mit kräftigem Faustschluss."],["dc.identifier.doi","10.1007/s00113-016-0259-0"],["dc.identifier.isi","000396116700014"],["dc.identifier.pmid","27770167"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/66240"],["dc.language.iso","de"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation.eissn","0177-5537"],["dc.relation.issn","1433-044X"],["dc.title","Versorgung einer komplexen jugendlichen Handwurzelfraktur. Eine seltene Verletzung am wachsenden Skelett"],["dc.title.alternative","Surgical treatment of a complex adolescent carpal fracture. A rare injury to the growing skeleton"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]
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  • 2022Journal Article
    [["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Nature Communications"],["dc.bibliographiccitation.volume","13"],["dc.contributor.author","Saul, Dominik"],["dc.contributor.author","Kosinsky, Robyn Laura"],["dc.contributor.author","Atkinson, Elizabeth J."],["dc.contributor.author","Doolittle, Madison L."],["dc.contributor.author","Zhang, Xu"],["dc.contributor.author","LeBrasseur, Nathan K."],["dc.contributor.author","Pignolo, Robert J."],["dc.contributor.author","Robbins, Paul D."],["dc.contributor.author","Niedernhofer, Laura J."],["dc.contributor.author","Ikeno, Yuji"],["dc.contributor.author","Khosla, Sundeep"],["dc.date.accessioned","2022-09-01T09:50:03Z"],["dc.date.available","2022-09-01T09:50:03Z"],["dc.date.issued","2022"],["dc.description.abstract","Abstract\n Although cellular senescence drives multiple age-related co-morbidities through the senescence-associated secretory phenotype, in vivo senescent cell identification remains challenging. Here, we generate a gene set (SenMayo) and validate its enrichment in bone biopsies from two aged human cohorts. We further demonstrate reductions in SenMayo in bone following genetic clearance of senescent cells in mice and in adipose tissue from humans following pharmacological senescent cell clearance. We next use SenMayo to identify senescent hematopoietic or mesenchymal cells at the single cell level from human and murine bone marrow/bone scRNA-seq data. Thus, SenMayo identifies senescent cells across tissues and species with high fidelity. Using this senescence panel, we are able to characterize senescent cells at the single cell level and identify key intercellular signaling pathways. SenMayo also represents a potentially clinically applicable panel for monitoring senescent cell burden with aging and other conditions as well as in studies of senolytic drugs."],["dc.description.sponsorship"," Dr. Mildred Scheel Stiftung fĂĽr Krebsforschung https://doi.org/10.13039/501100005973"],["dc.description.sponsorship"," Foundation for the National Institutes of Health https://doi.org/10.13039/100000009"],["dc.identifier.doi","10.1038/s41467-022-32552-1"],["dc.identifier.pii","32552"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/113610"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-597"],["dc.relation.eissn","2041-1723"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]
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  • 2019Journal Article Research Paper
    [["dc.bibliographiccitation.firstpage","18"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Operative Orthopädie und Traumatologie"],["dc.bibliographiccitation.lastpage","22"],["dc.bibliographiccitation.volume","32"],["dc.contributor.author","Saul, Dominik"],["dc.contributor.author","Roch, Jonathan"],["dc.contributor.author","Lehmann, Wolfgang"],["dc.contributor.author","Dresing, Klaus"],["dc.date.accessioned","2020-06-08T13:13:06Z"],["dc.date.available","2020-06-08T13:13:06Z"],["dc.date.issued","2019"],["dc.description.abstract","Ziel Komplette Anästhesie der Phalangen an Hand und Fuß. Indikationen Erkrankungen an Hand oder Fuß distal des Grundgelenks bis zum Endglied. Kontraindikationen Lokale Infektionen an der Injektionsstelle. Verletzungen proximal des Grundgelenks. Technik An der Basis des Fingers oder Zehs wird distal des Grundgelenks dorsoradial und -ulnar ein subkutanes Depot eines 0,5–2 %-igen Lokalanästhetikums gesetzt. Unter Vorschieben der Kanüle nach palmar werden dann weitere 0,5–1,5 ml appliziert, um eine komplette Anästhesie des Fingers/Zehs zu erreichen. Weiterbehandlung Die Wirkung der Lokalanästhesie ist selbstlimitierend. Ergebnisse Die Leitungsanästhesie nach Oberst bewirkt eine zuverlässige Betäubung von Finger und Zeh. Chirurgische Eingriffe distal des Grundgelenks lassen sich hiermit schmerzfrei durchführen."],["dc.description.abstract","Objective Complete anesthesia of the phalanges of the fingers and toes. Indications All lesions distal to the metacarpophalangeal/metatarsophalangeal joint. Contraindications Local infections at the injection site. Lesions proximal to the metacarpophalangeal/metatarsophalangeal joint. Technique A subcutaneous deposit of a 0.5–2% local anesthetic is administered dorsoradially and dorsoulnarly at the base of the metacarpophalangeal/metatarsophalangeal joint. With the cannula advanced to palmar, an additional 0.5–1.5 ml is then administered to achieve complete anesthesia. Postoperative management The effect of the local anesthesia is self-limiting. Results The Oberst block results in reliable anesthesia of the finger and toe. All surgical procedures distal to the metacarpophalangeal/metatarsophalangeal joint can be performed without pain."],["dc.identifier.doi","10.1007/s00064-019-00633-y"],["dc.identifier.pmid","31650198"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/66199"],["dc.language.iso","de"],["dc.relation.eissn","1439-0981"],["dc.relation.issn","0934-6694"],["dc.title","Leitungsanästhesie nach Oberst"],["dc.title.alternative","Oberst’s block anesthesia"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]
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  • 2020Journal Article Research Paper
    [["dc.bibliographiccitation.journal","European Journal of Plastic Surgery"],["dc.contributor.author","Stepniewski, Adam S."],["dc.contributor.author","Saul, Dominik"],["dc.contributor.author","Synn, Helen"],["dc.contributor.author","Felmerer, Gunther"],["dc.date.accessioned","2020-06-15T06:55:49Z"],["dc.date.available","2020-06-15T06:55:49Z"],["dc.date.issued","2020"],["dc.description.abstract","Background The first description of local fascio-cutaneous flaps used for the coverage of soft tissue defects of the limbs originates from the 1980s. Over the years, this technique has advanced, and in the meantime, a sub-group of flaps named perforator-based propeller flaps has gained increased attention. In our study, we aimed to demonstrate our experience of operating surgeries with perforator-based propeller flaps and to compare this technique with other flap techniques, which are to reconstruct tissue defects of the knee, lower leg, and foot. Methods A systematic retrospective search for flap procedures for defect reconstructions in the knee, lower leg, and foot from our database was performed. All data between January 2010 and August 2018 were considered. We identified 56 procedures performed on 14 female and 42 male patients with the mean age of 54.13 years. Reconstruction procedures consisted of 34 free flaps, 14 perforator-based propeller flaps, and eight other perforator-based flaps. Compared to free flaps, the perforator-based propeller flaps had shorter surgery duration by 46.6% (p < 0.0001) and the complication rate in the cases of perforator-based propeller flaps was reduced by 31.14% (p = 0.0315). Furthermore, the operations carried out with perforator-based propeller flaps resulted in a significantly lower rate of revisions by 36.03% (p = 0.0204), compared to those with free flaps. The majority of the donor sites of free flaps were self-closing with the direct suture (p = 0.004). Conclusions Based on our findings, we can propose the applicability of perforator-based flaps in treating defects of the knee, lower leg, and foot. With a correct indication, perforator-based propeller flap represents a promising alternative to free flaps, with its significantly shorter surgery duration, lower complications rate, and lower revision rate. However, both techniques of the free flap transfer and the transfer of local pedicle-based flap possess their advantages and disadvantages. Therefore, it is hard to define which microsurgical technique is exclusive in treating lower leg defects."],["dc.identifier.doi","10.1007/s00238-019-01619-6"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/66242"],["dc.language.iso","en"],["dc.relation.eissn","1435-0130"],["dc.relation.issn","0930-343X"],["dc.title","Surgical defect reconstructions in knee, lower leg, and foot with flaps: a retrospective analysis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]
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  • 2016Journal Article
    [["dc.bibliographiccitation.firstpage","31"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Journal of Bone and Mineral Metabolism"],["dc.bibliographiccitation.lastpage","39"],["dc.bibliographiccitation.volume","35"],["dc.contributor.author","Hoffmann, D. B."],["dc.contributor.author","Sehmisch, S."],["dc.contributor.author","Hofmann, A. M."],["dc.contributor.author","Eimer, C."],["dc.contributor.author","Komrakova, M."],["dc.contributor.author","Saul, D."],["dc.contributor.author","Wassmann, M."],["dc.contributor.author","StĂĽrmer, K. M."],["dc.contributor.author","Tezval, M."],["dc.date.accessioned","2018-10-08T06:30:06Z"],["dc.date.accessioned","2020-06-15T06:44:32Z"],["dc.date.available","2018-10-08T06:30:06Z"],["dc.date.available","2020-06-15T06:44:32Z"],["dc.date.issued","2016"],["dc.description.abstract","We investigated the combinatorial effects of whole-body vertical vibration (WBVV) with the primarily osteoanabolic parathyroid hormone (PTH) and the mainly antiresorptive strontium ranelate (SR) in a rat model of osteoporosis. Ovariectomies were performed on 76 three-month-old Sprague-Dawley rats (OVX, n = 76; NON-OVX, n = 12). After 8 weeks, the ovariectomized rats were divided into 6 groups. One group (OVX + PTH) received daily injections of PTH (40 Âµg/kg body weight/day) for 6 weeks. Another group (OVX + SR) was fed SR-supplemented chow (600 mg/kg body weight/day). Three groups (OVX + VIB, OVX + PTH + VIB, and OVX + SR + VIB) were treated with WBVV twice a day at 70 Hz for 15 min. Two groups (OVX + PTH + VIB, OVX + SR + VIB) were treated additionally with PTH and SR, respectively. The rats were killed at 14 weeks post-ovariectomy. The lumbar vertebrae and femora were removed for biomechanical and morphological assessment. PTH produced statistically significant improvements in biomechanical and structural properties, including bone mineral density (BMD) and trabecular bone quality. In contrast, SR treatment exerted mild effects, with significant effects in cortical thickness only. SR produced no significant improvement in biomechanical properties. WBVV as a single or an adjunctive therapy produced no significant improvements. In conclusion, vibration therapy administered as a single or dual treatment had no significant impact on bones affected by osteoporosis. PTH considerably improved bone quality in osteoporosis cases and is superior to treatment with SR."],["dc.identifier.doi","10.1007/s00774-016-0736-0"],["dc.identifier.pmid","26825660"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/66239"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation.eissn","1435-5604"],["dc.title","Comparison of parathyroid hormone and strontium ranelate in combination with whole-body vibration in a rat model of osteoporosis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]
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