Ribes, Sandra

[["dc.bibliographiccitation.firstpage","615"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Shock"],["dc.bibliographiccitation.lastpage","619"],["dc.bibliographiccitation.volume","38"],["dc.contributor.author","Diesselberg, Catharina"],["dc.contributor.author","Ribes, Sandra"],["dc.contributor.author","Michel, Uwe"],["dc.contributor.author","Redlich, Sandra"],["dc.contributor.author","Brueck, Wolfgang"],["dc.contributor.author","Nau, Roland"],["dc.contributor.author","Schuetze, Sandra"],["dc.date.accessioned","2018-11-07T09:03:01Z"],["dc.date.available","2018-11-07T09:03:01Z"],["dc.date.issued","2012"],["dc.description.abstract","Follistatin (FS) is the binding protein of activin A and inhibits its actions. The activin/FS system participates in the fine tuning of the immune response, and concentrations of activin A and FS are elevated in serum of patients with sepsis. Intraperitoneal injection of FS markedly reduced mortality after lipopolysaccharide-induced inflammation in a mouse model. Here, we investigated whether FS also influences the disease course in a mouse model of sepsis induced by intraperitoneal injection of Escherichia coli K1, a gram-negative bacterium frequently causing septic bacterial infections. Intraperitoneal injection of 10 mu g/mL FS 30 min before infection did not influence survival, weight, motor performance, or bacterial titers of the infected mice. Thus, we could not confirm the protective effect of FS observed during lipopolysaccharide-induced inflammation in our mouse model of E. coli sepsis. Although it is a promising therapeutic tool in chronic or acute inflammatory conditions not caused by virulent pathogens, FS does not seem to increase the resistance to bacterial infections."],["dc.identifier.doi","10.1097/SHK.0b013e3182748d96"],["dc.identifier.isi","000311338900007"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/24807"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.relation.issn","1540-0514"],["dc.relation.issn","1073-2322"],["dc.title","FOLLISTATIN DOES NOT INFLUENCE THE COURSE OF ESCHERICHIA COLI K1 SEPSIS IN A MOUSE MODEL"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","52"],["dc.bibliographiccitation.journal","Zeitschrift für Gerontologie und Geriatrie"],["dc.bibliographiccitation.lastpage","53"],["dc.bibliographiccitation.volume","47"],["dc.contributor.author","Nau, R."],["dc.contributor.author","Ribes, Sandra"],["dc.contributor.author","Djukic, M."],["dc.contributor.author","Redlich, Sandra"],["dc.contributor.author","Eiffert, Helmut"],["dc.date.accessioned","2018-11-07T09:36:20Z"],["dc.date.available","2018-11-07T09:36:20Z"],["dc.date.issued","2014"],["dc.identifier.isi","000359603600171"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/32593"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","Heidelberg"],["dc.relation.issn","1435-1269"],["dc.relation.issn","0948-6704"],["dc.title","Strategies for Increasing the Resistance of the central Nervous System against bacterial Infections"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","32"],["dc.bibliographiccitation.issue","1-2"],["dc.bibliographiccitation.journal","Journal of Neuroimmunology"],["dc.bibliographiccitation.lastpage","34"],["dc.bibliographiccitation.volume","244"],["dc.contributor.author","Redlich, Sandra"],["dc.contributor.author","Ribes, Sandra"],["dc.contributor.author","Schuetze, Sandra"],["dc.contributor.author","Czesnik, Dirk"],["dc.contributor.author","Nau, Roland"],["dc.date.accessioned","2018-11-07T09:12:37Z"],["dc.date.available","2018-11-07T09:12:37Z"],["dc.date.issued","2012"],["dc.description.abstract","The ability of microglial cells to phagocytose bacteria after stimulation with the endocannabinoid palmitoylethanolamide (PEA) was studied in vitro. PEA increased the phagocytosis of unencapsulated Streptococcus pneumoniae R6 and encapsulated Escherichia coli K1 by murine microglial cells significantly after 30 min of microglial. stimulation. This suggested that stimulation of microglial cells by PEA can increase the resistance of the brain against CNS infections. (C) 2012 Elsevier B.V. All rights reserved."],["dc.description.sponsorship","European Community [223111]"],["dc.identifier.doi","10.1016/j.jneuroim.2011.12.013"],["dc.identifier.isi","000302436300005"],["dc.identifier.pmid","22244572"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/26980"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Bv"],["dc.relation.issn","0165-5728"],["dc.title","Palmitoylethanolamide stimulates phagocytosis of Escherichia coli K1 and Streptococcus pneumoniae R6 by microglial cells"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","1-2"],["dc.bibliographiccitation.journal","Journal of Neuroimmunology"],["dc.bibliographiccitation.volume","275"],["dc.contributor.author","Schuetze, Sandra"],["dc.contributor.author","Kaufmann, Annika"],["dc.contributor.author","Ribes, Sandra"],["dc.contributor.author","Scheffel, Joerg"],["dc.contributor.author","Redlich, Sandra"],["dc.contributor.author","Hanisch, Uwe-karsten"],["dc.contributor.author","Brueck, Wolfgang"],["dc.contributor.author","Nau, Roland"],["dc.date.accessioned","2018-11-07T09:33:35Z"],["dc.date.available","2018-11-07T09:33:35Z"],["dc.date.issued","2014"],["dc.format.extent","92"],["dc.identifier.doi","10.1016/j.jneuroim.2014.08.246"],["dc.identifier.isi","000345192100238"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/31998"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Bv"],["dc.publisher.place","Amsterdam"],["dc.relation.conference","12th International Congress of Neuroimmunology (ISNI)"],["dc.relation.eventlocation","Mainz, GERMANY"],["dc.relation.issn","1872-8421"],["dc.relation.issn","0165-5728"],["dc.title","Reduced release of nitric oxide and different cytokines/chemokines by aged microglial cells upon activation of Toll-like receptors 2 and 4"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","16"],["dc.bibliographiccitation.issue","1-2"],["dc.bibliographiccitation.journal","Journal of Neuroimmunology"],["dc.bibliographiccitation.lastpage","23"],["dc.bibliographiccitation.volume","252"],["dc.contributor.author","Ribes, Sandra"],["dc.contributor.author","Adam, Nina"],["dc.contributor.author","Schuetze, Sandra"],["dc.contributor.author","Regen, Tommy"],["dc.contributor.author","Redlich, Sandra"],["dc.contributor.author","Janova, Hana"],["dc.contributor.author","Borisch, Angela"],["dc.contributor.author","Hanisch, Uwe-Karsten"],["dc.contributor.author","Nau, Roland"],["dc.date.accessioned","2018-11-07T09:03:27Z"],["dc.date.available","2018-11-07T09:03:27Z"],["dc.date.issued","2012"],["dc.description.abstract","Increasing the phagocytic activity of microglia could improve the resistance of immunocompromised patients to CNS infections. We studied the microglial responses upon stimulation with the Nod2 ligand muramyl dipeptide (MDP) alone or in combination with a TLR1/2, 3 or 4 agonist. MDP caused a mild release of NO, but induced neither a significant release of pro-inflammatory cytokines nor an expression of molecules associated with professional antigen presentation. Using the Escherichia coli K1 model, microglial pre-stimulation with MDP enhanced bacterial phagocytosis which was strengthened on TLR-pre-stimulated cells. Dual pre-stimulation of Nod2 and TLR1/2 or 4 caused maximal phagocytosis and intracellular killing. (c) 2012 Elsevier B.V. All rights reserved."],["dc.identifier.doi","10.1016/j.jneuroim.2012.07.012"],["dc.identifier.isi","000311132500002"],["dc.identifier.pmid","22889567"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/24904"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Bv"],["dc.relation.issn","1872-8421"],["dc.relation.issn","0165-5728"],["dc.title","The nucleotide-binding oligomerization domain-containing-2 ligand muramyl dipeptide enhances phagocytosis and intracellular killing of Escherichia coli K1 by Toll-like receptor agonists in microglial cells"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]