Palmitoylethanolamide stimulates phagocytosis of Escherichia coli K1 and Streptococcus pneumoniae R6 by microglial cells

ISSN
0165-5728
Date Issued
2012
Author(s)
Redlich, Sandra
Schuetze, Sandra
DOI
10.1016/j.jneuroim.2011.12.013
Abstract
The ability of microglial cells to phagocytose bacteria after stimulation with the endocannabinoid palmitoylethanolamide (PEA) was studied in vitro. PEA increased the phagocytosis of unencapsulated Streptococcus pneumoniae R6 and encapsulated Escherichia coli K1 by murine microglial cells significantly after 30 min of microglial. stimulation. This suggested that stimulation of microglial cells by PEA can increase the resistance of the brain against CNS infections. (C) 2012 Elsevier B.V. All rights reserved.