Schwarz, Alexander

[["dc.bibliographiccitation.journal","Mycoses"],["dc.bibliographiccitation.volume","55"],["dc.contributor.author","Bader, Oliver"],["dc.contributor.author","Schwarz, A."],["dc.contributor.author","Kraneveld, Eefje A."],["dc.contributor.author","Tangwattanachuleeporn, Marut"],["dc.contributor.author","Schmidt, P."],["dc.contributor.author","Jacobsen, Mette D."],["dc.contributor.author","Gross, U."],["dc.contributor.author","de Groot, Piet W. J."],["dc.contributor.author","Weig, Michael S."],["dc.date.accessioned","2018-11-07T09:09:43Z"],["dc.date.available","2018-11-07T09:09:43Z"],["dc.date.issued","2012"],["dc.format.extent","143"],["dc.identifier.isi","000305069800445"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/26326"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.publisher.place","Hoboken"],["dc.relation.issn","0933-7407"],["dc.title","Karyotypic and phenotypic plasticity of the Candida glabrata strain CBS138/ATCC2001"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Neurology"],["dc.bibliographiccitation.volume","78"],["dc.contributor.author","Balint, Bettina"],["dc.contributor.author","Haas, Juergen"],["dc.contributor.author","Schwarz, Alexander"],["dc.contributor.author","Fuerwentsches, Alexandra"],["dc.contributor.author","Ebinger, Friedrich"],["dc.contributor.author","Fritzsching, Benedikt"],["dc.contributor.author","Seidel, Ulrich"],["dc.contributor.author","Paul, Friedemann"],["dc.contributor.author","Huppke, Peter"],["dc.contributor.author","Gärtner, Jutta"],["dc.contributor.author","Wildemann, Brigitte"],["dc.date.accessioned","2018-11-07T09:11:32Z"],["dc.date.available","2018-11-07T09:11:32Z"],["dc.date.issued","2012"],["dc.identifier.isi","000303204801235"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/26742"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.publisher.place","Philadelphia"],["dc.relation.eventlocation","New Orleans, LA"],["dc.relation.issn","0028-3878"],["dc.title","B Cells and Subsets in Pediatric-Onset Relapsing-Remitting Multiple Sclerosis: Similarities and Differences to Adult-Onset Disease"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Der Internist"],["dc.bibliographiccitation.volume","57"],["dc.contributor.author","Czepluch, Frauke S."],["dc.contributor.author","Schwarz, A."],["dc.contributor.author","Tichelbaecker, Tobias"],["dc.contributor.author","Lotz, Joachim"],["dc.contributor.author","Hasenfuß, Gerd"],["dc.contributor.author","Schillinger, Wolfgang"],["dc.contributor.author","Jacobshagen, Claudius"],["dc.date.accessioned","2018-11-07T10:15:50Z"],["dc.date.available","2018-11-07T10:15:50Z"],["dc.date.issued","2016"],["dc.format.extent","S40"],["dc.identifier.isi","000375417500075"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/40896"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","New york"],["dc.relation.issn","1432-1289"],["dc.relation.issn","0020-9554"],["dc.title","The transfemoral Implantation of a 29 mm metal-free Aortic Valve Bioprosthesis in the elderly is associated with longer Procedure times and post interventional higher Flaps-Gradient"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","633"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","Journal of Molecular Medicine"],["dc.bibliographiccitation.lastpage","641"],["dc.bibliographiccitation.volume","78"],["dc.contributor.author","Hocher, B."],["dc.contributor.author","Dembowski, C."],["dc.contributor.author","Slowinski, T."],["dc.contributor.author","Friese, S. T."],["dc.contributor.author","Schwarz, A."],["dc.contributor.author","Siren, A. L."],["dc.contributor.author","Neumayer, H. H."],["dc.contributor.author","Thone-Reineke, C."],["dc.contributor.author","Bauer, C."],["dc.contributor.author","Nafz, B."],["dc.contributor.author","Ehrenreich, Hannelore"],["dc.date.accessioned","2018-11-07T09:35:17Z"],["dc.date.available","2018-11-07T09:35:17Z"],["dc.date.issued","2001"],["dc.description.abstract","The renal endothelin (ET) system, particularly the ET type B receptor, has been implicated in the regulation of sodium excretion and glomerular filtration rate (GFR). We analyzed kidney morphology and function in a rat strain characterized by complete absence of a functional ETB receptor. Due to Hirschsprung's disease limiting lifetime in these rats, studies were performed in 23-day-old rats. Kidney size and morphology (glomerular and interstitial matrix content, glomerular size and cell density and intrarenal vascular morphology) were normal in ETB-deficient rats. There were also no evidence of altered kidney cell cycle regulation in these rats. GFR was significantly lower, by 72% (P<0.001), in homozygous ETB-deficient rats than in wild-type rats. Fractional sodium excretion was likewise markedly reduced by 84% in homozygous ETB-deficient rats (P<0.001 versus wild-type rats). Treatment with the specific epithelial sodium channel blocker amiloride led to a much higher increase in fractional sodium excretion in ETB-deficient rats (934.2+/-73% in ETB-deficient rats versus 297+/-20% in wild-type rats, expressed as percentage of corresponding placebo treated control: P<0.001). Mean arterial blood pressure was elevated by 7.9 mmHg in homozygous ETB-deficient rats (P<0.05 versus wildtype rats). Our study demonstrates that ETB-deficiency causes early onset kidney dysfunction characterized by a markedly reduced sodium excretion, decreased GFR, and slightly elevated blood pressure. The complete absence of the ETB receptor causes in the kidney - in contrast to the colon - a functional rather than a developmental, neural crest cell dependent disease, since kidney morphology was normal in ETB-deficient rats. The much higher increase in the fractional sodium excretion in ETB-deficient rats after pharmacological blockade of the epithelial sodium channel indicates that the decreased fractional sodium excretion in ETB-deficient rats is most probably due to a lack of the inhibitory property of the ETB receptor on the epithelial sodium channel activity."],["dc.identifier.doi","10.1007/s001090000158"],["dc.identifier.isi","000166900800009"],["dc.identifier.pmid","11269510"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/32353"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0946-2716"],["dc.title","Impaired sodium excretion, decreased glomerular filtration rate and elevated blood pressure in endothelin receptor type B deficient rats"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","671"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","American Journal Of Pathology"],["dc.bibliographiccitation.lastpage","678"],["dc.bibliographiccitation.volume","165"],["dc.contributor.author","Schultz, J."],["dc.contributor.author","Schwarz, A."],["dc.contributor.author","Neidhold, S."],["dc.contributor.author","Burwinkel, M."],["dc.contributor.author","Riemer, C."],["dc.contributor.author","Simon, D."],["dc.contributor.author","Kopf, M."],["dc.contributor.author","Otto, Markus"],["dc.contributor.author","Baier, M."],["dc.date.accessioned","2018-11-07T10:46:30Z"],["dc.date.available","2018-11-07T10:46:30Z"],["dc.date.issued","2004"],["dc.description.abstract","Prion-induced chronic neurodegeneration has a substantial inflammatory component, and the activation of glia cells may play an important role in disease development and progression. However, the functional contribution of cytokines; to the development of the gliosis in vivo was never systematically studied. We report here that the expression of interleukin-1beta (IL-1beta), IL-1beta-converting enzyme, and IL-1 receptor type 1 (IL-1RI) is up-regulated in a murine scrapie model. The scrapic-induced gliosis in IL-1RI(-/-) mice was characterized by an attenuated activation of astrocytes in the asymptomatic stage of the disease and a reduced expression of CXCR3 ligands. Furthermore, the accumulation of the misfolded isoform of the prion protein PrPSc was significantly delayed in the IL-1RI(-/-) mice. These observations indicate that IIL-1 is a driver of the scrapie-associated astrocytosis and possibly the accompanying amyloid deposition. In addition, scrapie-infected IL-1RI-deficient (IL-1RI(-/-)) mice showed a delayed disease onset and significantly prolonged survival times suggesting that an anti-inflammatory therapeutical approach to suppress astrocyte activation and/or glial IL-1 expression may help to delay disease onset in established prion infections of the central nervous system."],["dc.identifier.doi","10.1016/S0002-9440(10)63331-7"],["dc.identifier.isi","000222893400030"],["dc.identifier.pmid","15277240"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/47759"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Soc Investigative Pathology, Inc"],["dc.relation.issn","0002-9440"],["dc.title","Role of interleukin-1 in prion disease-associated astrocyte activation"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","e52218"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","PLoS ONE"],["dc.bibliographiccitation.volume","7"],["dc.contributor.author","Bader, Oliver"],["dc.contributor.author","Schwarz, Alexander"],["dc.contributor.author","Kraneveld, Eefje A."],["dc.contributor.author","Tangwattanchuleeporn, Marut"],["dc.contributor.author","Schmidt, Pia"],["dc.contributor.author","Jacobsen, Mette D."],["dc.contributor.author","Gross, Uwe"],["dc.contributor.author","de Groot, Piet W. J."],["dc.contributor.author","Weig, Michael S."],["dc.date.accessioned","2018-11-07T09:02:13Z"],["dc.date.available","2018-11-07T09:02:13Z"],["dc.date.issued","2012"],["dc.description.abstract","Genomic plasticity is a mechanism for adaptation to environmental cues such as host responses and antifungal drug pressure in many fungi including the human pathogenic yeast Candida glabrata. In this study we evaluated the phenotypic and genotypic stability of the world-wide used C. glabrata reference strain CBS138/ ATCC2001 under laboratory conditions. A set of ten lineages of this wild type strain and genetically modified progenies were obtained from different scientific laboratories, and analyzed for genotypic and phenotypic alterations. Even though the derivates were indistinguishable by multi locus sequence typing, different phenotypic groups that correlated with specific karyotypic changes were observed. In addition, modifications in the adherence capacity to plastic surface emerged that were shown to correlate with quantitative changes in adhesin gene expression rather than subtelomeric gene loss or differences in the number of macrosatellite repeats within adhesin genes. These results confirm the genomic plasticity of C. glabrata and show that chromosomal aberrations and functional adaptations may occur not only during infection and under antimicrobial therapy, but also under laboratory conditions without extreme selective pressures. These alterations can significantly affect phenotypic properties such as cell surface attributes including adhesion and the cell wall carbohydrate composition and therefore, if unnoticed, may adulterate the outcome of genetic studies."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2012"],["dc.identifier.doi","10.1371/journal.pone.0052218"],["dc.identifier.isi","000312794500117"],["dc.identifier.pmid","23284942"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/8472"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/24630"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Public Library Science"],["dc.relation.issn","1932-6203"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Gross Karyotypic and Phenotypic Alterations among Different Progenies of the Candida glabrata CBS138/ATCC2001 Reference Strain"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1009"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren"],["dc.bibliographiccitation.lastpage","1015"],["dc.bibliographiccitation.volume","186"],["dc.contributor.author","Staab, Wieland"],["dc.contributor.author","Sohns, Christian"],["dc.contributor.author","Zwaka, Paul A."],["dc.contributor.author","Sohns, Jan Martin"],["dc.contributor.author","Schwarz, Alexander"],["dc.contributor.author","Schneider, S."],["dc.contributor.author","Vollmann, Dirk"],["dc.contributor.author","Zabel, Markus"],["dc.contributor.author","Hasenfuß, Gerd"],["dc.contributor.author","Lotz, Joachim"],["dc.date.accessioned","2017-09-07T11:45:26Z"],["dc.date.available","2017-09-07T11:45:26Z"],["dc.date.issued","2014"],["dc.description.abstract","Purpose: Evaluation of a new cardiac MDCT protocol using a split-bolus contrast injection protocol and single MDCT scan for reliable diagnosis of LA/LAA thrombi in comparison to TEE, optimizing radiation exposure and use of contrast agent. Materials and Methods: A total of 182 consecutive patients with drug refractory AF scheduled for PVI (62.6 % male, mean age: 64.1 +/- 10.2 years) underwent routine diagnostic work including TEE and cardiac MDCT for the evaluation of LA/LAA anatomy and thrombus formation between November 2010 and March 2012. Contrast media injection was split into a pre-bolus of 30 ml and main bolus of 70 ml iodinated contrast agent separated by a short time delay. Results: In this study, split-bolus cardiac MDCT identified 14 of 182 patients with filling defects of the LA/LAA. In all of these 14 patients, abnormalities were found in TEE. All 5 of the 14 patients with thrombus formation in cardiac MDCT were confirmed by TEE. Conclusion: MDCT was 100 % accurate for thrombus, with strong but not perfect overall results for SEC equivalent on MDCT. Key Points: Patients with no filling defect or thrombus in MDCT in the LA/LAA region are unlikely to have thrombus and may undergo PVI without TEE. Here, the role of an additional TEE in pre-procedural management prior to PVI in patients with AF has to be redefined. Using a split-bolus injection protocol increases the diagnostic accuracy of thrombus in the LA/LAA region."],["dc.identifier.doi","10.1055/s-0034-1366247"],["dc.identifier.gro","3142029"],["dc.identifier.isi","000344356700003"],["dc.identifier.pmid","24729408"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/3756"],["dc.language.iso","en"],["dc.notes.intern","WoS Import 2017-03-10"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation.eissn","1438-9010"],["dc.relation.issn","1438-9029"],["dc.title","Split-Bolus Single-Phase Cardiac Multidetector Computed Tomography for Reliable Detection of Left Atrial Thrombus: Comparison to Transesophageal Echocardiography"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1581"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","The International Journal of Cardiovascular Imaging"],["dc.bibliographiccitation.lastpage","1587"],["dc.bibliographiccitation.volume","33"],["dc.contributor.author","Sohns, Jan M."],["dc.contributor.author","Menke, Jan"],["dc.contributor.author","Schwarz, Alexander"],["dc.contributor.author","Bergau, Leonard"],["dc.contributor.author","Kowallick, Johannes T."],["dc.contributor.author","Schuster, Andreas"],["dc.contributor.author","Konietschke, Frank"],["dc.contributor.author","Placzek, Marius"],["dc.contributor.author","Weiberg, Desiree"],["dc.contributor.author","Nordlohne, Stefan"],["dc.contributor.author","Schmuck, Sebastian"],["dc.contributor.author","Schulz, Sebastian"],["dc.contributor.author","Derlin, Thorsten"],["dc.contributor.author","Staab, Wieland"],["dc.date.accessioned","2020-12-10T14:11:26Z"],["dc.date.available","2020-12-10T14:11:26Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1007/s10554-017-1145-8"],["dc.identifier.eissn","1573-0743"],["dc.identifier.issn","1569-5794"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/71072"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Incidental findings in cardiac magnetic resonance imaging: superiority of bSSFP over T1w-HASTE for extra-cardiac findings assessment"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Mycoses"],["dc.bibliographiccitation.volume","55"],["dc.contributor.author","Ichsan, Ichsan"],["dc.contributor.author","Bader, Oliver"],["dc.contributor.author","Schwarz, A."],["dc.contributor.author","Tangwattanachuleeporn, Marut"],["dc.contributor.author","Gross, U."],["dc.contributor.author","Jacobsen, M."],["dc.contributor.author","Odds, F."],["dc.contributor.author","Piet de, P."],["dc.contributor.author","Weig, Michael S."],["dc.date.accessioned","2018-11-07T09:09:43Z"],["dc.date.available","2018-11-07T09:09:43Z"],["dc.date.issued","2012"],["dc.format.extent","135"],["dc.identifier.isi","000305069800419"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/26323"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.publisher.place","Hoboken"],["dc.relation.issn","0933-7407"],["dc.title","Genotypic and phenotypic variability in a collection of clinical Candida glabrata strains"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","48"],["dc.bibliographiccitation.journal","Science Advances"],["dc.bibliographiccitation.volume","7"],["dc.contributor.author","Linsenmeier, Luise"],["dc.contributor.author","Mohammadi, Behnam"],["dc.contributor.author","Shafiq, Mohsin"],["dc.contributor.author","Frontzek, Karl"],["dc.contributor.author","Bär, Julia"],["dc.contributor.author","Shrivastava, Amulya N."],["dc.contributor.author","Damme, Markus"],["dc.contributor.author","Song, Feizhi"],["dc.contributor.author","Schwarz, Alexander"],["dc.contributor.author","Da Vela, Stefano"],["dc.contributor.author","Glatzel, Markus"],["dc.date.accessioned","2022-01-11T14:06:02Z"],["dc.date.available","2022-01-11T14:06:02Z"],["dc.date.issued","2021"],["dc.identifier.doi","10.1126/sciadv.abj1826"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/97810"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-507"],["dc.relation.eissn","2375-2548"],["dc.title","Ligands binding to the prion protein induce its proteolytic release with therapeutic potential in neurodegenerative proteinopathies"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]