Luther, Stefan

[["dc.bibliographiccitation.firstpage","51"],["dc.bibliographiccitation.journal","Progress in Biophysics and Molecular Biology"],["dc.bibliographiccitation.lastpage","60"],["dc.bibliographiccitation.volume","144"],["dc.contributor.author","Schlick, Susanne F."],["dc.contributor.author","Spreckelsen, Florian"],["dc.contributor.author","Tiburcy, Malte"],["dc.contributor.author","Iyer, Lavanya M."],["dc.contributor.author","Meyer, Tim"],["dc.contributor.author","Zelarayan, Laura C."],["dc.contributor.author","Luther, Stefan"],["dc.contributor.author","Parlitz, Ulrich"],["dc.contributor.author","Zimmermann, Wolfram-Hubertus"],["dc.contributor.author","Rehfeldt, Florian"],["dc.date.accessioned","2020-12-10T15:20:42Z"],["dc.date.available","2020-12-10T15:20:42Z"],["dc.date.issued","2019"],["dc.description.abstract","Cardiomyocyte and stroma cell cross-talk is essential for the formation of collagen-based engineered heart muscle, including engineered human myocardium (EHM). Fibroblasts are a main component of the myocardial stroma. We hypothesize that fibroblasts, by compacting the surrounding collagen network, support the self-organization of cardiomyocytes into a functional syncytium. With a focus on early self-organization processes in EHM, we studied the molecular and biophysical adaptations mediated by defined populations of fibroblasts and embryonic stem cell-derived cardiomyocytes in a collagen type I hydrogel. After a short phase of cell-independent collagen gelation (30 min), tissue compaction was progressively mediated by fibroblasts. Fibroblast-mediated tissue stiffening was attenuated in the presence of cardiomyocytes allowing for the assembly of stably contracting, force-generating EHM within 4 weeks. Comparative RNA-sequencing data corroborated that fibroblasts are particularly sensitive to the tissue compaction process, resulting in the fast activation of transcription profiles, supporting heart muscle development and extracellular matrix synthesis. Large amplitude oscillatory shear (LAOS) measurements revealed nonlinear strain stiffening at physiological strain amplitudes (>2%), which was reduced in the presence of cells. The nonlinear stress-strain response could be characterized by a mathematical model. Collectively, our study defines the interplay between fibroblasts and cardiomyocytes during human heart muscle self-organization in vitro and underscores the relevance of fibroblasts in the biological engineering of a cardiomyogenesis-supporting viscoelastic stroma. We anticipate that the established mathematical model will facilitate future attempts to optimize EHM for in vitro (disease modelling) and in vivo applications (heart repair)."],["dc.identifier.doi","10.1016/j.pbiomolbio.2018.11.011"],["dc.identifier.pmid","30553553"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/72769"],["dc.identifier.url","https://sfb1002.med.uni-goettingen.de/production/literature/publications/248"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.relation","SFB 1002: Modulatorische Einheiten bei Herzinsuffizienz"],["dc.relation","SFB 1002 | C04: Fibroblasten-Kardiomyozyten Interaktion im gesunden und erkrankten Herzen: Mechanismen und therapeutische Interventionen bei Kardiofibroblastopathien"],["dc.relation","SFB 1002 | S01: In vivo und in vitro Krankheitsmodelle"],["dc.relation.workinggroup","RG Luther (Biomedical Physics)"],["dc.relation.workinggroup","RG Tiburcy (Stem Cell Disease Modeling)"],["dc.relation.workinggroup","RG Zelarayán-Behrend (Developmental Pharmacology)"],["dc.relation.workinggroup","RG Zimmermann (Engineered Human Myocardium)"],["dc.rights","CC BY 4.0"],["dc.title","Agonistic and antagonistic roles of fibroblasts and cardiomyocytes on viscoelastic stiffening of engineered human myocardium"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","105275"],["dc.bibliographiccitation.journal","Communications in Nonlinear Science and Numerical Simulation"],["dc.bibliographiccitation.volume","86"],["dc.contributor.author","Barrio, Roberto"],["dc.contributor.author","Coombes, Stephen"],["dc.contributor.author","Desroches, Mathieu"],["dc.contributor.author","Fenton, Flavio"],["dc.contributor.author","Luther, Stefan"],["dc.contributor.author","Pueyo, Esther"],["dc.date.accessioned","2020-12-10T14:23:10Z"],["dc.date.available","2020-12-10T14:23:10Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1016/j.cnsns.2020.105275"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/71861"],["dc.identifier.url","https://sfb1002.med.uni-goettingen.de/production/literature/publications/351"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.relation","SFB 1002: Modulatorische Einheiten bei Herzinsuffizienz"],["dc.relation","SFB 1002 | C03: Erholung nach Herzinsuffizienz: Analyse der transmuralen mechano-elektrischen Funktionsstörung"],["dc.relation.workinggroup","RG Luther (Biomedical Physics)"],["dc.title","Excitable dynamics in neural and cardiac systems"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","overview_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","P2835"],["dc.bibliographiccitation.firstpage","591"],["dc.bibliographiccitation.issue","suppl_1"],["dc.bibliographiccitation.journal","European Heart Journal"],["dc.bibliographiccitation.volume","39"],["dc.contributor.author","Quinonez Uribe, R. A."],["dc.contributor.author","Luther, S."],["dc.contributor.author","Richter, C."],["dc.date.accessioned","2019-02-26T14:39:41Z"],["dc.date.available","2019-02-26T14:39:41Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1093/eurheartj/ehy565.P2835"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/57621"],["dc.identifier.url","https://sfb1002.med.uni-goettingen.de/production/literature/publications/273"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation","SFB 1002: Modulatorische Einheiten bei Herzinsuffizienz"],["dc.relation","SFB 1002 | C03: Erholung nach Herzinsuffizienz: Analyse der transmuralen mechano-elektrischen Funktionsstörung"],["dc.relation.issn","0195-668X"],["dc.relation.workinggroup","RG Luther (Biomedical Physics)"],["dc.title","Low-energy control of spatiotemporal cardiac dynamics using structured photo-stimulation"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","093701"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Chaos: An Interdisciplinary Journal of Nonlinear Science"],["dc.bibliographiccitation.volume","27"],["dc.contributor.author","Cherry, Elizabeth M."],["dc.contributor.author","Fenton, Flavio H."],["dc.contributor.author","Krogh-Madsen, Trine"],["dc.contributor.author","Luther, Stefan"],["dc.contributor.author","Parlitz, Ulrich"],["dc.date.accessioned","2020-12-10T18:12:37Z"],["dc.date.available","2020-12-10T18:12:37Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1063/1.5003940"],["dc.identifier.eissn","1089-7682"],["dc.identifier.issn","1054-1500"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/74442"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Introduction to Focus Issue: Complex Cardiac Dynamics"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.contributor.author","Hornung, D."],["dc.contributor.author","Biktashev, V. N."],["dc.contributor.author","Otani, N. F."],["dc.contributor.author","Shajahan, T. K."],["dc.contributor.author","Baig, T."],["dc.contributor.author","Berg, S."],["dc.contributor.author","Han, S."],["dc.contributor.author","Krinsky, V. I."],["dc.contributor.author","Luther, Stefan"],["dc.date.accessioned","2022-05-13T09:17:31Z"],["dc.date.available","2022-05-13T09:17:31Z"],["dc.date.issued","2017-02-28"],["dc.identifier.doi","10.6084/m9.figshare.c.3704707"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/107859"],["dc.identifier.url","https://sfb1002.med.uni-goettingen.de/production/literature/publications/220"],["dc.relation","SFB 1002: Modulatorische Einheiten bei Herzinsuffizienz"],["dc.relation","SFB 1002 | C03: Erholung nach Herzinsuffizienz: Analyse der transmuralen mechano-elektrischen Funktionsstörung"],["dc.relation.workinggroup","RG Luther (Biomedical Physics)"],["dc.title","Supplementary material from \"Mechanisms of vortices termination in the cardiac muscle\""],["dc.type","research_data"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Frontiers in Physiology"],["dc.bibliographiccitation.volume","4"],["dc.contributor.author","Gizzi, Alessio"],["dc.contributor.author","Cherry, Elizabeth M."],["dc.contributor.author","Gilmour, Robert F."],["dc.contributor.author","Luther, Stefan"],["dc.contributor.author","Filippi, Simonetta"],["dc.contributor.author","Fenton, Flavio H."],["dc.date.accessioned","2022-03-01T11:44:24Z"],["dc.date.available","2022-03-01T11:44:24Z"],["dc.date.issued","2013"],["dc.identifier.doi","10.3389/fphys.2013.00071"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/103015"],["dc.notes.intern","DOI-Import GROB-531"],["dc.relation.eissn","1664-042X"],["dc.title","Effects of Pacing Site and Stimulation History on Alternans Dynamics and the Development of Complex Spatiotemporal Patterns in Cardiac Tissue"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","063040"],["dc.bibliographiccitation.journal","New Journal of Physics"],["dc.bibliographiccitation.volume","19"],["dc.contributor.author","Stein, Sebastian"],["dc.contributor.author","Luther, Stefan"],["dc.contributor.author","Parlitz, Ulrich"],["dc.date.accessioned","2018-11-07T10:22:28Z"],["dc.date.available","2018-11-07T10:22:28Z"],["dc.date.issued","2017"],["dc.description.abstract","We investigate a system of two viscoelastically coupled, modified Van der Pol oscillators to compare their synchronization properties due to elastic and viscoelastic coupling. We show that viscoelastic coupling leads to in-phase synchronization while elastic coupling favours anti-phase synchronization. To study the impact of symmetry and nonlinearity, the restoring forces in the Van der Pol oscillators are extended to include nonlinear and asymmetric components. If the asymmetry, or rather the nonlinearity, of the restoring forces exceeds a certain threshold, only in-phase synchronized motion is found to be stable. Another important finding is that chaotic solutions can only be found if the restoring forces are asymmetric and the coupling incorporates viscosity."],["dc.description.sponsorship","German Research Foundation (DFG) [SFB 937]"],["dc.identifier.doi","10.1088/1367-2630/aa6d4a"],["dc.identifier.isi","000404761900003"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14652"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/42284"],["dc.notes.intern","Merged from goescholar"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Iop Publishing Ltd"],["dc.relation.haserratum","/handle/2/74922"],["dc.relation.issn","1367-2630"],["dc.relation.orgunit","Fakultät für Physik"],["dc.rights","CC BY 3.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/3.0/"],["dc.title","Impact of viscoelastic coupling on the synchronization of symmetric and asymmetric self-sustained oscillators"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","e13449"],["dc.bibliographiccitation.firstpage","1"],["dc.bibliographiccitation.issue","19"],["dc.bibliographiccitation.journal","Physiological Reports"],["dc.bibliographiccitation.lastpage","12"],["dc.bibliographiccitation.volume","5"],["dc.contributor.author","Mayer, Andreas"],["dc.contributor.author","Bittihn, Philip"],["dc.contributor.author","Luther, Stefan"],["dc.date.accessioned","2019-02-27T14:36:42Z"],["dc.date.available","2019-02-27T14:36:42Z"],["dc.date.issued","2017"],["dc.description.abstract","Spatiotemporal dynamics in cardiac tissue emerging from the coupling of individual cardiomyocytes underlie the heart's normal rhythm as well as undesired and possibly life‐threatening arrhythmias. While single cells and their transmembrane currents have been studied extensively, systematically investigating spatiotemporal dynamics is complicated by the nontrivial relationship between single‐cell and emergent tissue properties. Mathematical models have been employed to bridge this gap and contribute to a deepened understanding of the onset, development, and termination of arrhythmias. However, no such tissue‐level model currently exists for neonatal mice. Here, we build on a recent single‐cell model of neonatal mouse cardiomyocytes by Wang and Sobie (Am. J. Physiol. Heart Circ. Physiol. 294:H2565) to predict properties that are commonly used to gauge arrhythmogenicity of cardiac substrates. We modify the model to yield well‐defined behavior for common experimental protocols and construct a spatially extended version to study emergent tissue dynamics. We find a complex action potential duration (APD) restitution behavior characterized by a nonmonotonic dependence on pacing frequency. Electrotonic coupling in tissue leads not only to changes in action potential morphology but can also induce spatially concordant and discordant alternans not observed in the single‐cell model. In two‐dimensional tissue, our results show that the model supports stable functional reentry, whose frequency is in good agreement with that observed in adult mice. Our results can be used to further constrain and validate the mathematical model of neonatal mouse cardiomyocytes with future experiments."],["dc.identifier.doi","10.14814/phy2.13449"],["dc.identifier.pmid","28989116"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/57649"],["dc.identifier.url","https://sfb1002.med.uni-goettingen.de/production/literature/publications/186"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation","SFB 1002: Modulatorische Einheiten bei Herzinsuffizienz"],["dc.relation","SFB 1002 | C03: Erholung nach Herzinsuffizienz: Analyse der transmuralen mechano-elektrischen Funktionsstörung"],["dc.relation.issn","2051-817X"],["dc.relation.workinggroup","RG Luther (Biomedical Physics)"],["dc.rights","CC BY 4.0"],["dc.title","Complex restitution behavior and reentry in a cardiac tissue model for neonatal mice"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","230"],["dc.bibliographiccitation.issue","3-4"],["dc.bibliographiccitation.journal","Macromolecular Materials and Engineering"],["dc.bibliographiccitation.lastpage","237"],["dc.bibliographiccitation.volume","296"],["dc.contributor.author","van den Berg, Thomas H."],["dc.contributor.author","Wormgoor, Willem D."],["dc.contributor.author","Luther, Stefan"],["dc.contributor.author","Lohse, Detlef"],["dc.date.accessioned","2022-03-01T11:46:22Z"],["dc.date.available","2022-03-01T11:46:22Z"],["dc.date.issued","2011"],["dc.identifier.doi","10.1002/mame.201000339"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/103648"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-531"],["dc.relation.issn","1438-7492"],["dc.title","Phase-Sensitive Constant Temperature Anemometry"],["dc.title.alternative","Phase-Sensitive Constant Temperature Anemometry"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","157"],["dc.bibliographiccitation.lastpage","158"],["dc.contributor.author","Schlemmer, Alexander"],["dc.contributor.author","Zwirnmann, Henning"],["dc.contributor.author","Zabel, Markus"],["dc.contributor.author","Parlitz, Ulrich"],["dc.contributor.author","Luther, Stefan"],["dc.date.accessioned","2019-02-26T15:08:20Z"],["dc.date.available","2019-02-26T15:08:20Z"],["dc.date.issued","2014"],["dc.description.abstract","We evaluate several machine learning algorithms in the context of long-term prediction of cardiac diseases. Results from applying K Nearest Neighbors Classifiers (KNN), Support Vector Machines (SVM) and Random Forests (RF) to data from a cardiological long-term study suggests that multivariate methods can significantly improve classification results. SVMs were found to yield the best results in Matthews Correlation Coefficient and are most stable with respect to a varying number of features."],["dc.identifier.doi","10.1109/ESGCO.2014.6847567"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/57623"],["dc.identifier.url","https://sfb1002.med.uni-goettingen.de/production/literature/publications/53"],["dc.language.iso","en"],["dc.notes.status","fcwi"],["dc.publisher","IEEE"],["dc.publisher.place","Piscataway, NJ"],["dc.relation","SFB 1002: Modulatorische Einheiten bei Herzinsuffizienz"],["dc.relation","SFB 1002 | C03: Erholung nach Herzinsuffizienz: Analyse der transmuralen mechano-elektrischen Funktionsstörung"],["dc.relation.conference","8th Conference of the European Study Group on Cardiovascular Oscillations (ESGCO)"],["dc.relation.eventend","2014-05-28"],["dc.relation.eventlocation","Trento, Italy"],["dc.relation.eventstart","2014-05-25"],["dc.relation.isbn","978-1-4799-3969-5"],["dc.relation.isbn","978-1-4799-3968-8"],["dc.relation.isbn","978-1-4799-3970-1"],["dc.relation.ispartof","2014 8th Conference of the European Study Group on Cardiovascoular Oscillations (ESGCO 2014)"],["dc.relation.workinggroup","RG Luther (Biomedical Physics)"],["dc.title","Evaluation of Machine Learning Methods for the Long-Term Prediction of Cardiac Diseases"],["dc.type","conference_paper"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]