Lenk, Christian

[["dc.bibliographiccitation.firstpage","85"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Journal of Medical Ethics"],["dc.bibliographiccitation.lastpage","87"],["dc.bibliographiccitation.volume","30"],["dc.contributor.author","Lenk, C."],["dc.contributor.author","Radenbach, K."],["dc.contributor.author","Dahl, Matthias"],["dc.contributor.author","Wiesemann, Claudia"],["dc.date.accessioned","2017-10-16T10:54:28Z"],["dc.date.available","2017-10-16T10:54:28Z"],["dc.date.issued","2004"],["dc.description.abstract","Objectives: Clinical trials in humans in Germany—as in many other countries—must be approved by localresearch ethics committees (RECs). The current study has been designed to document and evaluatedecisions of chairpersons of RECs in the problematic field of non-therapeutic research with minors. Theauthors’ purpose was to examine whether non-therapeutic research was acceptable for chairpersons atall, and whether there was certainty on how to decide in research trials involving more than minimal risk.Design: In a questionnaire, REC chairpersons had to evaluate five different scenarios with (in parts) nontherapeuticresearch. The scenarios described realistic potential research projects with minors, involvingincreasing levels of risk for the research participants. The chairpersons had to decide whether therespective projects should be approved.Methods: A total of 49 German REC chairpersons were sent questionnaires; 29 questionnaires werereturned. The main measurements were approval or rejection of research scenarios.Results: Chairpersons of German RECs generally tend to accept non-therapeutic research with minors ifthe apparent risk for the participating children is low. If the risk is clearly higher than ‘‘minimal’’, thechairpersons’ decisions differ widely.Conclusion: The fact that there seem to be different attitudes of chairpersons to non-therapeutic researchwith minors is problematic from an ethical point of view. It suggests a general uncertainty about thestandards of protection for minor research participants in Germany. Therefore, further ethical and legalregulation of non-therapeutic research with minors in Germany seems necessary."],["dc.format.mimetype","application/pdf"],["dc.identifier.doi","10.1136/jme.2003.005900"],["dc.identifier.fs","17497"],["dc.identifier.gro","3146746"],["dc.identifier.pmid","14872082"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?goescholar/4135"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/9420"],["dc.language.iso","en"],["dc.notes.intern","Migrated from goescholar"],["dc.notes.status","final"],["dc.relation.issn","0306-6800"],["dc.rights","Goescholar"],["dc.rights.access","openAccess"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.subject","REC, research ethics committee"],["dc.subject.ddc","610"],["dc.title","Non-therapeutic research with minors: how do chairpersons of German research ethics committees decide?"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","no"],["dc.type.version","submitted_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1653"],["dc.bibliographiccitation.issue","27"],["dc.bibliographiccitation.journal","DMW - Deutsche Medizinische Wochenschrift"],["dc.bibliographiccitation.lastpage","1655"],["dc.bibliographiccitation.volume","130"],["dc.contributor.author","Lenk, C."],["dc.contributor.author","Biller-Andorno, N."],["dc.contributor.author","Alt-Epping, B."],["dc.contributor.author","Anders, M."],["dc.contributor.author","Wiesemann, C."],["dc.date.accessioned","2017-10-16T10:54:26Z"],["dc.date.available","2017-10-16T10:54:26Z"],["dc.date.issued","2005"],["dc.description.abstract","Mit dem Jahreswechsel 2003/2004 vollzog sich im stationären Sektor des deutschen Gesundheitswesens ein Wechsel von der bisherigen tagespauschalierten Vergütung medizinischer Leistungen hin zur Vergütung nach „Fallpauschalen” (diagnosis related groups, DRGs). Damit deutet sich zugleich ein Paradigmenwechsel in der Leistungsallokation an - weg von der gleichmäßigen Versorgung in der Fläche, hin zur Konzentration auf spezialisierte Zentren - dessen ethische Implikationen noch unklar sind. Einerseits erhofft man sich eine Reduzierung der Kosten im Bereich der stationären Krankenversorgung. Andererseits ist fraglich, ob diese Kostenreduktion nicht zu einer schlechteren Versorgung von multimorbiden und chronisch kranken Patienten führt. Das neue System dürfte zwar dem aktiven, autonom entscheidenden Patienten entgegenkommen, der ein Mehr an Informationen aus den geplanten Qualitätsberichten nutzt, um für sich ein Maximum an hochwertigen medizinischen Dienstleistungen zu realisieren. Auf der anderen Seite könnte das neue System aber Patientengruppen benachteiligen, die zur aktiven Nutzung solcher Informationen nicht oder weniger gut in der Lage sind. Ohne die Lage im deutschen Gesundheitswesen vor Einführung von Fallpauschalen positiv verklären zu wollen, sollen deshalb im vorliegenden Artikel anhand von Studienergebnissen aus den USA Konsequenzen abgeschätzt und in ihrer ethischen Dimension eingeordnet werden."],["dc.identifier.doi","10.1055/s-2005-871880"],["dc.identifier.gro","3146726"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/9398"],["dc.language.iso","de"],["dc.notes.status","final"],["dc.relation.issn","0012-0472"],["dc.title","Ethik und Fallpauschalen"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.peerReviewed","no"],["dspace.entity.type","Publication"]]

[["dc.contributor.author","Lenk, Christian"],["dc.contributor.author","Hoppe, Nils"],["dc.contributor.author","Beier, Katharina"],["dc.contributor.author","Wiesemann, Claudia"],["dc.date.accessioned","2017-10-16T10:54:28Z"],["dc.date.available","2017-10-16T10:54:28Z"],["dc.date.issued","2011"],["dc.description.abstract","The use of human tissue for medical research and scientific progress raises many ethical and legal challenges. The procurement, storage, and transfer of human tissue for research purposes have posed significant questions over recent years, and a number of high profile scandals in the UK prompted the publication of the Madden Report on Post Mortem Practice and Procedures in Irish hospitals in 2006. Additionally, tissue-related research tends to be most promising if samples and information are shared across national borders, but the heterogeneity of current rules and guidelines within the member states of the European Union calls all the more for clarification. This book explores many of the issues concerning biobank-related research and aims to provide answers to the most urgent questions by means of ethical, philosophical, and legal investigation. It provides insight into a wide range of interlinking research perspectives and serves as a reference to the state of play ethically and legally in Europe."],["dc.identifier.doi","10.1093/acprof:oso/9780199587551.001.0001"],["dc.identifier.gro","3146743"],["dc.identifier.isbn","978-0-19958-755-1"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/9417"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.publisher","Oxford University Press"],["dc.title","Human Tissue Research"],["dc.type","book"],["dc.type.internalPublication","unknown"],["dc.type.peerReviewed","no"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1473"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","European Journal of Pediatrics"],["dc.bibliographiccitation.lastpage","1478"],["dc.bibliographiccitation.volume","168"],["dc.contributor.author","Lenk, Christian"],["dc.contributor.author","Koch, Philipp"],["dc.contributor.author","Zappel, Hildegard"],["dc.contributor.author","Wiesemann, Claudia"],["dc.date.accessioned","2017-10-16T10:54:26Z"],["dc.date.available","2017-10-16T10:54:26Z"],["dc.date.issued","2009"],["dc.description.abstract","ff-label drug use in paediatrics is associated with an increased risk of adverse drug reactions. Any risk-benefit analysis has to be based on value judgments that should include parents' views. However, nothing is known so far about the parents' perspective on this critical issue. Therefore, a quantitative survey with parents of healthy and chronically ill children was carried out (n = 94). Knowledge about the practise of off-label use is generally poor in both groups. Surprisingly, this is also true for the parents of children with chronic disease. Nine percent of the parents of chronically ill children and 20% of the parents of healthy children would refuse treatment with an off-label drug. Parents who have poor knowledge about the practise of off-label use tend to refuse to volunteer their child for study participation. Therefore, the information of parents on the off-label use of drugs is important to meet ethical standards and to increase the parents' acceptance of medical studies with children."],["dc.identifier.doi","10.1007/s00431-009-0956-6"],["dc.identifier.gro","3146729"],["dc.identifier.pmid","19277709"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?goescholar/3759"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/9402"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","public"],["dc.relation.issn","0340-6199"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Off-label, off-limits? Parental awareness and attitudes towards off-label use in paediatrics"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.peerReviewed","no"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]