Lehmann, Wolfgang

[["dc.bibliographiccitation.firstpage","301"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Operative Orthopädie und Traumatologie"],["dc.bibliographiccitation.lastpage","310"],["dc.bibliographiccitation.volume","31"],["dc.contributor.author","Viezens, L."],["dc.contributor.author","Sehmisch, S."],["dc.contributor.author","Lehmann, W."],["dc.contributor.author","Weiser, L."],["dc.date.accessioned","2020-12-10T14:08:03Z"],["dc.date.available","2020-12-10T14:08:03Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1007/s00064-019-0609-5"],["dc.identifier.eissn","1439-0981"],["dc.identifier.issn","0934-6694"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16565"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/70360"],["dc.language.iso","de"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.intern","Merged from goescholar"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Pedikelsubtraktionsosteotomie zur Korrektur rigider Deformitäten"],["dc.title.alternative","Pedicle subtraction osteotomy to correct rigid deformities"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Journal of Endocrinological Investigation"],["dc.contributor.author","Komrakova, M."],["dc.contributor.author","Büchler, G."],["dc.contributor.author","Böker, K. O."],["dc.contributor.author","Lehmann, W."],["dc.contributor.author","Schilling, A. F."],["dc.contributor.author","Roch, P. J."],["dc.contributor.author","Taudien, S."],["dc.contributor.author","Hoffmann, D. B."],["dc.contributor.author","Sehmisch, S."],["dc.date.accessioned","2022-09-01T09:49:26Z"],["dc.date.available","2022-09-01T09:49:26Z"],["dc.date.issued","2022"],["dc.description.abstract","Abstract\n \n Purpose\n Enobosarm (EN), a selective androgen receptor modulator and raloxifene (RAL), a selective estrogen receptor modulator, have been shown to improve bone tissue in osteoporotic males. The present study evaluated the effects of a combination therapy of EN and RAL on bone properties in orchiectomized rats compared to the respective single treatments.\n \n \n Methods\n Eight-month-old male Sprague–Dawley rats were either left intact (Non-Orx) or orchiectomized (Orx). The Orx rats were divided into four groups (n = 15 each): 1) Orx, 2) EN treatment (Orx + EN), 3) RAL treatment (Orx + RAL), 4) combined treatment (Orx + EN + RAL). EN and RAL (0.4 mg and 7 mg/kg body weight/day) were applied immediately after Orx with a soy-free pelleted diet for up to 18 weeks. The lumbar spine and femora were examined by micro-CT, biomechanical, histomorphological, ashing, and gene expression analyses.\n \n \n Results\n EN exhibited an anabolic effect on bone, improving some of its parameters in Orx rats, but did not affect biomechanical properties. RAL exhibited antiresorptive activity, maintaining the biomechanical and trabecular parameters of Orx rats at the levels of Non-Orx rats. EN + RAL exerted a stronger effect than the single treatments, improving most of the bone parameters. Liver weight increased after all treatments; the kidney, prostate, and levator ani muscle weights increased after EN and EN + RAL treatments. BW was reduced due to a decreased food intake in the Orx + RAL group and due a reduced visceral fat weight in the Orx + EN + RAL group.\n \n \n Conclusion\n The EN + RAL treatment appeared to be promising in preventing male osteoporosis, but given the observed side effects on liver, kidney, and prostate weights, it requires further investigation."],["dc.description.sponsorship"," Deutsche Forschungsgemeinschaft http://dx.doi.org/10.13039/501100001659"],["dc.description.sponsorship"," Georg-August-Universität Göttingen 501100003385"],["dc.identifier.doi","10.1007/s40618-022-01865-9"],["dc.identifier.pii","1865"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/113421"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-597"],["dc.relation.eissn","1720-8386"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","A combined treatment with selective androgen and estrogen receptor modulators prevents bone loss in orchiectomized rats"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","224"],["dc.bibliographiccitation.issue","03"],["dc.bibliographiccitation.journal","OP-JOURNAL"],["dc.bibliographiccitation.lastpage","230"],["dc.bibliographiccitation.volume","33"],["dc.contributor.author","Oberthür, Swantje"],["dc.contributor.author","Sehmisch, Stephan"],["dc.contributor.author","Schilling, Arndt"],["dc.contributor.author","Lehmann, Wolfgang"],["dc.contributor.author","Siggelkow, Heide"],["dc.contributor.author","Hoffmann, Daniel"],["dc.date.accessioned","2019-10-14T07:07:03Z"],["dc.date.available","2019-10-14T07:07:03Z"],["dc.date.issued","2018"],["dc.description.abstract","Zusammenfassung Atypische Femurfrakturen (AFF) stellen einen Sonderfall in der Alterstraumatologie dar und machen im Hinblick auf die Gesamtzahl der Femurfrakturen nur einen geringen Anteil aus. Im Gegensatz zur klassischen Fraktur des proximalen Femurs sind AFF subtrochantär bzw. im Schaftbereich lokalisiert, entstehen häufig ohne adäquates Unfallereignis und zeigen charakteristische Merkmale im Röntgenbild. In vielen Fällen kommt es zu einem bilateralen Auftreten von AFF. Klinisch besteht oftmals Tage bis Monate vor der Diagnose einer AFF ein Prodromalschmerz im entsprechenden Bein bzw. der Leistengegend. Durch die American Society for Bone and Mineral Research (ASBMR) wurden Haupt- und Nebenkriterien zur Definition einer atypischen Femurfraktur erstellt. Diese sollen die Diagnosestellung erleichtern. Zu den Hauptkriterium zählen u. a. die peri- oder endostale Verdickung der lateralen Kortikalis sowie das Fehlen einer Frakturtrümmerzone. Um eine Fraktur als AFF zu definieren, müssen mindestens 4 der 5 Hauptkriterien erfüllt sein. Es gibt Evidenz für eine Korrelation zwischen AFF und der (Langzeit-)Einnahme von Bisphosphonaten. Atypische Femurfrakturen können jedoch auch ohne Bisphosphonateinnahme auftreten. Ist eine AFF diagnostiziert, sollte die Bisphosphonattherapie pausiert werden. Für die Therapie unterscheidet man zwischen kompletter und inkompletter Fraktur. Komplette AFF werden operativ zumeist mit einer Marknagelosteosynthese stabilisiert. Inkomplette Frakturen können konservativ therapiert werden – es gibt jedoch eine hohe Versagerrate mit Progress in eine komplette Fraktur, sodass bei persistierenden Schmerzen eher die prophylaktische Marknagelosteosynthese empfohlen wird. Der Behandlungsverlauf nach bisphosphonatassoziierten AFF ist häufiger mit perioperativen Komplikationen vergesellschaftet als die Behandlung von „typischen“ Femurfrakturen. Somit ist die Kenntnis der Pathophysiologie und der Therapieoptionen der Schlüssel zur erfolgreichen Behandlung dieser Verletzung."],["dc.identifier.doi","10.1055/s-0043-117830"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/62488"],["dc.language.iso","de"],["dc.relation.issn","0178-1715"],["dc.relation.issn","1439-2496"],["dc.title","Die atypische Femurfraktur als Sonderfall der Alterstraumatologie"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","275"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Operative Orthopädie und Traumatologie"],["dc.bibliographiccitation.lastpage","283"],["dc.bibliographiccitation.volume","31"],["dc.contributor.author","Viezens, Lennart"],["dc.contributor.author","Sehmisch, Stephan"],["dc.contributor.author","Weiser, Lukas"],["dc.contributor.author","Dreimann, Marc"],["dc.contributor.author","Lehmann, Wolfgang"],["dc.date.accessioned","2020-12-10T14:08:03Z"],["dc.date.available","2020-12-10T14:08:03Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1007/s00064-019-0615-7"],["dc.identifier.eissn","1439-0981"],["dc.identifier.issn","0934-6694"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16357"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/70363"],["dc.language.iso","de"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.intern","Merged from goescholar"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Dorsale Stabilisation der Halswirbelkörper HWK1/HWK2 modifiziert nach Goel-Harms mit HWK-1-Pedikelschrauben"],["dc.title.alternative","Dorsal stabilization of C1/C2 modified according to Goel-Harms with C1 pedicle screws"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","487"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","European Journal of Trauma and Emergency Surgery"],["dc.bibliographiccitation.lastpage","497"],["dc.bibliographiccitation.volume","46"],["dc.contributor.author","Spering, Christopher"],["dc.contributor.author","Lefering, Rolf"],["dc.contributor.author","Bouillon, Bertil"],["dc.contributor.author","Lehmann, Wolfgang"],["dc.contributor.author","von Eckardstein, Kajetan"],["dc.contributor.author","Dresing, Klaus"],["dc.contributor.author","Sehmisch, Stephan"],["dc.date.accessioned","2021-04-14T08:26:13Z"],["dc.date.available","2021-04-14T08:26:13Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1007/s00068-019-01229-8"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/81874"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","1863-9941"],["dc.relation.issn","1863-9933"],["dc.title","It is time for a change in the management of elderly severely injured patients! An analysis of 126,015 patients from the TraumaRegister DGU®"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","243"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Journal of Bone and Mineral Metabolism"],["dc.bibliographiccitation.lastpage","255"],["dc.bibliographiccitation.volume","37"],["dc.contributor.author","Hoffmann, D. B."],["dc.contributor.author","Komrakova, M."],["dc.contributor.author","Pflug, S."],["dc.contributor.author","Oertzen, M. von"],["dc.contributor.author","Saul, D."],["dc.contributor.author","Weiser, L."],["dc.contributor.author","Walde, T. A."],["dc.contributor.author","Wassmann, M."],["dc.contributor.author","Schilling, A. F."],["dc.contributor.author","Lehmann, W."],["dc.contributor.author","Sehmisch, S."],["dc.date.accessioned","2020-06-15T13:52:01Z"],["dc.date.available","2020-06-15T13:52:01Z"],["dc.date.issued","2018"],["dc.description.abstract","We investigated the combinatorial effects of whole-body vertical vibration (WBVV) with the primarily osteoanabolic parathyroid hormone (PTH) and the mainly antiresorptive strontium ranelate (SR) in a rat model of osteoporosis. Ovariectomies were performed on 76 three-month-old Sprague-Dawley rats (OVX, n = 76; NON-OVX, n = 12). After 8 weeks, the ovariectomized rats were divided into 6 groups. One group (OVX + PTH) received daily injections of PTH (40 µg/kg body weight/day) for 6 weeks. Another group (OVX + SR) was fed SR-supplemented chow (600 mg/kg body weight/day). Three groups (OVX + VIB, OVX + PTH + VIB, and OVX + SR + VIB) were treated with WBVV twice a day at 70 Hz for 15 min. Two groups (OVX + PTH + VIB, OVX + SR + VIB) were treated additionally with PTH and SR, respectively. The rats were killed at 14 weeks post-ovariectomy. The lumbar vertebrae and femora were removed for biomechanical and morphological assessment. PTH produced statistically significant improvements in biomechanical and structural properties, including bone mineral density (BMD) and trabecular bone quality. In contrast, SR treatment exerted mild effects, with significant effects in cortical thickness only. SR produced no significant improvement in biomechanical properties. WBVV as a single or an adjunctive therapy produced no significant improvements. In conclusion, vibration therapy administered as a single or dual treatment had no significant impact on bones affected by osteoporosis. PTH considerably improved bone quality in osteoporosis cases and is superior to treatment with SR."],["dc.identifier.doi","10.1007/s00774-018-0929-9"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/66263"],["dc.language.iso","en"],["dc.relation.issn","0914-8779"],["dc.title","Evaluation of Ostarine as a Selective Androgen Receptor Modulator in a Rat Model of Postmenopausal Osteoporosis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","284"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Operative Orthopädie und Traumatologie"],["dc.bibliographiccitation.lastpage","292"],["dc.bibliographiccitation.volume","31"],["dc.contributor.author","Weiser, Lukas"],["dc.contributor.author","Sehmisch, Stephan"],["dc.contributor.author","Lehmann, Wolfgang"],["dc.contributor.author","Viezens, Lennart"],["dc.date.accessioned","2020-12-10T14:08:03Z"],["dc.date.available","2020-12-10T14:08:03Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1007/s00064-019-0608-6"],["dc.identifier.eissn","1439-0981"],["dc.identifier.issn","0934-6694"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16356"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/70359"],["dc.language.iso","de"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.intern","Merged from goescholar"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Techniken zur Steigerung der Pedikelschraubenstabilität im osteoporotischen Knochen"],["dc.title.alternative","Techniques to increase pedicle screw stability in osteoporotic vertebrae"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","4"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Nutrition & Metabolism"],["dc.bibliographiccitation.volume","16"],["dc.contributor.author","Saul, Dominik"],["dc.contributor.author","Weber, Marie"],["dc.contributor.author","Zimmermann, Marc Hendrik"],["dc.contributor.author","Kosinsky, Robyn Laura"],["dc.contributor.author","Hoffmann, Daniel Bernd"],["dc.contributor.author","Menger, Björn"],["dc.contributor.author","Taudien, Stefan"],["dc.contributor.author","Lehmann, Wolfgang"],["dc.contributor.author","Komrakova, Marina"],["dc.contributor.author","Sehmisch, Stephan"],["dc.date.accessioned","2019-07-09T11:49:50Z"],["dc.date.accessioned","2020-06-09T07:03:29Z"],["dc.date.available","2019-07-09T11:49:50Z"],["dc.date.available","2020-06-09T07:03:29Z"],["dc.date.issued","2019"],["dc.description.abstract","Background Osteoporosis is one of the world’s major medical burdens in the twenty-first century. Pharmaceutical intervention currently focusses on decelerating bone loss, but phytochemicals such as baicalein, which is a lipoxygenase inhibitor, may rescue bone loss. Studies evaluating the effect of baicalein in vivo are rare. Methods We administered baicalein to sixty-one three-month-old female Sprague-Dawley rats. They were divided into five groups, four of which were ovariectomized (OVX) and one non-ovariectomized (NON-OVX). Eight weeks after ovariectomy, bilateral tibial osteotomy with plate osteosynthesis was performed and bone formation quantified. Baicalein was administered subcutaneously using three doses (C1: 1 mg/kg BW; C2: 10 mg/kg BW; and C3: 100 mg/kg BW) eight weeks after ovariectomy for four weeks. Finally, femora and tibiae were collected. Biomechanical tests, micro-CT, ashing, histological and gene expression analyses were performed. Results Biomechanical properties were unchanged in tibiae and reduced in femora. In tibiae, C1 treatment enhanced callus density and cortical width and decreased callus area. In the C3 group, callus formation was reduced during the first 3 weeks after osteotomy, correlating to a higher mRNA expression of Osteocalcin, Tartrate-resistant acid phosphatase and Rankl. In femora, baicalein treatments did not alter bone parameters. Conclusions Baicalein enhanced callus density and cortical width but impaired early callus formation in tibiae. In femora, it diminished the biomechanical properties and calcium-to-phosphate ratio. Thus, it is not advisable to apply baicalein to treat early bone fractures. To determine the exact effects on bone healing, further studies in which baicalein treatments are started at different stages of healing are needed."],["dc.identifier.doi","10.1186/s12986-018-0327-2"],["dc.identifier.pmid","30651746"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/15789"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/59640"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/66212"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","1743-7075"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Effect of the Lipoxygenase Inhibitor Baicalein on Bone Tissue and Bone Healing in Ovariectomized Rats"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","100224"],["dc.bibliographiccitation.journal","Bone Reports"],["dc.bibliographiccitation.volume","11"],["dc.contributor.author","Komrakova, M."],["dc.contributor.author","Rechholtz, C."],["dc.contributor.author","Pohlmann, N."],["dc.contributor.author","Lehmann, W."],["dc.contributor.author","Schilling, A. F."],["dc.contributor.author","Wigger, R."],["dc.contributor.author","Sehmisch, S."],["dc.contributor.author","Hoffmann, D. B."],["dc.date.accessioned","2019-09-24T08:05:04Z"],["dc.date.available","2019-09-24T08:05:04Z"],["dc.date.issued","2019"],["dc.description.abstract","Bisphosphonate alendronate (ALN), phytoestrogen 8-prenylnaringenin (8-PN) and the whole body vibration exert a favorable effect on osteoporotic bone. However, the impact of these treatments and the combination of pharmacological therapies with biomechanical stimulation on muscle and bone has not yet been explored in detail. The effect of ALN and 8-PN and their combination with the vibration (Vib) on skeletal muscle and bone healing was investigated in ovariectomized (Ovx) rats. Three-month old rats were Ovx (n = 78), or left intact (Non-Ovx; n = 12). Five weeks after Ovx, all rats were treated according to the group assignment (n = 12/13): 1) Non-Ovx; 2) Ovx; 3) Ovx + Vib; 4) Ovx + ALN; 5) Ovx + ALN + Vib; 6): Ovx + 8-PN; 7) Ovx + 8-PN + Vib. Treatments with ALN (0.58 mg/kg BW, in food), 8-PN (1.77 mg/kg BW, daily s.c. injections) and/or with vertical vibration (0.5 mm, 35 Hz, 1 g, 15 min, 2×/day, 5×/week) were conducted for ten weeks. Nine weeks after Ovx, all rats underwent bilateral tibia osteotomy with plate osteosynthesis and were sacrificed six weeks later. Vibration increased fiber size and capillary density in muscle, enlarged callus area and width, and decreased callus density in tibia, and elevated alkaline phosphatase in serum. ALN and ALN + Vib enhanced capillarization and lactate dehydrogenase activity in muscle. In tibia, ALN slowed bone healing, ALN + Vib increased callus width and density, enhanced callus formation rate and expression of osteogenic genes. 8-PN and 8-PN + Vib decreased fiber size and increased capillary density in muscle; callus density and cortical width were reduced in tibia. Vibration worsened 8-PN effect on bone healing decreasing the callus width and area. Our data suggest that Vib, ALN, 8-PN, or 8-PN + Vib do not appear to aid bone healing. ALN + Vib improved bone healing; however application is questionable since single treatments impaired bone healing. Muscle responds to the anti-osteoporosis treatments and should be included in the evaluation of the drugs."],["dc.identifier.doi","10.1016/j.bonr.2019.100224"],["dc.identifier.pmid","31516917"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16393"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/62450"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","2352-1872"],["dc.rights","CC BY-NC-ND 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc-nd/4.0"],["dc.title","Effect of alendronate or 8-prenylnaringenin applied as a single therapy or in combination with vibration on muscle structure and bone healing in ovariectomized rats"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Der Chirurg"],["dc.contributor.author","Oberthür, S."],["dc.contributor.author","Piatek, S."],["dc.contributor.author","Krause, H."],["dc.contributor.author","Rüther, H."],["dc.contributor.author","Roch, P. J."],["dc.contributor.author","Zoch, A."],["dc.contributor.author","Lehmann, W."],["dc.contributor.author","Sehmisch, S."],["dc.contributor.author","Klauser, M. R."],["dc.date.accessioned","2021-07-05T15:00:45Z"],["dc.date.available","2021-07-05T15:00:45Z"],["dc.date.issued","2021"],["dc.description.abstract","Zusammenfassung Hintergrund Die Behandlung der Femurschaftfrakturen bei Kindern war in den letzten Jahren einem zunehmenden Wandel unterzogen. Die früher dominierenden Therapieverfahren wurden durch minimal-invasive Techniken (z. B. elastisch stabile intramedulläre Nagelung [ESIN]) weitgehend abgelöst. Ziel der vorliegenden Studie war der Vergleich der Komplikationsraten in Abhängigkeit sowohl von Patientenfaktoren als auch von verschiedenen Behandlungsverfahren. Material und Methoden Bei der vorliegenden Arbeit handelt es sich um eine retrospektive röntgenmorphometrische Datenauswertung. Es wurden die Patientenakten und Röntgenbilder von 101 Kindern, die an zwei Level-I-Traumazentren behandelt wurden, ausgewertet. Ergebnisse In 19 % der Fälle wurde eine konservative Therapie durchgeführt. Bei den operativen Verfahren dominierte die ESIN-Technik ( n  = 60). Revisionspflichtige Komplikationen fanden sich nach konservativer Therapie bei ca. 10 % der Kinder. Bei den operativ behandelten Kindern musste in über 6 % der Fälle eine Revisionsoperation durchgeführt werden. Die ESIN-Stabilisierung zeigte bei den operativen Verfahren mit ca. 3 % die niedrigste Revisionsrate. Wurden im Verhältnis zum Markraumdurchmesser zu dünne ESIN-Drähte verwendet, so zeigte sich eine um 30 % höhere Komplikationswahrscheinlichkeit. Bei Kindern unter 3 Jahren und Adoleszenten war die Komplikationswahrscheinlichkeit erhöht. Diskussion In der durchgeführten Studie zeigt sich ein moderates Komplikationsrisiko bei der Behandlung von Femurschaftfrakturen bei Kindern. Das Komplikationsrisiko nach Fixateur-externe-Anlage und konservativer Behandlung war in dieser Studie am höchsten. Die ESIN-Technik zeigt insgesamt das geringste Komplikationsrisiko. Die vorliegende Arbeit konnte die bekannten Limitationen der ESIN-Technik in Abhängigkeit von Alter und Gewicht bestätigen."],["dc.description.abstract","Abstract Background The treatment of pediatric femoral shaft fractures has undergone an increasing change in recent years. The previously predominant treatment procedures were extensively replaced by minimally invasive techniques (e.g. elastic stable intramedullary nailing, ESIN). The aim of this study was the comparison of complication rates depending on patient factors as well as various treatment procedures. Material and methods This study involved a retrospective X‑ray morphometric evaluation of data. The patient files and X‑rays of 101 children who were treated at 2 level I trauma centers were analyzed. Results Conservative treatment was carried out in 19% of the cases. Among the surgical procedures the ESIN technique was predominant ( n  = 60). Complications that needed revision occurred in 10% of the children after conservative treatment. Revision surgery had to be carried out in more than 6% of the cases in children who were surgically treated. Among the surgical procedures ESIN stabilization demonstrated the lowest revision rate with only 3%. Children under three years and adolescents had a higher risk for developing complications. If the ESIN wires used were too thin in relation to the diameter of the medullary cavity there was an increased probability of complications of around 30%. Conclusion This study revealed a moderate risk of complications in the treatment of femoral shaft fractures in children. The risk of complications after external fixation and conservative treatment was the highest in this study. Overall, the ESIN technique showed the lowest risk of complications. The results of this study could confirm the known limitations of the ESIN technique depending on age and body weight."],["dc.identifier.doi","10.1007/s00104-021-01437-2"],["dc.identifier.pii","1437"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/87894"],["dc.language.iso","de"],["dc.notes.intern","DOI Import DOI-Import GROB-441"],["dc.relation.eissn","1433-0385"],["dc.relation.issn","0009-4722"],["dc.title","Die Komplikationsrate nach Femurschaftfrakturen im Kindes- und Jugendalter in Abhängigkeit von Patientenfaktoren und Behandlungsmaßnahmen"],["dc.title.translated","Complication rate after femoral shaft fractures in childhood and adolescence depending on patient factors and treatment measures"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]