Lehmann, Wolfgang

[["dc.bibliographiccitation.journal","Clinical Biochemistry"],["dc.contributor.author","Saul, D."],["dc.contributor.author","Hünicke, P."],["dc.contributor.author","Böker, K.O."],["dc.contributor.author","Spering, C."],["dc.contributor.author","Maheshwari, A.K."],["dc.contributor.author","Acharya, M."],["dc.contributor.author","Lehmann, W."],["dc.date.accessioned","2021-06-01T10:49:30Z"],["dc.date.available","2021-06-01T10:49:30Z"],["dc.date.issued","2021"],["dc.identifier.doi","10.1016/j.clinbiochem.2021.04.020"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/86310"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.relation.issn","0009-9120"],["dc.title","Predicting the disaster – The role of CRP in acetabular surgery"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","243"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Journal of Bone and Mineral Metabolism"],["dc.bibliographiccitation.lastpage","255"],["dc.bibliographiccitation.volume","37"],["dc.contributor.author","Hoffmann, D. B."],["dc.contributor.author","Komrakova, M."],["dc.contributor.author","Pflug, S."],["dc.contributor.author","Oertzen, M. von"],["dc.contributor.author","Saul, D."],["dc.contributor.author","Weiser, L."],["dc.contributor.author","Walde, T. A."],["dc.contributor.author","Wassmann, M."],["dc.contributor.author","Schilling, A. F."],["dc.contributor.author","Lehmann, W."],["dc.contributor.author","Sehmisch, S."],["dc.date.accessioned","2020-06-15T13:52:01Z"],["dc.date.available","2020-06-15T13:52:01Z"],["dc.date.issued","2018"],["dc.description.abstract","We investigated the combinatorial effects of whole-body vertical vibration (WBVV) with the primarily osteoanabolic parathyroid hormone (PTH) and the mainly antiresorptive strontium ranelate (SR) in a rat model of osteoporosis. Ovariectomies were performed on 76 three-month-old Sprague-Dawley rats (OVX, n = 76; NON-OVX, n = 12). After 8 weeks, the ovariectomized rats were divided into 6 groups. One group (OVX + PTH) received daily injections of PTH (40 µg/kg body weight/day) for 6 weeks. Another group (OVX + SR) was fed SR-supplemented chow (600 mg/kg body weight/day). Three groups (OVX + VIB, OVX + PTH + VIB, and OVX + SR + VIB) were treated with WBVV twice a day at 70 Hz for 15 min. Two groups (OVX + PTH + VIB, OVX + SR + VIB) were treated additionally with PTH and SR, respectively. The rats were killed at 14 weeks post-ovariectomy. The lumbar vertebrae and femora were removed for biomechanical and morphological assessment. PTH produced statistically significant improvements in biomechanical and structural properties, including bone mineral density (BMD) and trabecular bone quality. In contrast, SR treatment exerted mild effects, with significant effects in cortical thickness only. SR produced no significant improvement in biomechanical properties. WBVV as a single or an adjunctive therapy produced no significant improvements. In conclusion, vibration therapy administered as a single or dual treatment had no significant impact on bones affected by osteoporosis. PTH considerably improved bone quality in osteoporosis cases and is superior to treatment with SR."],["dc.identifier.doi","10.1007/s00774-018-0929-9"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/66263"],["dc.language.iso","en"],["dc.relation.issn","0914-8779"],["dc.title","Evaluation of Ostarine as a Selective Androgen Receptor Modulator in a Rat Model of Postmenopausal Osteoporosis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","18"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Operative Orthopädie und Traumatologie"],["dc.bibliographiccitation.lastpage","22"],["dc.bibliographiccitation.volume","32"],["dc.contributor.author","Saul, Dominik"],["dc.contributor.author","Roch, Jonathan"],["dc.contributor.author","Lehmann, Wolfgang"],["dc.contributor.author","Dresing, Klaus"],["dc.date.accessioned","2020-06-08T13:13:06Z"],["dc.date.available","2020-06-08T13:13:06Z"],["dc.date.issued","2019"],["dc.description.abstract","Ziel Komplette Anästhesie der Phalangen an Hand und Fuß. Indikationen Erkrankungen an Hand oder Fuß distal des Grundgelenks bis zum Endglied. Kontraindikationen Lokale Infektionen an der Injektionsstelle. Verletzungen proximal des Grundgelenks. Technik An der Basis des Fingers oder Zehs wird distal des Grundgelenks dorsoradial und -ulnar ein subkutanes Depot eines 0,5–2 %-igen Lokalanästhetikums gesetzt. Unter Vorschieben der Kanüle nach palmar werden dann weitere 0,5–1,5 ml appliziert, um eine komplette Anästhesie des Fingers/Zehs zu erreichen. Weiterbehandlung Die Wirkung der Lokalanästhesie ist selbstlimitierend. Ergebnisse Die Leitungsanästhesie nach Oberst bewirkt eine zuverlässige Betäubung von Finger und Zeh. Chirurgische Eingriffe distal des Grundgelenks lassen sich hiermit schmerzfrei durchführen."],["dc.description.abstract","Objective Complete anesthesia of the phalanges of the fingers and toes. Indications All lesions distal to the metacarpophalangeal/metatarsophalangeal joint. Contraindications Local infections at the injection site. Lesions proximal to the metacarpophalangeal/metatarsophalangeal joint. Technique A subcutaneous deposit of a 0.5–2% local anesthetic is administered dorsoradially and dorsoulnarly at the base of the metacarpophalangeal/metatarsophalangeal joint. With the cannula advanced to palmar, an additional 0.5–1.5 ml is then administered to achieve complete anesthesia. Postoperative management The effect of the local anesthesia is self-limiting. Results The Oberst block results in reliable anesthesia of the finger and toe. All surgical procedures distal to the metacarpophalangeal/metatarsophalangeal joint can be performed without pain."],["dc.identifier.doi","10.1007/s00064-019-00633-y"],["dc.identifier.pmid","31650198"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/66199"],["dc.language.iso","de"],["dc.relation.eissn","1439-0981"],["dc.relation.issn","0934-6694"],["dc.title","Leitungsanästhesie nach Oberst"],["dc.title.alternative","Oberst’s block anesthesia"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","4"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Nutrition & Metabolism"],["dc.bibliographiccitation.volume","16"],["dc.contributor.author","Saul, Dominik"],["dc.contributor.author","Weber, Marie"],["dc.contributor.author","Zimmermann, Marc Hendrik"],["dc.contributor.author","Kosinsky, Robyn Laura"],["dc.contributor.author","Hoffmann, Daniel Bernd"],["dc.contributor.author","Menger, Björn"],["dc.contributor.author","Taudien, Stefan"],["dc.contributor.author","Lehmann, Wolfgang"],["dc.contributor.author","Komrakova, Marina"],["dc.contributor.author","Sehmisch, Stephan"],["dc.date.accessioned","2019-07-09T11:49:50Z"],["dc.date.accessioned","2020-06-09T07:03:29Z"],["dc.date.available","2019-07-09T11:49:50Z"],["dc.date.available","2020-06-09T07:03:29Z"],["dc.date.issued","2019"],["dc.description.abstract","Background Osteoporosis is one of the world’s major medical burdens in the twenty-first century. Pharmaceutical intervention currently focusses on decelerating bone loss, but phytochemicals such as baicalein, which is a lipoxygenase inhibitor, may rescue bone loss. Studies evaluating the effect of baicalein in vivo are rare. Methods We administered baicalein to sixty-one three-month-old female Sprague-Dawley rats. They were divided into five groups, four of which were ovariectomized (OVX) and one non-ovariectomized (NON-OVX). Eight weeks after ovariectomy, bilateral tibial osteotomy with plate osteosynthesis was performed and bone formation quantified. Baicalein was administered subcutaneously using three doses (C1: 1 mg/kg BW; C2: 10 mg/kg BW; and C3: 100 mg/kg BW) eight weeks after ovariectomy for four weeks. Finally, femora and tibiae were collected. Biomechanical tests, micro-CT, ashing, histological and gene expression analyses were performed. Results Biomechanical properties were unchanged in tibiae and reduced in femora. In tibiae, C1 treatment enhanced callus density and cortical width and decreased callus area. In the C3 group, callus formation was reduced during the first 3 weeks after osteotomy, correlating to a higher mRNA expression of Osteocalcin, Tartrate-resistant acid phosphatase and Rankl. In femora, baicalein treatments did not alter bone parameters. Conclusions Baicalein enhanced callus density and cortical width but impaired early callus formation in tibiae. In femora, it diminished the biomechanical properties and calcium-to-phosphate ratio. Thus, it is not advisable to apply baicalein to treat early bone fractures. To determine the exact effects on bone healing, further studies in which baicalein treatments are started at different stages of healing are needed."],["dc.identifier.doi","10.1186/s12986-018-0327-2"],["dc.identifier.pmid","30651746"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/15789"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/59640"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/66212"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","1743-7075"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Effect of the Lipoxygenase Inhibitor Baicalein on Bone Tissue and Bone Healing in Ovariectomized Rats"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","130"],["dc.bibliographiccitation.journal","Clinical Biomechanics"],["dc.bibliographiccitation.lastpage","139"],["dc.bibliographiccitation.volume","73"],["dc.contributor.author","Roch, Paul Jonathan"],["dc.contributor.author","Wagner, Markus"],["dc.contributor.author","Weiland, Jan"],["dc.contributor.author","Gezzi, Riccardo"],["dc.contributor.author","Spiering, Stefan"],["dc.contributor.author","Lehmann, Wolfgang"],["dc.contributor.author","Saul, Dominik"],["dc.contributor.author","Weiser, Lukas"],["dc.contributor.author","Viezens, Lennart"],["dc.contributor.author","Wachowski, Martin Michael"],["dc.date.accessioned","2020-06-15T07:08:09Z"],["dc.date.available","2020-06-15T07:08:09Z"],["dc.date.issued","2020"],["dc.description.abstract","Information about kinematics in different functional spinal units before and after total disc arthroplasties is necessary to improve prostheses and determine indications. There is little information about the nonstationary instantaneous helical axis of rotation under lateral bending in the cervical spine before and after total disc arthroplasty."],["dc.identifier.doi","10.1016/j.clinbiomech.2020.01.007"],["dc.identifier.pmid","31982810"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/66244"],["dc.language.iso","en"],["dc.relation.eissn","1879-1271"],["dc.relation.issn","0268-0033"],["dc.title","Total disc arthroplasties change the kinematics of functional spinal units during lateral bending"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","109608"],["dc.bibliographiccitation.journal","Journal of Biomechanics"],["dc.bibliographiccitation.volume","100"],["dc.contributor.author","Roch, Paul Jonathan"],["dc.contributor.author","Wagner, Markus"],["dc.contributor.author","Weiland, Jan"],["dc.contributor.author","Spiering, Stefan"],["dc.contributor.author","Lehmann, Wolfgang"],["dc.contributor.author","Saul, Dominik"],["dc.contributor.author","Weiser, Lukas"],["dc.contributor.author","Viezens, Lennart"],["dc.contributor.author","Wachowski, Martin Michael"],["dc.date.accessioned","2020-06-08T13:20:06Z"],["dc.date.available","2020-06-08T13:20:06Z"],["dc.date.issued","2020"],["dc.description.abstract","Total disc arthroplasty (TDA) increases the risk of adjacent segment disease (ASD). Kinematic analyses are necessary to compare the intact condition (IC) with alterations after TDA to develop better prostheses. A well-established 6D measuring apparatus (resolution < 2.4 μm; 400 positions/cycle) was used. Kinematics of the flexion and extension of 8 human cervical spine segments (cFSU) C3/C4 and C5/C6 (67.9 ± 13.2 y) were analyzed in the IC and after TDA (Bryan® Cervical Disc [B-TDA], Prestige LP® Cervical Disc [P-TDA]). The migration of the instantaneous helical axis (IHA) and the stiffness of the segments were calculated. Analyses demonstrated a stretched U-curved IHA migration in the sagittal plane. The IHA positions were significantly more cranial in cFSU C5/C6 than in C3/C4 in IC and after either TDA (IC: p < 0.001; B-TDA: p = 0.001; P-TDA: p = 0.045). In cFSU C3/C4 IHA positions shifted anteriocranially after either TDA (p < 0.001). In cFSU C5/C6, the IHA positions were significantly more anterocranial after B-TDA than in IC and after P-TDA (anterior: p < 0.001; cranial: p = 0.005). After B-TDA, the IHA migration path length was significantly longer in cFSU C3/C4 than in C5/C6 (p = 0.007) and longer than in IC in both cFSU (C3/C4: p = 0.047; C5/C6: p < 0.001). Stiffness was increased after both TDA. Various kinematic alterations were observed after both TDA. Increased translation and IHA position shifting after both TDA might indicate abnormal strain and a derogated benefit of TDA. These results imply the most abnormal strain after B-TDA. The lower cFSU might be more susceptible to alterations after TDA than the upper cFSU."],["dc.identifier.doi","10.1016/j.jbiomech.2020.109608"],["dc.identifier.pmid","31926589"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/66200"],["dc.language.iso","en"],["dc.relation.eissn","1873-2380"],["dc.relation.issn","0021-9290"],["dc.title","Total disc arthroplasties alter the characteristics of the instantaneous helical axis of the cervical functional spinal units C3/C4 and C5/C6 during flexion and extension in in vitro conditions"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Journal of Orthopaedic Surgery"],["dc.bibliographiccitation.volume","28"],["dc.contributor.author","Saul, Dominik"],["dc.contributor.author","Fischer, Ann-Christin"],["dc.contributor.author","Lehmann, Wolfgang"],["dc.contributor.author","Dresing, Kai"],["dc.date.accessioned","2020-06-15T07:11:12Z"],["dc.date.available","2020-06-15T07:11:12Z"],["dc.date.issued","2020"],["dc.description.abstract","Purpose: Perioperative swelling and edema are the main factors that influence the time to definitive operative care, healing rate, as well as postoperative infection rate. Device-based negative pressure treatment is a new method to reduce post-traumatic and postoperative swelling of the upper extremities. The objective of this study was to evaluate a new negative pressure treatment with LymphaTouch® (Helsinki, Finland) to reduce perioperative swelling in upper extremity injuries. Methods: We analyzed 45 patients (26 female and 19 male) after operative treatment of upper extremity injuries. A predefined treatment algorithm of 30 min using LymphaTouch® was performed on the patients every day for five consecutive days. Swelling was measured according to the neutral-zero method with six points of measurement. Results: A total of 16 patients underwent an operation on their upper arm. An average of 3.5 measurements was performed per patient, with the start of therapy at a mean of 5.13 days after the operation. All of the measured circumferences except the elbow and 10 cm below the elbow were reduced from day 0 to 3. The percent reduction of swelling (relative to day 0) was 10.36%, 11.35%, 17.34%, and 3.25% for days 1–4, respectively. The greatest reduction of circumference was obtained in the metacarpus (−51.6%) and wrist (−33.1%). Conclusion: The LymphaTouch® system and a 30-min treatment program can reduce postoperative swelling of the upper arm, wrist, and hand on the first 5 days after surgery. The ease of learning and self-applicability of LymphaTouch® makes it interesting for further controlled randomized trials."],["dc.identifier.doi","10.1177/2309499020929166"],["dc.identifier.pmid","32500823"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/66245"],["dc.language.iso","en"],["dc.relation.eissn","2309-4990"],["dc.relation.issn","2309-4990"],["dc.title","Reduction of postoperative swelling with a negative pressure treatment - A prospective study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Frontiers in Bioengineering and Biotechnology"],["dc.bibliographiccitation.volume","9"],["dc.contributor.author","Gierig, Meike"],["dc.contributor.author","Liu, Fangrui"],["dc.contributor.author","Weiser, Lukas"],["dc.contributor.author","Lehmann, Wolfgang"],["dc.contributor.author","Wriggers, Peter"],["dc.contributor.author","Marino, Michele"],["dc.contributor.author","Saul, Dominik"],["dc.date.accessioned","2021-07-05T14:57:52Z"],["dc.date.available","2021-07-05T14:57:52Z"],["dc.date.issued","2021"],["dc.description.abstract","Background: Spinopelvic fractures and approaches of operative stabilization have been a source of controversial discussion. Biomechanical data support the benefit of a spinopelvic stabilization and minimally invasive procedures help to reduce the dissatisfying complication rate. The role of a cross connector within spinopelvic devices remains inconclusive. We aimed to analyze the effect of a cross connector in a finite element model (FE model). Study Design: A FE model of the L1-L5 spine segment with pelvis and a spinopelvic stabilization was reconstructed from patient-specific CT images. The biomechanical relevance of a cross connector in a Denis zone I (AO: 61-B2) sacrum fracture was assessed in the FE model by applying bending and twisting forces with and without a cross connector. Biomechanical outcomes from the numerical model were investigated also considering uncertainties in material properties and levels of osseointegration. Results: The designed FE model showed comparable values in range-of-motion (ROM) and stresses with reference to the literature. The superiority of the spinopelvic stabilization (L5/Os ilium) ± cross connector compared to a non-operative procedure was confirmed in all analyzed loading conditions by reduced ROM and principal stresses in the disk L5/S1, vertebral body L5 and the fracture area. By considering the combination of all loading cases, the presence of a cross connector reduced the maximum stresses in the fracture area of around 10%. This difference has been statistically validated ( p < 0.0001). Conclusion: The implementation of a spinopelvic stabilization (L5/Os ilium) in sacrum fractures sustained the fracture and led to enhanced biomechanical properties compared to a non-reductive procedure. While the additional cross connector did not alter the resulting ROM in L4/L5 or L5/sacrum, the reduction of the maximum stresses in the fracture area was significant."],["dc.description.abstract","Background: Spinopelvic fractures and approaches of operative stabilization have been a source of controversial discussion. Biomechanical data support the benefit of a spinopelvic stabilization and minimally invasive procedures help to reduce the dissatisfying complication rate. The role of a cross connector within spinopelvic devices remains inconclusive. We aimed to analyze the effect of a cross connector in a finite element model (FE model). Study Design: A FE model of the L1-L5 spine segment with pelvis and a spinopelvic stabilization was reconstructed from patient-specific CT images. The biomechanical relevance of a cross connector in a Denis zone I (AO: 61-B2) sacrum fracture was assessed in the FE model by applying bending and twisting forces with and without a cross connector. Biomechanical outcomes from the numerical model were investigated also considering uncertainties in material properties and levels of osseointegration. Results: The designed FE model showed comparable values in range-of-motion (ROM) and stresses with reference to the literature. The superiority of the spinopelvic stabilization (L5/Os ilium) ± cross connector compared to a non-operative procedure was confirmed in all analyzed loading conditions by reduced ROM and principal stresses in the disk L5/S1, vertebral body L5 and the fracture area. By considering the combination of all loading cases, the presence of a cross connector reduced the maximum stresses in the fracture area of around 10%. This difference has been statistically validated ( p < 0.0001). Conclusion: The implementation of a spinopelvic stabilization (L5/Os ilium) in sacrum fractures sustained the fracture and led to enhanced biomechanical properties compared to a non-reductive procedure. While the additional cross connector did not alter the resulting ROM in L4/L5 or L5/sacrum, the reduction of the maximum stresses in the fracture area was significant."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2021"],["dc.identifier.doi","10.3389/fbioe.2021.669321"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/87760"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-441"],["dc.relation.eissn","2296-4185"],["dc.relation.orgunit","Klinik für Unfallchirurgie, Orthopädie und Plastische Chirurgie"],["dc.rights","CC BY 4.0"],["dc.title","Biomechanical Effects of a Cross Connector in Sacral Fractures – A Finite Element Analysis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","100234"],["dc.bibliographiccitation.journal","Bone Reports"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Hoffmann, Daniel Bernd"],["dc.contributor.author","Popescu, Christian"],["dc.contributor.author","Komrakova, Marina"],["dc.contributor.author","Welte, Lena"],["dc.contributor.author","Saul, Dominik"],["dc.contributor.author","Lehmann, Wolfgang"],["dc.contributor.author","Hawellek, Thelonius"],["dc.contributor.author","Beil, Frank Timo"],["dc.contributor.author","Dakna, Mohammed"],["dc.contributor.author","Sehmisch, Stephan"],["dc.date.accessioned","2020-06-15T14:01:09Z"],["dc.date.available","2020-06-15T14:01:09Z"],["dc.date.issued","2020"],["dc.description.abstract","Introduction We evaluated the prevalence and influence of chronic hyponatremia in patients with low energy trauma. We also investigated the influence of medication and diseases on hyponatremia. Material and methods This retrospective study included 314 cases of proximal femoral fracture due to low energy trauma. Patients were treated in the University Medical Center Goettingen within 3 years. Hyponatremia was defined as serum sodium <135 mmol/L at admission. Results Overall, 15.6% of patients in the low energy trauma group had hyponatremia. Among patients older than 80 years, women showed distinctly higher rates of hyponatremia (female: 16.4%; male: 5.9%). In contrast only 4.7% of patients who underwent elective hip arthroplasty showed hyponatremia. Patients on sartanes and aldosterone antagonists showed significantly higher rates of hyponatremia. Alcoholism was significantly associated with hyponatremia. Conclusions We confirmed a high prevalence of chronic hyponatremia in patients with fractures due to low energy trauma. Our data underscore chronic hyponatremia as a contributing factor to hip fractures. Women older than 80 have a higher risk of developing hyponatremia. Sartanes, aldosterone antagonists, and alcohol disease are associated with hyponatremia. Treating hyponatremia may decrease the risk of fracture after low energy trauma. Therefore, physicians of different specialties should focus on treatment of chronic hyponatremia to reduce the fracture rate associated with low energy trauma."],["dc.identifier.doi","10.1016/j.bonr.2019.100234"],["dc.identifier.pmid","31909095"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/17137"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/66267"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","2352-1872"],["dc.rights","CC BY-NC-ND 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc-nd/4.0"],["dc.title","Chronic hyponatremia in patients with proximal femoral fractures after low energy trauma: A retrospective study in a level-1 trauma center"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","4985"],["dc.bibliographiccitation.issue","21"],["dc.bibliographiccitation.journal","Journal of Clinical Medicine"],["dc.bibliographiccitation.volume","10"],["dc.contributor.author","Meier, Marc-Pascal"],["dc.contributor.author","Bauer, Ina Juliana"],["dc.contributor.author","Maheshwari, Arvind K."],["dc.contributor.author","Husen, Martin"],["dc.contributor.author","Jäckle, Katharina"],["dc.contributor.author","Hubert, Jan"],["dc.contributor.author","Hawellek, Thelonius"],["dc.contributor.author","Lehmann, Wolfgang"],["dc.contributor.author","Saul, Dominik"],["dc.date.accessioned","2021-12-01T09:22:51Z"],["dc.date.available","2021-12-01T09:22:51Z"],["dc.date.issued","2021"],["dc.description.abstract","Background: While primary hip arthroplasty is the most common operative procedure in orthopedic surgery, a periprosthetic joint infection is its most severe complication. Early detection and prediction are crucial. In this study, we aimed to determine the value of postoperative C-reactive protein (CRP) and develop a formula to predict this rare, but devastating complication. Methods: We retrospectively evaluated 708 patients with primary hip arthroplasty. CRP, white blood cell count (WBC), and several patient characteristics were assessed for 20 days following the operative procedure. Results: Eight patients suffered an early acute periprosthetic infection. The maximum CRP predicted an infection with a sensitivity and specificity of 75% and 56.9%, respectively, while a binary logistic regression reached values of 75% and 80%. A multinominal logistic regression, however, was able to predict an early infection with a sensitivity and specificity of 87.5% and 78.9%. With a one-phase decay, 71.6% of the postoperative CRP-variance could be predicted. Conclusion: To predict early acute periprosthetic joint infection after primary hip arthroplasty, a multinominal logistic regression is the most promising approach. Including five parameters, an early infection can be predicted on day 5 after the operative procedure with 87.5% sensitivity, while it can be excluded with 78.9% specificity."],["dc.description.abstract","Background: While primary hip arthroplasty is the most common operative procedure in orthopedic surgery, a periprosthetic joint infection is its most severe complication. Early detection and prediction are crucial. In this study, we aimed to determine the value of postoperative C-reactive protein (CRP) and develop a formula to predict this rare, but devastating complication. Methods: We retrospectively evaluated 708 patients with primary hip arthroplasty. CRP, white blood cell count (WBC), and several patient characteristics were assessed for 20 days following the operative procedure. Results: Eight patients suffered an early acute periprosthetic infection. The maximum CRP predicted an infection with a sensitivity and specificity of 75% and 56.9%, respectively, while a binary logistic regression reached values of 75% and 80%. A multinominal logistic regression, however, was able to predict an early infection with a sensitivity and specificity of 87.5% and 78.9%. With a one-phase decay, 71.6% of the postoperative CRP-variance could be predicted. Conclusion: To predict early acute periprosthetic joint infection after primary hip arthroplasty, a multinominal logistic regression is the most promising approach. Including five parameters, an early infection can be predicted on day 5 after the operative procedure with 87.5% sensitivity, while it can be excluded with 78.9% specificity."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2021"],["dc.identifier.doi","10.3390/jcm10214985"],["dc.identifier.pii","jcm10214985"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/94497"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-478"],["dc.relation.eissn","2077-0383"],["dc.relation.orgunit","Klinik für Unfallchirurgie, Orthopädie und Plastische Chirurgie"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0/"],["dc.title","Predicting the Exception—CRP and Primary Hip Arthroplasty"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]