Mohr, Alexander

[["dc.bibliographiccitation.firstpage","442"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","American Journal of Neuroradiology"],["dc.bibliographiccitation.lastpage","446"],["dc.bibliographiccitation.volume","29"],["dc.contributor.author","Buhk, J.-H."],["dc.contributor.author","Elolf, Erck"],["dc.contributor.author","Jacob, Dorrit E."],["dc.contributor.author","Rustenbeck, H.-H."],["dc.contributor.author","Mohr, A."],["dc.contributor.author","Knauth, Michael"],["dc.date.accessioned","2018-11-07T11:17:17Z"],["dc.date.available","2018-11-07T11:17:17Z"],["dc.date.issued","2008"],["dc.description.abstract","BACKGROUND AND PURPOSE: The purpose of this work was to provide an intraindividual comparison of angiographic CT (ACT) and multisection CT (MSCT) in lumbar myelographic imaging and to evaluate possible benefits of ACT, which is a further development of rotational angiography providing image data of high spatial and CT-like contrast resolution. MATERIALS AND METHODS: In 26 patients with degenerative lumbar spine disease a lumbar ACT was performed in combination with conventional lumbar myelography and followed by postmyelographic. MSCT. Conventional lumbar myelography and lumbar ACT were performed with a flat panel detector-equipped angiographic device. Postmyelographic MSCT was performed with a 16-section CT scanner. Three experienced neuroradiologists rated anonymized sets of multiplanar reformatted CT and ACT images regarding diagnostic and technical parameters. The ratings were repeated after 2 months. Weighted K Statistics were calculated to describe the levels of intraobserver and interobserver agreement. RESULTS: The analysis shows that MSCT achieves higher ratings than ACT in all of the parameters asked. An adequate diagnostic quality was only assigned to 80% of the ACT acquisitions compared with 97% of the MSCT acquisitions. All of the mean K values were above 0.60, demonstrating a substantial intraobserver and interobserver agreement for MSCT, as well as for ACT. CONCLUSION: Using ACT, radiographic myelography and myelographic CT can be performed at the same imaging system. However, the results of our study show that the current myelographic ACT image quality fails to apply diagnostic standards. We, therefore, cannot recommend ACT as a general alternative to postmyelographic MSCT."],["dc.identifier.doi","10.3174/ajnr.A0853"],["dc.identifier.isi","000254066700008"],["dc.identifier.pmid","18065508"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/54769"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Soc Neuroradiology"],["dc.relation.issn","0195-6108"],["dc.title","A comparison of angiographic CT and multisection CT in lumbar myelographic imaging"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","397"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Experimental Neurology"],["dc.bibliographiccitation.lastpage","406"],["dc.bibliographiccitation.volume","211"],["dc.contributor.author","Linker, Ralf A."],["dc.contributor.author","Weller, Charlotte"],["dc.contributor.author","Luehder, Fred"],["dc.contributor.author","Mohr, Alexander"],["dc.contributor.author","Schmidt, Jens"],["dc.contributor.author","Knauth, Michael"],["dc.contributor.author","Metselaar, Josbert M."],["dc.contributor.author","Gold, Ralf"],["dc.date.accessioned","2018-11-07T11:14:26Z"],["dc.date.available","2018-11-07T11:14:26Z"],["dc.date.issued","2008"],["dc.description.abstract","Liposomal encapsulation leads to enhanced efficacy of glucocorticosteroids (GS) in treatment of autoimmune diseases. Here we compare liposomal prednisolone (PL) to liposomal methylprednisolone (MPL) in chronic-relapsing myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis (EAE), a model closely reflecting aspects of multiple sclerosis (MS). At the maximum of the first relapse, a single dose of PL or MPL was applied at 10 mg/kg or at 4 mg/kg and compared to classical methylprednisolone (MP) pulse therapy. PL at 10 mg/kg was superior to free MP with long-term efficacy and a sustained protection even during the second and third relapse. At the same time, in vivo magnetic resonance imaging of rat brains revealed a significant reduction of T2-lesions after PL application. Comparison of PL and MPL at 10 mg/kg disclosed superior effects for MPL with an enhanced reduction of inflammatory infiltration as well as preservation of myelin and axons. Dose titration experiments underscored a dose-dependent efficacy of liposomal GS with a sustained efficacy especially of the higher dosage. In histological analyses, PL10 was superior in reducing macrophage and T cell infiltration as well as demyelination and axonal loss while the lower dosages were still at least as effective as free MP. FACS analyses revealed an effect of liposome formulations on T cell numbers, the CD4/CD8 ratio, frequencies of regulatory T cells and adhesion molecule expression. In summary, liposomal GS and especially methylprednisolone formulations display an enhanced efficacy not only in acute inflammatory, but also in chronic demyelinating models of MS and confer long-term protection from relapses. These findings lay the groundwork for applying liposomal GS in clinical MS trials in the near future. (c) 2008 Elsevier Inc. All rights reserved."],["dc.identifier.doi","10.1016/j.expneurol.2008.02.005"],["dc.identifier.isi","000256272800012"],["dc.identifier.pmid","18394606"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/54122"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Academic Press Inc Elsevier Science"],["dc.relation.issn","0014-4886"],["dc.title","Liposomal glucocorticosteroids in treatment of chronic autoimmune demyelination: Long-term protective effects and enhanced efficacy of methylprednisolone formulations"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1905"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","Human Brain Mapping"],["dc.bibliographiccitation.lastpage","1915"],["dc.bibliographiccitation.volume","32"],["dc.contributor.author","Focke, Niels K."],["dc.contributor.author","Helms, Gunther"],["dc.contributor.author","Scheewe, Sebstian"],["dc.contributor.author","Pantel, Pia M."],["dc.contributor.author","Bachmann, Cornelius G."],["dc.contributor.author","Dechent, Peter"],["dc.contributor.author","Ebentheuer, Jens"],["dc.contributor.author","Mohr, Alexander"],["dc.contributor.author","Paulus, Walter J."],["dc.contributor.author","Trenkwalder, Claudia"],["dc.date.accessioned","2018-11-07T08:50:18Z"],["dc.date.available","2018-11-07T08:50:18Z"],["dc.date.issued","2011"],["dc.description.abstract","Voxel-based morphometry (VBM) shows a differentiated pattern in patients with atypical Parkinson syndrome but so far has had little impact in individual cases. It is desirable to translate VBM findings into clinical practice and individual classification. To this end, we examined whether a support vector machine (SVM) can provide useful accuracies for the differential diagnosis. We acquired a volumetric 3D T1-weighted MRI of 21 patients with idiopathic Parkinson syndrome (IPS), 11 multiple systems atrophy (MSA-P) and 10 progressive supranuclear palsy (PSP), and 22 healthy controls. Images were segmented, normalized, and compared at group level with SPM8 in a classical VBM design. Next, a SVM analysis was performed on an individual basis with leave-one-out cross-validation. VBM showed a strong white matter loss in the mesencephalon of patients with PSP, a putaminal grey matter loss in MSA, and a cerebellar grey matter loss in patients with PSP compared with IPS. The SVM allowed for an individual classification in PSP versus IPS with up to 96.8% accuracy with 90% sensitivity and 100% specificity. In MSA versus IPS, an accuracy of 71.9% was achieved; sensitivity, however, was low with 36.4%. Patients with IPS could not be differentiated from controls. In summary, a voxel-based SVM analysis allows for a reliable classification of individual cases in PSP that can be directly clinically useful. For patients with MSA and IPS, further developments like quantitative MRI are needed. Hum Brain Mapp 32:1905-1915, 2011. (C) 2011 Wiley Periodicals, Inc."],["dc.identifier.doi","10.1002/hbm.21161"],["dc.identifier.isi","000296850700012"],["dc.identifier.pmid","21246668"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/21663"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","1065-9471"],["dc.title","Individual Voxel-Based Subtype Prediction can Differentiate Progressive Supranuclear Palsy from Idiopathic Parkinson Syndrome and Healthy Controls"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","226"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Folia Neuropathologica"],["dc.bibliographiccitation.lastpage","233"],["dc.bibliographiccitation.volume","52"],["dc.contributor.author","Kallenberg, Kai"],["dc.contributor.author","Goldmann, Torben"],["dc.contributor.author","Menke, Jan"],["dc.contributor.author","Strik, Herwig"],["dc.contributor.author","Bock, Hans-Christoph"],["dc.contributor.author","Mohr, Alexander"],["dc.contributor.author","Buhk, Jan-Hendrik"],["dc.contributor.author","Frahm, Jens"],["dc.contributor.author","Dechent, Peter"],["dc.contributor.author","Knauth, Michael"],["dc.date.accessioned","2018-11-07T09:45:46Z"],["dc.date.available","2018-11-07T09:45:46Z"],["dc.date.issued","2014"],["dc.description.abstract","Introduction: Malignant brain tumors tend to migration and invasion of surrounding brain tissue. Histopathological studies reported malignant cells in macroscopically unsuspicious parenchyma (normal appearing white matter - NAWM) remote from the tumor localization. In early stages, diffuse interneural infiltration with changes of the apparent diffusion coefficient (ADC) and fractional anisotropy (FA) is hypothesized. Material and methods: Patients' ADC and FA values from NAWM of the hemisphere contralateral to a malignant glioma were compared to age- and sex-matched normal controls. Results: Apparent diffusion coefficient levels of the entire contra lateral hemisphere revealed a significant increase and a decrease of FA levels. An even more pronounced ADC increase was found in a region mirroring the glioma location. Conclusions: In patients with previously untreated anaplastic astrocytoma or glioblastoma, an increase of the ADC and a reduction of FA were found in the brain parenchyma of the hemisphere contralateral to the tumor localization. In the absence of visible MRI abnormalities, this may be an early indicator of microstructural changes of the NAWM attributed to malignant brain tumor."],["dc.description.sponsorship","Volkswagen Stiftung [ZN1635, ZN 2193]"],["dc.identifier.doi","10.5114/fn.2014.45563"],["dc.identifier.isi","000342712000002"],["dc.identifier.pmid","25310733"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/34702"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.relation.issn","1509-572X"],["dc.relation.issn","1641-4640"],["dc.title","Abnormalities in the normal appearing white matter of the cerebral hemisphere contralateral to a malignant brain tumor detected by diffusion tensor imaging"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","99"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Journal of Cerebral Blood Flow & Metabolism"],["dc.bibliographiccitation.lastpage","111"],["dc.bibliographiccitation.volume","26"],["dc.contributor.author","Bailey, Damian Miles"],["dc.contributor.author","Roukens, R."],["dc.contributor.author","Knauth, Michael"],["dc.contributor.author","Kallenberg, Kai"],["dc.contributor.author","Christ, S."],["dc.contributor.author","Mohr, A."],["dc.contributor.author","Genius, J."],["dc.contributor.author","Storch-Hagenlocher, B."],["dc.contributor.author","Meisel, F."],["dc.contributor.author","McEneny, J."],["dc.contributor.author","Young, I. S."],["dc.contributor.author","Steiner, Tamara"],["dc.contributor.author","Hess, Katharina"],["dc.contributor.author","Bartsch, P."],["dc.date.accessioned","2018-11-07T10:36:06Z"],["dc.date.available","2018-11-07T10:36:06Z"],["dc.date.issued","2006"],["dc.description.abstract","The present study combined molecular and neuroimaging techniques to examine if free radical-mediated damage to barrier function in hypoxia would result in extracellular edema, raise intracranial pressure (ICP) and account for the neurological symptoms typical of high-altitude headache (HAH) also known as acute mountain sickness (AMS). Twenty-two subjects were randomly exposed for 18 h to 12% (hypoxia) and 21% oxygen (O-2 (normoxia)) for collection of venous blood (0 h, 8 h, 15 h, 18 h) and CSF (18 h) after lumbar puncture (LP). Electron paramagnetic resonance (EPR) spectroscopy identified a clear increase in the blood and CSF concentration of O-2 and carbon-centered free radicals (P < 0.05 versus normoxia) subsequently identified as lipid-derived alkoxyl (LO center dot) and alkyl (LC center dot) species. Magnetic resonance imaging (MRI) demonstrated a mild increase in brain volume (7.0 +/- 4.8 mL or 0.6% +/- 0.4%, P < 0.05 versus normoxia) that resolved within 6 h of normoxic recovery. However, there was no detectable evidence for gross barrier dysfunction, elevated lumbar pressures, T-2 prolongation or associated neuronal and astroglial damage. Clinical AMS was diagnosed in 50% of subjects during the hypoxic trial and corresponding headache scores were markedly elevated (P < 0.05 versus non-AMS). A greater increase in brain volume was observed, though this was slight, independent of oxidative stress, barrier dysfunction, raised lumbar pressure, vascular damage and measurable evidence of cerebral edema and only apparent in the most severe of cases. These findings suggest that free-radical-mediated vasogenic edema is not an important pathophysiological event that contributes to the mild brain swelling observed in HAH."],["dc.identifier.doi","10.1038/sj.jcbfm.9600169"],["dc.identifier.isi","000235975500010"],["dc.identifier.pmid","15959459"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/45246"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Nature Publishing Group"],["dc.relation.issn","0271-678X"],["dc.title","Free radical-mediated damage to barrier function is not associated with altered brain morphology in high-altitude headache"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1226"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","American Journal of Neuroradiology"],["dc.bibliographiccitation.lastpage","1231"],["dc.bibliographiccitation.volume","31"],["dc.contributor.author","Psychogios, M.-N."],["dc.contributor.author","Buhk, J.-H."],["dc.contributor.author","Schramm, P."],["dc.contributor.author","Xyda, A."],["dc.contributor.author","Mohr, A."],["dc.contributor.author","Knauth, M."],["dc.date.accessioned","2021-06-01T10:48:42Z"],["dc.date.available","2021-06-01T10:48:42Z"],["dc.date.issued","2010"],["dc.identifier.doi","10.3174/ajnr.A2086"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/86027"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.relation.eissn","1936-959X"],["dc.relation.issn","0195-6108"],["dc.title","Feasibility of Angiographic CT in Peri-Interventional Diagnostic Imaging: A Comparative Study with Multidetector CT"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1184"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Journal of Neurology"],["dc.bibliographiccitation.lastpage","1188"],["dc.bibliographiccitation.volume","254"],["dc.contributor.author","von Lewinski, Friederike"],["dc.contributor.author","Werner, Carola"],["dc.contributor.author","Joern, Torsten"],["dc.contributor.author","Mohr, Alexander"],["dc.contributor.author","Sixel-Doering, Friederike"],["dc.contributor.author","Trenkwalder, Claudia"],["dc.date.accessioned","2018-11-07T10:59:09Z"],["dc.date.available","2018-11-07T10:59:09Z"],["dc.date.issued","2007"],["dc.description.abstract","Background Putaminal iron deposition is a histopathological feature of multiple system atrophy (MSA), which is not observed in patients with idiopathic Parkinson's disease (PD). T2 -weighted magnetic resonance imaging (MRI) gradient echo (GE) sequences are sensitive for paramagnetic susceptibility changes and therefore may support the clinical differential diagnosis between MSA and PD. Methods We evaluated putaminal signal intensities on 1.0 Tesla scans of 52 MSA patients, 88 patients with PD and 29 healthy control subjects. Results The typical finding in T2 GE sequences of MSA patients was a signal loss of the dorsolateral putamen, which showed a high specificity (>0.91), but was present in only a subpopulation of patients (sensitivity 0.64-0.69). The combination of the latter with additional presence of a hyperintense lateral rim in fluid attenuated inversion recovery (FLAIR) sequences increased the specificity to 0.97. Using a quantitative evaluation of putaminal signal intensities in defined regions of interest MSA and PD could be discriminated with a diagnostic accuracy (r) of up to 0.82. Conclusion Although the separation of groups remains incomplete, the use of T2 -weighted GE sequences combined with FLAIR may be helpful for the differential diagnosis of MSA versus PD considering its fast application, easy evaluation, broad availability, the specificity of findings and the presence of putaminal signal loss already at early disease stages."],["dc.identifier.doi","10.1007/s00415-006-0496-1"],["dc.identifier.isi","000249893200004"],["dc.identifier.pmid","17361340"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/50633"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Dr Dietrich Steinkopff Verlag"],["dc.relation.issn","0340-5354"],["dc.title","T2 -weighted MRI in diagnosis of multiple system atrophy - A practical approach for clinicians"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1956"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","American Journal of Neuroradiology"],["dc.bibliographiccitation.lastpage","1962"],["dc.bibliographiccitation.volume","32"],["dc.contributor.author","Psychogios, M.-N."],["dc.contributor.author","Wachter, D."],["dc.contributor.author","Mohr, A."],["dc.contributor.author","Schramm, P."],["dc.contributor.author","Frölich, A.-M."],["dc.contributor.author","Jung, K."],["dc.contributor.author","Rohde, V."],["dc.contributor.author","Knauth, M."],["dc.date.accessioned","2021-06-01T10:48:43Z"],["dc.date.available","2021-06-01T10:48:43Z"],["dc.date.issued","2011"],["dc.identifier.doi","10.3174/ajnr.A2611"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/86029"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.relation.eissn","1936-959X"],["dc.relation.issn","0195-6108"],["dc.title","Feasibility of Flat Panel Angiographic CT after Intravenous Contrast Agent Application in the Postoperative Evaluation of Patients with Clipped Aneurysms"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1604"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","Journal of Neurology"],["dc.bibliographiccitation.lastpage","1606"],["dc.bibliographiccitation.volume","254"],["dc.contributor.author","Chan, Andrew"],["dc.contributor.author","Lee, De-Hyung"],["dc.contributor.author","Linker, Ralf"],["dc.contributor.author","Mohr, Alexander"],["dc.contributor.author","Toyka, Klaus V."],["dc.contributor.author","Gold, Ralf"],["dc.date.accessioned","2018-11-07T10:57:12Z"],["dc.date.available","2018-11-07T10:57:12Z"],["dc.date.issued","2007"],["dc.identifier.doi","10.1007/s00415-007-0593-9"],["dc.identifier.isi","000251096000021"],["dc.identifier.pmid","17713826"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/50186"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Dr Dietrich Steinkopff Verlag"],["dc.relation.issn","0340-5354"],["dc.title","Rescue therapy with anti-CD20 treatment in neuroimmunologic breakthrough disease"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.subtype","letter_note"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","112"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","MULTIPLE SCLEROSIS"],["dc.bibliographiccitation.lastpage","115"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Linker, Ralf Andreas"],["dc.contributor.author","Mohr, A."],["dc.contributor.author","Cepek, L."],["dc.contributor.author","Gold, Ralf"],["dc.contributor.author","Prange, Hilmar"],["dc.date.accessioned","2018-11-07T10:24:16Z"],["dc.date.available","2018-11-07T10:24:16Z"],["dc.date.issued","2006"],["dc.description.abstract","Hypothermia is a rare condition in multiple sclerosis (MS). We report on a patient with a long-standing secondary progressive MS and six episodes of recurring hypothermia down to 29.9 degrees C with associated hypotension, bradycardia, coagulopathy and electrolyte dysequilibrium. Magnetic resonance imaging (MRI) demonstrated severe involvement of the corpus callosum with an associated lesion in the right posterior thalamus. These findings may link hypothermia in MS with callosal and associated thalamic pathology to Shapiro's syndrome, where agenesis of the corpus callosum and associated abnormalities are related to episodic spontaneous hypothermia. In MS, hypothermic episodes may be triggered by preceding infections, as shown in the present case."],["dc.identifier.doi","10.1191/135248506ms1268cr"],["dc.identifier.isi","000235338300017"],["dc.identifier.pmid","16459729"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/42624"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Hodder Arnold, Hodder Headline Plc"],["dc.relation.issn","1352-4585"],["dc.title","Core hypothermia in multiple sclerosis: case report with magnetic resonance imaging localization of a thalamic lesion"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]