Brelie, Christian von der

[["dc.bibliographiccitation.artnumber","395"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Journal of Experimental & Clinical Cancer Research"],["dc.bibliographiccitation.volume","40"],["dc.contributor.author","Menck, Kerstin"],["dc.contributor.author","Heinrichs, Saskia"],["dc.contributor.author","Wlochowitz, Darius"],["dc.contributor.author","Sitte, Maren"],["dc.contributor.author","Noeding, Helen"],["dc.contributor.author","Janshoff, Andreas"],["dc.contributor.author","Treiber, Hannes"],["dc.contributor.author","Ruhwedel, Torben"],["dc.contributor.author","Schatlo, Bawarjan"],["dc.contributor.author","von der Brelie, Christian"],["dc.contributor.author","Wiemann, Stefan"],["dc.contributor.author","Pukrop, Tobias"],["dc.contributor.author","Beißbarth, Tim"],["dc.contributor.author","Binder, Claudia"],["dc.contributor.author","Bleckmann, Annalen"],["dc.date.accessioned","2022-02-01T10:31:31Z"],["dc.date.accessioned","2022-08-18T12:32:54Z"],["dc.date.available","2022-02-01T10:31:31Z"],["dc.date.available","2022-08-18T12:32:54Z"],["dc.date.issued","2021-12-15"],["dc.date.updated","2022-07-29T12:18:08Z"],["dc.description.abstract","Abstract\r\n \r\n Background\r\n Breast cancer has been associated with activation of the WNT signaling pathway, although no driver mutations in WNT genes have been found yet. Instead, a high expression of the alternative WNT receptor ROR2 was observed, in particular in breast cancer brain metastases. However, its respective ligand and downstream signaling in this context remained unknown.\r\n \r\n \r\n Methods\r\n We modulated the expression of ROR2 in human breast cancer cells and characterized their gene and protein expression by RNA-Seq, qRT-PCR, immunoblots and reverse phase protein array (RPPA) combined with network analyses to understand the molecular basis of ROR2 signaling in breast cancer. Using co-immunoprecipitations, we verified the interaction of ROR2 with the identified ligand, WNT11. The functional consequences of WNT11/ROR2 signaling for tumor cell aggressiveness were assessed by microscopy, impedance sensing as well as viability and invasion assays. To evaluate the translational significance of our findings, we performed gene set enrichment, expression and survival analyses on human breast cancer brain metastases.\r\n \r\n \r\n Results\r\n We found ROR2 to be highly expressed in aggressive breast tumors and associated with worse metastasis-free survival. ROR2 overexpression induced a BRCAness-like phenotype in a cell-context specific manner and rendered cells resistant to PARP inhibition. High levels of ROR2 were furthermore associated with defects in cell morphology and cell-cell-contacts leading to increased tumor invasiveness. On a molecular level, ROR2 overexpression upregulated several non-canonical WNT ligands, in particular WNT11. Co-immunoprecipitation confirmed that WNT11 indeed interacts with the cysteine-rich domain of ROR2 and triggers its invasion-promoting signaling via RHO/ROCK. Knockdown of WNT11 reversed the pro-invasive phenotype and the cellular changes in ROR2-overexpressing cells.\r\n \r\n \r\n Conclusions\r\n Taken together, our study revealed a novel auto-stimulatory loop in which ROR2 triggers the expression of its own ligand, WNT11, resulting in enhanced tumor invasion associated with breast cancer metastasis."],["dc.identifier.citation","Journal of Experimental & Clinical Cancer Research. 2021 Dec 15;40(1):395"],["dc.identifier.doi","10.1186/s13046-021-02187-z"],["dc.identifier.pii","2187"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/98882"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/112913"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-517"],["dc.publisher","BioMed Central"],["dc.relation.eissn","1756-9966"],["dc.rights.holder","The Author(s)"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.subject","Breast cancer"],["dc.subject","Metastasis"],["dc.subject","ROR2"],["dc.subject","WNT11"],["dc.subject","BRCAness"],["dc.subject","Network analysis"],["dc.title","WNT11/ROR2 signaling is associated with tumor invasion and poor survival in breast cancer"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","5410"],["dc.bibliographiccitation.issue","21"],["dc.bibliographiccitation.journal","Cancers"],["dc.bibliographiccitation.volume","14"],["dc.contributor.affiliation","Fröhlich, Ellen; 1Department of Neurosurgery, University of Ulm, 89312 Günzburg, Germany"],["dc.contributor.affiliation","Sassenrath, Claudia; 2Department of Social Psychology, Institute of Psychology and Education, Faculty of Engering, Informatics and Psychology, University of Ulm, 89312 Günzburg, Germany"],["dc.contributor.affiliation","Nadji-Ohl, Minou; 3Department of Neurosurgery, Klinikum Stuttgart, 70174 Stuttgart, Germany"],["dc.contributor.affiliation","Unteroberdörster, Meike; 4Department of Neurosurgery, Charité—Universitätsmedizin Berlin, 12200 Berlin, Germany"],["dc.contributor.affiliation","Rückriegel, Stefan; 5Department of Neurosurgery, University of Würzburg, 97080 Würzburg, Germany"],["dc.contributor.affiliation","von der Brelie, Christian; 6Department of Neurosurgery, Johanniter—Kliniken Bonn, 53177 Bonn, Germany"],["dc.contributor.affiliation","Roder, Constantin; 7Department of Neurosurgery, University of Tübingen, 72076 Tübingen, Germany"],["dc.contributor.affiliation","Forster, Marie-Therese; 8Department of Neurosurgery, University of Frankfurt, 60528 Frankfurt am Main, Germany"],["dc.contributor.affiliation","Schommer, Stephan; 2Department of Social Psychology, Institute of Psychology and Education, Faculty of Engering, Informatics and Psychology, University of Ulm, 89312 Günzburg, Germany"],["dc.contributor.affiliation","Löhr, Mario; 4Department of Neurosurgery, Charité—Universitätsmedizin Berlin, 12200 Berlin, Germany"],["dc.contributor.affiliation","Pala, Andrej; 1Department of Neurosurgery, University of Ulm, 89312 Günzburg, Germany"],["dc.contributor.affiliation","Goebel, Simone; 9Department of Psychology, University of Kiel, 24118 Kiel, Germany"],["dc.contributor.affiliation","Mielke, Dorothee; 10Department of Neurosurgery, University of Göttingen, 37075 Göttingen, Germany"],["dc.contributor.affiliation","Gerlach, Rüdiger; 11Department of Neurosurgery, Helioskliniken Erfurt, 99089 Erfurt, Germany"],["dc.contributor.affiliation","Renovanz, Mirjam; 7Department of Neurosurgery, University of Tübingen, 72076 Tübingen, Germany"],["dc.contributor.affiliation","Wirtz, Christian Rainer; 1Department of Neurosurgery, University of Ulm, 89312 Günzburg, Germany"],["dc.contributor.affiliation","Onken, Julia; 4Department of Neurosurgery, Charité—Universitätsmedizin Berlin, 12200 Berlin, Germany"],["dc.contributor.affiliation","Czabanka, Marcus; 8Department of Neurosurgery, University of Frankfurt, 60528 Frankfurt am Main, Germany"],["dc.contributor.affiliation","Tatagiba, Marcos Soares; 7Department of Neurosurgery, University of Tübingen, 72076 Tübingen, Germany"],["dc.contributor.affiliation","Rohde, Veit; 11Department of Neurosurgery, Helioskliniken Erfurt, 99089 Erfurt, Germany"],["dc.contributor.affiliation","Ernestus, Ralf-Ingo; 5Department of Neurosurgery, University of Würzburg, 97080 Würzburg, Germany"],["dc.contributor.affiliation","Vajkoczy, Peter; 4Department of Neurosurgery, Charité—Universitätsmedizin Berlin, 12200 Berlin, Germany"],["dc.contributor.affiliation","Gansland, Oliver; 3Department of Neurosurgery, Klinikum Stuttgart, 70174 Stuttgart, Germany"],["dc.contributor.affiliation","Coburger, Jan; 1Department of Neurosurgery, University of Ulm, 89312 Günzburg, Germany"],["dc.contributor.author","Fröhlich, Ellen"],["dc.contributor.author","Sassenrath, Claudia"],["dc.contributor.author","Nadji-Ohl, Minou"],["dc.contributor.author","Unteroberdörster, Meike"],["dc.contributor.author","Rückriegel, Stefan"],["dc.contributor.author","von der Brelie, Christian"],["dc.contributor.author","Roder, Constantin"],["dc.contributor.author","Forster, Marie-Therese"],["dc.contributor.author","Schommer, Stephan"],["dc.contributor.author","Löhr, Mario"],["dc.contributor.author","Pala, Andrej"],["dc.contributor.author","Goebel, Simone"],["dc.contributor.author","Mielke, Dorothee"],["dc.contributor.author","Gerlach, Rüdiger"],["dc.contributor.author","Renovanz, Mirjam"],["dc.contributor.author","Wirtz, Christian Rainer"],["dc.contributor.author","Onken, Julia"],["dc.contributor.author","Czabanka, Marcus"],["dc.contributor.author","Tatagiba, Marcos Soares"],["dc.contributor.author","Rohde, Veit"],["dc.contributor.author","Ernestus, Ralf-Ingo"],["dc.contributor.author","Vajkoczy, Peter"],["dc.contributor.author","Gansland, Oliver"],["dc.contributor.author","Coburger, Jan"],["dc.date.accessioned","2022-12-07T15:46:16Z"],["dc.date.available","2022-12-07T15:46:16Z"],["dc.date.issued","2022-11-02"],["dc.date.updated","2022-12-07T10:28:36Z"],["dc.description.abstract","Simple Summary\r\n Current data show that resilience is an important factor in cancer patients’ well-being. We explored the resilience of patients with lower grade glioma (LGG) and the potentially influencing factors. Our data indicate that stigmatization and the functional status are significantly associated with the patients’ resilience. These factors should be identified and targeted therapeutically in clinical routines.\r\n \r\n \r\n Abstract\r\n Current data show that resilience is an important factor in cancer patients’ well-being. We aim to explore the resilience of patients with lower grade glioma (LGG) and the potentially influencing factors. We performed a cross-sectional assessment of adult patients with LGG who were enrolled in the LoG-Glio registry. By phone interview, we administered the following measures: Resilience Scale (RS-13), distress thermometer, Montreal Cognitive Assessment Test for visually impaired patients (MoCA-Blind), internalized stigmatization by brain tumor (ISBI), Eastern Cooperative Oncological Group performance status (ECOG), patients’ perspective questionnaire (PPQ) and typical clinical parameters. We calculated correlations and multivariate regression models. Of 74 patients who were assessed, 38% of those showed a low level of resilience. Our results revealed significant correlations of resilience with distress (p < 0.001, −0.49), MOCA (p = 0.003, 0.342), ECOG (p < 0.001, −0.602), stigmatization (p < 0.001, −0.558), pain (p < 0.001, −0.524), and occupation (p = 0.007, 0.329). In multivariate analyses, resilience was negatively associated with elevated ECOG (p = 0.020, β = −0.383) and stigmatization levels (p = 0.008, β = −0.350). Occupation showed a tendency towards a significant association with resilience (p = 0.088, β = −0.254). Overall, low resilience affected more than one third of our cohort. Low functional status is a specific risk factor for low resilience. The relevant influence of stigmatization on resilience is a novel finding for patients suffering from a glioma and should be routinely identified and targeted in clinical routine."],["dc.identifier.doi","10.3390/cancers14215410"],["dc.identifier.pii","cancers14215410"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/118467"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-621"],["dc.relation.eissn","2072-6694"],["dc.rights","CC BY 4.0"],["dc.title","Resilience in Lower Grade Glioma Patients"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","101639"],["dc.bibliographiccitation.journal","NeuroImage Clinical"],["dc.bibliographiccitation.volume","21"],["dc.contributor.author","Maier, Ilko L."],["dc.contributor.author","Hofer, Sabine"],["dc.contributor.author","Joseph, Arun A."],["dc.contributor.author","Merboldt, K.-Dietmar"],["dc.contributor.author","Eggert, Eva"],["dc.contributor.author","Behme, Daniel"],["dc.contributor.author","Schregel, Katharina"],["dc.contributor.author","Brelie, Christian von der"],["dc.contributor.author","Rohde, Veit"],["dc.contributor.author","Koch, Jan-Christoph"],["dc.contributor.author","Psychogios, Marios-Nikos"],["dc.contributor.author","Frahm, Jens"],["dc.contributor.author","Liman, Jan"],["dc.contributor.author","Bähr, Mathias"],["dc.date.accessioned","2019-07-09T11:50:09Z"],["dc.date.available","2019-07-09T11:50:09Z"],["dc.date.issued","2019"],["dc.description.abstract","BACKGROUND: Degenerative changes of the cervical spinal column are the most common cause of spinal cord lesions in the elderly. Conventional clinical, electrophysiological and radiological diagnostics of spinal cord compression are often inconsistent. MATERIALS AND METHODS: The feasibility and diagnostic potential of a novel T1 mapping method at 0.5 mm resolution and 4 s acquisition time was evaluated in 14 patients with degenerative cervical spinal canal stenosis (SCS) and 6 healthy controls. T1 mapping was performed in axial sections of the stenosis as well as above and below. All subjects received standard T2-weighted MRI of the cervical spine (including SCS-grading 0-III), electrophysiological and clinical examinations. RESULTS: Patients revealed significantly decreased T1 relaxation times of the compressed spinal cord within the SCS (912 ± 53 ms, mean ± standard deviation) in comparison to unaffected segments above (1027 ± 39 ms, p < .001) and below (1056 ± 93 ms, p < .001). There was no difference in mean T1 in unaffected segments in patients (p = .712) or between segments in controls (p = .443). Moreover, T1 values were significantly lower in grade II (881 ± 46 ms, p = .005) than in grade I SCS (954 ± 29 ms). Patients with central conduction deficit tended to have lower T1 values within the SCS than patients without (909 ± 50 ms vs 968 ± 7 ms, p = .069). CONCLUSION: Rapid high-resolution T1 mapping is a robust MRI method for quantifying spinal cord compression in patients with cervical SCS. It promises additional diagnostic insights and warrants more extended patient studies."],["dc.identifier.doi","10.1016/j.nicl.2018.101639"],["dc.identifier.pmid","30553763"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/15872"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/59713"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","2213-1582"],["dc.rights","CC BY-ND 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nd/4.0"],["dc.subject.ddc","610"],["dc.title","Quantification of spinal cord compression using T1 mapping in patients with cervical spinal canal stenosis - Preliminary experience"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]