Frauendorf, Holm

[["dc.bibliographiccitation.issue","58"],["dc.bibliographiccitation.journal","Chemical Communications"],["dc.bibliographiccitation.volume","51"],["dc.contributor.author","Hörner, Sebastian"],["dc.contributor.author","Uth, Christina"],["dc.contributor.author","Avrutina, Olga"],["dc.contributor.author","Frauendorf, Holm"],["dc.contributor.author","Wiessler, M."],["dc.contributor.author","Kolmar, Harald"],["dc.date.accessioned","2018-11-07T10:03:08Z"],["dc.date.available","2018-11-07T10:03:08Z"],["dc.date.issued","2015"],["dc.identifier.doi","10.1039/c5cc90302e"],["dc.identifier.isi","000357618200047"],["dc.identifier.pmid","26123240"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/38389"],["dc.language.iso","en"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.relation.eissn","1359-7345"],["dc.relation.issn","1364-548X"],["dc.title","Combination of inverse electron-demand Diels-Alder reaction with highly efficient oxime ligation expands the toolbox of site-selective peptide conjugations (vol 51, pg 11130, 2015)"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","11130"],["dc.bibliographiccitation.issue","55"],["dc.bibliographiccitation.journal","Chemical Communications"],["dc.bibliographiccitation.lastpage","11133"],["dc.bibliographiccitation.volume","51"],["dc.contributor.author","Hoerner, Sebastian"],["dc.contributor.author","Uth, Christina"],["dc.contributor.author","Avrutina, Olga"],["dc.contributor.author","Frauendorf, Holm"],["dc.contributor.author","Wiessler, M."],["dc.contributor.author","Kolmar, Harald"],["dc.date.accessioned","2018-11-07T10:03:09Z"],["dc.date.available","2018-11-07T10:03:09Z"],["dc.date.issued","2015"],["dc.description.abstract","A modular approach combining inverse electron-demand Diels-Alder coupling (DAR(inv)) and oxime ligation expands the toolbox of bioorthogonal peptide chemistry. Applicability of versatile site-specific bifunctional building blocks is demonstrated by generation of defined conjugates comprising linear, cystine-bridged and multi-disulfide functional peptides as well as their conjugation with hybrid silsesquioxane nanoparticles."],["dc.description.sponsorship","DFG priority program [SPP 1623]"],["dc.identifier.doi","10.1039/c5cc03434e"],["dc.identifier.isi","000356934500035"],["dc.identifier.pmid","26074398"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/38393"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Royal Soc Chemistry"],["dc.relation.issn","1364-548X"],["dc.relation.issn","1359-7345"],["dc.title","Combination of inverse electron-demand Diels-Alder reaction with highly efficient oxime ligation expands the toolbox of site-selective peptide conjugations"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","33"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","ChemBioChem"],["dc.bibliographiccitation.lastpage","37"],["dc.bibliographiccitation.volume","9"],["dc.contributor.author","Avrutina, Olga"],["dc.contributor.author","Schmoldt, Hans-Ulrich"],["dc.contributor.author","Gabrijelcic-Geiger, Dusica"],["dc.contributor.author","Wentzel, Alexander"],["dc.contributor.author","Frauendorf, Holm"],["dc.contributor.author","Sommerhoff, Christian P."],["dc.contributor.author","Diederichsen, Ulf"],["dc.contributor.author","Kolmar, Harald"],["dc.date.accessioned","2018-11-07T11:19:11Z"],["dc.date.available","2018-11-07T11:19:11Z"],["dc.date.issued","2008"],["dc.identifier.doi","10.1002/cbic.200700452"],["dc.identifier.isi","000252292200005"],["dc.identifier.pmid","18058774"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/55212"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-v C H Verlag Gmbh"],["dc.relation.issn","1439-4227"],["dc.title","Head-to-tail cyclized cystine-knot peptides by a combined recombinant and chemical route of synthesis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","4177"],["dc.bibliographiccitation.issue","20"],["dc.bibliographiccitation.journal","Organic & Biomolecular Chemistry"],["dc.bibliographiccitation.lastpage","4185"],["dc.bibliographiccitation.volume","7"],["dc.contributor.author","Avrutina, Olga"],["dc.contributor.author","Empting, Martin"],["dc.contributor.author","Fabritz, Sebastian"],["dc.contributor.author","Daneschdar, Matin"],["dc.contributor.author","Frauendorf, Holm"],["dc.contributor.author","Diederichsen, Ulf"],["dc.contributor.author","Kolmar, Harald"],["dc.date.accessioned","2018-11-07T08:35:17Z"],["dc.date.available","2018-11-07T08:35:17Z"],["dc.date.issued","2009"],["dc.description.abstract","Here we describe the facile generation of tetravalent peptide conjugates via a copper(I) catalyzed azide-alkyne cycloaddition (CuAAC) using a cyclic peptide template as a versatile conjugation scaffold. This stable and rigid framework is a conformationally constrained cyclic beta-sheet decorated with spatially defined alkyne moieties that serve as selectively addressable coupling sites. The proposed method allows for the effective coupling of unprotected peptide monomers in water at room temperature within comparatively short reaction times. The resulting conjugates display the ligands in an oriented manner, thus allowing for multivalent interactions with given target molecules, which may contribute to enhanced affinity and specificity. In addition, the selected scaffold offers an orthogonal coupling site for the incorporation of fluorescent labels or radioligands."],["dc.description.sponsorship","Deutsche Forschungsgemeinschaft [KO 1390/9-1]; BMBF"],["dc.identifier.doi","10.1039/b908261a"],["dc.identifier.isi","000270320300007"],["dc.identifier.pmid","19795056"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/18028"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Royal Soc Chemistry"],["dc.relation.issn","1477-0520"],["dc.title","Application of copper(I) catalyzed azide-alkyne [3+2] cycloaddition to the synthesis of template-assembled multivalent peptide conjugates"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","14842"],["dc.bibliographiccitation.issue","47"],["dc.bibliographiccitation.journal","Angewandte Chemie International Edition"],["dc.bibliographiccitation.lastpage","14846"],["dc.bibliographiccitation.volume","55"],["dc.contributor.author","Hörner, Sebastian"],["dc.contributor.author","Knauer, Sascha"],["dc.contributor.author","Uth, Christina"],["dc.contributor.author","Joest, Marina"],["dc.contributor.author","Schmidts, Volker"],["dc.contributor.author","Frauendorf, Holm"],["dc.contributor.author","Thiele, Christina Marie"],["dc.contributor.author","Avrutina, Olga"],["dc.contributor.author","Kolmar, Harald"],["dc.date.accessioned","2018-11-07T10:05:48Z"],["dc.date.available","2018-11-07T10:05:48Z"],["dc.date.issued","2016"],["dc.description.abstract","We report a comprehensive study on novel, highly efficient, and biodegradable hybrid molecular transporters. To this end, we designed a series of cell-penetrating, cube-octameric silsesquioxanes (COSS), and investigated cellular uptake by confocal microscopy and flow cytometry. A COSS with dense spatial arrangement of guanidinium groups displayed fast uptake kinetics and cell permeation at nanomolar concentrations in living HeLa cells. Efficient uptake was also observed in bacteria, yeasts, and archaea. The COSS-based carrier was significantly more potent than cell-penetrating peptides (CPPs) and displayed low toxicity. It efficiently delivered a covalently attached cytotoxic drug, doxorubicin, to living tumor cells. As the uptake of fluorescently labeled carrier remained in the presence of serum, the system could be considered particularly attractive for the in vivo delivery of therapeutics."],["dc.identifier.doi","10.1002/anie.201606065"],["dc.identifier.isi","000388252700066"],["dc.identifier.pmid","27774725"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/38972"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.relation.issn","1521-3773"],["dc.relation.issn","1433-7851"],["dc.title","Nanoscale Biodegradable Organic-Inorganic Hybrids for Efficient Cell Penetration and Drug Delivery"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","13420"],["dc.bibliographiccitation.issue","45"],["dc.bibliographiccitation.journal","Angewandte Chemie International Edition"],["dc.bibliographiccitation.lastpage","13424"],["dc.bibliographiccitation.volume","54"],["dc.contributor.author","Siegmund, Vanessa"],["dc.contributor.author","Schmelz, Stefan"],["dc.contributor.author","Dickgiesser, Stephan"],["dc.contributor.author","Beck, Jan"],["dc.contributor.author","Ebenig, Aileen"],["dc.contributor.author","Fittler, Heiko"],["dc.contributor.author","Frauendorf, Holm"],["dc.contributor.author","Piater, Birgit"],["dc.contributor.author","Betz, Ulrich A. K."],["dc.contributor.author","Avrutina, Olga"],["dc.contributor.author","Scrima, Andrea"],["dc.contributor.author","Fuchsbauer, Hans-Lothar"],["dc.contributor.author","Kolmar, Harald"],["dc.date.accessioned","2018-11-07T09:49:07Z"],["dc.date.available","2018-11-07T09:49:07Z"],["dc.date.issued","2015"],["dc.description.abstract","Based on the crystal structure of a natural protein substrate for microbial transglutaminase, an enzyme that catalyzes protein crosslinking, a recognition motif for site-specific conjugation was rationally designed. Conformationally locked by an intramolecular disulfide bond, this structural mimic of a native conjugation site ensured efficient conjugation of a reporter cargo to the therapeutic monoclonal antibody cetuximab without erosion of its binding properties."],["dc.identifier.doi","10.1002/anie.201504851"],["dc.identifier.isi","000363691500050"],["dc.identifier.pmid","26367875"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/35442"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-v C H Verlag Gmbh"],["dc.relation.issn","1521-3773"],["dc.relation.issn","1433-7851"],["dc.title","Locked by Design: A Conformationally Constrained Transglutaminase Tag Enables Efficient Site-Specific Conjugation"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2212"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Organic & Biomolecular Chemistry"],["dc.bibliographiccitation.lastpage","2218"],["dc.bibliographiccitation.volume","8"],["dc.contributor.author","Fabritz, Sebastian"],["dc.contributor.author","Heyl, Dirk"],["dc.contributor.author","Bagutski, Viktor"],["dc.contributor.author","Empting, Martin"],["dc.contributor.author","Rikowski, Eckhard"],["dc.contributor.author","Frauendorf, Holm"],["dc.contributor.author","Balog, Ildiko"],["dc.contributor.author","Fessner, Wolf-Dieter"],["dc.contributor.author","Schneider, Joerg. J."],["dc.contributor.author","Avrutina, Olga"],["dc.contributor.author","Kolmar, Harald"],["dc.date.accessioned","2018-11-07T08:48:20Z"],["dc.date.available","2018-11-07T08:48:20Z"],["dc.date.issued","2010"],["dc.description.abstract","Cube-octameric silsesquioxane (POSS) based conjugation scaffolds for copper catalysed azide-alkyne [3+2] cycloaddition are reported. The synthetic route to octaazido and octaalkyno functionalised POSS templates without cage rearrangements is described. A set of click couplings is conducted including the first effective conjugation with a fully unprotected functional peptide towards a POSS assembled peptide octamer."],["dc.description.sponsorship","Deutsche Forschungsgemeinschaft [KO 1390/9-1]; BMBF"],["dc.identifier.doi","10.1039/b923393h"],["dc.identifier.isi","000276786000028"],["dc.identifier.pmid","20401398"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/21179"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Royal Soc Chemistry"],["dc.relation.issn","1477-0520"],["dc.title","Towards click bioconjugations on cube-octameric silsesquioxane scaffolds"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]