Jung, Klaus

[["dc.bibliographiccitation.firstpage","574"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","American Journal of Orthodontics and Dentofacial Orthopedics"],["dc.bibliographiccitation.lastpage","582"],["dc.bibliographiccitation.volume","141"],["dc.contributor.author","Knoesel, Michael"],["dc.contributor.author","Bojes, Mariana"],["dc.contributor.author","Jung, Klaus"],["dc.contributor.author","Ziebolz, Dirk"],["dc.date.accessioned","2018-11-07T09:10:45Z"],["dc.date.available","2018-11-07T09:10:45Z"],["dc.date.issued","2012"],["dc.description.abstract","Introduction: There is a paucity of information with regard to the susceptibility of iatrogenic white spot lesion formation after inattentive, surplus orthodontic etching with 30% phosphoric acid and the subsequent provision or absence of adequate oral hygiene. Methods: Ninety sound enamel specimens were randomly allocated to 6 trial groups (n = 15 each) for etching with 30% phosphoric acid for either 15 seconds and standardized daily enamel brushing or no brushing, etching for 30 seconds with daily brushing or no brushing, or nonetched controls with brushing or no brushing. Nutritive acidic assaults were simulated by demineralization cycles 3 times per day for 1 hour with interim storage in artificial saliva. Lesion depths in terms of percentage of fluorescence loss (delta F, delta Q) and lesion extension compared with the baseline were assessed by using quantitative light-induced fluorescence after 2, 7, 14, 21, and 42 days. Etching duration, trial time elapse, and oral hygiene, as well as the significance of factor interactions, were analyzed with 3-way analysis of variance (alpha - 5%). Results: The impact of the factors of enamel brushing, trial time elapse, and etching each had a comparably significant effect on lesion progression. The effect of surplus etching on white spot lesion formation was significantly enhanced by the simultaneous absence of enamel brushing and also the progression of trial time. The combination of 30 seconds of surplus etching with inadequate oral hygiene was especially detrimental. Conclusions: Excessive surplus orthodontic etching of the complete labial enamel surface, instead of the bracket bases only, must be avoided to prevent iatrogenic white spot lesions. Etching times not exceeding 15 seconds are favorable. (Am J Orthod Dentofacial Orthop 2012;141:574-82)"],["dc.identifier.doi","10.1016/j.ajodo.2011.11.017"],["dc.identifier.isi","000303606100019"],["dc.identifier.pmid","22554751"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/26563"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Mosby-elsevier"],["dc.relation.issn","0889-5406"],["dc.title","Increased susceptibility for white spot lesions by surplus orthodontic etching exceeding bracket base area"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","9"],["dc.bibliographiccitation.lastpage","100"],["dc.contributor.author","Leha, Andreas"],["dc.contributor.author","Jung, Klaus"],["dc.contributor.author","Beißbarth, Tim"],["dc.date.accessioned","2020-04-02T10:43:45Z"],["dc.date.available","2020-04-02T10:43:45Z"],["dc.date.issued","2013"],["dc.identifier.doi","10.4230/OASIcs.GCB.2013.90"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/63516"],["dc.relation.eisbn","978-3-939897-59-0"],["dc.relation.eventlocation","Dagstuhl"],["dc.relation.eventstart","2013"],["dc.relation.ispartof","German Conference on Bioinformatics 2013"],["dc.title","Utilization of ordinal response structures in classification with high-dimensional expression data"],["dc.type","conference_paper"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","900"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Leukemia Research"],["dc.bibliographiccitation.lastpage","906"],["dc.bibliographiccitation.volume","37"],["dc.contributor.author","Braulke, Friederike"],["dc.contributor.author","Jung, Klaus"],["dc.contributor.author","Schanz, Julie"],["dc.contributor.author","Götze, Katharina S."],["dc.contributor.author","Müller-Thomas, Catharina"],["dc.contributor.author","Platzbecker, Uwe"],["dc.contributor.author","Germing, Ulrich"],["dc.contributor.author","Brümmendorf, Tim H."],["dc.contributor.author","Bug, Gesine"],["dc.contributor.author","Ottmann, Oliver G."],["dc.contributor.author","Giagounidis, Aristoteles A. N."],["dc.contributor.author","Stadler, Michael"],["dc.contributor.author","Hofmann, Wolf-Karsten"],["dc.contributor.author","Schafhausen, Philippe"],["dc.contributor.author","Lübbert, Michael"],["dc.contributor.author","Schlenk, Richard F."],["dc.contributor.author","Blau, Igor W."],["dc.contributor.author","Ganster, Christina"],["dc.contributor.author","Pfeiffer, Sebastian"],["dc.contributor.author","Shirneshan, Katayoon"],["dc.contributor.author","Metz, Michael"],["dc.contributor.author","Detken, Sven"],["dc.contributor.author","Seraphin, Jörg"],["dc.contributor.author","Jentsch-Ullrich, Kathleen"],["dc.contributor.author","Böhme, Angelika"],["dc.contributor.author","Schmidt, Burkhard C."],["dc.contributor.author","Trümper, Lorenz"],["dc.contributor.author","Haase, Detlef"],["dc.date.accessioned","2018-11-07T09:22:10Z"],["dc.date.available","2018-11-07T09:22:10Z"],["dc.date.issued","2013"],["dc.description.abstract","The gold standard of cytogenetic analysis in myelodysplastic syndromes (MDS) is conventional chromosome banding (CCB) analysis of bone marrow (BM) metaphases. Most aberrations can also be detected by fluorescence-in situ-hybridization (FISH). For this prospective multicenter German diagnostic study (www.clinicaltrials.gov: #NCT01355913) 360 patients, as yet, were followed up to 3 years by sequential FISH analyses of immunomagnetically enriched CD34+ peripheral blood (PB) cells using comprehensive FISH probe panels, resulting in a total number of 19,516 FISH analyses. We demonstrate that CD34+ PB FISH correlates significantly with CCB analysis and represents a feasible method for a reliable non-invasive cytogenetic monitoring from PB. (C) 2013 Elsevier Ltd. All rights reserved."],["dc.description.sponsorship","Celgene(R) Germany"],["dc.identifier.doi","10.1016/j.leukres.2013.03.019"],["dc.identifier.isi","000321111900012"],["dc.identifier.pmid","23623559"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/29278"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.notes.submitter","Najko"],["dc.relation.issn","0145-2126"],["dc.title","Molecular cytogenetic monitoring from CD34+peripheral blood cells in myelodysplastic syndromes: First results from a prospective multicenter German diagnostic study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","3"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Allergologie"],["dc.bibliographiccitation.lastpage","+"],["dc.bibliographiccitation.volume","33"],["dc.contributor.author","Kleine-Tebbe, Joerg"],["dc.contributor.author","Bufe, Albrecht"],["dc.contributor.author","Ebner, C."],["dc.contributor.author","Eigenmann, P."],["dc.contributor.author","Friedrichs, F."],["dc.contributor.author","Fuchs, Tina"],["dc.contributor.author","Huttegger, Isidor"],["dc.contributor.author","Jung, K."],["dc.contributor.author","Klimek, L."],["dc.contributor.author","Kopp, M."],["dc.contributor.author","Laessig, W."],["dc.contributor.author","Merk, Hans F"],["dc.contributor.author","Niggemann, B."],["dc.contributor.author","Rabe, U."],["dc.contributor.author","Saloga, Joachim"],["dc.contributor.author","Schmid-Grendelmeier, P."],["dc.contributor.author","Sitter, H."],["dc.contributor.author","Virchow, J. C."],["dc.contributor.author","Wagenmann, M."],["dc.contributor.author","Wedi, Bettina"],["dc.contributor.author","Worm, Margitta"],["dc.contributor.author","Hering, Thomas"],["dc.contributor.author","Koch, A."],["dc.contributor.author","Lenders, H."],["dc.contributor.author","Muesken, H."],["dc.contributor.author","Schnitzer, Stefan A."],["dc.contributor.author","Stuck, B. A."],["dc.contributor.author","Voigtmann, I."],["dc.contributor.author","Wehrmann, W."],["dc.contributor.author","Kaul, S."],["dc.contributor.author","Luther, B."],["dc.contributor.author","Schwalfenberg, A."],["dc.date.accessioned","2018-11-07T08:46:53Z"],["dc.date.available","2018-11-07T08:46:53Z"],["dc.date.issued","2010"],["dc.identifier.isi","000274075300002"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/20807"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Dustri-verlag Dr Karl Feistle"],["dc.relation.issn","0344-5062"],["dc.title","Specific immunotherapy (hyposensitization) for IgE-mediated allergic diseases"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","76"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","DMW - Deutsche Medizinische Wochenschrift"],["dc.bibliographiccitation.lastpage","81"],["dc.bibliographiccitation.volume","136"],["dc.contributor.author","Bramlage, Carsten Paul"],["dc.contributor.author","Cuneo, A."],["dc.contributor.author","Haertel, D."],["dc.contributor.author","Jung, K."],["dc.contributor.author","Witteck, C.-H."],["dc.contributor.author","Hoegel, R."],["dc.contributor.author","Mueller, Georg Anton"],["dc.contributor.author","Bramlage, Peter"],["dc.contributor.author","Tebbe, Ulrich"],["dc.date.accessioned","2018-11-07T09:01:06Z"],["dc.date.available","2018-11-07T09:01:06Z"],["dc.date.issued","2011"],["dc.description.abstract","Background and objective: Angioplasty in patients with renal artery stenosis aims at reducing blood pressure and at improving kidney function. Its efficacy has however been questioned by recent published data. It was the aim of this retrospective study to compare angioplasty with medical treatment in an unselected patient population. Methods: Data on 109 patients were retrospectively anlysed. This cohort included all those patients admitted to the Lippe-Detmold Hospital between 1992 and 2008 for renal artery stenosis. The data included blood pressure, creatinine-based calculated glomerular filtration rate (cGFR), any renal dialysis, cardiovascular risk factors, events and survival time after transluminal renal angioplasty or drug treatment, respectively. Results: Patients who had undergone angioplasty were younger (p = 0.04), had less cardiovascular co-morbidity (p < 0.01), but a higher degree of stenosis (p < 0.01). After a median follow-up of 32.5 (angioplasty) and 36.0 months (drug treatment), respectively, a significant decrease of cGFR was recorded in drug treated patients (- 16.2 ml/min, 95%, CI - 25.7 to - 6.7) but not in the angioplasty group (- 4.5 ml/min, 95%, CI - 13.5 to 4.5). There were no other significant differences were not observed. Conclusion: Younger patients with a high degree of renal artery stenosis but without generalized atherosclerosis more frequently underwent angioplasty in clinical practice. The smaller post-angioplasty reduction in the loss of renal function in this group needs to be validated in a prospective, randomized study."],["dc.identifier.doi","10.1055/s-0030-1269442"],["dc.identifier.isi","000286135500002"],["dc.identifier.pmid","21225553"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/24334"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Georg Thieme Verlag Kg"],["dc.relation.issn","0012-0472"],["dc.title","Renal artery stenosis: angioplasty or drug treatment?"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1467"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","International Journal of Radiation Oncology*Biology*Physics"],["dc.bibliographiccitation.lastpage","1478"],["dc.bibliographiccitation.volume","79"],["dc.contributor.author","Wolff, Hendrik Andreas"],["dc.contributor.author","Raus, Ismene"],["dc.contributor.author","Jung, Klaus"],["dc.contributor.author","Schueler, Phillip"],["dc.contributor.author","Herrmann, Markus Karl"],["dc.contributor.author","Hennies, Steffen"],["dc.contributor.author","Vorwerk, Hilke"],["dc.contributor.author","Hille, Andrea"],["dc.contributor.author","Hess, Clemens Friedrich"],["dc.contributor.author","Christiansen, Hans"],["dc.date.accessioned","2018-11-07T08:57:35Z"],["dc.date.available","2018-11-07T08:57:35Z"],["dc.date.issued","2011"],["dc.description.abstract","Purpose: To test for a possible correlation between high-grade acute organ toxicity during primary radiochemo-therapy and treatment outcome for patients with anal carcinoma. Methods and Materials: From 1991 to 2009, 72 patients with anal carcinoma were treated at our department (10 patients had stage I, 28 patients had stage II, 11 patients had stage IIIA, and 13 patients had stage IIIB cancer [Union Internationale Contre le Cancer criteria]). All patients received normofractionated (1.8 Gy/day, five times/week) whole-pelvis irradiation including iliac and inguinal lymph nodes with a cumulative dose of 50.4 Gy. Concomitant chemotherapy regimen consisted of two cycles of 5-fluorouracil (1,000 mg/m(2)total body surface area (TBSA)/day as continuous intravenous infusion on days 1-4 and 29-32) and mitomycin C (10 mg/m(2)/TBSA, intravenously on days 1 and 29). Toxicity during treatment was monitored weekly, and any incidence of Common Toxicity Criteria (CTC) grade of for skin reaction, cystitis, proctitis, or enteritis was assessed as high-grade acute organ toxicity for later analysis. Results: We found significant correlation between high-grade acute organ toxicity and overall survival, locoregional control, and stoma-free survival, which was independent in multivariate analysis from other possible prognostic factors: patients with a CTC acute organ toxicity grade of >= 3 had a 5-year overall survival rate of 97% compared to 30% in patients without (p < 0.01, multivariate analysis; 97% vs. 48%,p = 0.03 for locoregional control, and 95% vs. 59%, p = 0.05 for stoma-free survival). Conclusions: Our data indicate that normal tissue and tumor tissue may behave similarly with respect to treatment response, since high-grade acute organ toxicity during radiochemotherapy showed itself to be an independent prognostic marker in our patient population. This hypothesis should be further analyzed by using biomolecular and clinical levels in future clinical trials. (c) 2011 Elsevier Inc."],["dc.identifier.doi","10.1016/j.ijrobp.2010.01.010"],["dc.identifier.isi","000288980100027"],["dc.identifier.pmid","20605354"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/23433"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Inc"],["dc.relation.issn","1879-355X"],["dc.relation.issn","0360-3016"],["dc.title","HIGH-GRADE ACUTE ORGAN TOXICITY AS A POSITIVE PROGNOSTIC FACTOR IN PRIMARY RADIOCHEMOTHERAPY FOR ANAL CARCINOMA"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Onkologie"],["dc.bibliographiccitation.volume","35"],["dc.contributor.author","Braulke, Friederike"],["dc.contributor.author","Schanz, J."],["dc.contributor.author","Goetze, K."],["dc.contributor.author","Mueller-Thomas, Catharina"],["dc.contributor.author","Platzbecker, Uwe"],["dc.contributor.author","Ganster, Christina"],["dc.contributor.author","Jung, K."],["dc.contributor.author","Metz, M."],["dc.contributor.author","Detken, Sven"],["dc.contributor.author","Seraphn, J."],["dc.contributor.author","Bruemmendorf, Tim Hendrik"],["dc.contributor.author","Giagounidis, Aristoteles A. N."],["dc.contributor.author","Germing, U."],["dc.contributor.author","Jentsch-Ullrich, Kathleen"],["dc.contributor.author","Boehme, A."],["dc.contributor.author","Bug, G."],["dc.contributor.author","Ottmann, Oliver G."],["dc.contributor.author","Schafhausen, Philippe"],["dc.contributor.author","Stadler, M."],["dc.contributor.author","Hofmann, W.-K"],["dc.contributor.author","Schmidt, B."],["dc.contributor.author","Lubbert, M."],["dc.contributor.author","Schlenk, Richard F."],["dc.contributor.author","Blau, Igor W."],["dc.contributor.author","Truemper, Lorenz H."],["dc.contributor.author","Haase, Detlef"],["dc.date.accessioned","2018-11-07T09:04:53Z"],["dc.date.available","2018-11-07T09:04:53Z"],["dc.date.issued","2012"],["dc.format.extent","30"],["dc.identifier.isi","000310766700069"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/25200"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Karger"],["dc.publisher.place","Basel"],["dc.relation.issn","0378-584X"],["dc.title","Cytogenetic diagnostics of CD34+peripheral blood cells in MDS: Results from the multicenter German prospective diagnostic CD34+FISH study"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","663"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Virchows Archiv"],["dc.bibliographiccitation.lastpage","672"],["dc.bibliographiccitation.volume","464"],["dc.contributor.author","Rau, Tillman"],["dc.contributor.author","Agaimy, Abbas"],["dc.contributor.author","Gehoff, Anastasia"],["dc.contributor.author","Geppert, Carol"],["dc.contributor.author","Jung, Klaus"],["dc.contributor.author","Knobloch, Katharina"],["dc.contributor.author","Langner, Cord"],["dc.contributor.author","Lugli, Alessandro"],["dc.contributor.author","Groenbus-Lurkin, Irene"],["dc.contributor.author","Nagtegaal, Iris D."],["dc.contributor.author","Rueschoff, Josef"],["dc.contributor.author","Saegert, Xavier"],["dc.contributor.author","Sarbia, Mario"],["dc.contributor.author","Schneider-Stock, Regine"],["dc.contributor.author","Vieth, Michael"],["dc.contributor.author","Zwarthoff, Ellen C."],["dc.contributor.author","Hartmann, Arndt"],["dc.date.accessioned","2018-11-07T09:39:12Z"],["dc.date.available","2018-11-07T09:39:12Z"],["dc.date.issued","2014"],["dc.description.abstract","Criteria for the diagnosis of serrated colorectal lesions (hyperplastic polyp, sessile serrated adenoma without or with dysplasia-which we called mixed polyp-and traditional serrated adenoma) for which consensus has been reached should be validated for applicability in daily practice in terms of inter-observer reproducibility and their association with clinical features and (epi) genetic events. A study set was created from a consecutive series of colorectal polyps (n=1,926) by selecting all sessile serrated adenomas, traditional serrated adenomas and mixed polyps. We added consecutive series of hyperplastic polyps, classical adenomas and normal mucosa samples for a total of 200 specimens. With this series, we conducted an inter-observer study, encompassing ten pathologists with gastrointestinal pathology experience from five European countries, in three rounds in which all cases were microscopically evaluated. An assessment of single morphological criteria was included, and these were correlated with clinical parameters and the mutation status of KRAS, BRAF and PIK3CA and the methylation status of MLH1. Gender, age and localisation were significantly associated with certain types of lesions. Kappa statistics revealed moderate to good interobserver agreement for polyp classification (kappa = 0.56 to 0.63), but for single criteria, this varied considerably (kappa = 0.06 to 0.82). BRAF mutations were frequently found in hyperplastic polyps (86 %, 62/72) and sessile serrated adenomas (80 %, 41/51). KRAS mutations occurred more frequently in traditional serrated adenomas (78%, 7/9) and less so in classical adenomas (20 %, 10/51). Single morphological criteria for sessile serrated"],["dc.identifier.doi","10.1007/s00428-014-1569-7"],["dc.identifier.isi","000338727800005"],["dc.identifier.pmid","24728704"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/33228"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","1432-2307"],["dc.relation.issn","0945-6317"],["dc.title","Defined morphological criteria allow reliable diagnosis of colorectal serrated polyps and predict polyp genetics"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","662"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Annals of Otology Rhinology & Laryngology"],["dc.bibliographiccitation.lastpage","669"],["dc.bibliographiccitation.volume","118"],["dc.contributor.author","Roedel, Ralf M. W."],["dc.contributor.author","Matthias, Christoph"],["dc.contributor.author","Blomeyer, Barbara D."],["dc.contributor.author","Wolff, Hendrik Andreas"],["dc.contributor.author","Jung, Klaus"],["dc.contributor.author","Christiansen, Hans"],["dc.date.accessioned","2018-11-07T11:24:31Z"],["dc.date.available","2018-11-07T11:24:31Z"],["dc.date.issued","2009"],["dc.description.abstract","Objectives: Treatment methods for patients with cervical cancer of an unknown primary site (CUP) are still under discussion. The purpose of this retrospective study was to analyze the oncological follow-up of 58 patients treated for cervical CUP. Methods: From 1986 to 2006, 58 patients with cervical CUP were treated at the authors' institution. Treatment consisted of neck dissection alone in 8, irradiation or chemoradiation in 5, combined surgery and radiotherapy in 28, and surgery and radiochemotherapy in 17. Results: The 3-year and 5-year overall survival rates for all patients were 52.9% and 40.9%, respectively. The 3-year and 5-year disease-specific Survival rates were 50.9% and 39.7%, respectively. The 3-year and 5-year neck control rates were 73.7% and 67.3%, respectively. Neck dissection followed by radiochemotherapy was associated with the best 3-year and 5-year locoregional control rates. Extracapsular extension was a predictor of survival, but not of neck control. Distant metastases developed in about one third of all patients and were the most frequent cause of tumor-related death in cases of advanced neck disease. Conclusions: Despite the fact that regional control can be achieved in many cases, survival rates may be limited by distant metastasis, especially in patients with advanced neck disease."],["dc.identifier.isi","000270190000010"],["dc.identifier.pmid","19810608"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/56424"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Annals Publ Co"],["dc.relation.issn","0003-4894"],["dc.title","Impact of Distant Metastasis in Patients With Cervical Lymph Node Metastases From Cancer of an Unknown Primary Site"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","315"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","The Angle Orthodontist"],["dc.bibliographiccitation.lastpage","323"],["dc.bibliographiccitation.volume","86"],["dc.contributor.author","Knoesel, Michael"],["dc.contributor.author","Fendel, Christine"],["dc.contributor.author","Jung, Klaus"],["dc.contributor.author","Sandoval, Paulo"],["dc.contributor.author","Engelke, Wilfried G. H."],["dc.date.accessioned","2018-11-07T10:17:53Z"],["dc.date.available","2018-11-07T10:17:53Z"],["dc.date.issued","2016"],["dc.description.abstract","Objective: To test the null hypothesis of no significant difference between intraoral pressure characteristics in infants with cleft lip and palate (CLP) with or without presurgical orthopedic (PSO) plates (groups CLP and CLP-PSO), compared with noncleft infants. Materials and Methods: Intraoral atmospheric pressure assessments were performed on 17 subjects with preoperative CLP (m/f, 11/6; mean/SD, 4.76/0.92 months) and a matched control group (n = 24; m/f, 15/9; mean/SD, 4.88/0.9 months), for 200 seconds, simultaneously at the vestibulum (vestibular space [VS]) and at the palate (subpalatal space [SPS]), using a prepared pacifier connected to a digital manometer. Areas under the pressure curves (AUC), frequencies, durations, and magnitudes of swallowing peaks and pressure resting plateaus were compared between trial groups and locations (VS, SPS) using a two-factor analysis of variance for repeated measures, Kruskal-Wallis test, and Mann-Whitney U-test (alpha = .05). Results: The null hypothesis was rejected: Globally, there were statistically significant differences in intraoral pressure characteristics between groups CLP, CLP-PSO, and control (all P < .01), with significantly higher negative pressures (AUC) in the control subjects compared with those of CLP or CLP-PSO. There were significant effects by the location of pressure recordings (VS, SPS) and their interaction with all treatment groups. Differences between noncleft and CLP subjects were more pronounced in the VS than in the SPS. There was no significant effect by PSO. Conclusion: PSO does not improve deviated swallowing characteristics during suction in CLP infants."],["dc.identifier.doi","10.2319/021215-98.1"],["dc.identifier.isi","000371186300020"],["dc.identifier.pmid","25993249"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/41312"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","E H Angle Education Research Foundation, Inc"],["dc.relation.issn","1945-7103"],["dc.relation.issn","0003-3219"],["dc.title","Presurgical orthopedics by drink plates does not significantly normalize deglutition in infants with cleft lip and palate"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]