Schulz-Schaeffer, Walter Joachim

[["dc.bibliographiccitation.firstpage","985"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","EMERGING INFECTIOUS DISEASES"],["dc.bibliographiccitation.lastpage","988"],["dc.bibliographiccitation.volume","19"],["dc.contributor.author","Krasemann, Susanne"],["dc.contributor.author","Mearini, Giulia"],["dc.contributor.author","Kraemer, Elisabeth"],["dc.contributor.author","Wagenfuehr, Katja"],["dc.contributor.author","Schulz-Schaeffer, Walter J."],["dc.contributor.author","Neumann, Melanie"],["dc.contributor.author","Bodemer, Walter"],["dc.contributor.author","Kaup, Franz-Josef"],["dc.contributor.author","Beekes, Michael"],["dc.contributor.author","Carrier, Lucie"],["dc.contributor.author","Aguzzi, Adriano"],["dc.contributor.author","Glatzel, Markus"],["dc.date.accessioned","2018-11-07T09:23:46Z"],["dc.date.available","2018-11-07T09:23:46Z"],["dc.date.issued","2013"],["dc.description.abstract","Prion amyloidosis occurred in the heart of 1 of 3 macaques intraperitoneally inoculated with bovine spongiform encephalopathy prions. This macaque had a remarkably long duration of disease and signs of cardiac distress. Variant Creutzfeldt-Jakob disease, caused by transmission of bovine spongiform encephalopathy to humans, may manifest with cardiac symptoms from prion-amyloid cardiomyopathy."],["dc.identifier.doi","10.3201/eid1906.120906"],["dc.identifier.isi","000328173500020"],["dc.identifier.pmid","23735198"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/29660"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Centers Disease Control"],["dc.relation.issn","1080-6059"],["dc.relation.issn","1080-6040"],["dc.title","BSE-associated Prion-Amyloid Cardiomyopathy in Primates"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Prion"],["dc.bibliographiccitation.volume","5"],["dc.contributor.author","Daus, Martin L."],["dc.contributor.author","Breyer, Johanna"],["dc.contributor.author","Wagenfuehr, Katjs"],["dc.contributor.author","Wemheuer, Wiebke M."],["dc.contributor.author","Thomzig, Achim"],["dc.contributor.author","Schulz-Schaeffer, Walter J."],["dc.contributor.author","Beekes, Michael"],["dc.date.accessioned","2018-11-07T08:57:51Z"],["dc.date.available","2018-11-07T08:57:51Z"],["dc.date.issued","2011"],["dc.format.extent","101"],["dc.identifier.isi","000209066300231"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/23501"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Landes Bioscience"],["dc.publisher.place","Austin"],["dc.relation.issn","1933-690X"],["dc.relation.issn","1933-6896"],["dc.title","Pathological Prion Protein (PrPTSE) in Skeletal Muscles of Farmed and Free Ranging White-Tailed Deer Infected with Chronic Wasting Disease"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","712"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","EMERGING INFECTIOUS DISEASES"],["dc.bibliographiccitation.lastpage","720"],["dc.bibliographiccitation.volume","19"],["dc.contributor.author","Holznagel, Edgar"],["dc.contributor.author","Yutzy, Barbara"],["dc.contributor.author","Schulz-Schaeffer, Walter J."],["dc.contributor.author","Kruip, Carina"],["dc.contributor.author","Hahmann, Uwe"],["dc.contributor.author","Bierke, Paer"],["dc.contributor.author","Torres, Juan-Maria"],["dc.contributor.author","Kim, Yong-Sun"],["dc.contributor.author","Thomzig, Achim"],["dc.contributor.author","Beekes, Michael"],["dc.contributor.author","Hunsmann, Gerhard"],["dc.contributor.author","Loewer, Johannes"],["dc.date.accessioned","2018-11-07T09:24:48Z"],["dc.date.available","2018-11-07T09:24:48Z"],["dc.date.issued","2013"],["dc.description.abstract","Risk for human exposure to bovine spongiform encephalopathy (BSE) inducing agent was estimated in a nonhuman primate model. To determine attack rates, incubation times, and molecular signatures, we orally exposed 18 macaques to 1 high dose of brain material from cattle with BSE. Several macaques were euthanized at regular intervals starting at 1 year postinoculation, and others were observed until clinical signs developed. Among those who received >= 5 g BSE-inducing agent, attack rates were 100% and prions could be detected in peripheral tissues from 1 year postinoculation onward. The overall median incubation time was 4.6 years (3.7-5.3). However, for 3 macaques orally exposed on multiple occasions, incubation periods were at least 7-10 years. Before clinical signs were noted, we detected a non-type 2B signature, indicating the existence of atypical prion protein during the incubation period. This finding could affect diagnosis of variant Creutzfeldt-Jakob disease in humans and might be relevant for retrospective studies of positive tonsillectomy or appendectomy specimens because time of infection is unknown."],["dc.identifier.doi","10.3201/eid1905.120274"],["dc.identifier.isi","000328173400002"],["dc.identifier.pmid","23647575"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/29916"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Centers Disease Control"],["dc.relation.issn","1080-6059"],["dc.relation.issn","1080-6040"],["dc.title","Foodborne Transmission of Bovine Spongiform Encephalopathy to Nonhuman Primates"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2563"],["dc.bibliographiccitation.journal","Journal of General Virology"],["dc.bibliographiccitation.lastpage","2568"],["dc.bibliographiccitation.volume","90"],["dc.contributor.author","Cardone, Franco"],["dc.contributor.author","Thomzig, Achim"],["dc.contributor.author","Schulz-Schaeffer, Walter J."],["dc.contributor.author","Valanzano, Angelina"],["dc.contributor.author","Sbriccoli, Marco"],["dc.contributor.author","Abdel-Haq, Hanin"],["dc.contributor.author","Graziano, Silvia"],["dc.contributor.author","Pritzkow, Sandra"],["dc.contributor.author","Puopolo, Maria"],["dc.contributor.author","Brown, Paul"],["dc.contributor.author","Beekes, Michael"],["dc.contributor.author","Pocchiari, Maurizio"],["dc.date.accessioned","2018-11-07T11:23:51Z"],["dc.date.available","2018-11-07T11:23:51Z"],["dc.date.issued","2009"],["dc.description.abstract","The involvement of muscles in the pathogenesis of transmissible spongiform encephalopathies (TSEs) is irregular and unpredictable. We show that the TSE-specific protein (PrPTSE) is present in muscles of mice fed with a mouse-adapted strain of bovine spongiform encephalopathy as early as 100 days post-infection, corresponding to about one-third of the incubation period. The proportion of mice with PrPTSE-positive muscles and the number of muscles involved increased as infection progressed, but never attained more than a limited distribution, even at the clinical stage of disease. The appearance of PrPTSE in muscles during the preclinical stage of disease was probably due to the haematogenous/lymphatic spread of infectivity from the gastrointestinal tract to lymphatic tissues associated with muscles, whereas in symptomatic animals, the presence of PrPTSE in the nervous system, in neuromuscular junctions and in muscle fibres suggests a centrifugal spread from the central nervous system, as already observed in other TSE models."],["dc.description.sponsorship","EU; Deutsche Forschungsgemeinschaft (DFG) [TH 1376/2-1]"],["dc.identifier.doi","10.1099/vir.0.010801-0"],["dc.identifier.isi","000270499700030"],["dc.identifier.pmid","19535501"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/56276"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Soc General Microbiology"],["dc.relation.issn","0022-1317"],["dc.title","PrPTSE in muscle-associated lymphatic tissue during the preclinical stage of mice infected orally with bovine spongiform encephalopathy"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]