Buttler, Kerstin

[["dc.bibliographiccitation.firstpage","1"],["dc.bibliographiccitation.journal","Histochemistry and cell biology"],["dc.bibliographiccitation.lastpage","8"],["dc.contributor.author","Buttler, K."],["dc.contributor.author","Lohrberg, M."],["dc.contributor.author","Gross, G."],["dc.contributor.author","Weich, H. A."],["dc.contributor.author","Wilting, J."],["dc.date.accessioned","2019-07-09T11:42:09Z"],["dc.date.available","2019-07-09T11:42:09Z"],["dc.date.issued","2016-01-09"],["dc.description.abstract","The embryonic origin of lymphatic endothelial cells (LECs) has been a matter of controversy since more than a century. However, recent studies in mice have supported the concept that embryonic lymphangiogenesis is a complex process consisting of growth of lymphatics from specific venous segments as well as the integration of lymphangioblasts into the lymphatic networks. Similarly, the mechanisms of adult lymphangiogenesis are poorly understood and have rarely been studied. We have recently shown that endothelial progenitor cells isolated from the lung of adult mice have the capacity to form both blood vessels and lymphatics when grafted with Matrigel plugs into the skin of syngeneic mice. Here, we followed up on these experiments and studied the behavior of host leukocytes during lymphangiogenesis in the Matrigel plugs. We observed a striking co-localization of CD45(+) leukocytes with the developing lymphatics. Numerous CD45(+) cells expressed the LEC marker podoplanin and were obviously integrated into the lining of lymphatic capillaries. This indicates that, similar to inflammation-induced lymphangiogenesis in man, circulating CD45(+) cells of adult mice are capable of initiating lymphangiogenesis and of adopting a lymphvasculogenic cellular differentiation program. The data are discussed in the context of embryonic and inflammation-induced lymphangiogenesis."],["dc.identifier.doi","10.1007/s00418-015-1399-y"],["dc.identifier.pmid","26748643"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/12904"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/58601"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","1432-119X"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Integration of CD45-positive leukocytes into newly forming lymphatics of adult mice"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","163"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Angiogenesis"],["dc.bibliographiccitation.lastpage","172"],["dc.bibliographiccitation.volume","14"],["dc.contributor.author","Hemmen, Katherina"],["dc.contributor.author","Reinl, Tobias"],["dc.contributor.author","Buttler, Kerstin"],["dc.contributor.author","Behler, Friederike"],["dc.contributor.author","Dieken, Hauke"],["dc.contributor.author","Jaensch, Lothar"],["dc.contributor.author","Wilting, Joerg"],["dc.contributor.author","Weich, Herbert A."],["dc.date.accessioned","2018-11-07T08:56:20Z"],["dc.date.available","2018-11-07T08:56:20Z"],["dc.date.issued","2011"],["dc.description.abstract","Recently, we isolated and characterized resident endothelial progenitor cells from the lungs of adult mice. These cells have a high proliferation potential, are not transformed and can differentiate into blood- and lymph-vascular endothelial cells under in vitro and in vivo conditions. Here we studied the secretome of these cells by nanoflow liquid chromatographic mass spectrometry (LC-MS). For analysis, 3-day conditioned serum-free media were used. We found 133 proteins belonging to the categories of membrane-bound or secreted proteins. Thereby, several of the membrane-bound proteins also existed as released variants. Thirty-five proteins from this group are well known as endothelial cell- or angiogenesis-related proteins. The MS analysis of the secretome was supplemented and confirmed by fluorescence activated cell sorting analyses, ELISA measurements and immunocytological studies of selected proteins. The secretome data presented in this study provides a platform for the in-depth analysis of endothelial progenitor cells and characterizes potential cellular markers and signaling components in hem- and lymphangiogeneis."],["dc.identifier.doi","10.1007/s10456-011-9200-x"],["dc.identifier.isi","000291038200006"],["dc.identifier.pmid","21234671"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/23121"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0969-6970"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","High-resolution mass spectrometric analysis of the secretome from mouse lung endothelial progenitor cells"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","220"],["dc.bibliographiccitation.lastpage","229"],["dc.contributor.author","Wilting, Jörg"],["dc.contributor.author","Buttler, Kerstin"],["dc.contributor.author","Rössler, Jochen"],["dc.contributor.author","Norgall, Susanne"],["dc.contributor.author","Schweigerer, Lothar"],["dc.contributor.author","Weich, Herbert A."],["dc.contributor.author","Papoutsi, Maria"],["dc.contributor.editor","Chadwick, Derek J."],["dc.contributor.editor","Goode, Jamie"],["dc.date.accessioned","2021-06-02T10:44:30Z"],["dc.date.available","2021-06-02T10:44:30Z"],["dc.date.issued","2007"],["dc.identifier.doi","10.1002/9780470319413.ch17"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/87064"],["dc.notes.intern","DOI-Import GROB-425"],["dc.publisher","John Wiley & Sons, Ltd"],["dc.publisher.place","Chichester, UK"],["dc.relation.eisbn","978-0-470-31941-3"],["dc.relation.isbn","978-0-470-03428-6"],["dc.relation.ispartof","Vascular Development"],["dc.title","Embryonic Development and Malformation of Lymphatic Vessels"],["dc.type","book_chapter"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","42523"],["dc.bibliographiccitation.journal","Scientific Reports"],["dc.bibliographiccitation.volume","7"],["dc.contributor.author","Subashini, Chandramohan"],["dc.contributor.author","Dhanesh, Sivadasan Bindu"],["dc.contributor.author","Chen, Chih-Ming"],["dc.contributor.author","Riya, Paul Ann"],["dc.contributor.author","Meera, Vadakkath"],["dc.contributor.author","Divya, Thulasi Sheela"],["dc.contributor.author","Kuruvilla, Rejji"],["dc.contributor.author","Buttler, Kerstin"],["dc.contributor.author","James, Jackson"],["dc.date.accessioned","2018-11-07T10:27:23Z"],["dc.date.available","2018-11-07T10:27:23Z"],["dc.date.issued","2017"],["dc.description.abstract","The role of Wnt5a has been extensively explored in various aspects of development but its role in cerebellar development remains elusive. Here, for the first time we unravel the expression pattern and functional significance of Wnt5a in cerebellar development using Wnt5a(-/-) and Nestin-Cre mediated conditional knockout mouse models. We demonstrate that loss of Wnt5a results in cerebellar hypoplasia and depletion of GABAergic and glutamatergic neurons. Besides, Purkinje cells of the mutants displayed stunted, poorly branched dendritic arbors. Furthermore, we show that the overall reduction is due to decreased radial glial and granule neuron progenitor cell proliferation. At molecular level we provide evidence for non-canonical mode of action of Wnt5a and its regulation over genes associated with progenitor proliferation. Altogether our findings imply that Wnt5a signaling is a crucial regulator of cerebellar development and would aid in better understanding of cerebellar disease pathogenesis caused due to deregulation of Wnt signaling."],["dc.identifier.doi","10.1038/srep42523"],["dc.identifier.isi","000394221300001"],["dc.identifier.pmid","28205531"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14389"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/43226"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Nature Publishing Group"],["dc.relation.issn","2045-2322"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Wnt5a is a crucial regulator of neurogenesis during cerebellum development"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","4581"],["dc.bibliographiccitation.issue","34"],["dc.bibliographiccitation.journal","Current Medicinal Chemistry"],["dc.bibliographiccitation.lastpage","4592"],["dc.bibliographiccitation.volume","16"],["dc.contributor.author","Wilting, J."],["dc.contributor.author","Becker, J."],["dc.contributor.author","Buttler, K."],["dc.contributor.author","Weich, H."],["dc.date.accessioned","2021-06-01T10:48:33Z"],["dc.date.available","2021-06-01T10:48:33Z"],["dc.date.issued","2009"],["dc.description.abstract","Inflammation is a local or systemic tissue reaction caused by external or internal stimuli with the objective to remove the noxa, inhibit its further dissemination and eventually repair damaged tissue. Blood vessels and perivascular connective tissue are important regulators of the inflammatory process. After a short initial ischemic phase, inflamed tissue is characterized by hyperaemia and increased permeability of capillaries. Therefore, blood vessels have been in the focus of inflammation research for quite some time, whereas lymphatic vessels have been neglected. Their reactivity is not immediately obvious, and, their identification within the tissue has hardly been possible until lymphatic endothelial cell (LEC)-specific molecules have been identified a few years ago. This has opened up the possibility to study lymphatics in normal and diseased tissues, and to isolate LECs for transcriptome and proteome analyses. Initial studies now provide evidence that lymphatics are not just a passive route for circulating lymphocytes, but seem to be directly involved in both the induction and the resolution of inflammation. This review provides a summary on the basics of inflammation, the structure of lymphatics and their molecular markers, human inflammation-associated diseases and their relation to lymphatics, animal models to study the interaction of lymphatics and inflammation, and finally inflammation-associated molecules expressed in LECs. The integration of lymphatics into inflammation research opens up an exciting new field with great clinical potential."],["dc.identifier.doi","10.2174/092986709789760751"],["dc.identifier.isi","000271382900006"],["dc.identifier.pmid","19903150"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/85979"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Bentham Science Publ Ltd"],["dc.relation.issn","0929-8673"],["dc.relation.issn","1875-533X"],["dc.title","Lymphatics and Inflammation"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","50"],["dc.bibliographiccitation.journal","BMC Cell Biology"],["dc.bibliographiccitation.volume","11"],["dc.contributor.author","Schniedermann, Judith"],["dc.contributor.author","Rennecke, Moritz"],["dc.contributor.author","Buttler, Kerstin"],["dc.contributor.author","Richter, Georg"],["dc.contributor.author","Staedtler, Anna-Maria"],["dc.contributor.author","Norgall, Susanne"],["dc.contributor.author","Badar, Muhammad"],["dc.contributor.author","Barleon, Bernhard"],["dc.contributor.author","May, Tobias"],["dc.contributor.author","Wilting, Joerg"],["dc.contributor.author","Weich, Herbert A."],["dc.date.accessioned","2018-11-07T08:41:30Z"],["dc.date.available","2018-11-07T08:41:30Z"],["dc.date.issued","2010"],["dc.description.abstract","Background: Postnatal endothelial progenitor cells (EPCs) have been successfully isolated from whole bone marrow, blood and the walls of conduit vessels. They can, therefore, be classified into circulating and resident progenitor cells. The differentiation capacity of resident lung endothelial progenitor cells from mouse has not been evaluated. Results: In an attempt to isolate differentiated mature endothelial cells from mouse lung we found that the lung contains EPCs with a high vasculogenic capacity and capability of de novo vasculogenesis for blood and lymph vessels. Mouse lung microvascular endothelial cells (MLMVECs) were isolated by selection of CD31(+) cells. Whereas the majority of the CD31+ cells did not divide, some scattered cells started to proliferate giving rise to large colonies (> 3000 cells/colony). These highly dividing cells possess the capacity to integrate into various types of vessels including blood and lymph vessels unveiling the existence of local microvascular endothelial progenitor cells (LMEPCs) in adult mouse lung. EPCs could be amplified > passage 30 and still expressed panendothelial markers as well as the progenitor cell antigens, but not antigens for immune cells and hematopoietic stem cells. A high percentage of these cells are also positive for Lyve1, Prox1, podoplanin and VEGFR-3 indicating that a considerabe fraction of the cells are committed to develop lymphatic endothelium. Clonogenic highly proliferating cells from limiting dilution assays were also bipotent. Combined in vitro and in vivo spheroid and matrigel assays revealed that these EPCs exhibit vasculogenic capacity by forming functional blood and lymph vessels. Conclusion: The lung contains large numbers of EPCs that display commitment for both types of vessels, suggesting that lung blood and lymphatic endothelial cells are derived from a single progenitor cell."],["dc.identifier.doi","10.1186/1471-2121-11-50"],["dc.identifier.isi","000282731800001"],["dc.identifier.pmid","20594323"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/5672"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/19484"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Biomed Central Ltd"],["dc.relation.issn","1471-2121"],["dc.rights","CC BY 2.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/2.0"],["dc.title","Mouse lung contains endothelial progenitors with high capacity to form blood and lymphatic vessels"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","365"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Developmental Biology"],["dc.bibliographiccitation.lastpage","376"],["dc.bibliographiccitation.volume","381"],["dc.contributor.author","Buttler, Kerstin"],["dc.contributor.author","Becker, Jürgen"],["dc.contributor.author","Pukrop, Tobias"],["dc.contributor.author","Wilting, Jörg"],["dc.date.accessioned","2021-06-01T10:49:58Z"],["dc.date.available","2021-06-01T10:49:58Z"],["dc.date.issued","2013"],["dc.identifier.doi","10.1016/j.ydbio.2013.06.028"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/86479"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.relation.issn","0012-1606"],["dc.title","Maldevelopment of dermal lymphatics in Wnt5a-knockout-mice"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","17"],["dc.bibliographiccitation.lastpage","24"],["dc.contributor.author","Wilting, Jörg"],["dc.contributor.author","Papoutsi, Maria"],["dc.contributor.author","Buttler, Kerstin"],["dc.contributor.author","Becker, Jürgen"],["dc.contributor.editor","Rosen, Steven T."],["dc.contributor.editor","Leong, Stanley P. L."],["dc.date.accessioned","2021-06-02T10:44:20Z"],["dc.date.available","2021-06-02T10:44:20Z"],["dc.date.issued","2007"],["dc.identifier.doi","10.1007/978-0-387-69219-7_2"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/87003"],["dc.notes.intern","DOI-Import GROB-425"],["dc.publisher","Springer US"],["dc.publisher.place","Boston, MA"],["dc.relation.eisbn","978-0-387-69219-7"],["dc.relation.isbn","978-0-387-69218-0"],["dc.relation.ispartof","Cancer Metastasis And The Lymphovascular System: Basis For Rational Therapy"],["dc.title","Embryonic Development of the Lymphovascular System and Tumor Lymphangiogenesis"],["dc.type","book_chapter"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","112"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Pediatric Research"],["dc.bibliographiccitation.lastpage","117"],["dc.bibliographiccitation.volume","68"],["dc.contributor.author","Becker, Jürgen"],["dc.contributor.author","Wang, Baigang"],["dc.contributor.author","Pavlakovic, Helena"],["dc.contributor.author","Buttler, Kerstin"],["dc.contributor.author","Wilting, Jörg"],["dc.date.accessioned","2021-06-01T10:48:09Z"],["dc.date.available","2021-06-01T10:48:09Z"],["dc.date.issued","2010"],["dc.identifier.doi","10.1203/PDR.0b013e3181e5bc0f"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/85842"],["dc.notes.intern","DOI-Import GROB-425"],["dc.relation.eissn","1530-0447"],["dc.relation.issn","0031-3998"],["dc.title","Homeobox Transcription Factor Prox1 in Sympathetic Ganglia of Vertebrate Embryos: Correlation With Human Stage 4s Neuroblastoma"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2952"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","Developmental Dynamics"],["dc.bibliographiccitation.lastpage","2961"],["dc.bibliographiccitation.volume","236"],["dc.contributor.author","Kasten, Philipp"],["dc.contributor.author","Schnoeink, Gerrit"],["dc.contributor.author","Bergmann, Astrid"],["dc.contributor.author","Papoutsi, Maria"],["dc.contributor.author","Buttler, Kerstin"],["dc.contributor.author","Roessler, Jochen"],["dc.contributor.author","Weich, Herbert A."],["dc.contributor.author","Wilting, Joerg"],["dc.date.accessioned","2018-11-07T10:57:58Z"],["dc.date.available","2018-11-07T10:57:58Z"],["dc.date.issued","2007"],["dc.description.abstract","Lymphangioma is a disfiguring malformation of early childhood. A mouse lymphangioma model has been established by injecting Freund's incomplete adjuvant (FIA) intraperitoneally, but has not been compared with the human disease. We show that, in accordance with studies from the 1960s, the mouse model represents an oil-granuloma, made up of CD45-positive leukocytes and invaded by blood and lymph vessels. Several markers of lymphatic endothelial cells are expressed in both mouse and human, like CD31, Prox1, podoplanin, and Lyve-1. However, the human disease affects all parts of the lymphovascular tree. We observed convolutes of lymphatic capillaries, irregularly formed collectors with signs of disintegration, and large lymph cysts. We observed VEGFR-2 and -3 expression in both blood vessels and lymphatics of the patients, whereas in mouse VEGFR-2 was confined to activated blood vessels. The experimental mouse FIA model represents a vascularized oil-granuloma rather than a lymphangioma and reflects the complexity of human lymphangioma only partially."],["dc.description.sponsorship","NICHD NIH HHS [N01-HD-6-2915]"],["dc.identifier.doi","10.1002/dvdy.21298"],["dc.identifier.isi","000250192100025"],["dc.identifier.pmid","17879316"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/50377"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-liss"],["dc.relation.issn","1058-8388"],["dc.title","Similarities and differences of human and experimental mouse lymphangiomas"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]