Schubert, Andrea

[["dc.bibliographiccitation.firstpage","3899"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","Clinical Oral Investigations"],["dc.bibliographiccitation.lastpage","3909"],["dc.bibliographiccitation.volume","24"],["dc.contributor.author","Wassmann, Torsten"],["dc.contributor.author","Schubert, Andrea"],["dc.contributor.author","Malinski, Felix"],["dc.contributor.author","Rosentritt, Martin"],["dc.contributor.author","Krohn, Sebastian"],["dc.contributor.author","Techmer, Kirsten"],["dc.contributor.author","Bürgers, Ralf"],["dc.date.accessioned","2020-12-10T14:11:05Z"],["dc.date.available","2020-12-10T14:11:05Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1007/s00784-020-03257-w"],["dc.identifier.eissn","1436-3771"],["dc.identifier.issn","1432-6981"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/70959"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","The antimicrobial and cytotoxic effects of a copper-loaded zinc oxide phosphate cement"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","4580"],["dc.bibliographiccitation.issue","21"],["dc.bibliographiccitation.journal","Polymers"],["dc.bibliographiccitation.volume","14"],["dc.contributor.affiliation","Hampe, Tristan; 1Department of Prosthodontics, University Medical Center Göttingen, 37075 Göttingen, Germany"],["dc.contributor.affiliation","Liersch, Julia; 1Department of Prosthodontics, University Medical Center Göttingen, 37075 Göttingen, Germany"],["dc.contributor.affiliation","Wiechens, Bernhard; 1Department of Prosthodontics, University Medical Center Göttingen, 37075 Göttingen, Germany"],["dc.contributor.affiliation","Wassmann, Torsten; 1Department of Prosthodontics, University Medical Center Göttingen, 37075 Göttingen, Germany"],["dc.contributor.affiliation","Schubert, Andrea; 1Department of Prosthodontics, University Medical Center Göttingen, 37075 Göttingen, Germany"],["dc.contributor.affiliation","Alhussein, Mohammad; 3Molecular Phytopathology and Mycotoxin Research, University of Göttingen, 37077 Göttingen, Germany"],["dc.contributor.affiliation","Bürgers, Ralf; 1Department of Prosthodontics, University Medical Center Göttingen, 37075 Göttingen, Germany"],["dc.contributor.affiliation","Krohn, Sebastian; 1Department of Prosthodontics, University Medical Center Göttingen, 37075 Göttingen, Germany"],["dc.contributor.author","Hampe, Tristan"],["dc.contributor.author","Liersch, Julia"],["dc.contributor.author","Wiechens, Bernhard"],["dc.contributor.author","Wassmann, Torsten"],["dc.contributor.author","Schubert, Andrea"],["dc.contributor.author","Alhussein, Mohammad"],["dc.contributor.author","Bürgers, Ralf"],["dc.contributor.author","Krohn, Sebastian"],["dc.date.accessioned","2022-12-01T08:31:46Z"],["dc.date.available","2022-12-01T08:31:46Z"],["dc.date.issued","2022"],["dc.date.updated","2022-11-11T13:12:02Z"],["dc.description.abstract","This study aimed to investigate the release of common monomers from conventional (Dialog Vario, Enamel Plus HFO) and UDMA-based indirect veneering composites (VITA VM LC, GC Gradia). Ten cylindrical samples of each material were prepared (n = 40), immersed in HPLC grade water, and incubated for 24 h in an incubation shaker at 37 °C and 112 rpm. Extraction was performed following ISO 10993-12 and monomers were detected and quantified by HPLC-MS/MS. In all the samples, urethane dimethacrylate (UDMA) and bisphenol A (BPA) were quantifiable. Compared to water blanks, BPA levels were only elevated in the eluates from conventional composites. In all other samples, concentrations were in the range of extraneous BPA and were therefore clinically irrelevant. Low concentrations of Bisphenol A-glycidyl methacrylate (BisGMA) were found in one BPA-free composite and in both conventional materials. Statistical analyses showed that BPA-free materials released significantly less BisGMA and no BPA, while UDMA elution was comparable to elution from conventional materials. All measured concentrations were below reported effective cytotoxic concentrations. Considering these results, the substitution of BPA-derivatives with UDMA might be beneficial since BPA-associated adverse effects are ruled out. Further studies should be enrolled to test the biocompatibility of UDMA on cells of the oral environment."],["dc.description.sponsorship","German Society for Prosthodontics and Material Sciences (DGPro)"],["dc.description.sponsorship","Open-Access-Publikationsfonds 2022"],["dc.identifier.doi","10.3390/polym14214580"],["dc.identifier.pii","polym14214580"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/118262"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-621"],["dc.relation.eissn","2073-4360"],["dc.title","A Pilot Study on Monomer and Bisphenol A (BPA) Release from UDMA-Based and Conventional Indirect Veneering Composites"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","456"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Coatings"],["dc.bibliographiccitation.volume","9"],["dc.contributor.author","Schubert, Andrea"],["dc.contributor.author","Wassmann, Torsten"],["dc.contributor.author","Holtappels, Mareike"],["dc.contributor.author","Kurbad, Oliver"],["dc.contributor.author","Krohn, Sebastian"],["dc.contributor.author","Bürgers, Ralf"],["dc.date.accessioned","2019-07-31T12:13:35Z"],["dc.date.available","2019-07-31T12:13:35Z"],["dc.date.issued","2019"],["dc.description.abstract","Microbial adhesion to intraoral biomaterials is associated with surface roughness. For the prevention of oral pathologies, smooth surfaces with little biofilm formation are required. Ideally, appropriate roughness parameters make microbial adhesion predictable. Although a multitude of parameters are available, surface roughness is commonly described by the arithmetical mean roughness value (Ra). The present study investigates whether Ra is the most appropriate roughness parameter in terms of prediction for microbial adhesion to dental biomaterials. After four surface roughness modifications using standardized polishing protocols, zirconia, polymethylmethacrylate, polyetheretherketone, and titanium alloy specimens were characterized by Ra as well as 17 other parameters using confocal microscopy. Specimens of the tested materials were colonized by C. albicans or S. sanguinis for 2 h; the adhesion was measured via luminescence assays and correlated with the roughness parameters. The adhesion of C. albicans showed a tendency to increase with increasing the surface roughness—the adhesion of S. sanguinis showed no such tendency. Although Sa, that is, the arithmetical mean deviation of surface roughness, and Rdc, that is, the profile section height between two material ratios, showed higher correlations with the microbial adhesion than Ra, these di erences were not significant. Within the limitations of this in-vitro study, we conclude that Ra is a su cient roughness parameter in terms of prediction for initial microbial adhesion to dental biomaterials with polished surfaces."],["dc.identifier.doi","10.3390/coatings9070456"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16319"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/62242"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","final"],["dc.publisher","MDPI"],["dc.relation.eissn","2079-6412"],["dc.relation.issn","2079-6412"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Predictability of Microbial Adhesion to Dental Materials by Roughness Parameters"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","cre2.592"],["dc.bibliographiccitation.firstpage","650"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Clinical and Experimental Dental Research"],["dc.bibliographiccitation.lastpage","657"],["dc.bibliographiccitation.volume","8"],["dc.contributor.affiliation","Bürgers, Ralf; 1\r\nDepartment of Prosthodontics\r\nUniversity Medical Center Göttingen\r\nGöttingen Germany"],["dc.contributor.affiliation","Schubert, Andrea; 1\r\nDepartment of Prosthodontics\r\nUniversity Medical Center Göttingen\r\nGöttingen Germany"],["dc.contributor.affiliation","Müller, Jonas; 1\r\nDepartment of Prosthodontics\r\nUniversity Medical Center Göttingen\r\nGöttingen Germany"],["dc.contributor.affiliation","Krohn, Sebastian; 1\r\nDepartment of Prosthodontics\r\nUniversity Medical Center Göttingen\r\nGöttingen Germany"],["dc.contributor.affiliation","Rödiger, Matthias; 1\r\nDepartment of Prosthodontics\r\nUniversity Medical Center Göttingen\r\nGöttingen Germany"],["dc.contributor.affiliation","Leha, Andreas; 2\r\nDepartment of Medical Statistics\r\nUniversity Medical Center Göttingen\r\nGöttingen Germany"],["dc.contributor.author","Bürgers, Ralf"],["dc.contributor.author","Schubert, Andrea"],["dc.contributor.author","Müller, Jonas"],["dc.contributor.author","Krohn, Sebastian"],["dc.contributor.author","Rödiger, Matthias"],["dc.contributor.author","Leha, Andreas"],["dc.contributor.author","Wassmann, Torsten"],["dc.date.accessioned","2022-06-01T09:40:09Z"],["dc.date.available","2022-06-01T09:40:09Z"],["dc.date.issued","2022"],["dc.date.updated","2022-11-11T13:13:45Z"],["dc.description.abstract","Objectives\r\nEvidence on the biocompatibility of three-dimensional (3D)-printed and milled resins for oral splints is limited. This in vitro study assessed the influence of the manufacturing method on the cytotoxicity of oral splint resins on L929 cells and human gingival fibroblasts (GF1).\r\n\r\nMaterials and Methods\r\nStandardized specimens of four 3D-printed, two-milled, one-thermoformed, and one-pressed splint resin were incubated with L929 and GF1 cells for 24 h. Immunofluorescence and WST-8 assay were performed to evaluate cytotoxic effects. One-way analysis of variance and Tukey's multiple comparison test were applied with the variables “splint resin” and “manufacturing method” (p < .05).\r\n\r\nResults\r\nImmunofluorescence showed attachment of L929 and GF1 cells to the splint resins. Irrespective of the manufacturing method, the WST-8 assay revealed significant differences between splint resins for the viability of L929 and GF1 cells. L929 cells generally showed lower viability rates than GF1 cells. The evaluation of cell viability by the manufacturing method showed no significant differences between 3D printing, milling, and conventional methods.\r\n\r\nConclusions\r\nThe cytotoxic effects of 3D-printed, milled, and conventional oral splint resins were similar, indicating minor influence of the manufacturing method on biocompatibility. Cytotoxicity of the resins was below a critical threshold in GF1 cells. The chemical composition might be more crucial than the manufacturing method for the biocompatibility of splint resins."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2022"],["dc.identifier.doi","10.1002/cre2.592"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/108648"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-572"],["dc.relation.eissn","2057-4347"],["dc.relation.issn","2057-4347"],["dc.rights","CC BY 4.0"],["dc.rights.uri","http://creativecommons.org/licenses/by/4.0/"],["dc.title","Cytotoxicity of 3D‐printed, milled, and conventional oral splint resins to L929 cells and human gingival fibroblasts"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]