Schubert, Andrea

[["dc.bibliographiccitation.firstpage","1443"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","Acta Anaesthesiologica Scandinavica"],["dc.bibliographiccitation.lastpage","1448"],["dc.bibliographiccitation.volume","49"],["dc.contributor.author","Neumann, P."],["dc.contributor.author","Schubert, A."],["dc.contributor.author","Heuer, J. F."],["dc.contributor.author","Hinz, Jose Maria"],["dc.contributor.author","Quintel, M."],["dc.contributor.author","Klockgether-Radke, Adelbert"],["dc.date.accessioned","2018-11-07T10:54:25Z"],["dc.date.available","2018-11-07T10:54:25Z"],["dc.date.issued","2005"],["dc.description.abstract","Backround: During mechanical ventilatory support, spontaneous breathing has been linked to improved hemodynamics. These findings may be explained by a decrease in intrathoracic pressure which may improve venous return to the heart. Such a mechanism should result in a dose-response relation between the amount of spontaneous breathing and an increase in the global end-diastolic volume (GEDV) and cardiac output (Q(t)). Methods: To test this hypothesis, 15 patients were studied after major elective surgery during weaning from mechanical ventilation using bilevel positive airway pressure (BIPAP). BIPAP allows unrestricted spontaneous breathing during every phase of the respiratory cycle. Thus, ventilatory support was modified by changing the mechanical respiratory rate only, whereas inspiratory airway pressure and PEEP were kept constant. GEDV and Q(t) were measured by transpulmonary thermodilution. Results: GEDV (P = 0.055), stroke volume (P = 0.027) and subsequently also Q(t) (P < 0.001) increased when spontaneous breathing increased. In contrast, no difference was observed for central venous pressure (P = 0.19). Conclusion: The beneficial hemodynamic effects of spontaneous breathing during mechanical ventilatory support can partially be explained by improved venous return to the heart which increases stroke volume and Q(t)."],["dc.identifier.doi","10.1111/j.1399-6576.2005.00868.x"],["dc.identifier.isi","000232557500006"],["dc.identifier.pmid","16223387"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/49557"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Blackwell Publishing"],["dc.relation.issn","0001-5172"],["dc.title","Hemodynamic effects of spontaneous breathing in the post-operative period"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1188"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","Circulation Research"],["dc.bibliographiccitation.lastpage","1194"],["dc.bibliographiccitation.volume","87"],["dc.contributor.author","Schubert, A."],["dc.contributor.author","Cattaruzza, Marco"],["dc.contributor.author","Hecker, M."],["dc.contributor.author","Darmer, D."],["dc.contributor.author","Holtz, J."],["dc.contributor.author","Morawietz, H."],["dc.date.accessioned","2018-11-07T08:38:49Z"],["dc.date.available","2018-11-07T08:38:49Z"],["dc.date.issued","2000"],["dc.description.abstract","The flowing blood generates shear stress at the endothelial cell surface. The endothelial cells modify their phenotype by alterations in gene expression in response to different levels of fluid shear stress. To identify genes involved in this process, human umbilical vein endothelial cells were exposed to laminar shear stress (venous or arterial levels) in a cone-and-plate apparatus for 24 hours. Using the method of RNA arbitrarily primed polymerase chain reaction, we cloned a polymerase chain reaction fragment representing an mRNA species downregulated by arterial compared with venous shear stress (shear stress downregulated gene-1, SSD-1). According to Northern blot analysis, corresponding SSD-1 cDNA clones revealed a similar, time-dependent downregulation after 24 hours of arterial shear stress compared with venous shear stress or static controls. Three SSD-1 mRNA species of 2.8, 4.1, and 4.6 kb were expressed in a tissue-specific manner. The encoded amino acid sequence of the human endothelial SSD-1 isoform (4.1-kb mRNA species) revealed 80.4% identity and 90.9% homology to the bovine beta -tubulin folding cofactor D (tfcD) gene. Downregulation of tfcD mRNA expression by shear stress was defined at the level of transcription by nuclear run-on assays. The tfcD protein was downregulated by arterial shear stress. The shear stress-dependent downregulation of tfcD mRNA and protein was attenuated by the NO synthase inhibitor N omega -nitro-L-arginine methyl ester, Furthermore, the NO donor DETA-NO downregulated tfcD mRNA. Because tfcD was shown to be a microtubule-destabilizing protein, our data suggest a shear stress-dependent regulation of the microtubular dynamics in human endothelial cells."],["dc.identifier.isi","000165930800019"],["dc.identifier.pmid","11110777"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/18849"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.relation.issn","0009-7330"],["dc.title","Shear stress-dependent regulation of the human beta-tubulin folding cofactor D gene"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","194760352096706"],["dc.bibliographiccitation.journal","CARTILAGE"],["dc.contributor.author","Schminke, Boris"],["dc.contributor.author","Kauffmann, Philipp"],["dc.contributor.author","Schubert, Andrea"],["dc.contributor.author","Altherr, Manuel"],["dc.contributor.author","Gelis, Thomas"],["dc.contributor.author","Miosge, Nicolai"],["dc.date.accessioned","2021-04-14T08:31:21Z"],["dc.date.available","2021-04-14T08:31:21Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1177/1947603520967069"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/83568"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","1947-6043"],["dc.relation.issn","1947-6035"],["dc.title","SMURF1 and SMURF2 in Progenitor Cells from Articular Cartilage and Meniscus during Late-Stage Osteoarthritis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","3899"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","Clinical Oral Investigations"],["dc.bibliographiccitation.lastpage","3909"],["dc.bibliographiccitation.volume","24"],["dc.contributor.author","Wassmann, Torsten"],["dc.contributor.author","Schubert, Andrea"],["dc.contributor.author","Malinski, Felix"],["dc.contributor.author","Rosentritt, Martin"],["dc.contributor.author","Krohn, Sebastian"],["dc.contributor.author","Techmer, Kirsten"],["dc.contributor.author","Bürgers, Ralf"],["dc.date.accessioned","2020-12-10T14:11:05Z"],["dc.date.available","2020-12-10T14:11:05Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1007/s00784-020-03257-w"],["dc.identifier.eissn","1436-3771"],["dc.identifier.issn","1432-6981"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/70959"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","The antimicrobial and cytotoxic effects of a copper-loaded zinc oxide phosphate cement"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Onkologie"],["dc.bibliographiccitation.volume","33"],["dc.contributor.author","Gruendker, Carsten"],["dc.contributor.author","Olbrich, T."],["dc.contributor.author","Schubert, A."],["dc.contributor.author","Ziegler, Elke"],["dc.contributor.author","Emons, G."],["dc.date.accessioned","2018-11-07T08:46:28Z"],["dc.date.available","2018-11-07T08:46:28Z"],["dc.date.issued","2010"],["dc.format.extent","20"],["dc.identifier.isi","000274745200053"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/20697"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Karger"],["dc.publisher.place","Basel"],["dc.relation.issn","0378-584X"],["dc.title","Kisspeptin-10 inhibits directed migration GPR54-positive breast cancer cells"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","216"],["dc.bibliographiccitation.journal","Archives of Oral Biology"],["dc.bibliographiccitation.lastpage","222"],["dc.bibliographiccitation.volume","82"],["dc.contributor.author","Schubert, Andrea"],["dc.contributor.author","Schminke, Boris"],["dc.contributor.author","Miosge, Nicolai"],["dc.date.accessioned","2018-08-20T09:31:36Z"],["dc.date.available","2018-08-20T09:31:36Z"],["dc.date.issued","2017"],["dc.description.abstract","Periodontitis refers to inflammatory disease of the periodontal structures (the gingiva, dental cementum, periodontal ligament (PDL) and alveolar bone) that ultimately leads to their destruction. Whereas collagens are well-examined main components of the periodontium, little is known about the other structural proteins that make up this tissue. The aim of this study was to identify new extracellular matrix (ECM) components, including fibulins and matrilins, in the periodontium of mice. After sacrificing 14 mice (Sv/129 strain), jaws were prepared. Each tissue sample contained a molar and its surrounding alveolar bone. Immunohistochemistry was carried out on paraffin-embedded sections. Our results show that mice exhibit fibulin-3, -4 and -5 and matrilin-1, -2, -3 and -4 in PDL and in blood vessels of alveolar bone and PDL as well as in the pericellular matrix of osteocytes and cementocytes. In dental cementum, only fibulin-4 is expressed. For the first time, we show that fibulin-3, -4 and -5 and matrilin-1, -2, -3 and -4 are essential components of the periodontal tissues. Our findings indicate an association of these proteins with collagens and oxytalan fibers that might be of future interest in regenerative periodontitis therapy."],["dc.identifier.doi","10.1016/j.archoralbio.2017.06.008"],["dc.identifier.pmid","28654783"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16485"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/15410"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","final"],["dc.relation.eissn","1879-1506"],["dc.relation.eissn","0003-9969"],["dc.rights","CC BY-ND 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nd/4.0"],["dc.title","Fibulins and matrilins are novel structural components of the periodontium in the mouse"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Journal of the European Academy of Dermatology and Venereology"],["dc.contributor.author","Geier, J."],["dc.contributor.author","Ballmer‐Weber, B."],["dc.contributor.author","Buhl, T."],["dc.contributor.author","Rieker‐Schwienbacher, J."],["dc.contributor.author","Mahler, V."],["dc.contributor.author","Dickel, H."],["dc.contributor.author","Schubert, S."],["dc.contributor.author","Baron, Jens Malte"],["dc.contributor.author","Grabbe, Jürgen"],["dc.contributor.author","Siedlecki, Katharina"],["dc.contributor.author","Skudlik, Christoph"],["dc.contributor.authorgroup","for the IVDK"],["dc.date.accessioned","2022-04-01T10:03:25Z"],["dc.date.available","2022-04-01T10:03:25Z"],["dc.date.issued","2022"],["dc.identifier.doi","10.1111/jdv.17968"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/106163"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-530"],["dc.relation.eissn","1468-3083"],["dc.relation.issn","0926-9959"],["dc.rights.uri","http://creativecommons.org/licenses/by-nc-nd/4.0/"],["dc.title","Is benzyl alcohol a significant contact sensitizer?"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Oncology Research and Treatment"],["dc.bibliographiccitation.volume","39"],["dc.contributor.author","Schubert, A."],["dc.contributor.author","Bleckmann, Annalen"],["dc.contributor.author","Pukrop, Tobias"],["dc.contributor.author","Binder, Claudia"],["dc.date.accessioned","2018-11-07T10:07:37Z"],["dc.date.available","2018-11-07T10:07:37Z"],["dc.date.issued","2016"],["dc.format.extent","182"],["dc.identifier.isi","000385691300449"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/39315"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Karger"],["dc.publisher.place","Basel"],["dc.relation.issn","2296-5262"],["dc.relation.issn","2296-5270"],["dc.title","DVL3 in breast cancer and tumor progression"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","4580"],["dc.bibliographiccitation.issue","21"],["dc.bibliographiccitation.journal","Polymers"],["dc.bibliographiccitation.volume","14"],["dc.contributor.affiliation","Hampe, Tristan; 1Department of Prosthodontics, University Medical Center Göttingen, 37075 Göttingen, Germany"],["dc.contributor.affiliation","Liersch, Julia; 1Department of Prosthodontics, University Medical Center Göttingen, 37075 Göttingen, Germany"],["dc.contributor.affiliation","Wiechens, Bernhard; 1Department of Prosthodontics, University Medical Center Göttingen, 37075 Göttingen, Germany"],["dc.contributor.affiliation","Wassmann, Torsten; 1Department of Prosthodontics, University Medical Center Göttingen, 37075 Göttingen, Germany"],["dc.contributor.affiliation","Schubert, Andrea; 1Department of Prosthodontics, University Medical Center Göttingen, 37075 Göttingen, Germany"],["dc.contributor.affiliation","Alhussein, Mohammad; 3Molecular Phytopathology and Mycotoxin Research, University of Göttingen, 37077 Göttingen, Germany"],["dc.contributor.affiliation","Bürgers, Ralf; 1Department of Prosthodontics, University Medical Center Göttingen, 37075 Göttingen, Germany"],["dc.contributor.affiliation","Krohn, Sebastian; 1Department of Prosthodontics, University Medical Center Göttingen, 37075 Göttingen, Germany"],["dc.contributor.author","Hampe, Tristan"],["dc.contributor.author","Liersch, Julia"],["dc.contributor.author","Wiechens, Bernhard"],["dc.contributor.author","Wassmann, Torsten"],["dc.contributor.author","Schubert, Andrea"],["dc.contributor.author","Alhussein, Mohammad"],["dc.contributor.author","Bürgers, Ralf"],["dc.contributor.author","Krohn, Sebastian"],["dc.date.accessioned","2022-12-01T08:31:46Z"],["dc.date.available","2022-12-01T08:31:46Z"],["dc.date.issued","2022"],["dc.date.updated","2022-11-11T13:12:02Z"],["dc.description.abstract","This study aimed to investigate the release of common monomers from conventional (Dialog Vario, Enamel Plus HFO) and UDMA-based indirect veneering composites (VITA VM LC, GC Gradia). Ten cylindrical samples of each material were prepared (n = 40), immersed in HPLC grade water, and incubated for 24 h in an incubation shaker at 37 °C and 112 rpm. Extraction was performed following ISO 10993-12 and monomers were detected and quantified by HPLC-MS/MS. In all the samples, urethane dimethacrylate (UDMA) and bisphenol A (BPA) were quantifiable. Compared to water blanks, BPA levels were only elevated in the eluates from conventional composites. In all other samples, concentrations were in the range of extraneous BPA and were therefore clinically irrelevant. Low concentrations of Bisphenol A-glycidyl methacrylate (BisGMA) were found in one BPA-free composite and in both conventional materials. Statistical analyses showed that BPA-free materials released significantly less BisGMA and no BPA, while UDMA elution was comparable to elution from conventional materials. All measured concentrations were below reported effective cytotoxic concentrations. Considering these results, the substitution of BPA-derivatives with UDMA might be beneficial since BPA-associated adverse effects are ruled out. Further studies should be enrolled to test the biocompatibility of UDMA on cells of the oral environment."],["dc.description.sponsorship","German Society for Prosthodontics and Material Sciences (DGPro)"],["dc.description.sponsorship","Open-Access-Publikationsfonds 2022"],["dc.identifier.doi","10.3390/polym14214580"],["dc.identifier.pii","polym14214580"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/118262"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-621"],["dc.relation.eissn","2073-4360"],["dc.title","A Pilot Study on Monomer and Bisphenol A (BPA) Release from UDMA-Based and Conventional Indirect Veneering Composites"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","456"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Coatings"],["dc.bibliographiccitation.volume","9"],["dc.contributor.author","Schubert, Andrea"],["dc.contributor.author","Wassmann, Torsten"],["dc.contributor.author","Holtappels, Mareike"],["dc.contributor.author","Kurbad, Oliver"],["dc.contributor.author","Krohn, Sebastian"],["dc.contributor.author","Bürgers, Ralf"],["dc.date.accessioned","2019-07-31T12:13:35Z"],["dc.date.available","2019-07-31T12:13:35Z"],["dc.date.issued","2019"],["dc.description.abstract","Microbial adhesion to intraoral biomaterials is associated with surface roughness. For the prevention of oral pathologies, smooth surfaces with little biofilm formation are required. Ideally, appropriate roughness parameters make microbial adhesion predictable. Although a multitude of parameters are available, surface roughness is commonly described by the arithmetical mean roughness value (Ra). The present study investigates whether Ra is the most appropriate roughness parameter in terms of prediction for microbial adhesion to dental biomaterials. After four surface roughness modifications using standardized polishing protocols, zirconia, polymethylmethacrylate, polyetheretherketone, and titanium alloy specimens were characterized by Ra as well as 17 other parameters using confocal microscopy. Specimens of the tested materials were colonized by C. albicans or S. sanguinis for 2 h; the adhesion was measured via luminescence assays and correlated with the roughness parameters. The adhesion of C. albicans showed a tendency to increase with increasing the surface roughness—the adhesion of S. sanguinis showed no such tendency. Although Sa, that is, the arithmetical mean deviation of surface roughness, and Rdc, that is, the profile section height between two material ratios, showed higher correlations with the microbial adhesion than Ra, these di erences were not significant. Within the limitations of this in-vitro study, we conclude that Ra is a su cient roughness parameter in terms of prediction for initial microbial adhesion to dental biomaterials with polished surfaces."],["dc.identifier.doi","10.3390/coatings9070456"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16319"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/62242"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","final"],["dc.publisher","MDPI"],["dc.relation.eissn","2079-6412"],["dc.relation.issn","2079-6412"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Predictability of Microbial Adhesion to Dental Materials by Roughness Parameters"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]