Bodemer, Walter Wolfgang

[["dc.bibliographiccitation.firstpage","423"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Biochemical and Biophysical Research Communications"],["dc.bibliographiccitation.lastpage","428"],["dc.bibliographiccitation.volume","251"],["dc.contributor.author","Schröder, Björn"],["dc.contributor.author","Groschup, Martin"],["dc.contributor.author","Hunsmann, Gerhard"],["dc.contributor.author","Bodemer, Walter"],["dc.date.accessioned","2022-10-06T13:26:16Z"],["dc.date.available","2022-10-06T13:26:16Z"],["dc.date.issued","1998"],["dc.identifier.doi","10.1006/bbrc.1998.9481"],["dc.identifier.pii","S0006291X98994815"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/115045"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-602"],["dc.relation.issn","0006-291X"],["dc.relation.orgunit","Deutsches Primatenzentrum"],["dc.title","A Differentially Expressed Prion Gene mRNA Is Found in Prion-Infected Mouse Brains and in N2A Cells but Not in Uninfected Mice"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","101"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Clinical Immunology and Immunopathology"],["dc.bibliographiccitation.lastpage","105"],["dc.bibliographiccitation.volume","87"],["dc.contributor.author","Spring, Michael"],["dc.contributor.author","Stahl-Hennig, Christiane"],["dc.contributor.author","Nißlein, Thomas"],["dc.contributor.author","Locher, Christopher"],["dc.contributor.author","Fuchs, Dietmar"],["dc.contributor.author","Bodemer, Walter"],["dc.contributor.author","Hunsmann, Gerhard"],["dc.contributor.author","Dittmer, Ulf"],["dc.date.accessioned","2022-10-06T13:26:22Z"],["dc.date.available","2022-10-06T13:26:22Z"],["dc.date.issued","1998"],["dc.identifier.doi","10.1006/clin.1997.4511"],["dc.identifier.pii","S0090122997945116"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/115067"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-602"],["dc.relation.issn","0090-1229"],["dc.relation.orgunit","Deutsches Primatenzentrum"],["dc.title","Suppression of Viral Replication in a Long-Term Nonprogressing Rhesus Macaque Experimentally Infected with Pathogenic Simian Immunodeficiency Virus (SIV)"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Prion"],["dc.bibliographiccitation.volume","4"],["dc.contributor.author","Kiesel, Petra"],["dc.contributor.author","Gibson, Toby J."],["dc.contributor.author","Ciesielczyk, Barbara"],["dc.contributor.author","Bodemer, Monika"],["dc.contributor.author","Kaup, Franz-Josef"],["dc.contributor.author","Bodemer, Walter"],["dc.contributor.author","Zischler, Hans"],["dc.contributor.author","Zerr, Inga"],["dc.date.accessioned","2018-11-07T08:44:50Z"],["dc.date.available","2018-11-07T08:44:50Z"],["dc.date.issued","2010"],["dc.description.abstract","Alu DNA elements were long considered to be of no biological significance and thus have been only poorly defined. However, in the past Alu DNA elements with well-defined nucleotide sequences have been suspected to contribute to disease, but the role of Alu DNA element transcripts has rarely been investigated. For the first time, we determined in a real-time approach Alu DNA element transcription in buffy coat cells isolated from the blood of humans suffering from sporadic Creutzfeldt-Jakob disease (sCJD) and other neurodegenerative disorders. The reverse transcribed Alu transcripts were amplified and their cDNA sequences were aligned to genomic regions best fitted to database genomic Alu DNA element sequences deposited in the UCSC and NCBI data bases. Our cloned Alu RNA/cDNA sequences were widely distributed in the human genome and preferably belonged to the \"young\" Alu Y family. We also observed that some RNA/cDNA clones could be aligned to several chromosomes because of the same degree of identity and score to resident genomic Alu DNA elements. These elements, called paralogues, have purportedly been recently generated by retrotransposition. Along with cases of sCJD we also included cases of dementia and Alzheimer disease (AD). Each group revealed a divergent pattern of transcribed Alu elements. Chromosome 2 was the most preferred site in sCJD cases, besides chromosome 17; in AD cases chromosome 11 was overrepresented whereas chromosomes 2, 3 and 17 were preferred active Alu loci in controls. Chromosomes 2, 12 and 17 gave rise to Alu transcripts in dementia cases. The detection of putative Alu paralogues widely differed depending on the disease. A detailed data search revealed that some cloned Alu transcripts originated from RNA polymerase III transcription since the genomic sites of their Alu elements were found between genes. Other Alu DNA elements could be located close to or within coding regions of genes. In general, our observations suggest that identification and genomic localization of active Alu DNA elements could be further developed as a surrogate marker for differential gene expression in disease. A sufficient number of cases are necessary for statistical significance before Alu DNA elements can be considered useful to differentiate neurodegenerative diseases from controls."],["dc.identifier.isi","000280388200006"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/20288"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Landes Bioscience"],["dc.relation.issn","1933-6896"],["dc.title","Transcription of Alu DNA elements in blood cells of sporadic Creutzfeldt-Jakob disease (sCJD)"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","90"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Immunology Today"],["dc.bibliographiccitation.lastpage","91"],["dc.bibliographiccitation.volume","15"],["dc.contributor.author","Dittmer, Ulf"],["dc.contributor.author","Bodemer, Walter"],["dc.contributor.author","Hunsmann, Gerhard"],["dc.contributor.author","Voss, Gerald"],["dc.date.accessioned","2022-10-06T13:32:47Z"],["dc.date.available","2022-10-06T13:32:47Z"],["dc.date.issued","1994"],["dc.identifier.doi","10.1016/0167-5699(94)90141-4"],["dc.identifier.pii","0167569994901414"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/115453"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-602"],["dc.relation.issn","0167-5699"],["dc.relation.orgunit","Deutsches Primatenzentrum"],["dc.title","Immunization of macaque monkeys with low- and high-dose regimens of SIVmac results in different immune responses"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","501"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","Immunology Today"],["dc.bibliographiccitation.volume","16"],["dc.contributor.author","Dittmer, Ulf"],["dc.contributor.author","Spring, Michael"],["dc.contributor.author","Bodemer, Walter"],["dc.contributor.author","Hunsmann, Gerhard"],["dc.date.accessioned","2022-10-06T13:32:48Z"],["dc.date.available","2022-10-06T13:32:48Z"],["dc.date.issued","1995"],["dc.identifier.doi","10.1016/0167-5699(95)80037-9"],["dc.identifier.pii","0167569995800379"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/115455"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-602"],["dc.relation.issn","0167-5699"],["dc.relation.orgunit","Deutsches Primatenzentrum"],["dc.title","Cellular immune responses of macaques exposed to low doses of SIV"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","4025"],["dc.bibliographiccitation.issue","21"],["dc.bibliographiccitation.journal","Journal of Cell Science"],["dc.bibliographiccitation.lastpage","4036"],["dc.bibliographiccitation.volume","115"],["dc.contributor.author","Gauczynski, Sabine"],["dc.contributor.author","Krasemann, Susanne"],["dc.contributor.author","Bodemer, Walter"],["dc.contributor.author","Weiss, Stefan"],["dc.date.accessioned","2022-10-06T13:26:13Z"],["dc.date.available","2022-10-06T13:26:13Z"],["dc.date.issued","2002"],["dc.description.abstract","The Semliki-Forest virus (SFV) system was used to overexpress human wild-type and mutant prion proteins as well as FLAG-tagged human and bovine PrP in mammalian cells. The application of recombinant SFV vectors allowed a high-level production of highly glycosylated prion proteins with a molecular weight ranging from 25 to 30 kDa for recombinant wild-type human PrP and from 26 to 32 kDa for wild-type bovine PrP. Further, we report here the generation of recombinant mutant prion proteins that are associated with inherited human prion diseases such as fatal familial insomnia (FFI) and Creutzfeldt-Jakob disease (CJD). Both mutated variants, the FFI-associated PrP carrying a mutation at amino acid position 178 and the CJD-linked form containing an insertion of nine additional octarepeats reveal proteinase K resistance, one of the typical biochemical properties of the infectious scrapie isoform of the prion protein. By contrast, recombinant wild-type PrP was completely proteinase K sensitive when expressed in SFV-transfected BHK cells. The subcellular location of both PrP mutants at the cell surface and in intracellular compartments of transfected BHK cells was similar to that of wild-type PrP. In order to purify recombinant human and bovine PrP from cell lysates, a FLAG-tag was introduced either at the N-terminus behind the signal peptide or at the C-terminus close to the adhesion site of the GPI anchor. N-terminal insertion did not extensively influence the trafficking of the FLAG-tagged protein to the cell surface, whereas insertion close to the GPI attachment site clearly affected the transport of the majority of PrP to the cell membrane, probably resulting in their retention within the secretory pathway. All FLAG-tagged prion proteins were expressed efficiently in BHK cells and showed a typical glycosylation pattern, allowing their rapid and simple purification via anti-FLAG antibody chromatography."],["dc.identifier.doi","10.1242/jcs.00086"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/115032"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-602"],["dc.relation.eissn","1477-9137"],["dc.relation.issn","0021-9533"],["dc.relation.orgunit","Deutsches Primatenzentrum"],["dc.title","Recombinant human prion protein mutants huPrP D178N/M129 (FFI) and huPrP+9OR (fCJD) reveal proteinase K resistance"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

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[["dc.bibliographiccitation.firstpage","985"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","EMERGING INFECTIOUS DISEASES"],["dc.bibliographiccitation.lastpage","988"],["dc.bibliographiccitation.volume","19"],["dc.contributor.author","Krasemann, Susanne"],["dc.contributor.author","Mearini, Giulia"],["dc.contributor.author","Kraemer, Elisabeth"],["dc.contributor.author","Wagenfuehr, Katja"],["dc.contributor.author","Schulz-Schaeffer, Walter J."],["dc.contributor.author","Neumann, Melanie"],["dc.contributor.author","Bodemer, Walter"],["dc.contributor.author","Kaup, Franz-Josef"],["dc.contributor.author","Beekes, Michael"],["dc.contributor.author","Carrier, Lucie"],["dc.contributor.author","Aguzzi, Adriano"],["dc.contributor.author","Glatzel, Markus"],["dc.date.accessioned","2018-11-07T09:23:46Z"],["dc.date.available","2018-11-07T09:23:46Z"],["dc.date.issued","2013"],["dc.description.abstract","Prion amyloidosis occurred in the heart of 1 of 3 macaques intraperitoneally inoculated with bovine spongiform encephalopathy prions. This macaque had a remarkably long duration of disease and signs of cardiac distress. Variant Creutzfeldt-Jakob disease, caused by transmission of bovine spongiform encephalopathy to humans, may manifest with cardiac symptoms from prion-amyloid cardiomyopathy."],["dc.identifier.doi","10.3201/eid1906.120906"],["dc.identifier.isi","000328173500020"],["dc.identifier.pmid","23735198"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/29660"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Centers Disease Control"],["dc.relation.issn","1080-6059"],["dc.relation.issn","1080-6040"],["dc.title","BSE-associated Prion-Amyloid Cardiomyopathy in Primates"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","391"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Journal of Toxicology and Environmental Health, Part A"],["dc.bibliographiccitation.lastpage","401"],["dc.bibliographiccitation.volume","75"],["dc.contributor.author","Kiesel, Petra"],["dc.contributor.author","Kues, Andreas"],["dc.contributor.author","Kaup, Franz-Josef"],["dc.contributor.author","Bodemer, Walter"],["dc.contributor.author","Gibson, Toby J."],["dc.contributor.author","Zischler, Hans"],["dc.date.accessioned","2021-06-01T10:51:12Z"],["dc.date.available","2021-06-01T10:51:12Z"],["dc.date.issued","2012"],["dc.identifier.doi","10.1080/15287394.2012.670896"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/86929"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.relation.eissn","1087-2620"],["dc.relation.issn","1528-7394"],["dc.title","A Comparative Analysis to Study Editing of Small Noncoding BC200- and Alu Transcripts in Brain of Prion-Inoculated Rhesus Monkeys ( M. Mulatta )"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","173"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","AIDS Research and Human Retroviruses"],["dc.bibliographiccitation.lastpage","179"],["dc.bibliographiccitation.volume","16"],["dc.contributor.author","Tarantul, Vyacheslav Z."],["dc.contributor.author","Nikolaev, Alexey I."],["dc.contributor.author","Martynenko, Alina"],["dc.contributor.author","Hannig, Horst"],["dc.contributor.author","Hunsmann, Gerhard"],["dc.contributor.author","Bodemer, Walter"],["dc.date.accessioned","2022-10-06T13:34:39Z"],["dc.date.available","2022-10-06T13:34:39Z"],["dc.date.issued","2000"],["dc.identifier.doi","10.1089/088922200309511"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/115966"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-602"],["dc.relation.eissn","1931-8405"],["dc.relation.issn","0889-2229"],["dc.relation.orgunit","Deutsches Primatenzentrum"],["dc.title","Differential Gene Expression in B-Cell Non-Hodgkin's Lymphoma of SIV-Infected Monkey"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]