Hoch, Gerhard

[["dc.bibliographiccitation.firstpage","35"],["dc.bibliographiccitation.journal","Acta Physiologica"],["dc.bibliographiccitation.lastpage","36"],["dc.bibliographiccitation.volume","213"],["dc.contributor.author","Keppeler, Daniel"],["dc.contributor.author","Jeschke, Marcus"],["dc.contributor.author","Wrobel, C."],["dc.contributor.author","Hoch, Gerhard"],["dc.contributor.author","Gossler, Christian"],["dc.contributor.author","Schwarz, U. T."],["dc.contributor.author","Ruther, P."],["dc.contributor.author","Schwaerzle, M."],["dc.contributor.author","Hessler, R."],["dc.contributor.author","Salditt, Tim"],["dc.contributor.author","Kügler, Sebastian"],["dc.contributor.author","Moser, Tobias"],["dc.date.accessioned","2018-11-07T09:59:50Z"],["dc.date.available","2018-11-07T09:59:50Z"],["dc.date.issued","2015"],["dc.identifier.isi","000362554200073"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/37681"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.publisher.place","Hoboken"],["dc.title","In vivo application of optogenetics in the auditory system"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","673"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Neuroscience"],["dc.bibliographiccitation.lastpage","684"],["dc.bibliographiccitation.volume","149"],["dc.contributor.author","Pauli-Magnus, D."],["dc.contributor.author","Hoch, G."],["dc.contributor.author","Strenzke, N."],["dc.contributor.author","Anderson, S."],["dc.contributor.author","Jentsch, T. J."],["dc.contributor.author","Moser, T."],["dc.date.accessioned","2017-09-07T11:49:23Z"],["dc.date.available","2017-09-07T11:49:23Z"],["dc.date.issued","2007"],["dc.description.abstract","Sensorineural hearing loss (SNHL) comprises hearing disorders with diverse pathologies of the inner ear and the auditory nerve. To date, an unambiguous phenotypical characterization of the specific pathologies in an affected individual remains impossible. Here, we evaluated the use of scalp-recorded auditory steady-state responses (ASSR) and transient auditory brainstem responses (ABR) for differentiating the disease mechanisms underlying sensorineural hearing loss in well-characterized mouse models. We first characterized the ASSR evoked by sinusoidally amplitude-modulated tones in wild-type mice. ASSR were robustly elicited within three ranges of modulation frequencies below 200 Hz, from 200 to 600 Hz and beyond 600 Hz in most recordings. Using phase information we estimated the apparent ASSR latency to be about 3 ms, suggesting generation in the auditory brainstem. Auditory thresholds obtained by automated and visual analysis of ASSR recordings were comparable to those found with tone-burst evoked ABR in the same mice. We then recorded ASSR and ABR from mouse mutants bearing defects of either outer hair cell amplification (KC NQ4- knockout) or inner hair cell synaptic transmission (Bassoon-mutant). Both mutants showed an increase of ASSR and ABR thresholds of approximately 40 dB versus wild-type when investigated at 8 weeks of age. Mice with defective amplification displayed a steep rise of ASSR and ABR amplitudes with increasing sound intensity, presumably reflecting a strong recruitment of synchronously activated neural elements beyond threshold. In contrast, the amplitudes of ASSR and ABR responses of mice with impaired synaptic transmission grew very little with sound intensity. In summary, ASSR allow for a rapid, objective and frequency-specific hearing assessment and together with ABR and otoacoustic emissions can contribute to the differential diagnosis of SNHL. (C) 2007 IBRO. Published by Elsevier Ltd. All rights reserved."],["dc.identifier.doi","10.1016/j.neuroscience.2007.08.010"],["dc.identifier.gro","3143413"],["dc.identifier.isi","000251022900020"],["dc.identifier.pmid","17869440"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/925"],["dc.notes.intern","WoS Import 2017-03-10"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation.issn","0306-4522"],["dc.title","Detection and differentiation of sensorineural hearing loss in mice using auditory steady-state responses and transient auditory brainstem responses"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","444"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Nature Neuroscience"],["dc.bibliographiccitation.lastpage","453"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Meyer, Alexander C."],["dc.contributor.author","Frank, Thomas"],["dc.contributor.author","Khimich, Darina"],["dc.contributor.author","Hoch, Gerhard"],["dc.contributor.author","Riedel, Dietmar"],["dc.contributor.author","Chapochnikov, Nikolai M."],["dc.contributor.author","Yarin, Yury M."],["dc.contributor.author","Harke, Benjamin"],["dc.contributor.author","Hell, Stefan"],["dc.contributor.author","Egner, Alexander"],["dc.contributor.author","Moser, Tobias"],["dc.date.accessioned","2017-09-07T11:47:30Z"],["dc.date.available","2017-09-07T11:47:30Z"],["dc.date.issued","2009"],["dc.description.abstract","Cochlear inner hair cells (IHCs) transmit acoustic information to spiral ganglion neurons through ribbon synapses. Here we have used morphological and physiological techniques to ask whether synaptic mechanisms differ along the tonotopic axis and within IHCs in the mouse cochlea. We show that the number of ribbon synapses per IHC peaks where the cochlea is most sensitive to sound. Exocytosis, measured as membrane capacitance changes, scaled with synapse number when comparing apical and midcochlear IHCs. Synapses were distributed in the subnuclear portion of IHCs. High-resolution imaging of IHC synapses provided insights into presynaptic Ca2+ channel clusters and Ca2+ signals, synaptic ribbons and postsynaptic glutamate receptor clusters and revealed subtle differences in their average properties along the tonotopic axis. However, we observed substantial variability for presynaptic Ca2+ signals, even within individual IHCs, providing a candidate presynaptic mechanism for the divergent dynamics of spiral ganglion neuron spiking."],["dc.identifier.doi","10.1038/nn.2293"],["dc.identifier.gro","3143132"],["dc.identifier.isi","000264563100019"],["dc.identifier.pmid","19270686"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/612"],["dc.language.iso","en"],["dc.notes.intern","WoS Import 2017-03-10"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation.issn","1097-6256"],["dc.title","Tuning of synapse number, structure and function in the cochlea"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","e52069"],["dc.bibliographiccitation.issue","92"],["dc.bibliographiccitation.journal","Journal of Visualized Experiments"],["dc.contributor.author","Hernandez, Victor H."],["dc.contributor.author","Gehrt, Anna"],["dc.contributor.author","Jing, Zhizi"],["dc.contributor.author","Hoch, Gerhard"],["dc.contributor.author","Jeschke, Marcus"],["dc.contributor.author","Strenzke, Nicola"],["dc.contributor.author","Moser, Tobias"],["dc.date.accessioned","2017-09-07T11:45:27Z"],["dc.date.available","2017-09-07T11:45:27Z"],["dc.date.issued","2014"],["dc.description.abstract","Direct electrical stimulation of spiral ganglion neurons (SGNs) by cochlear implants (CIs) enables open speech comprehension in the majority of implanted deaf subjects(1-6). Nonetheless, sound coding with current CIs has poor frequency and intensity resolution due to broad current spread from each electrode contact activating a large number of SGNs along the tonotopic axis of the cochlea(7-9). Optical stimulation is proposed as an alternative to electrical stimulation that promises spatially more confined activation of SGNs and, hence, higher frequency resolution of coding. In recent years, direct infrared illumination of the cochlea has been used to evoke responses in the auditory nerve(10). Nevertheless it requires higher energies than electrical stimulation(10,11) and uncertainty remains as to the underlying mechanism(12). Here we describe a method based on optogenetics to stimulate SGNs with low intensity blue light, using transgenic mice with neuronal expression of channelrhodopsin 2 (ChR2)(13) or virus-mediated expression of the ChR2-variant CatCh(14). We used micro-light emitting diodes (mu LEDs) and fiber-coupled lasers to stimulate ChR2-expressing SGNs through a small artificial opening (cochleostomy) or the round window. We assayed the responses by scalp recordings of light-evoked potentials (optogenetic auditory brainstem response: oABR) or by microelectrode recordings from the auditory pathway and compared them with acoustic and electrical stimulation."],["dc.identifier.doi","10.3791/52069"],["dc.identifier.gro","3142038"],["dc.identifier.isi","000349303100063"],["dc.identifier.pmid","25350571"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/3856"],["dc.language.iso","en"],["dc.notes.intern","WoS Import 2017-03-10"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation.issn","1940-087X"],["dc.title","Optogenetic Stimulation of the Auditory Nerve. Towards an Optical Cochlear Prosthetic"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","28"],["dc.bibliographiccitation.issue","S327"],["dc.bibliographiccitation.journal","Proceedings of the International Astronomical Union"],["dc.bibliographiccitation.lastpage","33"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Manrique, S. J. González"],["dc.contributor.author","Denker, C."],["dc.contributor.author","Kuckein, C."],["dc.contributor.author","Yabar, A. Pastor"],["dc.contributor.author","Collados, M."],["dc.contributor.author","Verma, M."],["dc.contributor.author","Balthasar, H."],["dc.contributor.author","Diercke, A."],["dc.contributor.author","Fischer, C. E."],["dc.contributor.author","Gömöry, P."],["dc.contributor.author","González, N. Bello"],["dc.contributor.author","Schlichenmaier, R."],["dc.contributor.author","Armas, M. Cubas"],["dc.contributor.author","Berkefeld, T."],["dc.contributor.author","Feller, A."],["dc.contributor.author","Hoch, S."],["dc.contributor.author","Hofmann, A."],["dc.contributor.author","Lagg, A."],["dc.contributor.author","Nicklas, H."],["dc.contributor.author","Suárez, D. Orozco"],["dc.contributor.author","Schmidt, D."],["dc.contributor.author","Schmidt, W."],["dc.contributor.author","Sigwarth, M."],["dc.contributor.author","Sobotka, M."],["dc.contributor.author","Solanki, S. K."],["dc.contributor.author","Soltau, D."],["dc.contributor.author","Staude, J."],["dc.contributor.author","Strassmeier, K. G."],["dc.contributor.author","Volkmer, R."],["dc.contributor.author","von der Lühe, O."],["dc.contributor.author","Waldmann, T."],["dc.date.accessioned","2020-12-10T15:22:25Z"],["dc.date.available","2020-12-10T15:22:25Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1017/S1743921317000278"],["dc.identifier.eissn","1743-9221"],["dc.identifier.issn","1743-9213"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/73394"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Flows along arch filaments observed in the GRIS ‘very fast spectroscopic mode’"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","A3"],["dc.bibliographiccitation.journal","Astronomy and Astrophysics"],["dc.bibliographiccitation.volume","596"],["dc.contributor.author","Verma, M."],["dc.contributor.author","Denker, C."],["dc.contributor.author","Balthasar, H."],["dc.contributor.author","Kuckein, C."],["dc.contributor.author","Manrique, S. J. Gonzalez"],["dc.contributor.author","Sobotka, M."],["dc.contributor.author","Gonzalez, N. Bello"],["dc.contributor.author","Hoch, S."],["dc.contributor.author","Diercke, A."],["dc.contributor.author","Kummerow, P."],["dc.contributor.author","Berkefeld, T."],["dc.contributor.author","Collados, M."],["dc.contributor.author","Feller, A."],["dc.contributor.author","Hofmann, Albrecht W."],["dc.contributor.author","Kneer, F."],["dc.contributor.author","Lagg, A."],["dc.contributor.author","Loehner-Boettcher, J."],["dc.contributor.author","Nicklas, H."],["dc.contributor.author","Pastor Yabar, A."],["dc.contributor.author","Schlichenmaier, R."],["dc.contributor.author","Schmidt, D."],["dc.contributor.author","Schmidt, W."],["dc.contributor.author","Schubert, M."],["dc.contributor.author","Sigwarth, M."],["dc.contributor.author","Solanki, Parth K."],["dc.contributor.author","Soltau, D."],["dc.contributor.author","Staude, J."],["dc.contributor.author","Strassmeier, K. G."],["dc.contributor.author","Volkmer, R."],["dc.contributor.author","von der Luehe, O."],["dc.contributor.author","Waldmann, T."],["dc.date.accessioned","2018-11-07T10:04:59Z"],["dc.date.available","2018-11-07T10:04:59Z"],["dc.date.issued","2016"],["dc.description.abstract","Context. The solar magnetic field is responsible for all aspects of solar activity. Thus, emergence of magnetic flux at the surface is the first manifestation of the ensuing solar activity. Aims. Combining high-resolution and synoptic observations aims to provide a comprehensive description of flux emergence at photospheric level and of the growth process that eventually leads to a mature active region. Methods. The small active region NOAA 12118 emerged on 2014 July 17 and was observed one day later with the 1.5-m GREGOR solar telescope on 2014 July 18. High-resolution time-series of blue continuum and G-band images acquired in the blue imaging channel (BIC) of the GREGOR Fabry-Perot Interferometer (GFPI) were complemented by synoptic line-of-sight magnetograms and continuum images obtained with the Helioseismic and Magnetic Imager (HMI) onboard the Solar Dynamics Observatory (SDO). Horizontal proper motions and horizontal plasma velocities were computed with local correlation tracking (LCT) and the differential affine velocity estimator (DAVE), respectively. Morphological image processing was employed to measure the photometric and magnetic area, magnetic flux, and the separation profile of the emerging flux region during its evolution. Results. The computed growth rates for photometric area, magnetic area, and magnetic flux are about twice as high as the respective decay rates. The space-time diagram using HMI magnetograms of five days provides a comprehensive view of growth and decay. It traces a leaf-like structure, which is determined by the initial separation of the two polarities, a rapid expansion phase, a time when the spread stalls, and a period when the region slowly shrinks again. The separation rate of 0.26 km s(-1) is highest in the initial stage, and it decreases when the separation comes to a halt. Horizontal plasma velocities computed at four evolutionary stages indicate a changing pattern of inflows. In LCT maps we find persistent flow patterns such as outward motions in the outer part of the two major pores, a diverging feature near the trailing pore marking the site of upwelling plasma and flux emergence, and low velocities in the interior of dark pores. We detected many elongated rapidly expanding granules between the two major polarities, with dimensions twice as large as the normal granules."],["dc.identifier.doi","10.1051/0004-6361/201628380"],["dc.identifier.isi","000390797900035"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14276"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/38807"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Edp Sciences S A"],["dc.relation","info:eu-repo/grantAgreement/EC/FP7/312495/EU/High-Resolution Solar Physics Network/SOLARNET"],["dc.relation.issn","1432-0746"],["dc.relation.orgunit","Fakultät für Physik"],["dc.title","Horizontal flow fields in and around a small active region The transition period between flux emergence and decay"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","E4716"],["dc.bibliographiccitation.issue","32"],["dc.bibliographiccitation.journal","Proceedings of the National Academy of Sciences"],["dc.bibliographiccitation.lastpage","E4725"],["dc.bibliographiccitation.volume","113"],["dc.contributor.author","Ohn, Tzu-Lun"],["dc.contributor.author","Rutherford, Mark A."],["dc.contributor.author","Jing, Zhizi"],["dc.contributor.author","Jung, Sangyong"],["dc.contributor.author","Duque-Afonso, Carlos J."],["dc.contributor.author","Hoch, Gerhard"],["dc.contributor.author","Picher, Maria Magdalena"],["dc.contributor.author","Scharinger, Anja"],["dc.contributor.author","Strenzke, Nicola"],["dc.contributor.author","Moser, Tobias"],["dc.date.accessioned","2017-09-07T11:53:13Z"],["dc.date.available","2017-09-07T11:53:13Z"],["dc.date.issued","2016"],["dc.description.abstract","For sounds of a given frequency, spiral ganglion neurons (SGNs) with different thresholds and dynamic ranges collectively encode the wide range of audible sound pressures. Heterogeneity of synapses between inner hair cells (IHCs) and SGNs is an attractive candidate mechanism for generating complementary neural codes covering the entire dynamic range. Here, we quantified active zone (AZ) properties as a function of AZ position within mouse IHCs by combining patch clamp and imaging of presynaptic Ca2+ influx and by immunohistochemistry. We report substantial AZ heterogeneity whereby the voltage of half-maximal activation of Ca2+ influx ranged over ∼20 mV. Ca2+ influx at AZs facing away from the ganglion activated at weaker depolarizations. Estimates of AZ size and Ca2+ channel number were correlated and larger when AZs faced the ganglion. Disruption of the deafness gene GIPC3 in mice shifted the activation of presynaptic Ca2+ influx to more hyperpolarized potentials and increased the spontaneous SGN discharge. Moreover, Gipc3 disruption enhanced Ca2+ influx and exocytosis in IHCs, reversed the spatial gradient of maximal Ca2+ influx in IHCs, and increased the maximal firing rate of SGNs at sound onset. We propose that IHCs diversify Ca2+ channel properties among AZs and thereby contribute to decomposing auditory information into complementary representations in SGNs."],["dc.identifier.doi","10.1073/pnas.1605737113"],["dc.identifier.gro","3145053"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/2747"],["dc.language.iso","en"],["dc.notes.intern","Crossref Import"],["dc.notes.status","final"],["dc.relation.issn","0027-8424"],["dc.title","Hair cells use active zones with different voltage dependence of Ca2+influx to decompose sounds into complementary neural codes"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.peerReviewed","no"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1114"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Journal of Clinical Investigation"],["dc.bibliographiccitation.lastpage","1129"],["dc.bibliographiccitation.volume","124"],["dc.contributor.author","Hernandez, Victor H."],["dc.contributor.author","Gehrt, Anna"],["dc.contributor.author","Reuter, Kirsten"],["dc.contributor.author","Jing, Zhizi"],["dc.contributor.author","Jeschke, Marcus"],["dc.contributor.author","Schulz, Alejandro Mendoza"],["dc.contributor.author","Hoch, Gerhard"],["dc.contributor.author","Bartels, Matthias"],["dc.contributor.author","Vogt, Gerhard"],["dc.contributor.author","Garnham, Carolyn W."],["dc.contributor.author","Yawo, Hiromu"],["dc.contributor.author","Fukazawa, Yugo"],["dc.contributor.author","Augustine, George J."],["dc.contributor.author","Bamberg, Ernst"],["dc.contributor.author","Kügler, Sebastian"],["dc.contributor.author","Salditt, Tim"],["dc.contributor.author","Hoz, Livia de"],["dc.contributor.author","Strenzke, Nicola"],["dc.contributor.author","Moser, Tobias"],["dc.date.accessioned","2017-09-07T11:46:28Z"],["dc.date.available","2017-09-07T11:46:28Z"],["dc.date.issued","2014"],["dc.description.abstract","Auditory prostheses can partially restore speech comprehension when hearing fails. Sound coding with current prostheses is based on electrical stimulation of auditory neurons and has limited frequency resolution due to broad current spread within the cochlea. In contrast, optical stimulation can be spatially confined, which may improve frequency resolution. Here, we used animal models to characterize optogenetic stimulation, which is the optical stimulation of neurons genetically engineered to express the light-gated ion channel channelrhodopsin-2 (ChR2). Optogenetic stimulation of spiral ganglion neurons (SGNs) activated the auditory pathway, as demonstrated by recordings of single neuron and neuronal population responses. Furthermore, optogenetic stimulation of SGNs restored auditory activity in deaf mice. Approximation of the spatial spread of cochlear excitation by recording local field potentials (LFPs) in the inferior colliculus in response to suprathreshold optical, acoustic, and electrical stimuli indicated that optogenetic stimulation achieves better frequency resolution than monopolar electrical stimulation. Virus-mediated expression of a ChR2 variant with greater light sensitivity in SGNs reduced the amount of light required for responses and allowed neuronal spiking following stimulation up to 60 Hz. Our study demonstrates a strategy for optogenetic stimulation of the auditory pathway in rodents and lays the groundwork for future applications of cochlear optogenetics in auditory research and prosthetics."],["dc.identifier.doi","10.1172/JCI69050"],["dc.identifier.gro","3142178"],["dc.identifier.isi","000332347700030"],["dc.identifier.pmid","24509078"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/5399"],["dc.language.iso","en"],["dc.notes.intern","WoS Import 2017-03-10"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation.eissn","1558-8238"],["dc.relation.issn","0021-9738"],["dc.relation.orgunit","Institut für Röntgenphysik"],["dc.relation.workinggroup","RG Salditt (Structure of Biomolecular Assemblies and X-Ray Physics)"],["dc.subject.gro","x-ray imaging"],["dc.subject.gro","biomedical tomography"],["dc.title","Optogenetic stimulation of the auditory pathway"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1057"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","Astronomische Nachrichten"],["dc.bibliographiccitation.lastpage","1063"],["dc.bibliographiccitation.volume","337"],["dc.contributor.author","Manrique, S. J. Gonzalez"],["dc.contributor.author","Kuckein, C."],["dc.contributor.author","Pastor Yabar, A."],["dc.contributor.author","Collados, M."],["dc.contributor.author","Denker, C."],["dc.contributor.author","Fischer, C. E."],["dc.contributor.author","Gomory, P."],["dc.contributor.author","Diercke, A."],["dc.contributor.author","Gonzalez, N. Bello"],["dc.contributor.author","Schlichenmaier, R."],["dc.contributor.author","Balthasar, H."],["dc.contributor.author","Berkefeld, T."],["dc.contributor.author","Feller, A."],["dc.contributor.author","Hoch, S."],["dc.contributor.author","Hofmann, Albrecht W."],["dc.contributor.author","Kneer, F."],["dc.contributor.author","Lagg, A."],["dc.contributor.author","Nicklas, H."],["dc.contributor.author","Orozco Suarez, D."],["dc.contributor.author","Schmidt, D."],["dc.contributor.author","Schmidt, W."],["dc.contributor.author","Sigwarth, M."],["dc.contributor.author","Sobotka, M."],["dc.contributor.author","Solanki, Parth K."],["dc.contributor.author","Soltau, D."],["dc.contributor.author","Staude, J."],["dc.contributor.author","Strassmeier, K. G."],["dc.contributor.author","Verma, M."],["dc.contributor.author","Volkmer, R."],["dc.contributor.author","von der Luhe, O."],["dc.contributor.author","Waldmann, T."],["dc.date.accessioned","2018-11-07T10:06:06Z"],["dc.date.available","2018-11-07T10:06:06Z"],["dc.date.issued","2016"],["dc.description.abstract","The new generation of solar instruments provides better spectral, spatial, and temporal resolution for a better understanding of the physical processes that take place on the Sun. Multiple-component profiles are more commonly observed with these instruments. Particularly, the He i 10830 triplet presents such peculiar spectral profiles, which give information on the velocity and magnetic fine structure of the upper chromosphere. The purpose of this investigation is to describe a technique to efficiently fit the two blended components of the He i 10830 triplet, which are commonly observed when two atmospheric components are located within the same resolution element. The observations used in this study were taken on 2015 April 17 with the very fast spectroscopic mode of the GREGOR Infrared Spectrograph (GRIS) attached to the 1.5-m GREGOR solar telescope, located at the Observatorio del Teide, Tenerife, Spain. We apply a double-Lorentzian fitting technique using Levenberg-Marquardt least-squares minimization. This technique is very simple and much faster than inversion codes. Line-of-sight Doppler velocities can be inferred for a whole map of pixels within just a few minutes. Our results show sub-and supersonic downflow velocities of up to 32 km s(-1) for the fast component in the vicinity of footpoints of filamentary structures. The slow component presents velocities close to rest. (C) 2016 WILEY-VCH Verlag GmbH& Co. KGaA, Weinheim"],["dc.identifier.doi","10.1002/asna.201512433"],["dc.identifier.isi","000391297900011"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/39026"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-v C H Verlag Gmbh"],["dc.publisher.place","Weinheim"],["dc.relation.conference","12th Potsdam Thinkshop Conference on Dynamic Sun - Exploring the Many Facets of Solar Eruptive Events"],["dc.relation.eventlocation","Potsdam, GERMANY"],["dc.relation.issn","1521-3994"],["dc.relation.issn","0004-6337"],["dc.title","Fitting peculiar spectral profiles in He I 10830 angstrom absorption features"],["dc.type","conference_paper"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","205401"],["dc.bibliographiccitation.issue","20"],["dc.bibliographiccitation.journal","Journal of Physics D: Applied Physics"],["dc.bibliographiccitation.volume","47"],["dc.contributor.author","Gossler, Christian"],["dc.contributor.author","Bierbrauer, Colin"],["dc.contributor.author","Moser, Ruediger"],["dc.contributor.author","Kunzer, Michael"],["dc.contributor.author","Holc, Katarzyna"],["dc.contributor.author","Pletschen, Wilfried"],["dc.contributor.author","Koehler, Klaus"],["dc.contributor.author","Wagner, Joachim"],["dc.contributor.author","Schwaerzle, Michael"],["dc.contributor.author","Ruther, Patrick"],["dc.contributor.author","Paul, Oliver"],["dc.contributor.author","Neef, Jakob"],["dc.contributor.author","Keppeler, Daniel"],["dc.contributor.author","Hoch, Gerhard"],["dc.contributor.author","Moser, Tobias"],["dc.contributor.author","Schwarz, Ulrich T."],["dc.date.accessioned","2017-09-07T11:46:14Z"],["dc.date.available","2017-09-07T11:46:14Z"],["dc.date.issued","2014"],["dc.description.abstract","Currently available cochlear implants are based on electrical stimulation of the spiral ganglion neurons. Optical stimulation with arrays of micro-sized light-emitting diodes (mu LEDs) promises to increase the number of distinguishable frequencies. Here, the development of a flexible GaN-based micro-LED array as an optical cochlear implant is reported for application in a mouse model. The fabrication of 15 mu m thin and highly flexible devices is enabled by a laser-based layer transfer process of the GaN-LEDs from sapphire to a polyimide-on-silicon carrier wafer. The fabricated 50 x 50 mu m(2) LEDs are contacted via conducting paths on both p- and n-sides of the LEDs. Up to three separate channels could be addressed. The probes, composed of a linear array of the said mu LEDs bonded to the flexible polyimide substrate, are peeled off the carrier wafer and attached to flexible printed circuit boards. Probes with four mu LEDs and a width of 230 mu m are successfully implanted in the mouse cochlea both in vitro and in vivo. The LEDs emit 60 mu W at 1 mA after peel-off, corresponding to a radiant emittance of 6 mW mm(-2)."],["dc.identifier.doi","10.1088/0022-3727/47/20/205401"],["dc.identifier.gro","3142121"],["dc.identifier.isi","000335517500011"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/4777"],["dc.notes.intern","WoS Import 2017-03-10"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Iop Publishing Ltd"],["dc.relation.eissn","1361-6463"],["dc.relation.issn","0022-3727"],["dc.title","GaN-based micro-LED arrays on flexible substrates for optical cochlear implants"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dspace.entity.type","Publication"]]