Hellriegel, Martin

[["dc.bibliographiccitation.artnumber","e0165705"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","PLoS ONE"],["dc.bibliographiccitation.volume","11"],["dc.contributor.author","Eulenburg, Christine"],["dc.contributor.author","Suling, Anna"],["dc.contributor.author","Neuser, Petra"],["dc.contributor.author","Reuss, Alexander"],["dc.contributor.author","Canzler, Ulrich"],["dc.contributor.author","Fehm, Tanja"],["dc.contributor.author","Luyten, Alexander"],["dc.contributor.author","Hellriegel, Martin"],["dc.contributor.author","Woelber, Linn"],["dc.contributor.author","Mahner, Sven"],["dc.date.accessioned","2018-11-07T10:06:36Z"],["dc.date.available","2018-11-07T10:06:36Z"],["dc.date.issued","2016"],["dc.description.abstract","Propensity scoring (PS) is an established tool to account for measured confounding in non-randomized studies. These methods are sensitive to missing values, which are a common problem in observational data. The combination of multiple imputation of missing values and different propensity scoring techniques is addressed in this work. For a sample of lymph node-positive vulvar cancer patients, we re-analyze associations between the application of radiotherapy and disease-related and non-related survival. Inverse-probability-of-treatment-weighting (IPTW) and PS stratification are applied after multiple imputation by chained equation (MICE). Methodological issues are described in detail. Interpretation of the results and methodological limitations are discussed."],["dc.description.sponsorship","Medac oncology company"],["dc.identifier.doi","10.1371/journal.pone.0165705"],["dc.identifier.isi","000386714200041"],["dc.identifier.pmid","27802342"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/13939"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/39125"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Public Library Science"],["dc.relation.issn","1932-6203"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Propensity Scoring after Multiple Imputation in a Retrospective Study on Adjuvant Radiation Therapy in Lymph-Node Positive Vulvar Cancer"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","180"],["dc.bibliographiccitation.journal","European Journal of Cancer"],["dc.bibliographiccitation.lastpage","188"],["dc.bibliographiccitation.volume","69"],["dc.contributor.author","Woelber, Linn"],["dc.contributor.author","Griebel, Lis-Femke"],["dc.contributor.author","Eulenburg, Christine"],["dc.contributor.author","Sehouli, Jalid"],["dc.contributor.author","Jueckstock, Julia"],["dc.contributor.author","Hilpert, Felix"],["dc.contributor.author","de Gregorio, Nikolaus"],["dc.contributor.author","Hasenburg, Annette"],["dc.contributor.author","Ignatov, Atanas"],["dc.contributor.author","Hillemanns, Peter"],["dc.contributor.author","Fuerst, Sophie"],["dc.contributor.author","Strauss, Hans-Georg"],["dc.contributor.author","Baumann, Klaus H."],["dc.contributor.author","Thiel, Falk Clemens"],["dc.contributor.author","Mustea, Alexander"],["dc.contributor.author","Meier, Werner"],["dc.contributor.author","Harter, Philipp"],["dc.contributor.author","Wimberger, Pauline"],["dc.contributor.author","Hanker, Lars Christian"],["dc.contributor.author","Schmalfeldt, Barbara"],["dc.contributor.author","Canzler, Ulrich"],["dc.contributor.author","Fehm, Tanja"],["dc.contributor.author","Luyten, Alexander"],["dc.contributor.author","Hellriegel, Martin"],["dc.contributor.author","Kosse, Jens"],["dc.contributor.author","Heiss, Christoph"],["dc.contributor.author","Hantschmann, Peer"],["dc.contributor.author","Mallmann, Peter"],["dc.contributor.author","Tanner, Berno"],["dc.contributor.author","Pfisterer, Jacobus"],["dc.contributor.author","Richter, Barbara"],["dc.contributor.author","Neuser, Petra"],["dc.contributor.author","Mahner, Sven"],["dc.date.accessioned","2018-11-07T10:05:17Z"],["dc.date.available","2018-11-07T10:05:17Z"],["dc.date.issued","2016"],["dc.description.abstract","Aim of the study: A tumour-free pathological resection margin of >= 8 mm is considered state-of-the-art. Available evidence is based on heterogeneous cohorts. This study was designed to clarify the relevance of the resection margin for loco-regional control in vulvar cancer. Methods: AGO-CaRE-1 is a large retrospective study. Patients (n = 1618) with vulvar cancer >= FIGO stage IB treated at 29 German gynecologic-cancer-centres 1998-2008 were included. This subgroup analysis focuses on solely surgically treated node-negative patients with complete tumour resection (n = 289). Results: Of the 289 analysed patients, 141 (48.8%) had pT1b, 140 (48.4%) pT2 and 8 (2.8%) pT3 tumours. One hundred twenty-five (43.3%) underwent complete vulvectomy, 127 (43.9%) partial vulvectomy and 37 (12.8%) radical local excision. The median minimal resection margin was 5 mm (1 mm-33 mm); all patients received groin staging, in 86.5% with full dissection. Median follow-up was 35.1 months. 46 (15.9%) patients developed recurrence, thereof 34 (11.8%) at the vulva, after a median of 18.3 months. Vulvar recurrence rates were 12.6% in patients with a margin <8mm and 10.2% in patients with a margin >= 8 mm. When analysed as a continuous variable, the margin distance had no statistically significant impact on local recurrence (HR per mm increase: 0.930, 95% CI: 0.849-1.020; p=0.125). Multivariate analyses did also not reveal a significant association between the margin and local recurrence neither when analysed as continuous variable nor categorically based on the 8 mm cutoff. Results were consistent when looking at disease-free-survival and time-to-recurrence at any site (HR per mm increase: 0.949, 95% CI: 0.864-1.041; p = 0.267). Conclusions: The need for a minimal margin of 8 mm could not be confirmed in the large and homogeneous node-negative cohort of the AGO-CaRE database. (C) 2016 Elsevier Ltd. All rights reserved."],["dc.description.sponsorship","medac oncology"],["dc.identifier.doi","10.1016/j.ejca.2016.09.038"],["dc.identifier.isi","000388846300022"],["dc.identifier.pmid","27837710"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/38868"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Sci Ltd"],["dc.relation.issn","1879-0852"],["dc.relation.issn","0959-8049"],["dc.title","Role of tumour-free margin distance for loco-regional control in vulvar cancer-a subset analysis of the Arbeitsgemeinschaft Gynakologische Onkologie CaRE-1 multicenter study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","5592"],["dc.bibliographiccitation.issue","15_suppl"],["dc.bibliographiccitation.journal","Journal of Clinical Oncology"],["dc.bibliographiccitation.lastpage","5592"],["dc.bibliographiccitation.volume","37"],["dc.contributor.author","Woelber, Linn Lena"],["dc.contributor.author","Prieske, Katharina"],["dc.contributor.author","Eulenburg, Christine"],["dc.contributor.author","de Gregorio, Nikolaus"],["dc.contributor.author","Klapdor, Rüdiger"],["dc.contributor.author","Kalder, Matthias"],["dc.contributor.author","Braicu, Elena Ioana"],["dc.contributor.author","Fuerst, Sophie"],["dc.contributor.author","Klar, Maximillian"],["dc.contributor.author","Strauss, Hans-Georg"],["dc.contributor.author","Mehlhorn, Grit"],["dc.contributor.author","Meier, Werner"],["dc.contributor.author","Ignatov, Atanas"],["dc.contributor.author","Mustea, Alexander"],["dc.contributor.author","Jueckstock, Julia Kathrin"],["dc.contributor.author","Schmidt, Georg"],["dc.contributor.author","Bauerschlag, Dirk"],["dc.contributor.author","Hellriegel, Martin"],["dc.contributor.author","Mahner, Sven"],["dc.contributor.author","Burandt, Eike"],["dc.date.accessioned","2020-12-10T18:41:36Z"],["dc.date.available","2020-12-10T18:41:36Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1200/JCO.2019.37.15_suppl.5592"],["dc.identifier.eissn","1527-7755"],["dc.identifier.issn","0732-183X"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/77626"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","p53 and p16 expression profiles reveal three prognostically relevant subgroups in vulvar cancer: A TMA based study by the AGO-CaRE-translational study group."],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]