Hellriegel, Martin

[["dc.bibliographiccitation.firstpage","1905"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","European Journal of Cancer"],["dc.bibliographiccitation.lastpage","1914"],["dc.bibliographiccitation.volume","49"],["dc.contributor.author","du Bois, Andreas"],["dc.contributor.author","Ewald-Riegler, Nina"],["dc.contributor.author","de Gregorio, Nikolaus"],["dc.contributor.author","Reuss, Alexander"],["dc.contributor.author","Mahner, Sven"],["dc.contributor.author","Fotopoulou, Christina"],["dc.contributor.author","Kommoss, Friedrich"],["dc.contributor.author","Schmalfeldt, Barbara"],["dc.contributor.author","Hilpert, Felix"],["dc.contributor.author","Fehm, Tanja"],["dc.contributor.author","Burges, Alexander"],["dc.contributor.author","Meier, Werner"],["dc.contributor.author","Hillemanns, Peter"],["dc.contributor.author","Hanker, Lars"],["dc.contributor.author","Hasenburg, Annette"],["dc.contributor.author","Strauss, Hans-Georg"],["dc.contributor.author","Hellriegel, Martin"],["dc.contributor.author","Wimberger, Pauline"],["dc.contributor.author","Keyver-Paik, Mignon-Denise"],["dc.contributor.author","Baumann, Klaus"],["dc.contributor.author","Canzler, Ulrich"],["dc.contributor.author","Wollschlaeger, Kerstin"],["dc.contributor.author","Forner, Dirk"],["dc.contributor.author","Pfisterer, Jacobus"],["dc.contributor.author","Schroeder, Willibald"],["dc.contributor.author","Muenstedt, Karsten"],["dc.contributor.author","Richter, Barbara"],["dc.contributor.author","Kommoss, Stefan"],["dc.contributor.author","Hauptmann, Steffen"],["dc.date.accessioned","2018-11-07T09:25:05Z"],["dc.date.available","2018-11-07T09:25:05Z"],["dc.date.issued","2013"],["dc.description.abstract","Background: Borderline ovarian tumours (BOTs) are recognised as a unique entity of ovarian tumours that do not exert infiltrative destructive growth or stromal invasion. Prognosis of BOT is much better compared to the more common invasive epithelial ovarian cancer. Information regarding prognostic factors is inconclusive and no prospective studies exist that evaluate therapeutic strategies. We therefore started a retrospective-prospective cohort study to better understand BOT and identify scenarios in which future studies could be developed. Methods: Consecutive patients with BOT treated between 1998 and 2008 in 24 German centres were analysed. The retrospective part of the study retrieved patients' data from hospital records and clinical tumour registries while active follow-up and an independent central pathology review were carried out prospectively. Findings: BOT was confirmed in 950 patients, two thirds had serous BOT and 30.5% mucinous BOT. Most were diagnosed in stage I (82.3%); 7.6% and 10.1% had stages II and III, respectively. Overall, 74 patients (7.8%) experienced relapse and 43 (4.5%) died within the observation period. Multivariate analysis revealed higher stage, incomplete staging, tumour residuals, and organ preservation as independent prognostic factors for disease recurrence. Neither microinvasion nor micropapillary growth pattern showed any significant impact. Of 74 relapsed patients, 30% had malignant transformation to invasive ovarian cancer with five-year progression-free survival and overall survival of 12% and 50%, respectively. Interpretation: Prognosis of BOT correlates with tumour-related as well as surgery-related factors. The balance between recurrence risk and organ preservation and fertility-sparing surgery is an important issue deserving further research. (C) 2013 Elsevier Ltd. All rights reserved."],["dc.identifier.doi","10.1016/j.ejca.2013.01.035"],["dc.identifier.isi","000318610500013"],["dc.identifier.pmid","23490647"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/29985"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Sci Ltd"],["dc.relation.issn","0959-8049"],["dc.title","Borderline tumours of the ovary: A cohort study of the Arbeitsgmeinschaft Gynakologische Onkologie (AGO) Study Group"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","15"],["dc.bibliographiccitation.journal","Journal of Clinical Oncology"],["dc.bibliographiccitation.volume","32"],["dc.contributor.author","Woelber, Linn Lena"],["dc.contributor.author","Sehouli, Jalid"],["dc.contributor.author","Habermann, Anika"],["dc.contributor.author","Hillemanns, Peter"],["dc.contributor.author","Neuser, Petra"],["dc.contributor.author","Fuerst, Sophie"],["dc.contributor.author","Strauss, Hans-Georg"],["dc.contributor.author","Baumann, Klaus H."],["dc.contributor.author","Thiel, Falk Clemens"],["dc.contributor.author","Mustea, Alexander"],["dc.contributor.author","Meier, Werner"],["dc.contributor.author","Harter, Philipp"],["dc.contributor.author","Wimberger, Pauline"],["dc.contributor.author","Hanker, Lars Christian"],["dc.contributor.author","Schmalfeldt, Barbara"],["dc.contributor.author","Canzler, Ulrich"],["dc.contributor.author","Fehm, Tanja"],["dc.contributor.author","Luyten, Alexander"],["dc.contributor.author","Hellriegel, Martin"],["dc.contributor.author","Mahner, Sven"],["dc.date.accessioned","2018-11-07T09:40:10Z"],["dc.date.available","2018-11-07T09:40:10Z"],["dc.date.issued","2014"],["dc.identifier.isi","000358613203592"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/33447"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Soc Clinical Oncology"],["dc.publisher.place","Alexandria"],["dc.relation.conference","50th Annual Meeting of the American-Society-of-Clinical-Oncology"],["dc.relation.eventlocation","Chicago, IL"],["dc.relation.issn","1527-7755"],["dc.relation.issn","0732-183X"],["dc.title","Resection margin and locoregional control in vulvar cancer: A subset analysis of the AGO CARE-1 multicenter study."],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1221"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","Geburtshilfe und Frauenheilkunde"],["dc.bibliographiccitation.lastpage","1228"],["dc.bibliographiccitation.volume","80"],["dc.contributor.author","Woelber, Linn"],["dc.contributor.author","Bommert, Mareike"],["dc.contributor.author","Prieske, Katharina"],["dc.contributor.author","Fischer, Inger"],["dc.contributor.author","zu Eulenburg, Christine"],["dc.contributor.author","Vettorazzi, Eik"],["dc.contributor.author","Harter, Philipp"],["dc.contributor.author","Jueckstock, Julia"],["dc.contributor.author","Hilpert, Felix"],["dc.contributor.author","de Gregorio, Niko"],["dc.contributor.author","Iborra, Severine"],["dc.contributor.author","Sehouli, Jalid"],["dc.contributor.author","Ignatov, Atanas"],["dc.contributor.author","Hillemanns, Peter"],["dc.contributor.author","Fuerst, Sophie"],["dc.contributor.author","Strauss, Hans-Georg"],["dc.contributor.author","Baumann, Klaus"],["dc.contributor.author","Beckmann, Matthias"],["dc.contributor.author","Mustea, Alexander"],["dc.contributor.author","Meier, Werner"],["dc.contributor.author","Wimberger, Pauline"],["dc.contributor.author","Hanker, Lars"],["dc.contributor.author","Canzler, Ulrich"],["dc.contributor.author","Fehm, Tanja"],["dc.contributor.author","Luyten, Alexander"],["dc.contributor.author","Hellriegel, Martin"],["dc.contributor.author","Kosse, Jens"],["dc.contributor.author","Heiss, Christoph"],["dc.contributor.author","Hantschmann, Peer"],["dc.contributor.author","Mallmann, Peter"],["dc.contributor.author","Tanner, Berno"],["dc.contributor.author","Pfisterer, Jacobus"],["dc.contributor.author","Mahner, Sven"],["dc.contributor.author","Schmalfeldt, Barbara"],["dc.contributor.author","Jaeger, Anna"],["dc.date.accessioned","2021-04-14T08:26:19Z"],["dc.date.available","2021-04-14T08:26:19Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1055/a-1120-0138"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/81905"],["dc.language.iso","de"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","1438-8804"],["dc.relation.issn","0016-5751"],["dc.title","Pelvic Lymphadenectomy in Vulvar Cancer – Does it make sense?"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","72"],["dc.bibliographiccitation.journal","Oncology Research and Treatment"],["dc.bibliographiccitation.lastpage","73"],["dc.bibliographiccitation.volume","37"],["dc.contributor.author","Woelber, Linn Lena"],["dc.contributor.author","Jueckstock, Julia"],["dc.contributor.author","Hilpert, Felix"],["dc.contributor.author","Neuser, P."],["dc.contributor.author","Harter, Philipp"],["dc.contributor.author","de Gregorio, Nikolaus"],["dc.contributor.author","Iborra, Severine"],["dc.contributor.author","Sehouli, Jalid"],["dc.contributor.author","Habermann, Anika"],["dc.contributor.author","Hillemanns, Peter"],["dc.contributor.author","Fuerst, Sophie Teresa"],["dc.contributor.author","Strauss, H.-G."],["dc.contributor.author","Baumann, K. H."],["dc.contributor.author","Thiel, Falk Clemens"],["dc.contributor.author","Mustea, Alexander"],["dc.contributor.author","Meier, Werner"],["dc.contributor.author","du Bois, Andreas"],["dc.contributor.author","Wimberger, Pauline"],["dc.contributor.author","Hanker, Lars Christian"],["dc.contributor.author","Schmalfeldt, Barbara"],["dc.contributor.author","Canzler, Ulrich"],["dc.contributor.author","Fehm, Tanja"],["dc.contributor.author","Luyten, Alexander"],["dc.contributor.author","Hellriegel, Martin"],["dc.contributor.author","Kosse, Jens"],["dc.contributor.author","Heiss, Christoph"],["dc.contributor.author","Hantschmann, Peer"],["dc.contributor.author","Mallmann, Peter"],["dc.contributor.author","Tanner, Berno"],["dc.contributor.author","Pfisterer, Jacobus"],["dc.contributor.author","Richter, B."],["dc.contributor.author","Griebel, L.-F."],["dc.contributor.author","Mahner, Sven"],["dc.date.accessioned","2018-11-07T09:44:10Z"],["dc.date.available","2018-11-07T09:44:10Z"],["dc.date.issued","2014"],["dc.identifier.isi","000332306700235"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/34333"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Karger"],["dc.publisher.place","Basel"],["dc.relation.issn","2296-5262"],["dc.relation.issn","2296-5270"],["dc.title","Outcome parameters in node-negative vulvar cancer - subset analysis of the AGO CaRE-1 study"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1314"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Annals of Surgical Oncology"],["dc.bibliographiccitation.lastpage","1321"],["dc.bibliographiccitation.volume","24"],["dc.contributor.author","Klapdor, Ruediger"],["dc.contributor.author","Hillemanns, Peter"],["dc.contributor.author","Woelber, Linn"],["dc.contributor.author","Jueckstock, Julia"],["dc.contributor.author","Hilpert, Felix"],["dc.contributor.author","de Gregorio, Nikolaus"],["dc.contributor.author","Iborra, Severine"],["dc.contributor.author","Sehouli, Jalid"],["dc.contributor.author","Habermann, Anika"],["dc.contributor.author","Fuerst, Sophie Teresa"],["dc.contributor.author","Strauss, Hans Georg"],["dc.contributor.author","Baumann, Klaus"],["dc.contributor.author","Thiel, Falk"],["dc.contributor.author","Mustea, Alexander"],["dc.contributor.author","Meier, Werner"],["dc.contributor.author","Harter, Philipp"],["dc.contributor.author","Wimberger, Pauline"],["dc.contributor.author","Hanker, Lars"],["dc.contributor.author","Schmalfeldt, Barbara"],["dc.contributor.author","Canzler, Ulrich"],["dc.contributor.author","Fehm, Tanja"],["dc.contributor.author","Luyten, Alexander"],["dc.contributor.author","Hellriegel, Martin"],["dc.contributor.author","Kosse, Jens"],["dc.contributor.author","Heiss, Christoph"],["dc.contributor.author","Hantschmann, Peer"],["dc.contributor.author","Mallmann, Peter"],["dc.contributor.author","Tanner, Berno"],["dc.contributor.author","Pfisterer, Jacobus"],["dc.contributor.author","Richter, Barbara"],["dc.contributor.author","Jager, Martin"],["dc.contributor.author","Mahner, Sven"],["dc.date.accessioned","2018-11-07T10:24:39Z"],["dc.date.available","2018-11-07T10:24:39Z"],["dc.date.issued","2017"],["dc.description.abstract","Analyzing the large patient cohort of the multicenter AGO-CaRE-1 study, we compared isolated sentinel lymph node dissection (SLND) with radical lymph node dissection (LND) of the groin in relation to recurrence rates and survival. The AGO-CaRE-1 study retrospectively collected data on treatment patterns and follow-up of vulvar cancer patients [International Federation of Gynecology and Obstetrics (FIGO) stage 1B] treated at 29 gynecologic cancer centers between 1998 and 2008. This subgroup analysis evaluated the influence of SLND alone on progression-free survival (PFS) and overall survival (OS). In 487 (63.1%) of 772 included patients with tumors smaller than 4 cm, an LND was performed and no metastatic lymph nodes were detected (LN0). Another 69/772 (8.9%) women underwent SLND alone, showing a negative SLN (SLN0). Tumors in the LN0 group were larger and showed a deeper invasion (LN0 vs. SLN0 tumor diameter: 20.0 vs. 13.0 mm, p < 0.001; depth of invasion: 4.0 vs. 3.0 mm, p = 0.002). After a median follow-up of 33 months (0-156), no significant differences in relation to isolated groin recurrence rates (SLN0 3.0% vs. LN0 3.4%, p = 0.845) were detected. Similarly, univariate 3-year PFS analysis showed no significant differences between both groups (SLN0 82.7% vs. LN0 77.6%, p = 0.230). A multivariate Cox regression analysis, including tumor diameter, depth of invasion, age, grading, and lymphovascular space invasion was performed: PFS [hazard ratio (HR) 0.970, 95% confidence interval (CI) 0.517-1.821] and OS (HR 0.695, 95% CI 0.261-1.849) did not differ significantly between both cohorts. This subgroup analysis of the large AGO-CaRE-1 study showed similar results for groin LND and SLND alone with regard to recurrence rates and survival in node-negative patients with tumors < 4 cm."],["dc.description.sponsorship","Medac Oncology"],["dc.identifier.doi","10.1245/s10434-016-5687-0"],["dc.identifier.isi","000399013200026"],["dc.identifier.pmid","27896515"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/42702"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Springer"],["dc.relation.issn","1534-4681"],["dc.relation.issn","1068-9265"],["dc.title","Outcome After Sentinel Lymph Node Dissection in Vulvar Cancer: A Subgroup Analysis of the AGO-CaRE-1 Study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","565"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Gynecologic Oncology"],["dc.bibliographiccitation.lastpage","570"],["dc.bibliographiccitation.volume","154"],["dc.contributor.author","Klapdor, Rüdiger"],["dc.contributor.author","Wölber, Linn"],["dc.contributor.author","Hanker, Lars"],["dc.contributor.author","Schmalfeldt, Barbara"],["dc.contributor.author","Canzler, Ulrich"],["dc.contributor.author","Fehm, Tanja"],["dc.contributor.author","Luyten, Alexander"],["dc.contributor.author","Hellriegel, Martin"],["dc.contributor.author","Kosse, Jens"],["dc.contributor.author","Heiss, Christoph"],["dc.contributor.author","Hantschmann, Peer"],["dc.contributor.author","Mallmann, Peter"],["dc.contributor.author","Tanner, Berno"],["dc.contributor.author","Pfisterer, Jacobus"],["dc.contributor.author","Jückstock, Julia"],["dc.contributor.author","Hilpert, Felix"],["dc.contributor.author","de Gregorio, Nikolaus"],["dc.contributor.author","Hillemanns, Peter"],["dc.contributor.author","Fürst, Sophie Teresa"],["dc.contributor.author","Mahner, Sven"],["dc.date.accessioned","2020-12-10T15:21:47Z"],["dc.date.available","2020-12-10T15:21:47Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1016/j.ygyno.2019.06.013"],["dc.identifier.issn","0090-8258"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/73161"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Predictive factors for lymph node metastases in vulvar cancer. An analysis of the AGO-CaRE-1 multicenter study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","660"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","British Journal of Cancer"],["dc.bibliographiccitation.lastpage","666"],["dc.bibliographiccitation.volume","112"],["dc.contributor.author","Trillsch, F. F"],["dc.contributor.author","Mahner, Sven"],["dc.contributor.author","Vettorazzi, Eik"],["dc.contributor.author","Woelber, Linn Lena"],["dc.contributor.author","Reuss, Alexander"],["dc.contributor.author","Baumann, K."],["dc.contributor.author","Keyver-Paik, M. -D."],["dc.contributor.author","Canzler, Ulrich"],["dc.contributor.author","Wollschlaeger, Kerstin"],["dc.contributor.author","Forner, Dirk"],["dc.contributor.author","Pfisterer, Jacobus"],["dc.contributor.author","Schroeder, W."],["dc.contributor.author","Muenstedt, Karsten"],["dc.contributor.author","Richter, B."],["dc.contributor.author","Fotopoulou, Christina"],["dc.contributor.author","Schmalfeldt, Barbara"],["dc.contributor.author","Burges, Alexander"],["dc.contributor.author","Ewald-Riegler, Nina"],["dc.contributor.author","de Gregorio, Nikolaus"],["dc.contributor.author","Hilpert, Felix"],["dc.contributor.author","Fehm, Tanja"],["dc.contributor.author","Meier, Werner"],["dc.contributor.author","Hillemanns, Peter"],["dc.contributor.author","Hanker, Lars Christian"],["dc.contributor.author","Hasenburg, Annette"],["dc.contributor.author","Strauss, H-G"],["dc.contributor.author","Hellriegel, Martin"],["dc.contributor.author","Wimberger, Pauline"],["dc.contributor.author","Kommoss, Stefan"],["dc.contributor.author","Kommoss, Friedrich"],["dc.contributor.author","Hauptmann, Steffen"],["dc.contributor.author","du Bois, Andreas"],["dc.date.accessioned","2018-11-07T10:00:51Z"],["dc.date.available","2018-11-07T10:00:51Z"],["dc.date.issued","2015"],["dc.description.abstract","Background: Incomplete surgical staging is a negative prognostic factor for patients with borderline ovarian tumours (BOT). However, little is known about the prognostic impact of each individual staging procedure. Methods: Clinical parameters of 950 patients with BOT (confirmed by central reference pathology) treated between 1998 and 2008 at 24 German AGO centres were analysed. In 559 patients with serous BOT and adequate ovarian surgery, further recommended staging procedures (omentectomy, peritoneal biopsies, cytology) were evaluated applying Cox regression models with respect to progression-free survival (PFS). Results: For patients with one missing staging procedure, the hazard ratio (HR) for recurrence was 1.25 (95%-CI 0.66-2.39; P = 0.497). This risk increased with each additional procedure skipped reaching statistical significance in case of two (HR 1.95; 95%-CI 1.06-3.58; P = 0.031) and three missing steps (HR 2.37; 95%-CI 1.22-4.64; P = 0.011). The most crucial procedure was omentectomy which retained a statistically significant impact on PFS in multiple analysis (HR 1.91; 95%-CI 1.15-3.19; P = 0.013) adjusting for previously established prognostic factors as FIGO stage, tumour residuals, and fertility preservation. Conclusion: Individual surgical staging procedures contribute to the prognosis for patients with serous BOT. In this analysis, recurrence risk increased with each skipped surgical step. This should be considered when re-staging procedures following incomplete primary surgery are discussed."],["dc.identifier.doi","10.1038/bjc.2014.648"],["dc.identifier.isi","000349902600008"],["dc.identifier.pmid","25562434"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/37896"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Nature Publishing Group"],["dc.relation.issn","1532-1827"],["dc.relation.issn","0007-0920"],["dc.title","Surgical staging and prognosis in serous borderline ovarian tumours (BOT): A subanalysis of the AGO ROBOT study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","180"],["dc.bibliographiccitation.journal","European Journal of Cancer"],["dc.bibliographiccitation.lastpage","188"],["dc.bibliographiccitation.volume","69"],["dc.contributor.author","Woelber, Linn"],["dc.contributor.author","Griebel, Lis-Femke"],["dc.contributor.author","Eulenburg, Christine"],["dc.contributor.author","Sehouli, Jalid"],["dc.contributor.author","Jueckstock, Julia"],["dc.contributor.author","Hilpert, Felix"],["dc.contributor.author","de Gregorio, Nikolaus"],["dc.contributor.author","Hasenburg, Annette"],["dc.contributor.author","Ignatov, Atanas"],["dc.contributor.author","Hillemanns, Peter"],["dc.contributor.author","Fuerst, Sophie"],["dc.contributor.author","Strauss, Hans-Georg"],["dc.contributor.author","Baumann, Klaus H."],["dc.contributor.author","Thiel, Falk Clemens"],["dc.contributor.author","Mustea, Alexander"],["dc.contributor.author","Meier, Werner"],["dc.contributor.author","Harter, Philipp"],["dc.contributor.author","Wimberger, Pauline"],["dc.contributor.author","Hanker, Lars Christian"],["dc.contributor.author","Schmalfeldt, Barbara"],["dc.contributor.author","Canzler, Ulrich"],["dc.contributor.author","Fehm, Tanja"],["dc.contributor.author","Luyten, Alexander"],["dc.contributor.author","Hellriegel, Martin"],["dc.contributor.author","Kosse, Jens"],["dc.contributor.author","Heiss, Christoph"],["dc.contributor.author","Hantschmann, Peer"],["dc.contributor.author","Mallmann, Peter"],["dc.contributor.author","Tanner, Berno"],["dc.contributor.author","Pfisterer, Jacobus"],["dc.contributor.author","Richter, Barbara"],["dc.contributor.author","Neuser, Petra"],["dc.contributor.author","Mahner, Sven"],["dc.date.accessioned","2018-11-07T10:05:17Z"],["dc.date.available","2018-11-07T10:05:17Z"],["dc.date.issued","2016"],["dc.description.abstract","Aim of the study: A tumour-free pathological resection margin of >= 8 mm is considered state-of-the-art. Available evidence is based on heterogeneous cohorts. This study was designed to clarify the relevance of the resection margin for loco-regional control in vulvar cancer. Methods: AGO-CaRE-1 is a large retrospective study. Patients (n = 1618) with vulvar cancer >= FIGO stage IB treated at 29 German gynecologic-cancer-centres 1998-2008 were included. This subgroup analysis focuses on solely surgically treated node-negative patients with complete tumour resection (n = 289). Results: Of the 289 analysed patients, 141 (48.8%) had pT1b, 140 (48.4%) pT2 and 8 (2.8%) pT3 tumours. One hundred twenty-five (43.3%) underwent complete vulvectomy, 127 (43.9%) partial vulvectomy and 37 (12.8%) radical local excision. The median minimal resection margin was 5 mm (1 mm-33 mm); all patients received groin staging, in 86.5% with full dissection. Median follow-up was 35.1 months. 46 (15.9%) patients developed recurrence, thereof 34 (11.8%) at the vulva, after a median of 18.3 months. Vulvar recurrence rates were 12.6% in patients with a margin <8mm and 10.2% in patients with a margin >= 8 mm. When analysed as a continuous variable, the margin distance had no statistically significant impact on local recurrence (HR per mm increase: 0.930, 95% CI: 0.849-1.020; p=0.125). Multivariate analyses did also not reveal a significant association between the margin and local recurrence neither when analysed as continuous variable nor categorically based on the 8 mm cutoff. Results were consistent when looking at disease-free-survival and time-to-recurrence at any site (HR per mm increase: 0.949, 95% CI: 0.864-1.041; p = 0.267). Conclusions: The need for a minimal margin of 8 mm could not be confirmed in the large and homogeneous node-negative cohort of the AGO-CaRE database. (C) 2016 Elsevier Ltd. All rights reserved."],["dc.description.sponsorship","medac oncology"],["dc.identifier.doi","10.1016/j.ejca.2016.09.038"],["dc.identifier.isi","000388846300022"],["dc.identifier.pmid","27837710"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/38868"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Sci Ltd"],["dc.relation.issn","1879-0852"],["dc.relation.issn","0959-8049"],["dc.title","Role of tumour-free margin distance for loco-regional control in vulvar cancer-a subset analysis of the Arbeitsgemeinschaft Gynakologische Onkologie CaRE-1 multicenter study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Oncology Research and Treatment"],["dc.bibliographiccitation.volume","37"],["dc.contributor.author","Trillsch, F. F"],["dc.contributor.author","Mahner, Sven"],["dc.contributor.author","Ruetzel, J. D."],["dc.contributor.author","Vettorazzi, Eik"],["dc.contributor.author","Reuss, Alexander"],["dc.contributor.author","Hillemanns, Peter"],["dc.contributor.author","Hanker, Lars Christian"],["dc.contributor.author","Hasenburg, Annette"],["dc.contributor.author","Strauss, H.-G."],["dc.contributor.author","Hellriegel, Martin"],["dc.contributor.author","Wimberger, Pauline"],["dc.contributor.author","Klaus, Bent T."],["dc.contributor.author","Keyver-Paik, M.-D."],["dc.contributor.author","Canzler, Ulrich"],["dc.contributor.author","Wollschlaeger, Kerstin"],["dc.contributor.author","Forner, Dirk"],["dc.contributor.author","Pfisterer, Jacobus"],["dc.contributor.author","Schroeder, W."],["dc.contributor.author","Muenstedt, Karsten"],["dc.contributor.author","Richter, B."],["dc.contributor.author","Fotopoulou, Christina"],["dc.contributor.author","Schmalfeldt, Barbara"],["dc.contributor.author","Burges, Alexander"],["dc.contributor.author","Fehm, Tanja"],["dc.contributor.author","Meier, Werner"],["dc.contributor.author","Ewald-Riegler, Nina"],["dc.contributor.author","de Gregorio, Nikolaus"],["dc.contributor.author","Hilpert, Felix"],["dc.contributor.author","du Bois, Andreas"],["dc.date.accessioned","2018-11-07T09:44:09Z"],["dc.date.available","2018-11-07T09:44:09Z"],["dc.date.issued","2014"],["dc.format.extent","71"],["dc.identifier.isi","000332306700231"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/34332"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Karger"],["dc.publisher.place","Basel"],["dc.relation.issn","2296-5262"],["dc.relation.issn","2296-5270"],["dc.title","Prognostic impact of the time interval between primary and re-staging surgery in patients with borderline ovarian tumours (BOT): An analysis of the Arbeitsgemeinschaft Gynaekologische Onkologie (AGO) Study Group"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Oncology Research and Treatment"],["dc.bibliographiccitation.volume","37"],["dc.contributor.author","Hillemanns, Peter"],["dc.contributor.author","Woelber, Linn Lena"],["dc.contributor.author","Jueckstock, Julia"],["dc.contributor.author","Neuser, P."],["dc.contributor.author","Hilpert, Felix"],["dc.contributor.author","Harter, Philipp"],["dc.contributor.author","de Gregorio, Nikolaus"],["dc.contributor.author","Hasenburg, Annette"],["dc.contributor.author","Sehouli, Jalid"],["dc.contributor.author","Habermann, Anika"],["dc.contributor.author","Fuerst, Sophie Teresa"],["dc.contributor.author","Strauss, H.-G."],["dc.contributor.author","Baumann, K."],["dc.contributor.author","Thiel, Falk Clemens"],["dc.contributor.author","Mustea, Alexander"],["dc.contributor.author","Meier, Werner"],["dc.contributor.author","du Bois, Andreas"],["dc.contributor.author","Wimberger, Pauline"],["dc.contributor.author","Hanker, Lars Christian"],["dc.contributor.author","Schmalfeldt, Barbara"],["dc.contributor.author","Canzler, Ulrich"],["dc.contributor.author","Fehm, Tanja"],["dc.contributor.author","Luyten, Alexander"],["dc.contributor.author","Hellriegel, Martin"],["dc.contributor.author","Kosse, Jens"],["dc.contributor.author","Heiss, Christoph"],["dc.contributor.author","Hantschmann, Peer"],["dc.contributor.author","Mallmann, Peter"],["dc.contributor.author","Tanner, Berno"],["dc.contributor.author","Pfisterer, Jacobus"],["dc.contributor.author","Richter, B."],["dc.contributor.author","Petersen, C."],["dc.contributor.author","Mahner, Sven"],["dc.date.accessioned","2018-11-07T09:44:08Z"],["dc.date.available","2018-11-07T09:44:08Z"],["dc.date.issued","2014"],["dc.format.extent","70"],["dc.identifier.isi","000332306700230"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/34331"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Karger"],["dc.publisher.place","Basel"],["dc.relation.issn","2296-5262"],["dc.relation.issn","2296-5270"],["dc.title","AGO Vulva CaRE-1 multicenter study - adjuvant radio(chemo)therapy in vulvar cancer"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]