Jakobi, Tobias

[["dc.bibliographiccitation.firstpage","1"],["dc.bibliographiccitation.lastpage","14"],["dc.contributor.author","Jakobi, Tobias"],["dc.contributor.author","Breindl, Yana"],["dc.contributor.author","Busch, Andreas"],["dc.contributor.editor","Busch, Andreas"],["dc.contributor.editor","Breindl, Yana"],["dc.contributor.editor","Jakobi, Tobias"],["dc.date.accessioned","2020-10-20T18:42:40Z"],["dc.date.available","2020-10-20T18:42:40Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1007/978-3-658-02033-0_1"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/68015"],["dc.language.iso","de"],["dc.publisher","Springer VS"],["dc.publisher.place","Wiesbaden"],["dc.relation.doi","10.1007/978-3-658-02033-0_1"],["dc.relation.ispartof","Netzpolitik. Ein einführender Überblick"],["dc.relation.orgunit","Sozialwissenschaftliche Fakultät"],["dc.relation.orgunit","Institut für Politikwissenschaft"],["dc.relation.orgunit","Arbeitsbereich Vergleichende Politikwissenschaft & politische Ökonomie"],["dc.title","Einleitung"],["dc.type","book_chapter"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","844441"],["dc.bibliographiccitation.journal","Frontiers in Cardiovascular Medicine"],["dc.bibliographiccitation.volume","9"],["dc.contributor.author","Jakobi, Tobias"],["dc.contributor.author","Groß, Julia"],["dc.contributor.author","Cyganek, Lukas"],["dc.contributor.author","Doroudgar, Shirin"],["dc.date.accessioned","2022-07-01T07:35:28Z"],["dc.date.available","2022-07-01T07:35:28Z"],["dc.date.issued","2022"],["dc.description.abstract","Introduction Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease (COVID-19) has emerged as a major cause of morbidity and mortality worldwide, placing unprecedented pressure on healthcare. Cardiomyopathy is described in patients with severe COVID-19 and increasing evidence suggests that cardiovascular involvement portends a high mortality. To facilitate fast development of antiviral interventions, drugs initially developed to treat other diseases are currently being repurposed as COVID-19 treatments. While it has been shown that SARS-CoV-2 invades cells through the angiotensin-converting enzyme 2 receptor (ACE2), the effect of drugs currently repurposed to treat COVID-19 on the heart requires further investigation. Methods Human induced pluripotent stem cell-derived cardiac myocytes (hiPSC-CMs) were treated with five repurposed drugs (remdesivir, lopinavir/ritonavir, lopinavir/ritonavir/interferon beta (INF-β), hydroxychloroquine, and chloroquine) and compared with DMSO controls. Transcriptional profiling was performed to identify global changes in gene expression programs. Results RNA sequencing of hiPSC-CMs revealed significant changes in gene programs related to calcium handling and the endoplasmic reticulum stress response, most prominently for lopinavir/ritonavir and lopinavir/ritonavir/interferon-beta. The results of the differential gene expression analysis are available for interactive access at https://covid19drugs.jakobilab.org . Conclusion Transcriptional profiling in hiPSC-CMs treated with COVID-19 drugs identified unfavorable changes with lopinavir/ritonavir and lopinavir/ritonavir/INF-β in key cardiac gene programs that may negatively affect heart function."],["dc.identifier.doi","10.3389/fcvm.2022.844441"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/112179"],["dc.notes.intern","DOI-Import GROB-581"],["dc.relation.eissn","2297-055X"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0/"],["dc.title","Transcriptional Effects of Candidate COVID-19 Treatments on Cardiac Myocytes"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

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[["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Internet Policy Review"],["dc.bibliographiccitation.volume","9"],["dc.contributor.author","Schwanholz, Julia"],["dc.contributor.author","Jakobi, Tobias"],["dc.date.accessioned","2020-10-20T11:03:50Z"],["dc.date.available","2020-10-20T11:03:50Z"],["dc.date.issued","2020-10-15"],["dc.description.abstract","The Digital Agenda Committee of the Bundestag was a remarkable institutional change in Germany. It represents the first body of its kind among all EU member states. In this article, we analyse it in its first legislative session (2013-2017) and examine the case of data retention legislation to determine if it had the effect sought by internet policy entrepreneurs of the time. Thereby, we contribute to a better understanding of whether internet issues became institutionalised in the Bundestag and, generally, how new policies emerge. Our results show that the new committee did not promote and share a common policy image in the first session. However, it strongly drifted to become a venue for digital policy. International scholars can learn not only about the establishment of new committees in the German parliament but also about an analytical framework to analyse cases in other parliaments or institutional settings."],["dc.identifier.doi","10.14763/2020.4.1509"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/68013"],["dc.language.iso","en"],["dc.relation.doi","10.14763/2020.4.1509"],["dc.relation.orgunit","Sozialwissenschaftliche Fakultät"],["dc.relation.orgunit","Institut für Politikwissenschaft"],["dc.relation.orgunit","Arbeitsbereich Vergleichende Politikwissenschaft & politische Ökonomie"],["dc.title","There's a place for us? The Digital Agenda Committee and internet policy in the German Bundestag"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

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