Mielke, Dorothee

[["dc.bibliographiccitation.artnumber","e009273"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","BMJ Open"],["dc.bibliographiccitation.volume","5"],["dc.contributor.author","Giese, Henrik"],["dc.contributor.author","Sauvigny, Thomas"],["dc.contributor.author","Sakowitz, Oliver W."],["dc.contributor.author","Bierschneider, Michael"],["dc.contributor.author","Gueresir, Erdem"],["dc.contributor.author","Henker, Christian"],["dc.contributor.author","Hoehne, Julius"],["dc.contributor.author","Lindner, Dirk"],["dc.contributor.author","Mielke, Dorothee"],["dc.contributor.author","Pannewitz, Robert"],["dc.contributor.author","Rohde, Veit"],["dc.contributor.author","Scholz, Martin"],["dc.contributor.author","Schuss, Patrick"],["dc.contributor.author","Regelsberger, Jan"],["dc.date.accessioned","2018-11-07T10:02:48Z"],["dc.date.available","2018-11-07T10:02:48Z"],["dc.date.issued","2015"],["dc.description.abstract","Introduction: Owing to increasing numbers of decompressive craniectomies in patients with malignant middle cerebral artery infarction, cranioplastic surgery becomes more relevant. However, the current literature mainly consists of retrospective single-centre (evidence class III) studies. This leads to a wide variability of technical approaches and clinical outcomes. To improve our knowledge about the key elements of cranioplasty, which may help optimising clinical treatment and long-term outcome, a prospective multicentre registry across Germany, Austria and Switzerland will be established. Methods: All patients undergoing cranioplastic surgery in participating centres will be invited to join the registry. Technical methods, materials, medical history, adverse events and clinical outcome measures, including modified Rankin scale and EQ-5D, will be assessed at several time points. Patients will be accessible to inclusion either at initial decompressive surgery or when cranioplasty is planned. Scheduled monitoring will be carried out at time of inclusion and subsequently at time of discharge, if any readmission is necessary, and at follow-up presentation. Cosmetic results and patient satisfaction will also be assessed. Collected data will be managed and statistically analysed by an independent biometric institute. The primary endpoint will be mortality, need for operative revision and neurological status at 3 months following cranioplasty. Ethics and dissemination: Ethics approval was obtained at all participating centres. The registry will provide reliable prospective evidence on surgical techniques, used materials, adverse events and functional outcome, to optimise patient treatment. We expect this study to give new insights in the treatment of skull defects and to provide a basis for future evidence-based therapy regarding cranioplastic surgery."],["dc.description.sponsorship","IMBI"],["dc.identifier.doi","10.1136/bmjopen-2015-009273"],["dc.identifier.isi","000363484000093"],["dc.identifier.pmid","26423857"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/12546"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/38306"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Bmj Publishing Group"],["dc.relation.issn","2044-6055"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","German Cranial Reconstruction Registry (GCRR): protocol for a prospective, multicentre, open registry"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Frontiers in Neurology"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Abboud, Tammam"],["dc.contributor.author","Mielke, Dorothee"],["dc.contributor.author","Rohde, Veit"],["dc.date.accessioned","2022-04-01T10:03:16Z"],["dc.date.available","2022-04-01T10:03:16Z"],["dc.date.issued","2022"],["dc.description.abstract","Impedance measurement of human tissue can be performed either in vivo or ex vivo . The majority of the in-vivo approaches are non-invasive, and few are invasive. To date, there is no gold standard for impedance measurement of intracranial tissue. In addition, most of the techniques addressing this topic are still experimental and have not found their way into clinical practice. This review covers available impedance measurement approaches in the neuroscience in general and specifically addresses recent advances made in the application of impedance measurement in the field of surgical neurooncology. It will provide an understandable picture on impedance measurement and give an overview of limitations that currently hinders clinical application and require future technical and conceptual solutions."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2022"],["dc.identifier.doi","10.3389/fneur.2021.825012"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/106126"],["dc.notes.intern","DOI-Import GROB-530"],["dc.relation.eissn","1664-2295"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0/"],["dc.title","Mini Review: Impedance Measurement in Neuroscience and Its Prospective Application in the Field of Surgical Neurooncology"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","BMC Neurology"],["dc.bibliographiccitation.volume","20"],["dc.contributor.author","Tsogkas, Ioannis"],["dc.contributor.author","Malinova, Vesna"],["dc.contributor.author","Schregel, Katharina"],["dc.contributor.author","Mielke, Dorothee"],["dc.contributor.author","Behme, Daniel"],["dc.contributor.author","Rohde, Veit"],["dc.contributor.author","Knauth, Michael"],["dc.contributor.author","Psychogios, Marios-Nikos"],["dc.date.accessioned","2021-04-14T08:25:15Z"],["dc.date.available","2021-04-14T08:25:15Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1186/s12883-020-01792-3"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/17436"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/81571"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.notes.intern","Merged from goescholar"],["dc.relation.eissn","1471-2377"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Angioplasty with the scepter C dual lumen balloon catheter and postprocedural result evaluation in patients with subarachnoid hemorrhage related vasospasms"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Brain Pathology"],["dc.bibliographiccitation.volume","31"],["dc.contributor.affiliation","Stork, Lidia; 2Institute of Neuropathology University Medical Center Göttingen Göttingen Germany"],["dc.contributor.affiliation","Schildhaus, Hans‐Ulrich; 3Institute of Pathology University Medical Center Göttingen Göttingen Germany"],["dc.contributor.affiliation","Stadelmann, Christine; 2Institute of Neuropathology University Medical Center Göttingen Göttingen Germany"],["dc.contributor.affiliation","Rohde, Veit; 1Department of Neurosurgery University Medical Center Göttingen Göttingen Germany"],["dc.contributor.affiliation","Mielke, Dorothee; 1Department of Neurosurgery University Medical Center Göttingen Göttingen Germany"],["dc.contributor.author","Abboud, Tammam"],["dc.contributor.author","Stork, Lidia"],["dc.contributor.author","Schildhaus, Hans‐Ulrich"],["dc.contributor.author","Stadelmann, Christine"],["dc.contributor.author","Rohde, Veit"],["dc.contributor.author","Mielke, Dorothee"],["dc.date.accessioned","2021-08-12T07:45:21Z"],["dc.date.available","2021-08-12T07:45:21Z"],["dc.date.issued","2021"],["dc.date.updated","2022-03-21T14:18:32Z"],["dc.description.abstract","image"],["dc.description.sponsorship","Open-Access-Finanzierung durch die Universitätsmedizin Göttingen 2021"],["dc.identifier.doi","10.1111/bpa.12995"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/88437"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-448"],["dc.relation.eissn","1750-3639"],["dc.relation.issn","1015-6305"],["dc.relation.orgunit","Klinik für Neurochirurgie"],["dc.rights","CC BY 4.0"],["dc.title","An unusual lymphoid lesion mimicking meningioma"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","e0227349"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","PLoS One"],["dc.bibliographiccitation.volume","15"],["dc.contributor.author","Mielke, Dorothee"],["dc.contributor.author","Bleuel, Kim"],["dc.contributor.author","Stadelmann, Christine"],["dc.contributor.author","Rohde, Veit"],["dc.contributor.author","Malinova, Vesna"],["dc.contributor.editor","Psychogios, Marios-Nikos"],["dc.date.accessioned","2021-04-14T08:27:01Z"],["dc.date.available","2021-04-14T08:27:01Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1371/journal.pone.0227349"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/17325"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/82145"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.notes.intern","Merged from goescholar"],["dc.relation.eissn","1932-6203"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","The ESAS-score: A histological severity grading system of subarachnoid hemorrhage using the modified double hemorrhage model in rats"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1245"],["dc.bibliographiccitation.journal","Clinical Ophthalmology"],["dc.bibliographiccitation.lastpage","1254"],["dc.bibliographiccitation.volume","Volume 16"],["dc.contributor.author","Lauermann, Peer"],["dc.contributor.author","Klingelhöfer, Anthea"],["dc.contributor.author","Mielke, Dorothee"],["dc.contributor.author","Bahlmann, Dirk"],["dc.contributor.author","Hoerauf, Hans"],["dc.contributor.author","Koscielny, Juergen"],["dc.contributor.author","Sucker, Christoph"],["dc.contributor.author","Feltgen, Nicolas"],["dc.contributor.author","van Oterendorp, Christian"],["dc.date.accessioned","2022-06-01T09:39:46Z"],["dc.date.available","2022-06-01T09:39:46Z"],["dc.date.issued","2022"],["dc.description.abstract","Purpose: To evaluate the influences and risk factors for severe bleeding complications during glaucoma surgery, and to investigate the\r\nrole of antiplatelet (AP) and anticoagulant (AC) agents.\r\nMethods: This prospective study enrolled patients undergoing trabeculectomy, trabeculotomy (with Trabectome® or Kahook Dual\r\nBlade®), viscocanaloplasty and Ahmed or Baerveldt implants. Bleeding severity was graded on an ordinal scale ranging from 0 to 5.\r\nImmediately after surgery and one day later, the incidence and severity of bleeding events was documented on a standardized form. A grade\r\n≥3 was defined as severe bleeding. The influence of known systemic disorders, the type of anesthesia, surgical procedure, intraoperative\r\nblood pressure, and the use of or change in AP or AC agents on intraoperative bleeding were analyzed.\r\nResults: Data from 89 eyes undergoing glaucoma procedures were included (age 71.3y ± 10.5). We observed severe intraoperative\r\nbleeding in 8 eyes (9%) and found that concomitant diseases such as the history of a deep vein thrombosis or peripheral arterial\r\nocclusive disease, and the type of surgical procedure (trabeculectomy and viscocanaloplasty) were significantly associated with severe\r\nbleeding events. By contrast, the use of AP/ AC agents had no significant influence on severe intraoperative bleeding events.\r\nConclusion: According to the results of our study cohort, glaucoma procedures entailing scleral manipulations (trabeculectomy and\r\nviscocanaloplasty) and concomitant diseases such as the history of a deep vein thrombosis or peripheral arterial occlusive disease\r\ninfluence the risk of severe intraoperative bleeding events, we detected no increased risk related to concomitant antiplatelet and/ or\r\nanticoagulant medication use."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2022"],["dc.identifier.doi","10.2147/OPTH.S361867"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/108560"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-572"],["dc.relation.eissn","1177-5483"],["dc.rights","CC BY-NC 3.0"],["dc.title","Risk Factors for Severe Bleeding Complications in Glaucoma Surgery and the Role of Antiplatelet or Anticoagulant Agents"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","165"],["dc.bibliographiccitation.issue","3-6"],["dc.bibliographiccitation.journal","Cerebrovascular Diseases"],["dc.bibliographiccitation.lastpage","170"],["dc.bibliographiccitation.volume","48"],["dc.contributor.author","Malinova, Vesna"],["dc.contributor.author","Iliev, Bogdan"],["dc.contributor.author","Mielke, Dorothee"],["dc.contributor.author","Rohde, Veit"],["dc.date.accessioned","2020-12-10T18:37:52Z"],["dc.date.available","2020-12-10T18:37:52Z"],["dc.date.issued","2019-11-13"],["dc.description.abstract","Objective: Intracerebral hemorrhage (ICH) is associated with high morbidity and mortality. Prognosis estimation would be helpful for the treatment decision making in ICH patients. The ICH-score was published in 2001 to estimate the 30-day mortality in conservatively treated patients with ICH. We evaluated the reproducibility of the ICH-score in ICH patients undergoing fibrinolytic therapy. Methods: We performed a retrospective analysis of patients with supratentorial ICH managed by fibrinolytic therapy and evaluated the 30-day mortality. The ICH-score was then applied to match the mortality in our patients with the mortality predicted by the ICH-score. The ICH-score is based on parameters available at admission: age, hematoma volume, intraventricular expansion, and clinical status according to the Glasgow Coma Scale. Results: A total of 233 patients were analyzed. The 30-day mortality rate was 30% (70/233). An age of ≥80 years was associated with a significantly higher mortality rate (OR 2.26, chi-square test p = 0.01). A hematoma volume of ≥30 mL led significantly more often to 30-day mortality (OR 3.72, chi-square test p = 0.01). The mortality was significantly higher in the patients with intraventricular hemorrhage (2.97, chi-square test p = 0.003). The ICH-score showed a significant correlation with mortality (chi-square test, p \\u0026lt; 0.0001). The following mortality rates were estimated using the ICH-score in our cohort: 1 = 0% (0/13), 2 = 0% (0/51), 3 = 1.3% (1/82), 4 = 43% (13/31), 5 = 100% (56/56). Conclusion: The ICH-score not only allows a reliable estimation of the 30-day mortality in patients with ICH treated conservatively but also treated by clot lysis. Compared to conservative treatment, the fibrinolytic therapy reduced the 30-day mortality in the patients with ICH-scores 1–4. Patients with ICH-score 5 do not have a benefit of fibrinolytic therapy and should no longer be considered to be candidates for fibrinolytic therapy."],["dc.identifier.doi","10.1159/000504246"],["dc.identifier.eissn","1421-9786"],["dc.identifier.issn","1015-9770"],["dc.identifier.pmid","31722333"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/77125"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.publisher","S. Karger AG"],["dc.relation.eissn","1421-9786"],["dc.relation.issn","1015-9770"],["dc.rights","https://www.karger.com/Services/SiteLicenses"],["dc.title","Intracerebral Hemorrhage-Score Allows a Reliable Prediction of Mortality in Patients with Spontaneous Intracerebral Hemorrhage Managed by Fibrinolytic Therapy"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1307"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Brain Stimulation"],["dc.bibliographiccitation.lastpage","1316"],["dc.bibliographiccitation.volume","14"],["dc.contributor.author","Abboud, Tammam"],["dc.contributor.author","Hahn, Günter"],["dc.contributor.author","Just, Anita"],["dc.contributor.author","Paidhungat, Mihika"],["dc.contributor.author","Nazarenus, Angelina"],["dc.contributor.author","Mielke, Dorothee"],["dc.contributor.author","Rohde, Veit"],["dc.date.accessioned","2021-10-01T09:57:48Z"],["dc.date.available","2021-10-01T09:57:48Z"],["dc.date.issued","2021"],["dc.description.sponsorship","Open-Access-Publikationsfonds 2021"],["dc.identifier.doi","10.1016/j.brs.2021.08.023"],["dc.identifier.pii","S1935861X21002254"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/89918"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-469"],["dc.relation.issn","1935-861X"],["dc.relation.orgunit","Klinik für Neurochirurgie"],["dc.rights","CC BY-NC-ND 4.0"],["dc.title","An insight into electrical resistivity of white matter and brain tumors"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","PloS one"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Malinova, Vesna"],["dc.contributor.author","Psychogios, Marios-Nikos"],["dc.contributor.author","Tsogkas, Ioannis"],["dc.contributor.author","Koennecke, Birte"],["dc.contributor.author","Bleuel, Kim"],["dc.contributor.author","Iliev, Bogdan"],["dc.contributor.author","Rohde, Veit"],["dc.contributor.author","Mielke, Dorothee"],["dc.contributor.editor","Etminan, Nima"],["dc.date.accessioned","2018-10-08T09:08:05Z"],["dc.date.available","2018-10-08T09:08:05Z"],["dc.date.issued","2017"],["dc.description.abstract","Magnetic resonance (MR) imaging has been used for the detection of cerebral vasospasm (VSP) related infarction in experimental subarachnoid hemorrhage (eSAH) in rats. Conventional angiography is generally used to visualize VSP, which is an invasive technique with a possible increase in morbidity and mortality. In this study we evaluated the validity of MR-angiography (MRA) in detecting VSP and its feasibility to define VSP severity grades after eSAH in rats."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2017"],["dc.fs.pkfprnr","66455"],["dc.identifier.doi","10.1371/journal.pone.0171121"],["dc.identifier.fs","625670"],["dc.identifier.pmid","28182715"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14242"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/15875"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","final"],["dc.relation.eissn","1932-6203"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","MR-angiography allows defining severity grades of cerebral vasospasm in an experimental double blood injection subarachnoid hemorrhage model in rats"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","5410"],["dc.bibliographiccitation.issue","21"],["dc.bibliographiccitation.journal","Cancers"],["dc.bibliographiccitation.volume","14"],["dc.contributor.affiliation","Fröhlich, Ellen; 1Department of Neurosurgery, University of Ulm, 89312 Günzburg, Germany"],["dc.contributor.affiliation","Sassenrath, Claudia; 2Department of Social Psychology, Institute of Psychology and Education, Faculty of Engering, Informatics and Psychology, University of Ulm, 89312 Günzburg, Germany"],["dc.contributor.affiliation","Nadji-Ohl, Minou; 3Department of Neurosurgery, Klinikum Stuttgart, 70174 Stuttgart, Germany"],["dc.contributor.affiliation","Unteroberdörster, Meike; 4Department of Neurosurgery, Charité—Universitätsmedizin Berlin, 12200 Berlin, Germany"],["dc.contributor.affiliation","Rückriegel, Stefan; 5Department of Neurosurgery, University of Würzburg, 97080 Würzburg, Germany"],["dc.contributor.affiliation","von der Brelie, Christian; 6Department of Neurosurgery, Johanniter—Kliniken Bonn, 53177 Bonn, Germany"],["dc.contributor.affiliation","Roder, Constantin; 7Department of Neurosurgery, University of Tübingen, 72076 Tübingen, Germany"],["dc.contributor.affiliation","Forster, Marie-Therese; 8Department of Neurosurgery, University of Frankfurt, 60528 Frankfurt am Main, Germany"],["dc.contributor.affiliation","Schommer, Stephan; 2Department of Social Psychology, Institute of Psychology and Education, Faculty of Engering, Informatics and Psychology, University of Ulm, 89312 Günzburg, Germany"],["dc.contributor.affiliation","Löhr, Mario; 4Department of Neurosurgery, Charité—Universitätsmedizin Berlin, 12200 Berlin, Germany"],["dc.contributor.affiliation","Pala, Andrej; 1Department of Neurosurgery, University of Ulm, 89312 Günzburg, Germany"],["dc.contributor.affiliation","Goebel, Simone; 9Department of Psychology, University of Kiel, 24118 Kiel, Germany"],["dc.contributor.affiliation","Mielke, Dorothee; 10Department of Neurosurgery, University of Göttingen, 37075 Göttingen, Germany"],["dc.contributor.affiliation","Gerlach, Rüdiger; 11Department of Neurosurgery, Helioskliniken Erfurt, 99089 Erfurt, Germany"],["dc.contributor.affiliation","Renovanz, Mirjam; 7Department of Neurosurgery, University of Tübingen, 72076 Tübingen, Germany"],["dc.contributor.affiliation","Wirtz, Christian Rainer; 1Department of Neurosurgery, University of Ulm, 89312 Günzburg, Germany"],["dc.contributor.affiliation","Onken, Julia; 4Department of Neurosurgery, Charité—Universitätsmedizin Berlin, 12200 Berlin, Germany"],["dc.contributor.affiliation","Czabanka, Marcus; 8Department of Neurosurgery, University of Frankfurt, 60528 Frankfurt am Main, Germany"],["dc.contributor.affiliation","Tatagiba, Marcos Soares; 7Department of Neurosurgery, University of Tübingen, 72076 Tübingen, Germany"],["dc.contributor.affiliation","Rohde, Veit; 11Department of Neurosurgery, Helioskliniken Erfurt, 99089 Erfurt, Germany"],["dc.contributor.affiliation","Ernestus, Ralf-Ingo; 5Department of Neurosurgery, University of Würzburg, 97080 Würzburg, Germany"],["dc.contributor.affiliation","Vajkoczy, Peter; 4Department of Neurosurgery, Charité—Universitätsmedizin Berlin, 12200 Berlin, Germany"],["dc.contributor.affiliation","Gansland, Oliver; 3Department of Neurosurgery, Klinikum Stuttgart, 70174 Stuttgart, Germany"],["dc.contributor.affiliation","Coburger, Jan; 1Department of Neurosurgery, University of Ulm, 89312 Günzburg, Germany"],["dc.contributor.author","Fröhlich, Ellen"],["dc.contributor.author","Sassenrath, Claudia"],["dc.contributor.author","Nadji-Ohl, Minou"],["dc.contributor.author","Unteroberdörster, Meike"],["dc.contributor.author","Rückriegel, Stefan"],["dc.contributor.author","von der Brelie, Christian"],["dc.contributor.author","Roder, Constantin"],["dc.contributor.author","Forster, Marie-Therese"],["dc.contributor.author","Schommer, Stephan"],["dc.contributor.author","Löhr, Mario"],["dc.contributor.author","Pala, Andrej"],["dc.contributor.author","Goebel, Simone"],["dc.contributor.author","Mielke, Dorothee"],["dc.contributor.author","Gerlach, Rüdiger"],["dc.contributor.author","Renovanz, Mirjam"],["dc.contributor.author","Wirtz, Christian Rainer"],["dc.contributor.author","Onken, Julia"],["dc.contributor.author","Czabanka, Marcus"],["dc.contributor.author","Tatagiba, Marcos Soares"],["dc.contributor.author","Rohde, Veit"],["dc.contributor.author","Ernestus, Ralf-Ingo"],["dc.contributor.author","Vajkoczy, Peter"],["dc.contributor.author","Gansland, Oliver"],["dc.contributor.author","Coburger, Jan"],["dc.date.accessioned","2022-12-07T15:46:16Z"],["dc.date.available","2022-12-07T15:46:16Z"],["dc.date.issued","2022-11-02"],["dc.date.updated","2022-12-07T10:28:36Z"],["dc.description.abstract","Simple Summary\r\n Current data show that resilience is an important factor in cancer patients’ well-being. We explored the resilience of patients with lower grade glioma (LGG) and the potentially influencing factors. Our data indicate that stigmatization and the functional status are significantly associated with the patients’ resilience. These factors should be identified and targeted therapeutically in clinical routines.\r\n \r\n \r\n Abstract\r\n Current data show that resilience is an important factor in cancer patients’ well-being. We aim to explore the resilience of patients with lower grade glioma (LGG) and the potentially influencing factors. We performed a cross-sectional assessment of adult patients with LGG who were enrolled in the LoG-Glio registry. By phone interview, we administered the following measures: Resilience Scale (RS-13), distress thermometer, Montreal Cognitive Assessment Test for visually impaired patients (MoCA-Blind), internalized stigmatization by brain tumor (ISBI), Eastern Cooperative Oncological Group performance status (ECOG), patients’ perspective questionnaire (PPQ) and typical clinical parameters. We calculated correlations and multivariate regression models. Of 74 patients who were assessed, 38% of those showed a low level of resilience. Our results revealed significant correlations of resilience with distress (p < 0.001, −0.49), MOCA (p = 0.003, 0.342), ECOG (p < 0.001, −0.602), stigmatization (p < 0.001, −0.558), pain (p < 0.001, −0.524), and occupation (p = 0.007, 0.329). In multivariate analyses, resilience was negatively associated with elevated ECOG (p = 0.020, β = −0.383) and stigmatization levels (p = 0.008, β = −0.350). Occupation showed a tendency towards a significant association with resilience (p = 0.088, β = −0.254). Overall, low resilience affected more than one third of our cohort. Low functional status is a specific risk factor for low resilience. The relevant influence of stigmatization on resilience is a novel finding for patients suffering from a glioma and should be routinely identified and targeted in clinical routine."],["dc.identifier.doi","10.3390/cancers14215410"],["dc.identifier.pii","cancers14215410"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/118467"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-621"],["dc.relation.eissn","2072-6694"],["dc.rights","CC BY 4.0"],["dc.title","Resilience in Lower Grade Glioma Patients"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]