Lange, Peter

[["dc.bibliographiccitation.firstpage","410"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Brain Sciences"],["dc.bibliographiccitation.volume","12"],["dc.contributor.affiliation","Konen, Franz Felix; 1Clinical Neuroimmunology and Neurochemistry, Department of Neurology, Hannover Medical School, 30625 Hannover, Germany; konen.felix@mh-hannover.de (F.F.K.); wurster.ulrich@mh-hannover.de (U.W.); jendretzky.konstantin@mh-hannover.de (K.F.J.); gingele.stefan@mh-hannover.de (S.G.); moehn.nora@mh-hannover.de (N.M.); suehs.kurt-wolfram@mh-hannover.de (K.-W.S.); stangel.martin@mh-hannover.de (M.S.); skripuletz.thomas@mh-hannover.de (T.S.)"],["dc.contributor.affiliation","Lange, Peter; 2Department of Neurology, University Medical Center Göttingen (UMG), 37075 Göttingen, Germany; peter-la@med.uni-goettingen.de"],["dc.contributor.affiliation","Wurster, Ulrich; 1Clinical Neuroimmunology and Neurochemistry, Department of Neurology, Hannover Medical School, 30625 Hannover, Germany; konen.felix@mh-hannover.de (F.F.K.); wurster.ulrich@mh-hannover.de (U.W.); jendretzky.konstantin@mh-hannover.de (K.F.J.); gingele.stefan@mh-hannover.de (S.G.); moehn.nora@mh-hannover.de (N.M.); suehs.kurt-wolfram@mh-hannover.de (K.-W.S.); stangel.martin@mh-hannover.de (M.S.); skripuletz.thomas@mh-hannover.de (T.S.)"],["dc.contributor.affiliation","Jendretzky, Konstantin Fritz; 1Clinical Neuroimmunology and Neurochemistry, Department of Neurology, Hannover Medical School, 30625 Hannover, Germany; konen.felix@mh-hannover.de (F.F.K.); wurster.ulrich@mh-hannover.de (U.W.); jendretzky.konstantin@mh-hannover.de (K.F.J.); gingele.stefan@mh-hannover.de (S.G.); moehn.nora@mh-hannover.de (N.M.); suehs.kurt-wolfram@mh-hannover.de (K.-W.S.); stangel.martin@mh-hannover.de (M.S.); skripuletz.thomas@mh-hannover.de (T.S.)"],["dc.contributor.affiliation","Gingele, Stefan; 1Clinical Neuroimmunology and Neurochemistry, Department of Neurology, Hannover Medical School, 30625 Hannover, Germany; konen.felix@mh-hannover.de (F.F.K.); wurster.ulrich@mh-hannover.de (U.W.); jendretzky.konstantin@mh-hannover.de (K.F.J.); gingele.stefan@mh-hannover.de (S.G.); moehn.nora@mh-hannover.de (N.M.); suehs.kurt-wolfram@mh-hannover.de (K.-W.S.); stangel.martin@mh-hannover.de (M.S.); skripuletz.thomas@mh-hannover.de (T.S.)"],["dc.contributor.affiliation","Möhn, Nora; 1Clinical Neuroimmunology and Neurochemistry, Department of Neurology, Hannover Medical School, 30625 Hannover, Germany; konen.felix@mh-hannover.de (F.F.K.); wurster.ulrich@mh-hannover.de (U.W.); jendretzky.konstantin@mh-hannover.de (K.F.J.); gingele.stefan@mh-hannover.de (S.G.); moehn.nora@mh-hannover.de (N.M.); suehs.kurt-wolfram@mh-hannover.de (K.-W.S.); stangel.martin@mh-hannover.de (M.S.); skripuletz.thomas@mh-hannover.de (T.S.)"],["dc.contributor.affiliation","Sühs, Kurt-Wolfram; 1Clinical Neuroimmunology and Neurochemistry, Department of Neurology, Hannover Medical School, 30625 Hannover, Germany; konen.felix@mh-hannover.de (F.F.K.); wurster.ulrich@mh-hannover.de (U.W.); jendretzky.konstantin@mh-hannover.de (K.F.J.); gingele.stefan@mh-hannover.de (S.G.); moehn.nora@mh-hannover.de (N.M.); suehs.kurt-wolfram@mh-hannover.de (K.-W.S.); stangel.martin@mh-hannover.de (M.S.); skripuletz.thomas@mh-hannover.de (T.S.)"],["dc.contributor.affiliation","Stangel, Martin; 1Clinical Neuroimmunology and Neurochemistry, Department of Neurology, Hannover Medical School, 30625 Hannover, Germany; konen.felix@mh-hannover.de (F.F.K.); wurster.ulrich@mh-hannover.de (U.W.); jendretzky.konstantin@mh-hannover.de (K.F.J.); gingele.stefan@mh-hannover.de (S.G.); moehn.nora@mh-hannover.de (N.M.); suehs.kurt-wolfram@mh-hannover.de (K.-W.S.); stangel.martin@mh-hannover.de (M.S.); skripuletz.thomas@mh-hannover.de (T.S.)"],["dc.contributor.affiliation","Skripuletz, Thomas; 1Clinical Neuroimmunology and Neurochemistry, Department of Neurology, Hannover Medical School, 30625 Hannover, Germany; konen.felix@mh-hannover.de (F.F.K.); wurster.ulrich@mh-hannover.de (U.W.); jendretzky.konstantin@mh-hannover.de (K.F.J.); gingele.stefan@mh-hannover.de (S.G.); moehn.nora@mh-hannover.de (N.M.); suehs.kurt-wolfram@mh-hannover.de (K.-W.S.); stangel.martin@mh-hannover.de (M.S.); skripuletz.thomas@mh-hannover.de (T.S.)"],["dc.contributor.affiliation","Schwenkenbecher, Philipp; 1Clinical Neuroimmunology and Neurochemistry, Department of Neurology, Hannover Medical School, 30625 Hannover, Germany; konen.felix@mh-hannover.de (F.F.K.); wurster.ulrich@mh-hannover.de (U.W.); jendretzky.konstantin@mh-hannover.de (K.F.J.); gingele.stefan@mh-hannover.de (S.G.); moehn.nora@mh-hannover.de (N.M.); suehs.kurt-wolfram@mh-hannover.de (K.-W.S.); stangel.martin@mh-hannover.de (M.S.); skripuletz.thomas@mh-hannover.de (T.S.)"],["dc.contributor.author","Konen, Franz Felix"],["dc.contributor.author","Lange, Peter"],["dc.contributor.author","Wurster, Ulrich"],["dc.contributor.author","Jendretzky, Konstantin Fritz"],["dc.contributor.author","Gingele, Stefan"],["dc.contributor.author","Möhn, Nora"],["dc.contributor.author","Sühs, Kurt-Wolfram"],["dc.contributor.author","Stangel, Martin"],["dc.contributor.author","Skripuletz, Thomas"],["dc.contributor.author","Schwenkenbecher, Philipp"],["dc.date.accessioned","2022-04-01T10:02:04Z"],["dc.date.available","2022-04-01T10:02:04Z"],["dc.date.issued","2022"],["dc.date.updated","2022-04-08T08:24:49Z"],["dc.description.abstract","Background: Cerebrospinal fluid (CSF) samples from patients with non-inflammatory neurological diseases are used for control groups in biomarker studies. Since large amounts of CSF are withdrawn, patients with idiopathic intracranial hypertension (IIH) or normal pressure hydrocephalus (NPH) are especially suitable. The serially taken CSF portions are usually collected in different tubes. We aimed to investigate whether the later random choice of one of these tubes for CSF investigations might harbor the risk of different CSF protein findings due to the so-called ventriculo-lumbar CSF gradient. Methods: Patients with IIH (9) and NPH (7) were included. CSF was serially taken and collected in six tubes of 5 mL each. Concentrations and CSF-serum quotients of immunoglobulins, albumin and the virus-specific antibody index (AI) were determined in the first, fourth and sixth CSF fraction. Results: CSF immunoglobulin and albumin concentrations and CSF-serum protein quotients were significantly lower in the fourth and sixth CSF fraction compared with the first CSF fraction. Virus-specific AI did not significantly differ in the different CSF fractions. Conclusions: CSF protein analytics should be performed in the first CSF fraction in order to avoid different measurement results and achieve comparability within a control group and between different control and patient groups."],["dc.identifier.doi","10.3390/brainsci12030410"],["dc.identifier.pii","brainsci12030410"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/105817"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-530"],["dc.relation.eissn","2076-3425"],["dc.rights","Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/)."],["dc.title","The Influence of the Ventricular-Lumbar Gradient on Cerebrospinal Fluid Analysis in Serial Samples"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","e1062"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Neurology - Neuroimmunology Neuroinflammation"],["dc.bibliographiccitation.volume","8"],["dc.contributor.author","Schwenkenbecher, Philipp"],["dc.contributor.author","Skripuletz, Thomas"],["dc.contributor.author","Lange, Peter"],["dc.contributor.author","Dürr, Marc"],["dc.contributor.author","Konen, Felix F."],["dc.contributor.author","Möhn, Nora"],["dc.contributor.author","Ringelstein, Marius"],["dc.contributor.author","Menge, Til"],["dc.contributor.author","Friese, Manuel A."],["dc.contributor.author","Melzer, Nico"],["dc.contributor.author","Sühs, Kurt-Wolfram"],["dc.date.accessioned","2021-12-01T09:22:29Z"],["dc.date.available","2021-12-01T09:22:29Z"],["dc.date.issued","2021"],["dc.description.abstract","Background and Objectives Neurotropic viruses are suspected to play a role in the pathogenesis of autoimmune diseases of the CNS such as the association between the Epstein-Barr virus (EBV) and multiple sclerosis (MS). A group of autoimmune encephalitis (AE) is linked to antibodies against neuronal cell surface proteins. Because CNS infection with the herpes simplex virus can trigger anti–NMDA receptor (NMDAR) encephalitis, a similar mechanism for EBV and other neurotropic viruses could be postulated. To investigate for previous viral infections of the CNS, intrathecally produced virus-specific antibody synthesis was determined in patients with AE. Methods Antibody-specific indices (AIs) against EBV and measles, rubella, varicella zoster, herpes simplex virus, and cytomegalovirus were determined in 27 patients having AE (anti-NMDAR encephalitis, n = 21, and LGI1 encephalitis, n = 6) and in 2 control groups comprising of 30 patients with MS and 21 patients with noninflammatory CNS diseases (NIND), which were sex and age matched. Results An intrathecal synthesis of antibodies against EBV was found in 5/27 (19%) patients with AE and 2/30 (7%) of the patients with MS. All these patients had also at least 1 additional elevated virus-specific AI. In contrast, in none of the patients with NIND, an elevated virus-specific AI was detected. Discussion Intrathecally produced antibodies against EBV can be found in patients with AE and MS but only together with antibodies against different neurotropic viruses. Evidence of these antibodies is the result of a polyspecific immune response similar yet distinct from MS response rather than an elapsed infection of the CNS."],["dc.description.abstract","Background and Objectives Neurotropic viruses are suspected to play a role in the pathogenesis of autoimmune diseases of the CNS such as the association between the Epstein-Barr virus (EBV) and multiple sclerosis (MS). A group of autoimmune encephalitis (AE) is linked to antibodies against neuronal cell surface proteins. Because CNS infection with the herpes simplex virus can trigger anti–NMDA receptor (NMDAR) encephalitis, a similar mechanism for EBV and other neurotropic viruses could be postulated. To investigate for previous viral infections of the CNS, intrathecally produced virus-specific antibody synthesis was determined in patients with AE. Methods Antibody-specific indices (AIs) against EBV and measles, rubella, varicella zoster, herpes simplex virus, and cytomegalovirus were determined in 27 patients having AE (anti-NMDAR encephalitis, n = 21, and LGI1 encephalitis, n = 6) and in 2 control groups comprising of 30 patients with MS and 21 patients with noninflammatory CNS diseases (NIND), which were sex and age matched. Results An intrathecal synthesis of antibodies against EBV was found in 5/27 (19%) patients with AE and 2/30 (7%) of the patients with MS. All these patients had also at least 1 additional elevated virus-specific AI. In contrast, in none of the patients with NIND, an elevated virus-specific AI was detected. Discussion Intrathecally produced antibodies against EBV can be found in patients with AE and MS but only together with antibodies against different neurotropic viruses. Evidence of these antibodies is the result of a polyspecific immune response similar yet distinct from MS response rather than an elapsed infection of the CNS."],["dc.identifier.doi","10.1212/NXI.0000000000001062"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/94413"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-478"],["dc.relation.eissn","2332-7812"],["dc.title","Intrathecal Antibody Production Against Epstein-Barr, Herpes Simplex, and Other Neurotropic Viruses in Autoimmune Encephalitis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Fluids and Barriers of the CNS"],["dc.bibliographiccitation.volume","16"],["dc.contributor.author","Möhn, Nora"],["dc.contributor.author","Luo, Yi"],["dc.contributor.author","Skripuletz, Thomas"],["dc.contributor.author","Schwenkenbecher, Philipp"],["dc.contributor.author","Zerr, Inga"],["dc.contributor.author","Lange, Peter"],["dc.contributor.author","Stangel, Martin"],["dc.date.accessioned","2020-12-10T18:39:01Z"],["dc.date.available","2020-12-10T18:39:01Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1186/s12987-019-0148-3"],["dc.identifier.eissn","2045-8118"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16460"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/77514"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.intern","Merged from goescholar"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Tau-protein concentrations are not elevated in cerebrospinal fluid of patients with progressive multifocal leukoencephalopathy"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]