Lange, Peter

[["dc.bibliographiccitation.firstpage","272"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","International Journal of Radiation Biology"],["dc.bibliographiccitation.lastpage","281"],["dc.bibliographiccitation.volume","94"],["dc.contributor.author","Gomolka, Maria"],["dc.contributor.author","Oestreicher, Ursula"],["dc.contributor.author","Rößler, Ute"],["dc.contributor.author","Samaga, Daniel"],["dc.contributor.author","Endesfelder, David"],["dc.contributor.author","Lang, Peter"],["dc.contributor.author","Neumaier, Klement"],["dc.contributor.author","Belka, Claus"],["dc.contributor.author","Niemeyer, Markus"],["dc.contributor.author","Kiechle, Marion"],["dc.contributor.author","Hasbargen, Uwe"],["dc.contributor.author","Hübener, Christoph"],["dc.contributor.author","Kirlum, Hans-Joachim"],["dc.contributor.author","Kulka, Ulrike"],["dc.contributor.author","Rosenberger, Albert"],["dc.contributor.author","Walsh, Linda"],["dc.contributor.author","Baatout, Sarah"],["dc.contributor.author","Kesminiene, Ausrele"],["dc.contributor.author","Lindholm, Carita"],["dc.date.accessioned","2020-12-10T18:14:55Z"],["dc.date.available","2020-12-10T18:14:55Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1080/09553002.2018.1419302"],["dc.identifier.eissn","1362-3095"],["dc.identifier.issn","0955-3002"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/74665"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Age-dependent differences in DNA damage after in vitro CT exposure"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1"],["dc.bibliographiccitation.issue","1-2"],["dc.bibliographiccitation.journal","Clinica Chimica Acta"],["dc.bibliographiccitation.lastpage","12"],["dc.bibliographiccitation.volume","292"],["dc.contributor.author","Smirnov, Alexander V."],["dc.contributor.author","Tumani, Hayrettin"],["dc.contributor.author","Henne, Sergej"],["dc.contributor.author","Barchfeld, Sandra"],["dc.contributor.author","Olgemöller, Ulrike"],["dc.contributor.author","Wiltfang, Jens"],["dc.contributor.author","Lange, Peter"],["dc.contributor.author","Mäder, Michael"],["dc.contributor.author","Nau, Roland"],["dc.date.accessioned","2017-09-07T11:45:22Z"],["dc.date.available","2017-09-07T11:45:22Z"],["dc.date.issued","2000"],["dc.description.abstract","Glutamine synthetase (GS) activity is higher in the neocortex but not in the hippocampal formation of rabbit brain during Streptococcus pneumoniae meningitis compared to the respective brain region of uninfected control animals. One-dimensional polyacrylamide gel electrophoresis (1D-SDS-PAGE) revealed an apparent molecular mass (Mr) of 44 000 Dalton (Da) for GS from rabbit brain. After two-dimensional gel electrophoresis (2D-PAGE), followed by Coomassie-blue staining, GS separated into three distinct spots (S1, S2, S3). One additional spot (S4) occurred on the immunoblot. All four GS spots exhibited the same Mr (44 000 Da), but differed in their isoelectric points. Densitometric evaluation of the two-dimensional maps revealed a strong increase of optical density (OD) of S3 in the frontal cortex of infected animals. The calculated OD ratio S3/S2 in the frontal cortex from rabbits with meningitis was 1.75±0.68 (mean±standard deviation). Compared to controls (0.85±0.39), this value was significantly increased (p=0.0006). In the hippocampal formation, the ratio S3/S2 was nearly unchanged during meningitis. It is suggested that the ratio S3/S2 may indicate a neuroprotective feature of rabbit brain during meningitis since neuronal apoptosis occurs only in the dentate gyrus and not in the frontal cortex."],["dc.identifier.doi","10.1016/s0009-8981(99)00180-1"],["dc.identifier.gro","3151752"],["dc.identifier.pmid","10686272"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/8576"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.notes.submitter","chake"],["dc.relation.issn","0009-8981"],["dc.title","Glutamine synthetase in experimental meningitis: increased ratio of the subunits 3 and 2 may indicate enhanced activity"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","no"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","126"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Dementia and Geriatric Cognitive Disorders"],["dc.bibliographiccitation.lastpage","134"],["dc.bibliographiccitation.volume","32"],["dc.contributor.author","Fronek, Kathrin"],["dc.contributor.author","Spreer, Annette"],["dc.contributor.author","Eiffert, Helmut"],["dc.contributor.author","Nau, Roland"],["dc.contributor.author","Lange, Peter"],["dc.date.accessioned","2018-11-07T08:51:09Z"],["dc.date.available","2018-11-07T08:51:09Z"],["dc.date.issued","2011"],["dc.description.abstract","Background/Aims: Determination of marker proteins of neuronal degeneration in cerebrospinal fluid (CSF) is of increasing importance. However, preanalytical problems may compromise the results. Methods: We studied the influence of the transport tube material and shaking at room temperature on the CSF concentrations of beta-amyloid and tau protein determined by enzyme immunoassays. Results: The materials of the transport tube moderately influenced the CSF concentrations of beta-amyloid and tau protein. Polyethylene and polypropylene tubes were well suited, but glass, polycarbonate and polystyrene tubes caused a decrease in the CSF beta-amyloid and tau protein concentrations. The strongest impact, however, was caused by bacterial contamination of samples. Contamination with high concentrations of Pseudomonas aeruginosa and related species rendered beta-amyloid undetectable and strongly diminished tau protein concentrations. The effects of several Gram-positive bacteria were less pronounced. Addition of 0.1% sodium azide prior to bacterial contamination increased the interval at which CSF could be kept at room temperature without a substantial reduction of the beta-amyloid or tau protein concentration. Conclusion: Polyethylene or polypropylene tubes are suitable transport vessels for CSF samples. Bacterial contamination during sampling and portioning must be avoided. Addition of sodium azide may be an option when transport of the sample is delayed. Copyright (C) 2011 S. Karger AG, Basel"],["dc.identifier.doi","10.1159/000330912"],["dc.identifier.fs","580959"],["dc.identifier.isi","000295875400006"],["dc.identifier.pmid","21952521"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/21862"],["dc.language.iso","en"],["dc.notes","This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively."],["dc.notes.intern","Merged from goescholar"],["dc.notes.intern","In goescholar merged with http://resolver.sub.uni-goettingen.de/purl?gs-1/8159"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","S. Karger AG"],["dc.relation.eissn","1421-9824"],["dc.relation.issn","1420-8008"],["dc.rights","Goescholar"],["dc.rights.access","openAccess"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.subject.mesh","Amyloid beta-Peptides"],["dc.subject.mesh","Cerebrospinal Fluid"],["dc.subject.mesh","Cerebrospinal Fluid Proteins"],["dc.subject.mesh","Dementia"],["dc.subject.mesh","Enzyme-Linked Immunosorbent Assay"],["dc.subject.mesh","Equipment Design"],["dc.subject.mesh","Humans"],["dc.subject.mesh","Pseudomonas aeruginosa"],["dc.subject.mesh","Quality Control"],["dc.subject.mesh","Specimen Handling"],["dc.subject.mesh","Stenotrophomonas maltophilia"],["dc.subject.mesh","tau Proteins"],["dc.title","Bacterial Contamination and the Transport Vial Material Affect Cerebrospinal Fluid Concentrations of beta-Amyloid and Tau Protein as Determined by Enzyme Immunoassay"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","15"],["dc.bibliographiccitation.firstpage","1"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Fluids and Barriers of the CNS"],["dc.bibliographiccitation.lastpage","5"],["dc.bibliographiccitation.volume","13"],["dc.contributor.author","Djukic, Marija"],["dc.contributor.author","Spreer, Annette"],["dc.contributor.author","Lange, Peter"],["dc.contributor.author","Bunkowski, Stephanie"],["dc.contributor.author","Wiltfang, Jens"],["dc.contributor.author","Nau, Roland"],["dc.date.accessioned","2017-09-07T11:44:33Z"],["dc.date.available","2017-09-07T11:44:33Z"],["dc.date.issued","2016"],["dc.description.abstract","Background The composition of the cerebrospinal fluid (CSF) is not homogeneous, and concentrations of proteins from different origins diverge among ventricular, cisternal and lumbar CSF fractions. Concentrations of blood-derived proteins increase and of brain-derived proteins decrease from ventricular to lumbar fractions. We studied whether the origin of the CSF portion analysed may affect results in CSF analysis for dementia. Methods In 16 geriatric patients with suspected normal pressure hydrocephalus [age 82.5 (76/87) years; median (25th/75th percentile)] a lumbar spinal tap of 40 ml was performed. The CSF was sequentially collected in 8 fractions of 5 ml with the 1st fraction corresponding to lumbar CSF, the 8th to cisterna magna-near CSF. Fractions were analysed for total protein, albumin, Tau protein (Tau), phosphorylated Tau (pTau), Amyloid beta 1–42 (Aβ1–42), Amyloid beta 1–40 (Aβ1–40), and the Aβ1–42/Aβ1–40 ratio. Results The concentrations of total protein and albumin increased from cisternal to lumbar fractions due to diffusion-related accumulation from blood to CSF with significantly higher concentrations in fraction 1 compared to fraction 8. The concentrations of Tau showed a non-significant trend towards decreased values in lumbar samples, and pTau was slightly, but significantly decreased in the lumbar fraction 1 [26.5 (22.5/35.0) pg/ml] compared to the cistern-near fraction 8 [27.0 (24.2/36.3) pg/ml] (p = 0.02, Wilcoxon signed rank test). Aβ1-42, Aβ1-40, and the Aβ1-42/Aβ1-40 ratio remained almost constant. Conclusions According to the flow-related diverging dynamics of blood-derived and brain-derived proteins in CSF, the concentrations of Tau and pTau tended to be lower in lumbar compared to cisternal CSF fractions after a spinal tap of 40 ml. The differences reached statistical significance for pTau only. The small differences will not affect clinical interpretation of markers of dementia in the vast majority of cases."],["dc.identifier.doi","10.1186/s12987-016-0039-9"],["dc.identifier.gro","3151687"],["dc.identifier.pmid","27581842"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/13876"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/8505"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","final"],["dc.notes.submitter","chake"],["dc.relation.issn","2045-8118"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Small cisterno-lumbar gradient of phosphorylated Tau protein in geriatric patients with suspected normal pressure hydrocephalus"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","no"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","353"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Zeitschrift für Gerontologie und Geriatrie"],["dc.bibliographiccitation.lastpage","357"],["dc.bibliographiccitation.volume","46"],["dc.contributor.author","Djukic, M."],["dc.contributor.author","Schulz, Daniela"],["dc.contributor.author","Schmidt, H."],["dc.contributor.author","Lange, P."],["dc.contributor.author","Nau, R."],["dc.date.accessioned","2018-11-07T09:24:19Z"],["dc.date.available","2018-11-07T09:24:19Z"],["dc.date.issued","2013"],["dc.description.abstract","The chemical composition of the cerebrospinal fluid (CSF) is age-dependent. Routine CSF parameters, the indications for lumbar puncture (LP), and the most frequent complications were retrospectively studied in patients older (n = 167) and younger (n = 36) than 65 years. In the absence of meningeal inflammation, the mean CSF lactate level of patients older than 65 years was slightly but significantly higher than the mean CSF lactate level of younger patients. The lactate level of patients with otherwise normal CSF findings correlated significantly with the age of the patients. In the absence of meningeal inflammation, the CSF-to-serum albumin ratio (Q(Albumin)) was significantly higher in older patients than in younger ones. The most frequent indication for LP, suspected infection of the central nervous system (CNS) (n = 110), was confirmed in 12.7% of patients. The only LP complication documented was headache in two patients. Elevations of Q(Albumin) and CSF lactate levels appear to be nonspecific findings in elderly patients. Suspected infections, the most frequent indication for LP, were confirmed by CSF analysis in more than 10% of patients. The very low complication rate of LP makes it a very valuable tool in the diagnostic routine for older patients with CNS diseases."],["dc.description.sponsorship","Robert Bosch Foundation; Sparkasse Gottingen"],["dc.identifier.doi","10.1007/s00391-012-0380-9"],["dc.identifier.isi","000319477500009"],["dc.identifier.pmid","22903361"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/29793"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","Heidelberg"],["dc.relation.issn","0948-6704"],["dc.title","Cerebrospinal fluid findings in geriatric patients from 2008 to 2011"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","314"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Acta Neurologica Belgica"],["dc.bibliographiccitation.lastpage","320"],["dc.bibliographiccitation.volume","110"],["dc.contributor.author","Moldrich, G."],["dc.contributor.author","Lange, P."],["dc.contributor.author","Strik, Herwig Matthias"],["dc.date.accessioned","2018-11-07T08:35:56Z"],["dc.date.available","2018-11-07T08:35:56Z"],["dc.date.issued","2010"],["dc.description.abstract","Objective: the diagnostic impact of carcinoembryonic antigen (CEA) was evaluated in serum and CSF of cancer and control patients. Methods: 97 analyses of CEA in CSF and serum from 83 cancer patients were compared with 41 cases without malignancy. CEA diffusion dynamics were evaluated with IgA CSF/serum quotients (Q 10). Intrathecal synthesis of CEA was analysed both by calculating an index Q CEA/Q IgA and within the IgA-diagram. Results: in 73 samples without synthesis of IgA or CEA, both quotients correlated well with a mean Q CEA/Q IgA of 1.1 (95% CI 0.97-1.2). The Q CEA/Q IgA was significantly higher in metastasizing adenocarcinomas than in controls or other malignancies. In leptomeningeal disease from adenocarcinoma, Q CEA/Q IgA was significantly higher than in controls, while patients with CNS and/or bone metastases had intermediate values. The sensitivity to detect leptomeningeal disease was 91% and 69% for brain metastases. Q CEA/Q IgA and CEA synthesis assessed with the IgA diagram were equally sensitive. Conclusions: evaluation of CEA in the IgA diagram is feasible and of clinical value. The consideration of intrathecal CEA synthesis correlates better with the clinical status than absolute CSF-CEA or the correlation with albumin."],["dc.identifier.isi","000286162900007"],["dc.identifier.pmid","21305861"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/18195"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Acta Medica Belgica"],["dc.relation.issn","0300-9009"],["dc.title","Carcinoembryonic Antigen in the CSF of Cancer Patients - the value of intrathecal synthesis and correlation with IgA-diffusion dynamics"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","125"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Neurology"],["dc.bibliographiccitation.lastpage","128"],["dc.bibliographiccitation.volume","61"],["dc.contributor.author","Rostasy, Kevin"],["dc.contributor.author","Reiber, Hansotto"],["dc.contributor.author","Pohl, Daniela"],["dc.contributor.author","Lange, P."],["dc.contributor.author","Ohlenbusch, Andreas"],["dc.contributor.author","Eiffert, Helmut"],["dc.contributor.author","Maass, M."],["dc.contributor.author","Hanefeld, Folker"],["dc.date.accessioned","2018-11-07T10:37:41Z"],["dc.date.available","2018-11-07T10:37:41Z"],["dc.date.issued","2003"],["dc.description.abstract","The authors investigated the frequency and quantity of intrathecal antibody synthesis against Chlamydia pneumoniae and the presence of C pneumoniae antigen in 25 children with MS. C pneumoniae genome was present in two children. In seven children an intrathecal synthesis of C pneumoniae antibodies was detected, representing only a small part of the total intrathecal immunoglobulin G, suggesting that this intrathecal synthesis is part of a polyspecific, oligoclonal immune response."],["dc.identifier.isi","000183978800030"],["dc.identifier.pmid","12847174"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/45630"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.relation.issn","0028-3878"],["dc.title","Chlamydia pneumoniae in children with MS - Frequency and quantity of intrathecal antibodies"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","410"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Brain Sciences"],["dc.bibliographiccitation.volume","12"],["dc.contributor.affiliation","Konen, Franz Felix; 1Clinical Neuroimmunology and Neurochemistry, Department of Neurology, Hannover Medical School, 30625 Hannover, Germany; konen.felix@mh-hannover.de (F.F.K.); wurster.ulrich@mh-hannover.de (U.W.); jendretzky.konstantin@mh-hannover.de (K.F.J.); gingele.stefan@mh-hannover.de (S.G.); moehn.nora@mh-hannover.de (N.M.); suehs.kurt-wolfram@mh-hannover.de (K.-W.S.); stangel.martin@mh-hannover.de (M.S.); skripuletz.thomas@mh-hannover.de (T.S.)"],["dc.contributor.affiliation","Lange, Peter; 2Department of Neurology, University Medical Center Göttingen (UMG), 37075 Göttingen, Germany; peter-la@med.uni-goettingen.de"],["dc.contributor.affiliation","Wurster, Ulrich; 1Clinical Neuroimmunology and Neurochemistry, Department of Neurology, Hannover Medical School, 30625 Hannover, Germany; konen.felix@mh-hannover.de (F.F.K.); wurster.ulrich@mh-hannover.de (U.W.); jendretzky.konstantin@mh-hannover.de (K.F.J.); gingele.stefan@mh-hannover.de (S.G.); moehn.nora@mh-hannover.de (N.M.); suehs.kurt-wolfram@mh-hannover.de (K.-W.S.); stangel.martin@mh-hannover.de (M.S.); skripuletz.thomas@mh-hannover.de (T.S.)"],["dc.contributor.affiliation","Jendretzky, Konstantin Fritz; 1Clinical Neuroimmunology and Neurochemistry, Department of Neurology, Hannover Medical School, 30625 Hannover, Germany; konen.felix@mh-hannover.de (F.F.K.); wurster.ulrich@mh-hannover.de (U.W.); jendretzky.konstantin@mh-hannover.de (K.F.J.); gingele.stefan@mh-hannover.de (S.G.); moehn.nora@mh-hannover.de (N.M.); suehs.kurt-wolfram@mh-hannover.de (K.-W.S.); stangel.martin@mh-hannover.de (M.S.); skripuletz.thomas@mh-hannover.de (T.S.)"],["dc.contributor.affiliation","Gingele, Stefan; 1Clinical Neuroimmunology and Neurochemistry, Department of Neurology, Hannover Medical School, 30625 Hannover, Germany; konen.felix@mh-hannover.de (F.F.K.); wurster.ulrich@mh-hannover.de (U.W.); jendretzky.konstantin@mh-hannover.de (K.F.J.); gingele.stefan@mh-hannover.de (S.G.); moehn.nora@mh-hannover.de (N.M.); suehs.kurt-wolfram@mh-hannover.de (K.-W.S.); stangel.martin@mh-hannover.de (M.S.); skripuletz.thomas@mh-hannover.de (T.S.)"],["dc.contributor.affiliation","Möhn, Nora; 1Clinical Neuroimmunology and Neurochemistry, Department of Neurology, Hannover Medical School, 30625 Hannover, Germany; konen.felix@mh-hannover.de (F.F.K.); wurster.ulrich@mh-hannover.de (U.W.); jendretzky.konstantin@mh-hannover.de (K.F.J.); gingele.stefan@mh-hannover.de (S.G.); moehn.nora@mh-hannover.de (N.M.); suehs.kurt-wolfram@mh-hannover.de (K.-W.S.); stangel.martin@mh-hannover.de (M.S.); skripuletz.thomas@mh-hannover.de (T.S.)"],["dc.contributor.affiliation","Sühs, Kurt-Wolfram; 1Clinical Neuroimmunology and Neurochemistry, Department of Neurology, Hannover Medical School, 30625 Hannover, Germany; konen.felix@mh-hannover.de (F.F.K.); wurster.ulrich@mh-hannover.de (U.W.); jendretzky.konstantin@mh-hannover.de (K.F.J.); gingele.stefan@mh-hannover.de (S.G.); moehn.nora@mh-hannover.de (N.M.); suehs.kurt-wolfram@mh-hannover.de (K.-W.S.); stangel.martin@mh-hannover.de (M.S.); skripuletz.thomas@mh-hannover.de (T.S.)"],["dc.contributor.affiliation","Stangel, Martin; 1Clinical Neuroimmunology and Neurochemistry, Department of Neurology, Hannover Medical School, 30625 Hannover, Germany; konen.felix@mh-hannover.de (F.F.K.); wurster.ulrich@mh-hannover.de (U.W.); jendretzky.konstantin@mh-hannover.de (K.F.J.); gingele.stefan@mh-hannover.de (S.G.); moehn.nora@mh-hannover.de (N.M.); suehs.kurt-wolfram@mh-hannover.de (K.-W.S.); stangel.martin@mh-hannover.de (M.S.); skripuletz.thomas@mh-hannover.de (T.S.)"],["dc.contributor.affiliation","Skripuletz, Thomas; 1Clinical Neuroimmunology and Neurochemistry, Department of Neurology, Hannover Medical School, 30625 Hannover, Germany; konen.felix@mh-hannover.de (F.F.K.); wurster.ulrich@mh-hannover.de (U.W.); jendretzky.konstantin@mh-hannover.de (K.F.J.); gingele.stefan@mh-hannover.de (S.G.); moehn.nora@mh-hannover.de (N.M.); suehs.kurt-wolfram@mh-hannover.de (K.-W.S.); stangel.martin@mh-hannover.de (M.S.); skripuletz.thomas@mh-hannover.de (T.S.)"],["dc.contributor.affiliation","Schwenkenbecher, Philipp; 1Clinical Neuroimmunology and Neurochemistry, Department of Neurology, Hannover Medical School, 30625 Hannover, Germany; konen.felix@mh-hannover.de (F.F.K.); wurster.ulrich@mh-hannover.de (U.W.); jendretzky.konstantin@mh-hannover.de (K.F.J.); gingele.stefan@mh-hannover.de (S.G.); moehn.nora@mh-hannover.de (N.M.); suehs.kurt-wolfram@mh-hannover.de (K.-W.S.); stangel.martin@mh-hannover.de (M.S.); skripuletz.thomas@mh-hannover.de (T.S.)"],["dc.contributor.author","Konen, Franz Felix"],["dc.contributor.author","Lange, Peter"],["dc.contributor.author","Wurster, Ulrich"],["dc.contributor.author","Jendretzky, Konstantin Fritz"],["dc.contributor.author","Gingele, Stefan"],["dc.contributor.author","Möhn, Nora"],["dc.contributor.author","Sühs, Kurt-Wolfram"],["dc.contributor.author","Stangel, Martin"],["dc.contributor.author","Skripuletz, Thomas"],["dc.contributor.author","Schwenkenbecher, Philipp"],["dc.date.accessioned","2022-04-01T10:02:04Z"],["dc.date.available","2022-04-01T10:02:04Z"],["dc.date.issued","2022"],["dc.date.updated","2022-04-08T08:24:49Z"],["dc.description.abstract","Background: Cerebrospinal fluid (CSF) samples from patients with non-inflammatory neurological diseases are used for control groups in biomarker studies. Since large amounts of CSF are withdrawn, patients with idiopathic intracranial hypertension (IIH) or normal pressure hydrocephalus (NPH) are especially suitable. The serially taken CSF portions are usually collected in different tubes. We aimed to investigate whether the later random choice of one of these tubes for CSF investigations might harbor the risk of different CSF protein findings due to the so-called ventriculo-lumbar CSF gradient. Methods: Patients with IIH (9) and NPH (7) were included. CSF was serially taken and collected in six tubes of 5 mL each. Concentrations and CSF-serum quotients of immunoglobulins, albumin and the virus-specific antibody index (AI) were determined in the first, fourth and sixth CSF fraction. Results: CSF immunoglobulin and albumin concentrations and CSF-serum protein quotients were significantly lower in the fourth and sixth CSF fraction compared with the first CSF fraction. Virus-specific AI did not significantly differ in the different CSF fractions. Conclusions: CSF protein analytics should be performed in the first CSF fraction in order to avoid different measurement results and achieve comparability within a control group and between different control and patient groups."],["dc.identifier.doi","10.3390/brainsci12030410"],["dc.identifier.pii","brainsci12030410"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/105817"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-530"],["dc.relation.eissn","2076-3425"],["dc.rights","Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/)."],["dc.title","The Influence of the Ventricular-Lumbar Gradient on Cerebrospinal Fluid Analysis in Serial Samples"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","11"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Glia"],["dc.bibliographiccitation.lastpage","18"],["dc.bibliographiccitation.volume","30"],["dc.contributor.author","Tumani, Hayrettin"],["dc.contributor.author","Smirnov, Alexey"],["dc.contributor.author","Barchfeld, S."],["dc.contributor.author","Olgemoller, U."],["dc.contributor.author","Maier, K."],["dc.contributor.author","Lange, P."],["dc.contributor.author","Bruck, Wolfgang W."],["dc.contributor.author","Nau, R."],["dc.date.accessioned","2018-11-07T09:12:10Z"],["dc.date.available","2018-11-07T09:12:10Z"],["dc.date.issued","2000"],["dc.description.abstract","Apoptosis of dentate granular cells in the hippocampal formation during bacterial meningitis may be mediated by glutamate toxicity. For this reason, we studied the relationship between glutamine synthetase activity and regional neuronal apoptosis in rabbits with experimental pneumococcal meningitis. The duration of meningitis was 24 h, and the treatment was started 16 h after infection. Significant increases of glutamine synthetase protein concentration (P < 0.05) were found in the frontal cortex of rabbits with meningitis (n = 7) and rabbits with meningitis receiving ceftriaxone treatment (n = 12) as compared to the control animals (n = 14). No significant differences were seen in the hippocampal formation. The enzymatic activity of glutamine synthetase also was elevated in the frontal cortex (P < 0.05), but not in the hippocampal formation of rabbits with meningitis. After intravenous administration of L-methionine sulfoximine (specific inhibitor of glutamine synthetase) in rabbits with meningitis treated with ceftriaxone (n = 10), the concentration of neuron-specific enolase in CSF (P = 0.025) and the density of apoptotic neurons in the dentate gyrus quantified with the in-situ tailing reaction (P = 0.043) were higher than in meningitic animals receiving only ceftriaxone (n = 10). In conclusion, the inability of hippocampal glutamine synthetase to metabolize excess amounts of glutamate may contribute to neuronal apoptosis in the hippocampal formation during meningitis. GLIA 30:11-18, 2000. (C) 2000 Wiley-Liss, Inc."],["dc.identifier.doi","10.1002/(SICI)1098-1136(200003)30:1<11::AID-GLIA2>3.0.CO;2-E"],["dc.identifier.isi","000086084500002"],["dc.identifier.pmid","10696140"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/26890"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-liss"],["dc.relation.issn","0894-1491"],["dc.title","Inhibition of glutamine synthetase in rabbit pneumococcal meningitis is associated with neuronal apoptosis in the dentate gyrus"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Clinical Case Reports"],["dc.bibliographiccitation.volume","10"],["dc.contributor.author","Giotaki, Ioanna"],["dc.contributor.author","Gross, Uwe"],["dc.contributor.author","Lange, Peter"],["dc.contributor.author","Rustenbeck, Hans-Heino"],["dc.contributor.author","Bahn, Erik"],["dc.contributor.author","Nau, Roland"],["dc.date.accessioned","2022-05-02T08:09:51Z"],["dc.date.available","2022-05-02T08:09:51Z"],["dc.date.issued","2022"],["dc.description.abstract","The outcome of chronic meningitis depends to a large degree on the causative pathogen and the interval between onset of symptoms and diagnosis. We present a patient with a delayed diagnosis and several complications, for whom adequate therapy resulted in a favorable outcome. In a 76-year-old male patient, Candida albicans meningitis was diagnosed 4 months after the onset of symptoms. CSF findings (protein >1000 mg/L, predominance of intrathecal immunoglobulin A synthesis, lactate concentrations of approx. 10 mmol/L, leukocyte counts around 1000/μl, variable differential leukocyte counts) resembled tuberculous meningitis. In spite of the long interval without treatment, voriconazole 200 mg every 12 h for 7 weeks followed by fluconazole 300 mg/day maintenance therapy for 7 months led to a recovery with only mild deficits. The case illustrates that 1. C. albicans can cause chronic meningitis in patients without severe immune defects, 2. patients can survive C. albicans meningitis with mild long-term sequelae even when diagnosis and adequate treatment are delayed, and 3. voriconazole as a sole agent may be suitable for treatment of C. albicans meningitis."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2022"],["dc.identifier.doi","10.1002/ccr3.5664"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/107483"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-561"],["dc.relation.eissn","2050-0904"],["dc.relation.issn","2050-0904"],["dc.rights","CC BY-NC 4.0"],["dc.rights.uri","http://creativecommons.org/licenses/by-nc/4.0/"],["dc.title","Chronic Candida albicans meningitis misdiagnosed as polymyalgia rheumatica and successfully treated with voriconazole"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]