Lange, Peter

[["dc.bibliographiccitation.firstpage","126"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Dementia and Geriatric Cognitive Disorders"],["dc.bibliographiccitation.lastpage","134"],["dc.bibliographiccitation.volume","32"],["dc.contributor.author","Fronek, Kathrin"],["dc.contributor.author","Spreer, Annette"],["dc.contributor.author","Eiffert, Helmut"],["dc.contributor.author","Nau, Roland"],["dc.contributor.author","Lange, Peter"],["dc.date.accessioned","2018-11-07T08:51:09Z"],["dc.date.available","2018-11-07T08:51:09Z"],["dc.date.issued","2011"],["dc.description.abstract","Background/Aims: Determination of marker proteins of neuronal degeneration in cerebrospinal fluid (CSF) is of increasing importance. However, preanalytical problems may compromise the results. Methods: We studied the influence of the transport tube material and shaking at room temperature on the CSF concentrations of beta-amyloid and tau protein determined by enzyme immunoassays. Results: The materials of the transport tube moderately influenced the CSF concentrations of beta-amyloid and tau protein. Polyethylene and polypropylene tubes were well suited, but glass, polycarbonate and polystyrene tubes caused a decrease in the CSF beta-amyloid and tau protein concentrations. The strongest impact, however, was caused by bacterial contamination of samples. Contamination with high concentrations of Pseudomonas aeruginosa and related species rendered beta-amyloid undetectable and strongly diminished tau protein concentrations. The effects of several Gram-positive bacteria were less pronounced. Addition of 0.1% sodium azide prior to bacterial contamination increased the interval at which CSF could be kept at room temperature without a substantial reduction of the beta-amyloid or tau protein concentration. Conclusion: Polyethylene or polypropylene tubes are suitable transport vessels for CSF samples. Bacterial contamination during sampling and portioning must be avoided. Addition of sodium azide may be an option when transport of the sample is delayed. Copyright (C) 2011 S. Karger AG, Basel"],["dc.identifier.doi","10.1159/000330912"],["dc.identifier.fs","580959"],["dc.identifier.isi","000295875400006"],["dc.identifier.pmid","21952521"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/21862"],["dc.language.iso","en"],["dc.notes","This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively."],["dc.notes.intern","Merged from goescholar"],["dc.notes.intern","In goescholar merged with http://resolver.sub.uni-goettingen.de/purl?gs-1/8159"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","S. Karger AG"],["dc.relation.eissn","1421-9824"],["dc.relation.issn","1420-8008"],["dc.rights","Goescholar"],["dc.rights.access","openAccess"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.subject.mesh","Amyloid beta-Peptides"],["dc.subject.mesh","Cerebrospinal Fluid"],["dc.subject.mesh","Cerebrospinal Fluid Proteins"],["dc.subject.mesh","Dementia"],["dc.subject.mesh","Enzyme-Linked Immunosorbent Assay"],["dc.subject.mesh","Equipment Design"],["dc.subject.mesh","Humans"],["dc.subject.mesh","Pseudomonas aeruginosa"],["dc.subject.mesh","Quality Control"],["dc.subject.mesh","Specimen Handling"],["dc.subject.mesh","Stenotrophomonas maltophilia"],["dc.subject.mesh","tau Proteins"],["dc.title","Bacterial Contamination and the Transport Vial Material Affect Cerebrospinal Fluid Concentrations of beta-Amyloid and Tau Protein as Determined by Enzyme Immunoassay"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","125"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Neurology"],["dc.bibliographiccitation.lastpage","128"],["dc.bibliographiccitation.volume","61"],["dc.contributor.author","Rostasy, Kevin"],["dc.contributor.author","Reiber, Hansotto"],["dc.contributor.author","Pohl, Daniela"],["dc.contributor.author","Lange, P."],["dc.contributor.author","Ohlenbusch, Andreas"],["dc.contributor.author","Eiffert, Helmut"],["dc.contributor.author","Maass, M."],["dc.contributor.author","Hanefeld, Folker"],["dc.date.accessioned","2018-11-07T10:37:41Z"],["dc.date.available","2018-11-07T10:37:41Z"],["dc.date.issued","2003"],["dc.description.abstract","The authors investigated the frequency and quantity of intrathecal antibody synthesis against Chlamydia pneumoniae and the presence of C pneumoniae antigen in 25 children with MS. C pneumoniae genome was present in two children. In seven children an intrathecal synthesis of C pneumoniae antibodies was detected, representing only a small part of the total intrathecal immunoglobulin G, suggesting that this intrathecal synthesis is part of a polyspecific, oligoclonal immune response."],["dc.identifier.isi","000183978800030"],["dc.identifier.pmid","12847174"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/45630"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.relation.issn","0028-3878"],["dc.title","Chlamydia pneumoniae in children with MS - Frequency and quantity of intrathecal antibodies"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","909"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","Scandinavian Journal of Infectious Diseases"],["dc.bibliographiccitation.lastpage","913"],["dc.bibliographiccitation.volume","33"],["dc.contributor.author","Wellmer, A."],["dc.contributor.author","Prange, J."],["dc.contributor.author","Gerber, Joachim"],["dc.contributor.author","Zysk, G."],["dc.contributor.author","Lange, P."],["dc.contributor.author","Michel, Uwe"],["dc.contributor.author","Eiffert, Helmut"],["dc.contributor.author","Nau, R."],["dc.date.accessioned","2018-11-07T09:39:30Z"],["dc.date.available","2018-11-07T09:39:30Z"],["dc.date.issued","2001"],["dc.description.abstract","Increased total CSF lactate is an important indicator differentiating bacterial from aseptic meningitis. Bacteria can produce D- and L-lactate; mammalian cells produce only L-lactate. We measured D- and L-lactate production of Streptococcus pneumoniae, Staphylococcus aureus, Neisseria meningitidis and Escherichia coli in vitro, of S. pneumoniae and E. coli in rabbit experimental meningitis and of various common pathogens in CSF from patients with bacterial meningitis. Despite marked in vitro production of D-lactate by S. aureus (maximum: 4.59 mmol/l; i.e. 34.9% of total lactate), N. meningitidis (4.62 mmol/l; i.e. 98.1%) and E. coli (3.14 mmol/l; i.e. 97.2%), minimal amounts were measured in human S. aureus (0.38 mmol/l; i.e. 1.3% of total lactate) or N. meningitidis (0.28 mmol/l; i.e. 3.9%) and experimental E. coli meningitis (0.75 mmol/l; i.e. 4.4%). In only 9 of 54 human CSF samples did D-lactate exceed 0.15 mmol/l. S. pneumoniae did not produce significant amounts of D-lactate in vitro (maximum; 0.55 mmol/l; i.e. 2.7% of total lactate), in experimental meningitis (0.18 mmol/l; i.e. 3%) or in human cases of meningitis (0.28 mmol/l; i.e. 1.9%). In conclusion, increased total CSF lactate in meningitis consists mainly of L-lactate and originates predominantly from host cells. CSF D-lactate is of limited diagnostic value."],["dc.identifier.isi","000173355800006"],["dc.identifier.pmid","11868764"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/33300"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Taylor & Francis As"],["dc.publisher.place","Oslo"],["dc.relation.conference","40th Interscience Conference on Antimicrobial Agents and Chemotherapy"],["dc.relation.eventlocation","TORONTO, CANADA"],["dc.relation.issn","0036-5548"],["dc.title","D- and L-lactate in rabbit and human bacterial meningitis"],["dc.type","conference_paper"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","50"],["dc.bibliographiccitation.journal","Journal of Neurology"],["dc.bibliographiccitation.lastpage","51"],["dc.bibliographiccitation.volume","258"],["dc.contributor.author","Djukic, M."],["dc.contributor.author","Schmidt-Samoa, Carsten"],["dc.contributor.author","Lange, P."],["dc.contributor.author","Spreer, Annette"],["dc.contributor.author","Neubieser, K."],["dc.contributor.author","Eiffert, Helmut"],["dc.contributor.author","Nau, R."],["dc.contributor.author","Schmidt, H."],["dc.date.accessioned","2018-11-07T08:56:33Z"],["dc.date.available","2018-11-07T08:56:33Z"],["dc.date.issued","2011"],["dc.identifier.isi","000289992800134"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/23181"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","Heidelberg"],["dc.relation.conference","21st Meeting of the European-Neurological-Society"],["dc.relation.eventlocation","Lisbon, PORTUGAL"],["dc.relation.issn","0340-5354"],["dc.title","Cerebrospinal fluid findings in adults with acute neuroborreliosis"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","147"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Infection"],["dc.bibliographiccitation.lastpage","155"],["dc.bibliographiccitation.volume","45"],["dc.contributor.author","Henkel, Katrin"],["dc.contributor.author","Lange, Peter"],["dc.contributor.author","Eiffert, Helmut"],["dc.contributor.author","Nau, Roland"],["dc.contributor.author","Spreer, Annette"],["dc.date.accessioned","2020-12-10T14:14:44Z"],["dc.date.available","2020-12-10T14:14:44Z"],["dc.date.issued","2016"],["dc.identifier.doi","10.1007/s15010-016-0933-8"],["dc.identifier.eissn","1439-0973"],["dc.identifier.issn","0300-8126"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/71466"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Infections in the differential diagnosis of Bell’s palsy: a plea for performing CSF analysis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]