Now showing 1 - 10 of 18
  • 2018Journal Article
    [["dc.bibliographiccitation.firstpage","272"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","International Journal of Radiation Biology"],["dc.bibliographiccitation.lastpage","281"],["dc.bibliographiccitation.volume","94"],["dc.contributor.author","Gomolka, Maria"],["dc.contributor.author","Oestreicher, Ursula"],["dc.contributor.author","Rößler, Ute"],["dc.contributor.author","Samaga, Daniel"],["dc.contributor.author","Endesfelder, David"],["dc.contributor.author","Lang, Peter"],["dc.contributor.author","Neumaier, Klement"],["dc.contributor.author","Belka, Claus"],["dc.contributor.author","Niemeyer, Markus"],["dc.contributor.author","Kiechle, Marion"],["dc.contributor.author","Hasbargen, Uwe"],["dc.contributor.author","Hübener, Christoph"],["dc.contributor.author","Kirlum, Hans-Joachim"],["dc.contributor.author","Kulka, Ulrike"],["dc.contributor.author","Rosenberger, Albert"],["dc.contributor.author","Walsh, Linda"],["dc.contributor.author","Baatout, Sarah"],["dc.contributor.author","Kesminiene, Ausrele"],["dc.contributor.author","Lindholm, Carita"],["dc.date.accessioned","2020-12-10T18:14:55Z"],["dc.date.available","2020-12-10T18:14:55Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1080/09553002.2018.1419302"],["dc.identifier.eissn","1362-3095"],["dc.identifier.issn","0955-3002"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/74665"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Age-dependent differences in DNA damage after in vitro CT exposure"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]
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  • 2000Journal Article
    [["dc.bibliographiccitation.firstpage","1"],["dc.bibliographiccitation.issue","1-2"],["dc.bibliographiccitation.journal","Clinica Chimica Acta"],["dc.bibliographiccitation.lastpage","12"],["dc.bibliographiccitation.volume","292"],["dc.contributor.author","Smirnov, Alexander V."],["dc.contributor.author","Tumani, Hayrettin"],["dc.contributor.author","Henne, Sergej"],["dc.contributor.author","Barchfeld, Sandra"],["dc.contributor.author","Olgemöller, Ulrike"],["dc.contributor.author","Wiltfang, Jens"],["dc.contributor.author","Lange, Peter"],["dc.contributor.author","Mäder, Michael"],["dc.contributor.author","Nau, Roland"],["dc.date.accessioned","2017-09-07T11:45:22Z"],["dc.date.available","2017-09-07T11:45:22Z"],["dc.date.issued","2000"],["dc.description.abstract","Glutamine synthetase (GS) activity is higher in the neocortex but not in the hippocampal formation of rabbit brain during Streptococcus pneumoniae meningitis compared to the respective brain region of uninfected control animals. One-dimensional polyacrylamide gel electrophoresis (1D-SDS-PAGE) revealed an apparent molecular mass (Mr) of 44 000 Dalton (Da) for GS from rabbit brain. After two-dimensional gel electrophoresis (2D-PAGE), followed by Coomassie-blue staining, GS separated into three distinct spots (S1, S2, S3). One additional spot (S4) occurred on the immunoblot. All four GS spots exhibited the same Mr (44 000 Da), but differed in their isoelectric points. Densitometric evaluation of the two-dimensional maps revealed a strong increase of optical density (OD) of S3 in the frontal cortex of infected animals. The calculated OD ratio S3/S2 in the frontal cortex from rabbits with meningitis was 1.75±0.68 (mean±standard deviation). Compared to controls (0.85±0.39), this value was significantly increased (p=0.0006). In the hippocampal formation, the ratio S3/S2 was nearly unchanged during meningitis. It is suggested that the ratio S3/S2 may indicate a neuroprotective feature of rabbit brain during meningitis since neuronal apoptosis occurs only in the dentate gyrus and not in the frontal cortex."],["dc.identifier.doi","10.1016/s0009-8981(99)00180-1"],["dc.identifier.gro","3151752"],["dc.identifier.pmid","10686272"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/8576"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.notes.submitter","chake"],["dc.relation.issn","0009-8981"],["dc.title","Glutamine synthetase in experimental meningitis: increased ratio of the subunits 3 and 2 may indicate enhanced activity"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","no"],["dspace.entity.type","Publication"]]
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  • 2013Journal Article
    [["dc.bibliographiccitation.firstpage","353"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Zeitschrift für Gerontologie und Geriatrie"],["dc.bibliographiccitation.lastpage","357"],["dc.bibliographiccitation.volume","46"],["dc.contributor.author","Djukic, M."],["dc.contributor.author","Schulz, Daniela"],["dc.contributor.author","Schmidt, H."],["dc.contributor.author","Lange, P."],["dc.contributor.author","Nau, R."],["dc.date.accessioned","2018-11-07T09:24:19Z"],["dc.date.available","2018-11-07T09:24:19Z"],["dc.date.issued","2013"],["dc.description.abstract","The chemical composition of the cerebrospinal fluid (CSF) is age-dependent. Routine CSF parameters, the indications for lumbar puncture (LP), and the most frequent complications were retrospectively studied in patients older (n = 167) and younger (n = 36) than 65 years. In the absence of meningeal inflammation, the mean CSF lactate level of patients older than 65 years was slightly but significantly higher than the mean CSF lactate level of younger patients. The lactate level of patients with otherwise normal CSF findings correlated significantly with the age of the patients. In the absence of meningeal inflammation, the CSF-to-serum albumin ratio (Q(Albumin)) was significantly higher in older patients than in younger ones. The most frequent indication for LP, suspected infection of the central nervous system (CNS) (n = 110), was confirmed in 12.7% of patients. The only LP complication documented was headache in two patients. Elevations of Q(Albumin) and CSF lactate levels appear to be nonspecific findings in elderly patients. Suspected infections, the most frequent indication for LP, were confirmed by CSF analysis in more than 10% of patients. The very low complication rate of LP makes it a very valuable tool in the diagnostic routine for older patients with CNS diseases."],["dc.description.sponsorship","Robert Bosch Foundation; Sparkasse Gottingen"],["dc.identifier.doi","10.1007/s00391-012-0380-9"],["dc.identifier.isi","000319477500009"],["dc.identifier.pmid","22903361"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/29793"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","Heidelberg"],["dc.relation.issn","0948-6704"],["dc.title","Cerebrospinal fluid findings in geriatric patients from 2008 to 2011"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]
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  • 2010Journal Article
    [["dc.bibliographiccitation.firstpage","314"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Acta Neurologica Belgica"],["dc.bibliographiccitation.lastpage","320"],["dc.bibliographiccitation.volume","110"],["dc.contributor.author","Moldrich, G."],["dc.contributor.author","Lange, P."],["dc.contributor.author","Strik, Herwig Matthias"],["dc.date.accessioned","2018-11-07T08:35:56Z"],["dc.date.available","2018-11-07T08:35:56Z"],["dc.date.issued","2010"],["dc.description.abstract","Objective: the diagnostic impact of carcinoembryonic antigen (CEA) was evaluated in serum and CSF of cancer and control patients. Methods: 97 analyses of CEA in CSF and serum from 83 cancer patients were compared with 41 cases without malignancy. CEA diffusion dynamics were evaluated with IgA CSF/serum quotients (Q 10). Intrathecal synthesis of CEA was analysed both by calculating an index Q CEA/Q IgA and within the IgA-diagram. Results: in 73 samples without synthesis of IgA or CEA, both quotients correlated well with a mean Q CEA/Q IgA of 1.1 (95% CI 0.97-1.2). The Q CEA/Q IgA was significantly higher in metastasizing adenocarcinomas than in controls or other malignancies. In leptomeningeal disease from adenocarcinoma, Q CEA/Q IgA was significantly higher than in controls, while patients with CNS and/or bone metastases had intermediate values. The sensitivity to detect leptomeningeal disease was 91% and 69% for brain metastases. Q CEA/Q IgA and CEA synthesis assessed with the IgA diagram were equally sensitive. Conclusions: evaluation of CEA in the IgA diagram is feasible and of clinical value. The consideration of intrathecal CEA synthesis correlates better with the clinical status than absolute CSF-CEA or the correlation with albumin."],["dc.identifier.isi","000286162900007"],["dc.identifier.pmid","21305861"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/18195"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Acta Medica Belgica"],["dc.relation.issn","0300-9009"],["dc.title","Carcinoembryonic Antigen in the CSF of Cancer Patients - the value of intrathecal synthesis and correlation with IgA-diffusion dynamics"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]
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  • 2003Journal Article
    [["dc.bibliographiccitation.firstpage","125"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Neurology"],["dc.bibliographiccitation.lastpage","128"],["dc.bibliographiccitation.volume","61"],["dc.contributor.author","Rostasy, Kevin"],["dc.contributor.author","Reiber, Hansotto"],["dc.contributor.author","Pohl, Daniela"],["dc.contributor.author","Lange, P."],["dc.contributor.author","Ohlenbusch, Andreas"],["dc.contributor.author","Eiffert, Helmut"],["dc.contributor.author","Maass, M."],["dc.contributor.author","Hanefeld, Folker"],["dc.date.accessioned","2018-11-07T10:37:41Z"],["dc.date.available","2018-11-07T10:37:41Z"],["dc.date.issued","2003"],["dc.description.abstract","The authors investigated the frequency and quantity of intrathecal antibody synthesis against Chlamydia pneumoniae and the presence of C pneumoniae antigen in 25 children with MS. C pneumoniae genome was present in two children. In seven children an intrathecal synthesis of C pneumoniae antibodies was detected, representing only a small part of the total intrathecal immunoglobulin G, suggesting that this intrathecal synthesis is part of a polyspecific, oligoclonal immune response."],["dc.identifier.isi","000183978800030"],["dc.identifier.pmid","12847174"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/45630"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.relation.issn","0028-3878"],["dc.title","Chlamydia pneumoniae in children with MS - Frequency and quantity of intrathecal antibodies"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]
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  • 2000Journal Article
    [["dc.bibliographiccitation.firstpage","11"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Glia"],["dc.bibliographiccitation.lastpage","18"],["dc.bibliographiccitation.volume","30"],["dc.contributor.author","Tumani, Hayrettin"],["dc.contributor.author","Smirnov, Alexey"],["dc.contributor.author","Barchfeld, S."],["dc.contributor.author","Olgemoller, U."],["dc.contributor.author","Maier, K."],["dc.contributor.author","Lange, P."],["dc.contributor.author","Bruck, Wolfgang W."],["dc.contributor.author","Nau, R."],["dc.date.accessioned","2018-11-07T09:12:10Z"],["dc.date.available","2018-11-07T09:12:10Z"],["dc.date.issued","2000"],["dc.description.abstract","Apoptosis of dentate granular cells in the hippocampal formation during bacterial meningitis may be mediated by glutamate toxicity. For this reason, we studied the relationship between glutamine synthetase activity and regional neuronal apoptosis in rabbits with experimental pneumococcal meningitis. The duration of meningitis was 24 h, and the treatment was started 16 h after infection. Significant increases of glutamine synthetase protein concentration (P < 0.05) were found in the frontal cortex of rabbits with meningitis (n = 7) and rabbits with meningitis receiving ceftriaxone treatment (n = 12) as compared to the control animals (n = 14). No significant differences were seen in the hippocampal formation. The enzymatic activity of glutamine synthetase also was elevated in the frontal cortex (P < 0.05), but not in the hippocampal formation of rabbits with meningitis. After intravenous administration of L-methionine sulfoximine (specific inhibitor of glutamine synthetase) in rabbits with meningitis treated with ceftriaxone (n = 10), the concentration of neuron-specific enolase in CSF (P = 0.025) and the density of apoptotic neurons in the dentate gyrus quantified with the in-situ tailing reaction (P = 0.043) were higher than in meningitic animals receiving only ceftriaxone (n = 10). In conclusion, the inability of hippocampal glutamine synthetase to metabolize excess amounts of glutamate may contribute to neuronal apoptosis in the hippocampal formation during meningitis. GLIA 30:11-18, 2000. (C) 2000 Wiley-Liss, Inc."],["dc.identifier.doi","10.1002/(SICI)1098-1136(200003)30:1<11::AID-GLIA2>3.0.CO;2-E"],["dc.identifier.isi","000086084500002"],["dc.identifier.pmid","10696140"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/26890"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-liss"],["dc.relation.issn","0894-1491"],["dc.title","Inhibition of glutamine synthetase in rabbit pneumococcal meningitis is associated with neuronal apoptosis in the dentate gyrus"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]
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  • 2017-06Journal Article
    [["dc.bibliographiccitation.firstpage","710"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Alzheimer's & Dementia: The Journal of the Alzheimer's Association"],["dc.bibliographiccitation.lastpage","719"],["dc.bibliographiccitation.volume","13"],["dc.contributor.author","Llorens, Franc"],["dc.contributor.author","Kruse, Niels"],["dc.contributor.author","Schmitz, Matthias"],["dc.contributor.author","Gotzmann, Nadine"],["dc.contributor.author","Golanska, Ewa"],["dc.contributor.author","Thüne, Katrin"],["dc.contributor.author","Zejneli, Orgeta"],["dc.contributor.author","Kanata, Eirini"],["dc.contributor.author","Knipper, Tobias"],["dc.contributor.author","Cramm, Maria"],["dc.contributor.author","Lange, Peter"],["dc.contributor.author","Zafar, Saima"],["dc.contributor.author","Sikorska, Beata"],["dc.contributor.author","Liberski, Pawel P."],["dc.contributor.author","Mitrova, Eva"],["dc.contributor.author","Varges, Daniela"],["dc.contributor.author","Schmidt, Christian"],["dc.contributor.author","Sklaviadis, Theodoros"],["dc.contributor.author","Mollenhauer, Brit"],["dc.contributor.author","Zerr, Inga"],["dc.date.accessioned","2018-10-08T13:38:00Z"],["dc.date.available","2018-10-08T13:38:00Z"],["dc.date.issued","2017-06"],["dc.description.abstract","Accurate diagnosis of prion diseases and discrimination from alternative dementias gain importance in the clinical routine, but partial overlap in cerebrospinal fluid (CSF) biomarkers impedes absolute discrimination in the differential diagnostic context. We established the clinical parameters for prion disease diagnosis for the quantification of CSF α-synuclein in patients with sporadic (n = 234) and genetic (n = 56) prion diseases, in cases with cognitive impairment/dementia or neurodegenerative disease (n = 278), and in the neurologic control group (n = 111). An optimal cutoff value of 680 pg/mL α-synuclein results in 94% sensitivity and 96% specificity when diagnosing sporadic Creutzfeldt-Jakob disease (CJD). Genetic CJD cases showed increased CSF α-synuclein values. No increased α-synuclein levels were detected in non-CJD cases with rapid progression course. Detection of α-synuclein in the CSF of patients with suspected CJD is a valuable diagnostic test reaching almost full discrimination from non-prion disease cases. These data highlight the utility of CSF α-synuclein quantification in front of classical CSF biomarkers in clinical routine."],["dc.fs.pkfprnr","61006"],["dc.identifier.doi","10.1016/j.jalz.2016.09.013"],["dc.identifier.fs","631450"],["dc.identifier.pmid","27870938"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/15884"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation.eissn","1552-5279"],["dc.title","Evaluation of α-synuclein as a novel cerebrospinal fluid biomarker in different forms of prion diseases"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]
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  • 2021Journal Article
    [["dc.bibliographiccitation.firstpage","e1062"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Neurology - Neuroimmunology Neuroinflammation"],["dc.bibliographiccitation.volume","8"],["dc.contributor.author","Schwenkenbecher, Philipp"],["dc.contributor.author","Skripuletz, Thomas"],["dc.contributor.author","Lange, Peter"],["dc.contributor.author","Dürr, Marc"],["dc.contributor.author","Konen, Felix F."],["dc.contributor.author","Möhn, Nora"],["dc.contributor.author","Ringelstein, Marius"],["dc.contributor.author","Menge, Til"],["dc.contributor.author","Friese, Manuel A."],["dc.contributor.author","Melzer, Nico"],["dc.contributor.author","Sühs, Kurt-Wolfram"],["dc.date.accessioned","2021-12-01T09:22:29Z"],["dc.date.available","2021-12-01T09:22:29Z"],["dc.date.issued","2021"],["dc.description.abstract","Background and Objectives Neurotropic viruses are suspected to play a role in the pathogenesis of autoimmune diseases of the CNS such as the association between the Epstein-Barr virus (EBV) and multiple sclerosis (MS). A group of autoimmune encephalitis (AE) is linked to antibodies against neuronal cell surface proteins. Because CNS infection with the herpes simplex virus can trigger anti–NMDA receptor (NMDAR) encephalitis, a similar mechanism for EBV and other neurotropic viruses could be postulated. To investigate for previous viral infections of the CNS, intrathecally produced virus-specific antibody synthesis was determined in patients with AE. Methods Antibody-specific indices (AIs) against EBV and measles, rubella, varicella zoster, herpes simplex virus, and cytomegalovirus were determined in 27 patients having AE (anti-NMDAR encephalitis, n = 21, and LGI1 encephalitis, n = 6) and in 2 control groups comprising of 30 patients with MS and 21 patients with noninflammatory CNS diseases (NIND), which were sex and age matched. Results An intrathecal synthesis of antibodies against EBV was found in 5/27 (19%) patients with AE and 2/30 (7%) of the patients with MS. All these patients had also at least 1 additional elevated virus-specific AI. In contrast, in none of the patients with NIND, an elevated virus-specific AI was detected. Discussion Intrathecally produced antibodies against EBV can be found in patients with AE and MS but only together with antibodies against different neurotropic viruses. Evidence of these antibodies is the result of a polyspecific immune response similar yet distinct from MS response rather than an elapsed infection of the CNS."],["dc.description.abstract","Background and Objectives Neurotropic viruses are suspected to play a role in the pathogenesis of autoimmune diseases of the CNS such as the association between the Epstein-Barr virus (EBV) and multiple sclerosis (MS). A group of autoimmune encephalitis (AE) is linked to antibodies against neuronal cell surface proteins. Because CNS infection with the herpes simplex virus can trigger anti–NMDA receptor (NMDAR) encephalitis, a similar mechanism for EBV and other neurotropic viruses could be postulated. To investigate for previous viral infections of the CNS, intrathecally produced virus-specific antibody synthesis was determined in patients with AE. Methods Antibody-specific indices (AIs) against EBV and measles, rubella, varicella zoster, herpes simplex virus, and cytomegalovirus were determined in 27 patients having AE (anti-NMDAR encephalitis, n = 21, and LGI1 encephalitis, n = 6) and in 2 control groups comprising of 30 patients with MS and 21 patients with noninflammatory CNS diseases (NIND), which were sex and age matched. Results An intrathecal synthesis of antibodies against EBV was found in 5/27 (19%) patients with AE and 2/30 (7%) of the patients with MS. All these patients had also at least 1 additional elevated virus-specific AI. In contrast, in none of the patients with NIND, an elevated virus-specific AI was detected. Discussion Intrathecally produced antibodies against EBV can be found in patients with AE and MS but only together with antibodies against different neurotropic viruses. Evidence of these antibodies is the result of a polyspecific immune response similar yet distinct from MS response rather than an elapsed infection of the CNS."],["dc.identifier.doi","10.1212/NXI.0000000000001062"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/94413"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-478"],["dc.relation.eissn","2332-7812"],["dc.title","Intrathecal Antibody Production Against Epstein-Barr, Herpes Simplex, and Other Neurotropic Viruses in Autoimmune Encephalitis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]
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  • 2001Conference Paper
    [["dc.bibliographiccitation.firstpage","909"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","Scandinavian Journal of Infectious Diseases"],["dc.bibliographiccitation.lastpage","913"],["dc.bibliographiccitation.volume","33"],["dc.contributor.author","Wellmer, A."],["dc.contributor.author","Prange, J."],["dc.contributor.author","Gerber, Joachim"],["dc.contributor.author","Zysk, G."],["dc.contributor.author","Lange, P."],["dc.contributor.author","Michel, Uwe"],["dc.contributor.author","Eiffert, Helmut"],["dc.contributor.author","Nau, R."],["dc.date.accessioned","2018-11-07T09:39:30Z"],["dc.date.available","2018-11-07T09:39:30Z"],["dc.date.issued","2001"],["dc.description.abstract","Increased total CSF lactate is an important indicator differentiating bacterial from aseptic meningitis. Bacteria can produce D- and L-lactate; mammalian cells produce only L-lactate. We measured D- and L-lactate production of Streptococcus pneumoniae, Staphylococcus aureus, Neisseria meningitidis and Escherichia coli in vitro, of S. pneumoniae and E. coli in rabbit experimental meningitis and of various common pathogens in CSF from patients with bacterial meningitis. Despite marked in vitro production of D-lactate by S. aureus (maximum: 4.59 mmol/l; i.e. 34.9% of total lactate), N. meningitidis (4.62 mmol/l; i.e. 98.1%) and E. coli (3.14 mmol/l; i.e. 97.2%), minimal amounts were measured in human S. aureus (0.38 mmol/l; i.e. 1.3% of total lactate) or N. meningitidis (0.28 mmol/l; i.e. 3.9%) and experimental E. coli meningitis (0.75 mmol/l; i.e. 4.4%). In only 9 of 54 human CSF samples did D-lactate exceed 0.15 mmol/l. S. pneumoniae did not produce significant amounts of D-lactate in vitro (maximum; 0.55 mmol/l; i.e. 2.7% of total lactate), in experimental meningitis (0.18 mmol/l; i.e. 3%) or in human cases of meningitis (0.28 mmol/l; i.e. 1.9%). In conclusion, increased total CSF lactate in meningitis consists mainly of L-lactate and originates predominantly from host cells. CSF D-lactate is of limited diagnostic value."],["dc.identifier.isi","000173355800006"],["dc.identifier.pmid","11868764"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/33300"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Taylor & Francis As"],["dc.publisher.place","Oslo"],["dc.relation.conference","40th Interscience Conference on Antimicrobial Agents and Chemotherapy"],["dc.relation.eventlocation","TORONTO, CANADA"],["dc.relation.issn","0036-5548"],["dc.title","D- and L-lactate in rabbit and human bacterial meningitis"],["dc.type","conference_paper"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]
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  • 2008Conference Abstract
    [["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Clinical Research in Cardiology"],["dc.bibliographiccitation.volume","97"],["dc.contributor.author","Kuehne, Titus"],["dc.contributor.author","Mueller, S."],["dc.contributor.author","Sarikouch, Samir"],["dc.contributor.author","Beerbaum, Philipp"],["dc.contributor.author","Gutberlet, Matthias"],["dc.contributor.author","Franke, D."],["dc.contributor.author","Sax, Ulrich"],["dc.contributor.author","Lange, P."],["dc.date.accessioned","2018-11-07T11:11:12Z"],["dc.date.available","2018-11-07T11:11:12Z"],["dc.date.issued","2008"],["dc.format.extent","688"],["dc.identifier.isi","000258897900078"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/53374"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Dr Dietrich Steinkopff Verlag"],["dc.publisher.place","Heidelberg"],["dc.relation.issn","1861-0684"],["dc.title","The Tele-radio-logical network for central interpretation and archiving of MRT-image date: 3 years experience in cardiac-vascular research grouping"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]
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