Eichele, Gregor

[["dc.bibliographiccitation.firstpage","176"],["dc.bibliographiccitation.issue","6295"],["dc.bibliographiccitation.journal","Science"],["dc.bibliographiccitation.lastpage","178"],["dc.bibliographiccitation.volume","353"],["dc.contributor.author","Faubel, Regina"],["dc.contributor.author","Westendorf, Christian"],["dc.contributor.author","Bodenschatz, Eberhard"],["dc.contributor.author","Eichele, Gregor"],["dc.date.accessioned","2022-06-08T08:00:32Z"],["dc.date.available","2022-06-08T08:00:32Z"],["dc.date.issued","2016"],["dc.description.abstract","Going with the flow The interstitial spaces of the brain are filled with cerebrospinal fluid (CSF). Faubel et al. studied fluid transport in the third ventricle of the brain of mice, rats, and pigs. Sophisticated, state-of-the-art fluid dynamic studies revealed a complex pattern of cilia beating that leads to an intricate network of “highways” of CSF flow. This flow rapidly and efficiently transports and partitions CSF. Science , this issue p. 176"],["dc.description.abstract","A cilia-based transport network that suggests how cerebrospinal fluid constituents are actively distributed is revealed in the brain."],["dc.description.abstract","Cerebrospinal fluid conveys many physiologically important signaling factors through the ventricular cavities of the brain. We investigated the transport of cerebrospinal fluid in the third ventricle of the mouse brain and discovered a highly organized pattern of cilia modules, which collectively give rise to a network of fluid flows that allows for precise transport within this ventricle. We also discovered a cilia-based switch that reliably and periodically alters the flow pattern so as to create a dynamic subdivision that may control substance distribution in the third ventricle. Complex flow patterns were also present in the third ventricles of rats and pigs. Our work suggests that ciliated epithelia can generate and maintain complex, spatiotemporally regulated flow networks."],["dc.identifier.doi","10.1126/science.aae0450"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/111110"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-575"],["dc.relation.eissn","1095-9203"],["dc.relation.issn","0036-8075"],["dc.title","Cilia-based flow network in the brain ventricles"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","20190154"],["dc.bibliographiccitation.issue","1792"],["dc.bibliographiccitation.journal","Philosophical Transactions of the Royal Society B: Biological Sciences"],["dc.bibliographiccitation.volume","375"],["dc.contributor.author","Eichele, Gregor"],["dc.contributor.author","Bodenschatz, Eberhard"],["dc.contributor.author","Ditte, Zuzana"],["dc.contributor.author","Günther, Ann-Kathrin"],["dc.contributor.author","Kapoor, Shoba"],["dc.contributor.author","Wang, Yong"],["dc.contributor.author","Westendorf, Christian"],["dc.date.accessioned","2022-06-08T07:59:13Z"],["dc.date.available","2022-06-08T07:59:13Z"],["dc.date.issued","2019"],["dc.description.abstract","The brain ventricles are interconnected, elaborate cavities that traverse the brain. They are filled with cerebrospinal fluid (CSF) that is, to a large part, produced by the choroid plexus, a secretory epithelium that reaches into the ventricles. CSF is rich in cytokines, growth factors and extracellular vesicles that glide along the walls of ventricles, powered by bundles of motile cilia that coat the ventricular wall. We review the cellular and biochemical properties of the ventral part of the third ventricle that is surrounded by the hypothalamus. In particular, we consider the recently discovered intricate network of cilia-driven flows that characterize this ventricle and discuss the potential physiological significance of this flow for the directional transport of CSF signals to cellular targets located either within the third ventricle or in the adjacent hypothalamic brain parenchyma. Cilia-driven streams of signalling molecules offer an exciting perspective on how fluid-borne signals are dynamically transmitted in the brain. This article is part of the Theo Murphy meeting issue ‘Unity and diversity of cilia in locomotion and transport’."],["dc.description.sponsorship","Max-Planck-Gesellschaft"],["dc.identifier.doi","10.1098/rstb.2019.0154"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/110677"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-575"],["dc.relation.eissn","1471-2970"],["dc.relation.issn","0962-8436"],["dc.rights.uri","https://royalsociety.org/journals/ethics-policies/data-sharing-mining/"],["dc.title","Cilia-driven flows in the brain third ventricle"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","417"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Methods"],["dc.bibliographiccitation.lastpage","423"],["dc.bibliographiccitation.volume","53"],["dc.contributor.author","Eichele, Gregor"],["dc.contributor.author","Diez-Roux, Graciana"],["dc.date.accessioned","2021-06-01T10:49:59Z"],["dc.date.available","2021-06-01T10:49:59Z"],["dc.date.issued","2011"],["dc.identifier.doi","10.1016/j.ymeth.2010.12.020"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/86484"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.relation.issn","1046-2023"],["dc.title","High-throughput analysis of gene expression on tissue sections by in situ hybridization"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","e2017364118"],["dc.bibliographiccitation.issue","25"],["dc.bibliographiccitation.journal","Proceedings of the National Academy of Sciences of the United States of America"],["dc.bibliographiccitation.volume","118"],["dc.contributor.author","Hubbard, Jeffrey"],["dc.contributor.author","Kobayashi Frisk, Mio"],["dc.contributor.author","Ruppert, Elisabeth"],["dc.contributor.author","Tsai, Jessica W."],["dc.contributor.author","Fuchs, Fanny"],["dc.contributor.author","Robin-Choteau, Ludivine"],["dc.contributor.author","Husse, Jana"],["dc.contributor.author","Calvel, Laurent"],["dc.contributor.author","Eichele, Gregor"],["dc.contributor.author","Bourgin, Patrice"],["dc.date.accessioned","2021-07-05T14:57:28Z"],["dc.date.available","2021-07-05T14:57:28Z"],["dc.date.issued","2021"],["dc.description.abstract","Artificial lighting, day-length changes, shift work, and transmeridian travel all lead to sleep–wake disturbances. The nychthemeral sleep–wake cycle (SWc) is known to be controlled by output from the central circadian clock in the suprachiasmatic nuclei (SCN), which is entrained to the light–dark cycle. Additionally, via intrinsically photosensitive retinal ganglion cells containing the photopigment melanopsin (Opn4), short-term light–dark alternations exert direct and acute influences on sleep and waking. However, the extent to which longer exposures typically experienced across the 24-h day exert such an effect has never been clarified or quantified, as disentangling sustained direct light effects (SDLE) from circadian effects is difficult. Recording sleep in mice lacking a circadian pacemaker, either through transgenesis ( Syt10 cre/cre Bmal1 fl/- ) or SCN lesioning and/or melanopsin-based phototransduction ( Opn4 −/− ), we uncovered, contrary to prevailing assumptions, that the contribution of SDLE is as important as circadian-driven input in determining SWc amplitude. Specifically, SDLE were primarily mediated (>80%) through melanopsin, of which half were then relayed through the SCN, revealing an ancillary purpose for this structure, independent of its clock function in organizing SWc. Based on these findings, we designed a model to estimate the effect of atypical light–dark cycles on SWc. This model predicted SWc amplitude in mice exposed to simulated transequatorial or transmeridian paradigms. Taken together, we demonstrate this SDLE is a crucial mechanism influencing behavior on par with the circadian system. In a broader context, these findings mandate considering SDLE, in addition to circadian drive, for coping with health consequences of atypical light exposure in our society."],["dc.description.abstract","Artificial lighting, day-length changes, shift work, and transmeridian travel all lead to sleep–wake disturbances. The nychthemeral sleep–wake cycle (SWc) is known to be controlled by output from the central circadian clock in the suprachiasmatic nuclei (SCN), which is entrained to the light–dark cycle. Additionally, via intrinsically photosensitive retinal ganglion cells containing the photopigment melanopsin (Opn4), short-term light–dark alternations exert direct and acute influences on sleep and waking. However, the extent to which longer exposures typically experienced across the 24-h day exert such an effect has never been clarified or quantified, as disentangling sustained direct light effects (SDLE) from circadian effects is difficult. Recording sleep in mice lacking a circadian pacemaker, either through transgenesis ( Syt10 cre/cre Bmal1 fl/- ) or SCN lesioning and/or melanopsin-based phototransduction ( Opn4 −/− ), we uncovered, contrary to prevailing assumptions, that the contribution of SDLE is as important as circadian-driven input in determining SWc amplitude. Specifically, SDLE were primarily mediated (>80%) through melanopsin, of which half were then relayed through the SCN, revealing an ancillary purpose for this structure, independent of its clock function in organizing SWc. Based on these findings, we designed a model to estimate the effect of atypical light–dark cycles on SWc. This model predicted SWc amplitude in mice exposed to simulated transequatorial or transmeridian paradigms. Taken together, we demonstrate this SDLE is a crucial mechanism influencing behavior on par with the circadian system. In a broader context, these findings mandate considering SDLE, in addition to circadian drive, for coping with health consequences of atypical light exposure in our society."],["dc.identifier.doi","10.1073/pnas.2017364118"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/87650"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-441"],["dc.relation.eissn","1091-6490"],["dc.relation.issn","0027-8424"],["dc.title","Dissecting and modeling photic and melanopsin effects to predict sleep disturbances induced by irregular light exposure in mice"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","560a"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Biophysical Journal"],["dc.bibliographiccitation.volume","114"],["dc.contributor.author","Antonschmidt, Leif"],["dc.contributor.author","Dervisoglu, Riza"],["dc.contributor.author","Ryazanov, Sergey"],["dc.contributor.author","Leonov, Andrei"],["dc.contributor.author","Wegstroth, Melanie"],["dc.contributor.author","Giller, Karin"],["dc.contributor.author","Becker, Stefan"],["dc.contributor.author","Lee, Joon"],["dc.contributor.author","Lal, Ratneshwar"],["dc.contributor.author","Eichele, Gregor"],["dc.contributor.author","Griesinger, Christian"],["dc.date.accessioned","2022-03-01T11:44:59Z"],["dc.date.available","2022-03-01T11:44:59Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1016/j.bpj.2017.11.3064"],["dc.identifier.pii","S0006349517342960"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/103181"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-531"],["dc.relation.issn","0006-3495"],["dc.title","The Small Molecule anle138b Shows Interaction with α-Synuclein Oligomers in Phospholipid Membranes"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","e178"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","PLoS Genetics"],["dc.bibliographiccitation.volume","3"],["dc.contributor.author","Visel, Axel"],["dc.contributor.author","Carson, James"],["dc.contributor.author","Oldekamp, Judit"],["dc.contributor.author","Warnecke, Marei"],["dc.contributor.author","Jakubcakova, Vladimira"],["dc.contributor.author","Zhou, Xunlei"],["dc.contributor.author","Shaw, Chad A"],["dc.contributor.author","Alvarez-Bolado, Gonzalo"],["dc.contributor.author","Eichele, Gregor"],["dc.contributor.editor","Beier, David"],["dc.date.accessioned","2021-06-01T10:48:18Z"],["dc.date.available","2021-06-01T10:48:18Z"],["dc.date.issued","2007"],["dc.identifier.doi","10.1371/journal.pgen.0030178"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/85889"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.relation.eissn","1553-7404"],["dc.title","Regulatory Pathway Analysis by High-Throughput In Situ Hybridization"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","831"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Neuron"],["dc.bibliographiccitation.lastpage","843"],["dc.bibliographiccitation.volume","54"],["dc.contributor.author","Jakubcakova, Vladimira"],["dc.contributor.author","Oster, Henrik"],["dc.contributor.author","Tamanini, Filippo"],["dc.contributor.author","Cadenas, Cristina"],["dc.contributor.author","Leitges, Michael"],["dc.contributor.author","van der Horst, Gijsbertus T.J."],["dc.contributor.author","Eichele, Gregor"],["dc.date.accessioned","2021-06-01T10:49:49Z"],["dc.date.available","2021-06-01T10:49:49Z"],["dc.date.issued","2007"],["dc.identifier.doi","10.1016/j.neuron.2007.04.031"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/86424"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.relation.issn","0896-6273"],["dc.title","Light Entrainment of the Mammalian Circadian Clock by a PRKCA-Dependent Posttranslational Mechanism"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","71"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","The EMBO Journal"],["dc.bibliographiccitation.lastpage","82"],["dc.bibliographiccitation.volume","31"],["dc.contributor.author","Whelan, Gabriela"],["dc.contributor.author","Kreidl, Emanuel"],["dc.contributor.author","Wutz, Gordana"],["dc.contributor.author","Egner, Alexander"],["dc.contributor.author","Peters, Jan-Michael"],["dc.contributor.author","Eichele, Gregor"],["dc.date.accessioned","2021-06-01T10:50:32Z"],["dc.date.available","2021-06-01T10:50:32Z"],["dc.date.issued","2011"],["dc.identifier.doi","10.1038/emboj.2011.381"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/86698"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.relation.issn","0261-4189"],["dc.title","Cohesin acetyltransferase Esco2 is a cell viability factor and is required for cohesion in pericentric heterochromatin"],["dc.title.alternative","Esco2 acetylates PCH cohesin"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","379"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Journal of Biological Rhythms"],["dc.bibliographiccitation.lastpage","389"],["dc.bibliographiccitation.volume","26"],["dc.contributor.author","Husse, Jana"],["dc.contributor.author","Zhou, Xunlei"],["dc.contributor.author","Shostak, Anton"],["dc.contributor.author","Oster, Henrik"],["dc.contributor.author","Eichele, Gregor"],["dc.date.accessioned","2021-06-01T10:47:54Z"],["dc.date.available","2021-06-01T10:47:54Z"],["dc.date.issued","2011"],["dc.description.abstract","Surgical lesion of the suprachiasmatic nuclei (SCN) profoundly affects the circadian timing system. A complication of SCN ablations is the concomitant scission of SCN afferents and efferents. Genetic disruption of the molecular clockwork in the SCN provides a complementary, less invasive experimental approach. The authors report the generation and functional analysis of a new Cre recombinase driver mouse that evokes homologous recombination with high efficiency in the SCN. They inserted the Cre recombinase cDNA into the Synaptotagmin10 ( Syt10) locus, a gene strongly expressed in the SCN. Heterozygous Synaptotagmin10-Cre ( Syt10 Cre ) mice have no obvious circadian locomotor phenotype, and homozygous animals show slightly reduced light-induced phase delays. Crosses of Syt10 Cre mice with β-galactosidase reporter animals revealed strong Cre activity in the vast majority of SCN cells. Cre activity is not detected in nonneuronal tissues with the exception of the testis. The authors demonstrate that conditionally deleting the clock gene Bmal1 using the Syt10 Cre driver renders animals arrhythmic."],["dc.identifier.doi","10.1177/0748730411415363"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/85760"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.relation.eissn","1552-4531"],["dc.relation.issn","0748-7304"],["dc.title","Synaptotagmin10-Cre, a Driver to Disrupt Clock Genes in the SCN"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","12276"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","Journal of Extracellular Vesicles"],["dc.bibliographiccitation.volume","11"],["dc.contributor.author","Ditte, Zuzana"],["dc.contributor.author","Silbern, Ivan"],["dc.contributor.author","Ditte, Peter"],["dc.contributor.author","Urlaub, Henning"],["dc.contributor.author","Eichele, Gregor"],["dc.date.accessioned","2022-12-01T08:31:21Z"],["dc.date.available","2022-12-01T08:31:21Z"],["dc.date.issued","2022"],["dc.identifier.doi","10.1002/jev2.12276"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/118153"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-621"],["dc.relation.eissn","2001-3078"],["dc.relation.issn","2001-3078"],["dc.title","Extracellular vesicles derived from the choroid plexus trigger the differentiation of neural stem cells"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]