Leonov, Andrei

[["dc.bibliographiccitation.firstpage","E4971"],["dc.bibliographiccitation.issue","25"],["dc.bibliographiccitation.journal","Proceedings of the National Academy of Sciences of the United States of America"],["dc.bibliographiccitation.lastpage","E4977"],["dc.bibliographiccitation.volume","114"],["dc.contributor.author","Turriani, Elisa"],["dc.contributor.author","Lázaro, Diana F."],["dc.contributor.author","Ryazanov, Sergey"],["dc.contributor.author","Leonov, Andrei"],["dc.contributor.author","Giese, Armin"],["dc.contributor.author","Schön, Margarete"],["dc.contributor.author","Schön, Michael P."],["dc.contributor.author","Griesinger, Christian"],["dc.contributor.author","Outeiro, Tiago F."],["dc.contributor.author","Arndt-Jovin, Donna J."],["dc.contributor.author","Becker, Dorothea"],["dc.date.accessioned","2018-04-23T11:47:36Z"],["dc.date.available","2018-04-23T11:47:36Z"],["dc.date.issued","2017"],["dc.description.abstract","Recent epidemiological and clinical studies have reported a significantly increased risk for melanoma in people with Parkinson’s disease. Because no evidence could be obtained that genetic factors are the reason for the association between these two diseases, we hypothesized that of the three major Parkinson’s disease-related proteins—α-synuclein, LRRK2, and Parkin—α-synuclein might be a major link. Our data, presented here, demonstrate that α-synuclein promotes the survival of primary and metastatic melanoma cells, which is the exact opposite of the effect that α-synuclein has on dopaminergic neurons, where its accumulation causes neuronal dysfunction and death. Because this detrimental effect of α-synuclein on neurons can be rescued by the small molecule anle138b, we explored its effect on melanoma cells. We found that treatment with anle138b leads to massive melanoma cell death due to a major dysregulation of autophagy, suggesting that α-synuclein is highly beneficial to advanced melanoma because it ensures that autophagy is maintained at a homeostatic level that promotes and ensures the cell’s survival."],["dc.identifier.doi","10.1073/pnas.1700200114"],["dc.identifier.gro","3142238"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/13362"],["dc.language.iso","en"],["dc.notes.intern","lifescience updates Crossref Import"],["dc.notes.status","final"],["dc.relation.issn","0027-8424"],["dc.title","Treatment with diphenyl–pyrazole compound anle138b/c reveals that α-synuclein protects melanoma cells from autophagic cell death"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.peerReviewed","no"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","S38"],["dc.bibliographiccitation.journal","Magnetic Resonance in Chemistry"],["dc.bibliographiccitation.lastpage","S44"],["dc.bibliographiccitation.volume","50"],["dc.contributor.author","Schmidt, Manuel"],["dc.contributor.author","Sun, Han"],["dc.contributor.author","Leonov, Andrei"],["dc.contributor.author","Griesinger, Christian"],["dc.contributor.author","Reinscheid, Uwe M."],["dc.date.accessioned","2017-09-07T11:48:20Z"],["dc.date.available","2017-09-07T11:48:20Z"],["dc.date.issued","2012"],["dc.description.abstract","A new chiral alignment medium for dimethyl sulfoxide, methanol, and water as solvents was developed. Because both enantiomers of the gel are available, it is possible to enantiodiscriminate natural products such as strychnine HCl that naturally occurs as single enantiomer. With the two methods of achieving anisotropy, namely stretching and confinement, the degree of alignment can be adjusted, and the director changed from horizontal to vertical. This increases the applicability. Three compounds were enantiodiscriminated on the basis of residual dipolar coupling data: mefloquine HCl, strychnine HCl, and menthylamine HCl. Copyright (C) 2012 John Wiley & Sons, Ltd."],["dc.identifier.doi","10.1002/mrc.3886"],["dc.identifier.gro","3142431"],["dc.identifier.isi","000319964200007"],["dc.identifier.pmid","23280659"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/8207"],["dc.notes.intern","WoS Import 2017-03-10"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","0749-1581"],["dc.title","Chiral discrimination of amines by anisotropic NMR parameters using chiral polyacrylamide-based gels"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","3752"],["dc.bibliographiccitation.issue","19"],["dc.bibliographiccitation.journal","The Journal of Neuroscience"],["dc.bibliographiccitation.lastpage","3769"],["dc.bibliographiccitation.volume","39"],["dc.contributor.author","Gong, Jing"],["dc.contributor.author","Szego, Éva M."],["dc.contributor.author","Leonov, Andrei"],["dc.contributor.author","Benito, Eva"],["dc.contributor.author","Becker, Stefan"],["dc.contributor.author","Fischer, Andre"],["dc.contributor.author","Zweckstetter, Markus"],["dc.contributor.author","Outeiro, Tiago"],["dc.contributor.author","Schneider, Anja"],["dc.date.accessioned","2020-12-10T18:42:35Z"],["dc.date.available","2020-12-10T18:42:35Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1523/JNEUROSCI.2070-18.2019"],["dc.identifier.pmid","30796158"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/78015"],["dc.identifier.url","https://sfb1286.uni-goettingen.de/literature/publications/13"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.relation","SFB 1286: Quantitative Synaptologie"],["dc.relation","SFB 1286 | B06: Die Rolle von RNA in Synapsenphysiologie und Neurodegeneration"],["dc.relation.workinggroup","RG A. Fischer (Epigenetics and Systems Medicine in Neurodegenerative Diseases)"],["dc.relation.workinggroup","RG Outeiro (Experimental Neurodegeneration)"],["dc.title","Translocator Protein Ligand Protects against Neurodegeneration in the MPTP Mouse Model of Parkinsonism"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","4421"],["dc.bibliographiccitation.issue","19"],["dc.bibliographiccitation.journal","The Journal of Physical Chemistry A"],["dc.bibliographiccitation.lastpage","4428"],["dc.bibliographiccitation.volume","104"],["dc.contributor.author","Leonov, A."],["dc.contributor.author","Marstokk, K. M."],["dc.contributor.author","de Meijere, Armin"],["dc.contributor.author","Mollendahl, H."],["dc.date.accessioned","2018-11-07T10:50:48Z"],["dc.date.available","2018-11-07T10:50:48Z"],["dc.date.issued","2000"],["dc.description.abstract","The microwave spectra of 1-ethenylcyclopropan-1-ol, (CH2)(2)C(OH)C=CH2, and one deuterated species, (CH2)(2)C(OD)C=CH2, have been investigated in the 11.0-60.0 GHz region. The (ac,ap)- and (ac,ac1)-conformers denoted Syn 1 and Skew 1 were assigned. Each of these two forms is stabilized with an intramolecular hydrogen bond formed between the hydrogen atom of the hydroxyl group and the pi electrons of the double bond. In the Syn 1 rotamer the C=C-C-O chain of atoms takes a syn conformation (dihedral angle = -2.6 degrees) and the H-O-C-C= link of atoms is gauche (dihedral angle = -67.2 degrees from syn). The C=C-C-O link of atoms takes a skew conformation (dihedral angle = 132.1 degrees from syn) in the Skew 1 rotamer, while the H-O-C-C= dihedral angle is -67.1 degrees. Syn 1 is preferred by 4.9(6) kJ mol(-1) relative to Skew 1. Syn 1 is virtually a hybrid of the most stable conformer of unsubstituted ethenylcyclopropane, and unsubstituted cyclopropanol, Skew 1, is the corresponding hybrid of the second rotamer of ethenylcyclopropane and the most stable one of cyclopropanol. The spectrum of Syn 1 is perturbed by tunneling of the hydroxyl group. An analysis yielded 2280.184(60) MHz for the tunneling frequency and 39.82(19) MHz for the Coriolis coupling term mu(ca) for the normal species. The corresponding values were 72.401(27) and 5.2(10) MHz, respectively, for the deuterated species. A potential function for the tunneling motion consisting of three cosine terms was found to have the following potential constants: V-1 -918.2, V-2 = -900.0, and V-3 = 418.0 cm(-1). This double-minimum function yields a barrier of 16.6(50) kJ mol(-1) at the anti position and 10.6(30) kJ mol(-1) at syn. The microwave work has been assisted by ab initio computations at the MP2/cc-pVTZ level of theory as well as density functional theory calculations at the B3LYP/6-31G level. These calculations indicate that there are only three stable rotameric forms of the molecule. The gas-phase IR spectrum in the O-H stretching region revealed a broad and complex band red-shifted by roughly 50 cm(-1) presumably as a result of internal hydrogen bonding."],["dc.identifier.doi","10.1021/jp9940755"],["dc.identifier.isi","000087003200011"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/48739"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Chemical Soc"],["dc.relation.issn","1089-5639"],["dc.title","Microwave spectrum, conformational equilibrium, intramolecular hydrogen bonding, tunneling, and quantum chemical calculations for 1-ethenylcyclopropan-1-ol"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","15114"],["dc.bibliographiccitation.issue","49"],["dc.bibliographiccitation.journal","Journal of the American Chemical Society"],["dc.bibliographiccitation.lastpage","+"],["dc.bibliographiccitation.volume","129"],["dc.contributor.author","Schuetz, Anne"],["dc.contributor.author","Junker, Jochen"],["dc.contributor.author","Leonov, Andrei"],["dc.contributor.author","Lange, Oliver F."],["dc.contributor.author","Molinski, Tadeusz F."],["dc.contributor.author","Griesinger, Christian"],["dc.date.accessioned","2017-09-07T11:49:21Z"],["dc.date.available","2017-09-07T11:49:21Z"],["dc.date.issued","2007"],["dc.description.abstract","Sagittamide A is a long-chain acyclic M,CO-dicarboxylic acid with eight stereocenters, The central hexahydroxyhexane moiety carries six of them. For this moiety, two different relative stereochemical assignments were published in 2006. In this communication, one relative configuration is clearly singled out based on NOEs, J - and residual dipolar couplings despite conformational averaging that is present in this moiety. The proposed NMR method relies on the measurement of dipolar couplings in recently introduced alignment media that are compatible with organic solvents, and cross validating the NMR determined ensemble of conformations against the residual dipolar couplings. The method is easily applicable to many other stereochemical problems."],["dc.identifier.doi","10.1021/ja075876l"],["dc.identifier.gro","3143398"],["dc.identifier.isi","000251477400012"],["dc.identifier.pmid","17999506"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/908"],["dc.notes.intern","WoS Import 2017-03-10"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Amer Chemical Soc"],["dc.relation.issn","0002-7863"],["dc.title","Stereochemistry of sagittamide a from residual dipolar coupling enhanced NMR"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","924"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Journal of Neuropathology and Experimental Neurology"],["dc.bibliographiccitation.lastpage","933"],["dc.bibliographiccitation.volume","74"],["dc.contributor.author","Shi, Song"],["dc.contributor.author","Wagner, Jens"],["dc.contributor.author","Mitteregger-Kretzschmar, Gerda"],["dc.contributor.author","Ryazanov, Sergey"],["dc.contributor.author","Leonov, Andrei"],["dc.contributor.author","Griesinger, Christian"],["dc.contributor.author","Giese, Armin"],["dc.date.accessioned","2017-09-07T11:43:35Z"],["dc.date.available","2017-09-07T11:43:35Z"],["dc.date.issued","2015"],["dc.description.abstract","Prion diseases are fatal neurodegenerative diseases characterized by accumulation of the pathogenic prion protein PrPSc in the brain. We established quantitative real-time quaking-induced conversion for the measurement of minute amounts of PrPSc in body fluids such as urine. Using this approach, we monitored the efficacy of antiprion therapy by quantifying the seeding activity of PrPSc from the brain and urine of mice after prion infection. We found that the aggregation inhibitor anle138b decreased the levels of PrPSc in the brain and urine. Importantly, variations of PrPSc levels in the urine closely corresponded to those in the brain. Our findings indicate that quantification of urinary PrPSc enables measurement of prion disease progression in body fluids and can substitute for immunodetection in brain tissue. We expect PrPSc quantification biologic fluids (such as urine and cerebrospinal fluid) with quantitative real-time quaking-induced conversion to emerge as a valuable noninvasive diagnostic tool for monitoring disease progression and the efficacy of therapeutic approaches in animal studies and human clinical trials of prion diseases. Moreover, highly sensitive methods for quantifying pathologic aggregate seeds might provide novel molecular biomarkers for other neurodegenerative diseases that may involve prion-like mechanisms (protein aggregation and spreading), such as Alzheimer disease and Parkinson disease."],["dc.identifier.doi","10.1097/NEN.0000000000000233"],["dc.identifier.gro","3141840"],["dc.identifier.isi","000360142900007"],["dc.identifier.pmid","26247395"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/1656"],["dc.language.iso","en"],["dc.notes.intern","WoS Import 2017-03-10"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation.issn","0022-3069"],["dc.title","Quantitative Real-Time Quaking-Induced Conversion Allows Monitoring of Disease-Modifying Therapy in the Urine of Prion-Infected Mice"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","800"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Biochimica et Biophysica Acta (BBA) - General Subjects"],["dc.bibliographiccitation.lastpage","807"],["dc.bibliographiccitation.volume","1862"],["dc.contributor.author","Reiner, Anne M."],["dc.contributor.author","Schmidt, Felix"],["dc.contributor.author","Ryazanov, Sergey"],["dc.contributor.author","Leonov, Andrei"],["dc.contributor.author","Weckbecker, Daniel"],["dc.contributor.author","Deeg, Andreas A."],["dc.contributor.author","Griesinger, Christian"],["dc.contributor.author","Giese, Armin"],["dc.contributor.author","Zinth, Wolfgang"],["dc.date.accessioned","2018-01-17T11:27:13Z"],["dc.date.available","2018-01-17T11:27:13Z"],["dc.date.issued","2017"],["dc.description.abstract","Recently diphenyl-pyrazole (DPP) compounds and especially anle138b were found to reduce the aggregation of α-synuclein or Tau protein in vitro as well as in a mouse model of neurodegenerative diseases . Direct interaction of the DPPs with the fibrillar structure was identified by fluorescence spectroscopy. Thereby a strong dependence of the fluorescence on the surroundings could be identified ."],["dc.identifier.doi","10.1016/j.bbagen.2017.12.007"],["dc.identifier.pmid","29273222"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/11675"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.title","Photophysics of diphenyl-pyrazole compounds in solutions and α-synuclein aggregates"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","3333"],["dc.bibliographiccitation.issue","23"],["dc.bibliographiccitation.journal","ChemBioChem"],["dc.bibliographiccitation.lastpage","3337"],["dc.bibliographiccitation.volume","21"],["dc.contributor.author","Täubert, Sebastian"],["dc.contributor.author","Zhang, Yong‐Hui"],["dc.contributor.author","Martinez, Mitcheell Maestre"],["dc.contributor.author","Siepel, Florian"],["dc.contributor.author","Wöltjen, Edith"],["dc.contributor.author","Leonov, Andrei"],["dc.contributor.author","Griesinger, Christian"],["dc.date.accessioned","2022-03-01T11:45:10Z"],["dc.date.available","2022-03-01T11:45:10Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1002/cbic.202000417"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/103237"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-531"],["dc.relation.eissn","1439-7633"],["dc.relation.issn","1439-4227"],["dc.rights.uri","http://creativecommons.org/licenses/by-nc-nd/4.0/"],["dc.title","Lanthanide Tagging of Oligonucleotides to Nucleobase for Paramagnetic NMR"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1884"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Biochimica et Biophysica Acta (BBA) - General Subjects"],["dc.bibliographiccitation.lastpage","1890"],["dc.bibliographiccitation.volume","1850"],["dc.contributor.author","Deeg, Andreas A."],["dc.contributor.author","Reiner, Anne M."],["dc.contributor.author","Schmidt, Felix"],["dc.contributor.author","Schueder, Florian"],["dc.contributor.author","Ryazanov, Sergey"],["dc.contributor.author","Ruf, Viktoria C."],["dc.contributor.author","Giller, Karin"],["dc.contributor.author","Becker, Stefan"],["dc.contributor.author","Leonov, Andrei"],["dc.contributor.author","Griesinger, Christian"],["dc.contributor.author","Giese, Armin"],["dc.contributor.author","Zinth, Wolfgang"],["dc.date.accessioned","2017-09-07T11:43:35Z"],["dc.date.available","2017-09-07T11:43:35Z"],["dc.date.issued","2015"],["dc.description.abstract","Background: Special diphenyl-pyrazole compounds and in particular anle138b were found to reduce the progression of prion and Parkinson's disease in animal models. The therapeutic impact of these compounds was attributed to the modulation of a-synuclein and prion-protein aggregation related to these diseases. Methods: Photophysical and photochemical properties of the diphenyl-pyrazole compounds anle138b, anle186b and sery313b and their interaction with monomeric and aggregated a-synuclein were studied by fluorescence techniques. Results: The fluorescence emission of diphenyl-pyrazole is strongly increased upon incubation with a-synuclein fibrils, while no change in fluorescence emission is found when brought in contact with monomeric a-synuclein. This points to a distinct interaction between diphenyl-pyrazole and the fibrillar structure with a high binding affinity (K-d = 190 +/- 120 nM) for anle138b. Several a-synuclein proteins form a hydrophobic binding pocket for the diphenyl-pyrazole compound. A UV-induced dehalogenation reaction was observed for anle138b which is modulated by the hydrophobic environment of the fibrils. Conclusion: Fluorescence of the investigated diphenyl-pyrazole compounds strongly increases upon binding to fibrillar a-synuclein structures. Binding at high affinity occurs to hydrophobic pockets in the fibrils. General significance: The observed particular fluorescence properties of the diphenyl-pyrazole molecules open new possibilities for the investigation of the mode of action of these compounds in neurodegenerative diseases. The high binding affinity to aggregates and the strong increase in fluorescence upon binding make the compounds promising fluorescence markers for the analysis of aggregation-dependent epitopes. (C) 2015 Elsevier B.V. All rights reserved."],["dc.identifier.doi","10.1016/j.bbagen.2015.05.021"],["dc.identifier.gro","3141841"],["dc.identifier.isi","000359173900026"],["dc.identifier.pmid","26028294"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/1667"],["dc.language.iso","en"],["dc.notes.intern","WoS Import 2017-03-10"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation.eissn","1872-8006"],["dc.relation.issn","0304-4165"],["dc.title","Anle138b and related compounds are aggregation specific fluorescence markers and reveal high affinity binding to ot-synuclein aggregates"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","472"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","European Journal of Organic Chemistry"],["dc.bibliographiccitation.lastpage","478"],["dc.contributor.author","de Meijere, Armin"],["dc.contributor.author","Leonov, A."],["dc.contributor.author","Heiner, T."],["dc.contributor.author","Noltemeyer, M."],["dc.contributor.author","Bes, M. T."],["dc.date.accessioned","2018-11-07T10:41:13Z"],["dc.date.available","2018-11-07T10:41:13Z"],["dc.date.issued","2003"],["dc.description.abstract","High-pressure-induced inverse-electron-demand hetero-Diels-Alder reactions of ethyl trans-4-ethoxy-2-oxo-3-butenoate (2a) and methyl trans-4-benzyloxy-2-oxo-3-butenoate (2b) with benzyl (cyclopropylidenemethyl) ether (1) each yielded mixtures of two separable diastereomeric esters 7a (64%) and 7b (80%) which, in three subsequent steps, led to the 3-ethylated and 3-benzylated alpha- and beta-anomeric benzyl spiro[2-deoxy-(D,L)-arabino-hexopyranoside-2,1'-cyclopropanes] alpha-10a,b and beta-10a,b, respectively. The relative configuration of beta-10a was proved by an X-ray crystal structure analysis. Deprotection of beta-10b was achieved by Pd-catalyzed hydrogenation in dimethylacetamide leading to spiro[2-deoxy-alpha/beta-2-(D,L)-arabino-hexopyranoside-2,1'-cyclopropane] (4)."],["dc.identifier.isi","000180805100009"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/46486"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-v C H Verlag Gmbh"],["dc.relation.issn","1434-193X"],["dc.title","De novo synthesis of racemic spirocyclopropane-annelated 2-deoxyhexose derivatives"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]