El Shafie, Rami

[["dc.bibliographiccitation.firstpage","253"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Neurosurgery"],["dc.bibliographiccitation.lastpage","260"],["dc.bibliographiccitation.volume","84"],["dc.contributor.author","El Shafie, Rami A."],["dc.contributor.author","Paul, Angela"],["dc.contributor.author","Bernhardt, Denise"],["dc.contributor.author","Lang, Kristin"],["dc.contributor.author","Welzel, Thomas"],["dc.contributor.author","Sprave, Tanja"],["dc.contributor.author","Hommertgen, Adriane"],["dc.contributor.author","Krisam, Johannes"],["dc.contributor.author","Schmitt, Daniela"],["dc.contributor.author","Klüter, Sebastian"],["dc.contributor.author","Schubert, Kai"],["dc.contributor.author","Klose, Christina"],["dc.contributor.author","Kieser, Meinhard"],["dc.contributor.author","Debus, Jürgen"],["dc.contributor.author","Rieken, Stefan"],["dc.date.accessioned","2020-07-16T09:11:12Z"],["dc.date.available","2020-07-16T09:11:12Z"],["dc.date.issued","2019"],["dc.description.abstract","Stereotactic radiosurgery (SRS) of brain metastases (BM) is recommended in oligometastatic scenarios as a less toxic treatment alternative to whole-brain radiotherapy. Recent findings support SRS for patients with multiple (>3) BM. Furthermore, advances in MR imaging have facilitated the detection of very small BM, as advances in SRS technology have facilitated the highly conformal and simultaneous treatment of multiple target lesions."],["dc.identifier.doi","10.1093/neuros/nyy026"],["dc.identifier.pmid","29554321"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/67096"],["dc.language.iso","en"],["dc.relation.eissn","1524-4040"],["dc.relation.issn","0148-396X"],["dc.title","Robotic Radiosurgery for Brain Metastases Diagnosed With Either SPACE or MPRAGE Sequence (CYBER-SPACE)-A Single-Center Prospective Randomized Trial"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","641"],["dc.bibliographiccitation.journal","Frontiers in Oncology"],["dc.bibliographiccitation.volume","8"],["dc.contributor.author","El Shafie, Rami A."],["dc.contributor.author","Böhm, Karina"],["dc.contributor.author","Weber, Dorothea"],["dc.contributor.author","Lang, Kristin"],["dc.contributor.author","Schlaich, Fabian"],["dc.contributor.author","Adeberg, Sebastian"],["dc.contributor.author","Paul, Angela"],["dc.contributor.author","Haefner, Matthias F."],["dc.contributor.author","Katayama, Sonja"],["dc.contributor.author","Hörner-Rieber, Juliane"],["dc.contributor.author","Hoegen, Philipp"],["dc.contributor.author","Löw, Sarah"],["dc.contributor.author","Debus, Jürgen"],["dc.contributor.author","Rieken, Stefan"],["dc.contributor.author","Bernhardt, Denise"],["dc.date.accessioned","2020-07-16T10:33:04Z"],["dc.date.available","2020-07-16T10:33:04Z"],["dc.date.issued","2018"],["dc.description.abstract","Introduction: The purpose of this article is to report our institution's 10-year experience on palliative radiotherapy for the treatment of leptomeningeal carcinomatosis (LC), assessing survival, neurologic outcome, and prognostic factors. Patients and methods: We retrospectively analyzed 110 patients who received palliative radiotherapy for LC between 2008 and 2018. The most common histologies were breast cancer (n = 43, 39.1%) and non-small cell lung cancer (NSCLC) (n = 31, 28.2%). Radiotherapy was administered as whole-brain radiotherapy (WBRT) (n = 51, 46.4%), focal spinal RT (n = 11, 10.0%) or both (n = 47, 42.7%). Twenty-five patients (22.7%) were selected for craniospinal irradiation. Clinical performance and neurologic function were quantified on the neurologic function scale (NFS) before and in response to therapy. A Cox Proportional Hazards model with univariate and multivariate analysis was fitted for survival. Results: Ninety-eight patients (89.1%) died and 12 (10.9%) were alive at the time of analysis. Median OS from LC diagnosis and from the beginning of RT was 13.9 weeks (IQR: 7.1-34.0) and 9.9 weeks (IQR: 5.3-26.3), respectively. In univariate analysis, prognostic of longer OS were a Karnofsky performance scale index (KPI) of ≥70% (HR 0.20, 95%-CI: [0.13; 0.32], p < 0.001), initially moderate neurological deficits (NFS ≤2) (HR 0.32, 95% CI: [0.19; 0.52], p < 0.001), symptom response to RT (HR 0.41, 95%-CI: [0.26; 0.67], p < 0.001) and the administration of systemic therapy (HR 0.51, 95%-CI: [0.33; 0.78], p = 0.002). Prognostic of inferior OS were high-grade myelosuppression (HR 1.78, 95% CI: [1.06; 3.00], p = 0.03) and serum LDH levels >500 U/l (HR 3.62, 95% CI: [1.76; 7.44], p < 0.001). Clinical performance, symptom response and serum LDH stayed independently prognostic for survival in multivariate analysis. RT was well-tolerated and except for grade III myelosuppression in 19 cases (17.3%), no high-grade acute toxicities were observed. Neurologic symptom stabilization was achieved in 83 cases (75.5%) and a sizeable improvement in 39 cases (35.5%). Conclusion: Radiotherapy is a well-tolerated and efficacious means of providing symptom palliation for patients with LC, delaying neurologic deterioration while probably not directly influencing survival. Prognostic factors such as clinical performance, neurologic response and serum LDH can be used for patient stratification to facilitate treatment decisions."],["dc.identifier.doi","10.3389/fonc.2018.00641"],["dc.identifier.pmid","30671384"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/67172"],["dc.language.iso","en"],["dc.relation.issn","2234-943X"],["dc.title","Palliative Radiotherapy for Leptomeningeal Carcinomatosis-Analysis of Outcome, Prognostic Factors, and Symptom Response"],["dc.type","journal_article"],["dc.type.internalPublication","no"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","127"],["dc.bibliographiccitation.journal","Cancer Management and Research"],["dc.bibliographiccitation.lastpage","136"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Lang, Kristin"],["dc.contributor.author","El Shafie, Rami A."],["dc.contributor.author","Akbaba, Sati"],["dc.contributor.author","Koschny, Ronald"],["dc.contributor.author","Bougatf, Nina"],["dc.contributor.author","Bernhardt, Denise"],["dc.contributor.author","Welte, Stefan E."],["dc.contributor.author","Adeberg, Sebastian"],["dc.contributor.author","Häfner, Matthias"],["dc.contributor.author","Kargus, Steffen"],["dc.contributor.author","Plinkert, Peter K."],["dc.contributor.author","Debus, Jürgen"],["dc.contributor.author","Rieken, Stefan"],["dc.date.accessioned","2020-07-16T10:32:31Z"],["dc.date.available","2020-07-16T10:32:31Z"],["dc.date.issued","2020"],["dc.description.abstract","The primary aim of our study was to evaluate percutaneous endoscopic gastrostomy (PEG) tube placement depending on body weight and body mass index in patients undergoing radiotherapy (RT) for head and neck cancer (HNC). A secondary aim was to evaluate the course of weight change following PEG placement."],["dc.identifier.doi","10.2147/CMAR.S218432"],["dc.identifier.pmid","32021429"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/67165"],["dc.language.iso","en"],["dc.relation.issn","1179-1322"],["dc.title","Percutaneous Endoscopic Gastrostomy Tube Placement in Patients with Head and Neck Cancer Treated with Radiotherapy"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","332.e3"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Clinical Lung Cancer"],["dc.bibliographiccitation.lastpage","340.e3"],["dc.bibliographiccitation.volume","22"],["dc.contributor.author","Regnery, Sebastian"],["dc.contributor.author","Eichkorn, Tanja"],["dc.contributor.author","Weykamp, Fabian"],["dc.contributor.author","Held, Thomas"],["dc.contributor.author","Weusthof, Katharina"],["dc.contributor.author","Dinges, Lisa-Antonia"],["dc.contributor.author","El Shafie, Rami A."],["dc.contributor.author","Winter, Hauke"],["dc.contributor.author","Thomas, Michael"],["dc.contributor.author","Debus, Jürgen"],["dc.contributor.author","Adeberg, Sebastian"],["dc.contributor.author","Hörner-Rieber, Juliane"],["dc.date.accessioned","2022-11-17T10:17:58Z"],["dc.date.available","2022-11-17T10:17:58Z"],["dc.date.issued","2021"],["dc.description.abstract","Delivery of stereotactic body radiotherapy (SBRT) to ultracentral lung tumors remains a major challenge, with potentially excessive SBRT-related toxicity. This study investigates a risk-optimized approach to ultracentral SBRT in an elderly and comorbid patient cohort."],["dc.identifier.doi","10.1016/j.cllc.2020.11.003"],["dc.identifier.pmid","33281061"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/117098"],["dc.language.iso","en"],["dc.relation.eissn","1938-0690"],["dc.relation.issn","1525-7304"],["dc.title","Safety and Efficacy of Stereotactic Body Radiotherapy in Ultracentral Lung Tumors Using a Risk-optimized Fractionation Scheme"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1557"],["dc.bibliographiccitation.journal","Frontiers in Oncology"],["dc.bibliographiccitation.volume","10"],["dc.contributor.author","Weykamp, Fabian"],["dc.contributor.author","El Shafie, Rami A."],["dc.contributor.author","König, Laila"],["dc.contributor.author","Seidensaal, Katharina"],["dc.contributor.author","Forster, Tobias"],["dc.contributor.author","Arians, Nathalie"],["dc.contributor.author","Regnery, Sebastian"],["dc.contributor.author","Hoegen, Philipp"],["dc.contributor.author","Deutsch, Thomas M."],["dc.contributor.author","Schneeweiss, Andreas"],["dc.contributor.author","Debus, Jürgen"],["dc.contributor.author","Hörner-Rieber, Juliane"],["dc.date.accessioned","2022-11-17T11:12:24Z"],["dc.date.available","2022-11-17T11:12:24Z"],["dc.date.issued","2020"],["dc.description.abstract","Purpose: Several prognostic indexes for overall survival (OS) after radiotherapy of brain metastases in breast cancer patients exist but are mainly validated for whole-brain radiotherapy or not specifically for breast cancer patients. To date, no such index provides information beyond mere OS. Methods: We retrospectively analyzed 95 breast cancer patients treated with stereotactic radiosurgery for 203 brain metastases. The Kaplan-Meier method with log-rank test was used to assess OS, local control (LC), distant cranial control (DCC), and extracranial control (EC). Cox regression was applied to detect prognostic outcome factors. A point scoring system was designed to stratify patients based on outcome. Nine established prognostic indexes were analyzed using the concordance index (c-index). Results: Two out of nine analyzed prognostic indexes for OS showed a significant c-index, the breast graded prognostic assessment (bGPA; 0.631; 95% CI, 0.514-0.748; p = 0.037) and the modified bGPA (mod-bGPA; 0.662; 95% CI, 0.547-0.777; p = 0.010). Significant results from multivariate analysis (Karnofsky Performance Score, Her2/neu receptor status, extracranial control) were used to generate a new point system: the breast cancer stereotactic radiotherapy score (bSRS), which discriminated three significantly different prognostic groups, for LC, DCC, EC, and OS, respectively. However, the c-index was only significant for OS (0.689; 95% CI, 0.577-0.802; p = 0.003). Conclusions: The new bSRS score was superior to the bGPA and mod-bGPA scores for prognosis of OS. The bSRS is easy to use and the first tool, which might also provide outcome assessment beyond mere OS. Future studies need to validate these findings."],["dc.identifier.doi","10.3389/fonc.2020.01557"],["dc.identifier.pmid","33014802"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/117113"],["dc.language.iso","en"],["dc.relation.issn","2234-943X"],["dc.title","Validation of Nine Different Prognostic Grading Indexes for Radiosurgery of Brain Metastases in Breast Cancer Patients and Development of an All-Encompassing Prognostic Tool"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","803"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","International Journal of Radiation Oncology, Biology, Physics"],["dc.bibliographiccitation.lastpage","811"],["dc.bibliographiccitation.volume","105"],["dc.contributor.author","Held, Thomas"],["dc.contributor.author","Windisch, Paul"],["dc.contributor.author","Akbaba, Sati"],["dc.contributor.author","Lang, Kristin"],["dc.contributor.author","El Shafie, Rami"],["dc.contributor.author","Bernhardt, Denise"],["dc.contributor.author","Plinkert, Peter"],["dc.contributor.author","Kargus, Steffen"],["dc.contributor.author","Rieken, Stefan"],["dc.contributor.author","Herfarth, Klaus"],["dc.contributor.author","Debus, Jürgen"],["dc.contributor.author","Adeberg, Sebastian"],["dc.date.accessioned","2020-07-10T08:22:49Z"],["dc.date.available","2020-07-10T08:22:49Z"],["dc.date.issued","2019"],["dc.description.abstract","This study aimed to assess the feasibility of carbon ion reirradiation (CIR) for recurrent head and neck cancer (HNC)."],["dc.identifier.doi","10.1016/j.ijrobp.2019.07.021"],["dc.identifier.pmid","31349059"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/67015"],["dc.language.iso","en"],["dc.relation.eissn","1879-355X"],["dc.relation.issn","0360-3016"],["dc.title","Carbon Ion Reirradiation for Recurrent Head and Neck Cancer: A Single-Institutional Experience"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","564857"],["dc.bibliographiccitation.journal","Frontiers in Oncology"],["dc.bibliographiccitation.volume","10"],["dc.contributor.author","Hoegen, Philipp"],["dc.contributor.author","Lang, Clemens"],["dc.contributor.author","Akbaba, Sati"],["dc.contributor.author","Häring, Peter"],["dc.contributor.author","Splinter, Mona"],["dc.contributor.author","Miltner, Annette"],["dc.contributor.author","Bachmann, Marion"],["dc.contributor.author","Stahl-Arnsberger, Christiane"],["dc.contributor.author","Brechter, Thomas"],["dc.contributor.author","El Shafie, Rami A."],["dc.contributor.author","Weykamp, Fabian"],["dc.contributor.author","König, Laila"],["dc.contributor.author","Debus, Jürgen"],["dc.contributor.author","Hörner-Rieber, Juliane"],["dc.date.accessioned","2022-11-17T11:12:39Z"],["dc.date.available","2022-11-17T11:12:39Z"],["dc.date.issued","2020"],["dc.description.abstract","To evaluate the potential of cone-beam-CT (CB-CT) guided adaptive radiotherapy (ART) for locally advanced non-small cell lung cancer (NSCLC) for sparing of surrounding organs-at-risk (OAR)."],["dc.identifier.doi","10.3389/fonc.2020.564857"],["dc.identifier.pmid","33363005"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/117114"],["dc.language.iso","en"],["dc.relation.issn","2234-943X"],["dc.title","Cone-Beam-CT Guided Adaptive Radiotherapy for Locally Advanced Non-small Cell Lung Cancer Enables Quality Assurance and Superior Sparing of Healthy Lung"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","86"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Radiation oncology"],["dc.bibliographiccitation.volume","13"],["dc.contributor.author","El Shafie, Rami A."],["dc.contributor.author","Czech, Maja"],["dc.contributor.author","Kessel, Kerstin A."],["dc.contributor.author","Habermehl, Daniel"],["dc.contributor.author","Weber, Dorothea"],["dc.contributor.author","Rieken, Stefan"],["dc.contributor.author","Bougatf, Nina"],["dc.contributor.author","Jäkel, Oliver"],["dc.contributor.author","Debus, Jürgen"],["dc.contributor.author","Combs, Stephanie E."],["dc.date.accessioned","2020-07-16T10:31:06Z"],["dc.date.available","2020-07-16T10:31:06Z"],["dc.date.issued","2018-05-08"],["dc.description.abstract","With the advance of modern irradiation techniques, the role of radiotherapy (RT) for intracranial meningioma has increased significantly throughout the past years. Despite that tumor's generally favorable outcome with local control rates of up to 90% after ten years, progression after RT does occur. In those cases, re-irradiation is often difficult due to the limited radiation tolerance of the surrounding tissue. The aim of this analysis is to determine the value of particle therapy with its better dose conformity and higher biological efficacy for re-irradiating recurrent intracranial meningioma. It was performed within the framework of the \"clinical research group heavy ion therapy\" and funded by the German Research Council (DFG, KFO 214)."],["dc.identifier.doi","10.1186/s13014-018-1026-x"],["dc.identifier.pmid","29739417"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/67146"],["dc.language.iso","en"],["dc.relation.issn","1748-717X"],["dc.title","Evaluation of particle radiotherapy for the re-irradiation of recurrent intracranial meningioma"],["dc.type","journal_article"],["dc.type.internalPublication","no"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","312"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Journal of Contemporary Brachytherapy"],["dc.bibliographiccitation.lastpage","319"],["dc.bibliographiccitation.volume","11"],["dc.contributor.author","Forster, Tobias"],["dc.contributor.author","Akbaba, Sati"],["dc.contributor.author","Schmitt, Daniela"],["dc.contributor.author","Krug, David"],["dc.contributor.author","El Shafie, Rami"],["dc.contributor.author","Oelmann-Avendano, Jan"],["dc.contributor.author","Lindel, Katja"],["dc.contributor.author","König, Laila"],["dc.contributor.author","Arians, Nathalie"],["dc.contributor.author","Bernhardt, Denise"],["dc.contributor.author","Marmé, Frederik"],["dc.contributor.author","Schneeweiss, Andreas"],["dc.contributor.author","Heil, Jörg"],["dc.contributor.author","Sohn, Christof"],["dc.contributor.author","Debus, Jürgen"],["dc.contributor.author","Hörner-Rieber, Juliane"],["dc.date.accessioned","2022-11-17T11:12:00Z"],["dc.date.available","2022-11-17T11:12:00Z"],["dc.date.issued","2019-08"],["dc.description.abstract","The aim of this study is to evaluate the efficacy and toxicity of post-operative partial breast re-irradiation with multi-catheter brachytherapy after second breast conserving therapy (BCT) in patients with small, low-risk ipsilateral breast tumor recurrence (IBTR)."],["dc.identifier.doi","10.5114/jcb.2019.87001"],["dc.identifier.pmid","31523231"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/117123"],["dc.language.iso","en"],["dc.relation.issn","1689-832X"],["dc.title","Second breast conserving therapy after ipsilateral breast tumor recurrence - a 10-year experience of re-irradiation"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","e10916"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Journal of Medical Internet Research. Mhealth & Uhealth"],["dc.bibliographiccitation.volume","6"],["dc.contributor.author","El Shafie, Rami A."],["dc.contributor.author","Weber, Dorothea"],["dc.contributor.author","Bougatf, Nina"],["dc.contributor.author","Sprave, Tanja"],["dc.contributor.author","Oetzel, Dieter"],["dc.contributor.author","Huber, Peter E."],["dc.contributor.author","Debus, Jürgen"],["dc.contributor.author","Nicolay, Nils H."],["dc.date.accessioned","2022-11-17T11:12:14Z"],["dc.date.available","2022-11-17T11:12:14Z"],["dc.date.issued","2018-08-30"],["dc.description.abstract","Consumer electronics and Web-enabled mobile devices are playing an increasing role in patient care, and their use in the oncologic sector opens up promising possibilities in the fields of supportive cancer care and systematic patient follow-up."],["dc.identifier.doi","10.2196/10916"],["dc.identifier.pmid","30166275"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/117110"],["dc.language.iso","en"],["dc.relation.issn","2291-5222"],["dc.title","Supportive Care in Radiotherapy Based on a Mobile App: Prospective Multicenter Survey"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]