Markus, Marietta Andrea

[["dc.bibliographiccitation.firstpage","1163"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Journal of Synchrotron Radiation"],["dc.bibliographiccitation.lastpage","1172"],["dc.bibliographiccitation.volume","24"],["dc.contributor.author","Nicolas, Jan-David"],["dc.contributor.author","Bernhardt, Marten"],["dc.contributor.author","Markus, Andrea"],["dc.contributor.author","Alves, Frauke"],["dc.contributor.author","Burghammer, Manfred"],["dc.contributor.author","Salditt, Tim"],["dc.date.accessioned","2018-04-23T11:48:57Z"],["dc.date.available","2018-04-23T11:48:57Z"],["dc.date.issued","2017"],["dc.description.abstract","A scanning X-ray diffraction study of cardiac tissue has been performed, covering the entire cross section of a mouse heart slice. To this end, moderate focusing by compound refractive lenses to micrometer spot size, continuous scanning, data acquisition by a fast single-photon-counting pixel detector, and fully automated analysis scripts have been combined. It was shown that a surprising amount of structural data can be harvested from such a scan, evaluating the local scattering intensity, interfilament spacing of the muscle tissue, the filament orientation, and the degree of anisotropy. The workflow of data analysis is described and a data analysis toolbox with example data for general use is provided. Since many cardiomyopathies rely on the structural integrity of the sarcomere, the contractile unit of cardiac muscle cells, the present study can be easily extended to characterize tissue from a diseased heart."],["dc.identifier.doi","10.1107/s1600577517011936"],["dc.identifier.gro","3142464"],["dc.identifier.pii","S1600577517011936"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/13614"],["dc.language.iso","en"],["dc.notes.intern","lifescience updates Crossref Import"],["dc.notes.status","final"],["dc.relation.eissn","1600-5775"],["dc.relation.issn","1600-5775"],["dc.relation.orgunit","Institut für Röntgenphysik"],["dc.relation.workinggroup","RG Salditt (Structure of Biomolecular Assemblies and X-Ray Physics)"],["dc.rights.uri","http://journals.iucr.org/services/copyrightpolicy.html"],["dc.subject.gro","x-ray scattering"],["dc.title","Scanning X-ray diffraction on cardiac tissue: automatized data analysis and processing"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","no"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Journal of Bone and Mineral Research"],["dc.bibliographiccitation.volume","29"],["dc.contributor.author","Hoffmann, Oskar"],["dc.contributor.author","Fowler, Tristan"],["dc.contributor.author","Kampleitner, Carina"],["dc.contributor.author","Poocza, Leander"],["dc.contributor.author","Markus, Andrea"],["dc.contributor.author","Dullin, Christian"],["dc.contributor.author","Hildebrand, Gerhard"],["dc.contributor.author","Alves, Frauke"],["dc.contributor.author","Liefeith, Klaus"],["dc.date.accessioned","2018-11-07T09:44:47Z"],["dc.date.available","2018-11-07T09:44:47Z"],["dc.date.issued","2014"],["dc.identifier.isi","000356598701523"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/34470"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.publisher.place","Hoboken"],["dc.relation.eventlocation","Houston, TX"],["dc.title","Pre-clinical screening of novel two-photon photopolymerized biomaterials for bone implantation."],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Frontiers in Bioengineering and Biotechnology"],["dc.bibliographiccitation.volume","8"],["dc.contributor.author","Ramos-Gomes, Fernanda"],["dc.contributor.author","Ferreira, Nathalia"],["dc.contributor.author","Kraupner, Alexander"],["dc.contributor.author","Alves, Frauke"],["dc.contributor.author","Markus, M. Andrea"],["dc.date.accessioned","2021-04-14T08:31:13Z"],["dc.date.available","2021-04-14T08:31:13Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.3389/fbioe.2020.588922"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/83517"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","2296-4185"],["dc.title","Ex vivo Live Cell Imaging of Nanoparticle-Cell Interactions in the Mouse Lung"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","96"],["dc.bibliographiccitation.lastpage","97"],["dc.bibliographiccitation.volume","Life Sciences and Cultural Heritage, Elettra - SYRMEP"],["dc.contributor.author","Dullin, Christian"],["dc.contributor.author","dal Monego, Simeone"],["dc.contributor.author","Larsson, Emanuel"],["dc.contributor.author","Mohammadi, Sara"],["dc.contributor.author","Krenkel, Martin"],["dc.contributor.author","Garrovo, Chiara"],["dc.contributor.author","Biffi, Stefania"],["dc.contributor.author","Lorenzon, Andrea"],["dc.contributor.author","Markus, Andrea"],["dc.contributor.author","Napp, Joanna"],["dc.contributor.author","Salditt, Tim"],["dc.contributor.author","Accardo, Agostino"],["dc.contributor.author","Alves, Frauke"],["dc.contributor.author","Tromba, G."],["dc.date.accessioned","2020-03-11T09:34:33Z"],["dc.date.available","2020-03-11T09:34:33Z"],["dc.date.issued","2015"],["dc.description.abstract","We successfully applied synchrotron in-line phase contrast CT in combination with single distance phase retrieval to image lungs of asthmatic and healthy mice in high resolution in situ. The increased image quality in phase contrast CT added functional contrast to CT which enabled simultaneous i\\) anatomical imaging for the discrimination of asthmatic from healthy mice based on alterations of their lung structure as well as ii\\) functional imaging to track the location of barium sulfate loaded intratracheally instilled alveolar macrophages. Link to fulltext: http://www.elettra.eu/images/Documents/SCIENCE/Elettra%20HL%202015.pdf"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/63295"],["dc.language.iso","en"],["dc.publisher","Elettra - Sincrotrone Trieste"],["dc.publisher.place","Trieste"],["dc.relation.ispartof","ELETTRA HIGHLIGHTS 2014-2015"],["dc.title","Simultaneous localization of labelled macrophages and structural analysis of asthmatic mice by phase contrast CT"],["dc.type","book_chapter"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","4"],["dc.contributor.author","Nicolas, J. D."],["dc.contributor.author","Markus, Marietta Andrea"],["dc.contributor.author","Alves, Frauke"],["dc.contributor.author","Frohn, Jasper"],["dc.contributor.author","Reichardt, Marius"],["dc.contributor.author","Töpperwien, Mareike"],["dc.contributor.author","Salditt, Tim"],["dc.contributor.editor","Wang, Geng"],["dc.contributor.editor","Müller-Myhsok, Bertram"],["dc.date.accessioned","2020-06-26T10:11:47Z"],["dc.date.available","2020-06-26T10:11:47Z"],["dc.date.issued","2017"],["dc.description.abstract","In this work we present x-ray phase-contrast tomography of heart tissue from mouse, combining computed tomography (CT) scans with laboratory and synchrotron radiation. The work serves as a proof-of-concept that the cyto-architecture and in particular the myofibril orientation can be assessed in three dimensions (3D) by phase-contrast CT. We demonstrate the synergistic use of laboratory μ -CT and of the high resolution synchrotron setup based on waveguide optics. Details on preparation, instrumentation and analysis are given, as a state of the art reference for heart tissue tomography, and as a starting point for further progress."],["dc.identifier.doi","10.1117/12.2276648"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/66750"],["dc.language.iso","en"],["dc.notes.preprint","yes"],["dc.relation.eventend","2017-09-25"],["dc.relation.eventlocation","San Diego"],["dc.relation.eventstart","2017-09-25"],["dc.relation.isbn","9781510612396"],["dc.relation.isbn","9781510612402"],["dc.relation.iserratumof","yes"],["dc.relation.orgunit","Institut für Röntgenphysik"],["dc.relation.workinggroup","RG Salditt (Structure of Biomolecular Assemblies and X-Ray Physics)"],["dc.subject.gro","x-ray optics"],["dc.subject.gro","x-ray imaging"],["dc.subject.gro","biomedical tomography"],["dc.title","Nanoscale holographic tomography of heart tissue with x-ray waveguide optics"],["dc.type","conference_paper"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","138"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Genomics"],["dc.bibliographiccitation.lastpage","144"],["dc.bibliographiccitation.volume","107"],["dc.contributor.author","Markus, M. Andrea"],["dc.contributor.author","Yang, Yee Hwa J."],["dc.contributor.author","Morris, Brian J."],["dc.date.accessioned","2021-06-01T10:49:58Z"],["dc.date.available","2021-06-01T10:49:58Z"],["dc.date.issued","2016"],["dc.identifier.doi","10.1016/j.ygeno.2016.02.003"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/86480"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.relation.issn","0888-7543"],["dc.title","Transcriptome-wide targets of alternative splicing by RBM4 and possible role in cancer"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","11642"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","ACS Nano"],["dc.bibliographiccitation.lastpage","11657"],["dc.bibliographiccitation.volume","9"],["dc.contributor.author","Markus, M. Andrea"],["dc.contributor.author","Napp, Joanna"],["dc.contributor.author","Behnke, Thomas"],["dc.contributor.author","Mitkovski, Miso"],["dc.contributor.author","Monecke, Sebastian"],["dc.contributor.author","Dullin, Christian"],["dc.contributor.author","Kilfeather, Stephen"],["dc.contributor.author","Dressel, Ralf"],["dc.contributor.author","Resch-Genger, Ute"],["dc.contributor.author","Alves, Frauke"],["dc.date.accessioned","2018-11-07T09:48:05Z"],["dc.date.available","2018-11-07T09:48:05Z"],["dc.date.issued","2015"],["dc.description.abstract","Molecular imaging of inflammatory lung diseases, such as asthma, has been limited to date. The recruitment of innate immune cells to the airways is central to the inflammation process. This study exploits these cells for imaging purposes within the lung, using inhaled polystyrene nanoparticles loaded with the near-infrared fluorescence dye Itrybe (Itrybe-NPs). By means of in vivo and ex vivo fluorescence reflectance imaging of an ovalbumin-based allergic airway inflammation (AA!) model in hairless SKH-1 mice, we show that subsequent to intranasal application of Itrybe-NPs, AAI lungs display fluorescence intensities significantly higher than those in lungs of control mice for at least 24 h. Ex vivo immunofluorescence analysis of lung tissue demonstrates the uptake of Itrybe-NPs predominantly by CD68(+)CD11c(+)ECF-(L+MHCIIlow) cells, identifying them as alveolar M2 macrophages in the peribronchial and alveolar areas. The in vivo results were validated by confocal microscopy, overlapping tile analysis, and flow cytometry, showing an amount of Itrybe-NP-containing macrophages in lungs of AAI mice significantly larger than that in controls. A small percentage of NP-containing cells were identified as dendritic cells. Flow cytometry of tracheobronchial lymph nodes showed that Itrybe-NPs were negligible in lung draining lymph nodes 24 h after inhalation. This imaging approach may advance preclinical monitoring of AAI in vivo over time and aid the investigation of the role that macrophages play during lung inflammation. Furthermore, it allows for tracking of inhaled nanoparticles and can hence be utilized for studies of the fate of potential new nanotherapeutics."],["dc.identifier.doi","10.1021/acsnano.5b04026"],["dc.identifier.isi","000367280100014"],["dc.identifier.pmid","26513457"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/35240"],["dc.identifier.url","https://sfb1002.med.uni-goettingen.de/production/literature/publications/97"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.relation","SFB 1002: Modulatorische Einheiten bei Herzinsuffizienz"],["dc.relation","SFB 1002 | C05: Bedeutung von zellulären Immunreaktionen für das kardiale Remodeling und die Therapie der Herzinsuffizienz durch Stammzelltransplantation"],["dc.relation.issn","1936-086X"],["dc.relation.issn","1936-0851"],["dc.relation.workinggroup","RG Dressel"],["dc.title","Tracking of Inhaled Near-Infrared Fluorescent Nanoparticles in Lungs of SKH-1 Mice with Allergic Airway Inflammation"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","BIO-PROTOCOL"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Ramos-Gomes, Fernanda"],["dc.contributor.author","Ferreira, Nathalia"],["dc.contributor.author","Alves, Frauke"],["dc.contributor.author","Markus, Marietta"],["dc.date.accessioned","2022-04-01T10:03:14Z"],["dc.date.available","2022-04-01T10:03:14Z"],["dc.date.issued","2022"],["dc.identifier.doi","10.21769/BioProtoc.4293"],["dc.identifier.pii","e4293"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/106117"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-530"],["dc.relation.issn","2331-8325"],["dc.title","An Alternative Technique for Monitoring the Live Interaction of Monocytes and Tumor Cells with Nanoparticles in the Mouse Lung"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","L763"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","American Journal of Physiology. Lung Cellular and Molecular Physiology"],["dc.bibliographiccitation.lastpage","L771"],["dc.bibliographiccitation.volume","313"],["dc.contributor.author","Markus, M. Andrea"],["dc.contributor.author","Borowik, Sergej"],["dc.contributor.author","Reichardt, Marius"],["dc.contributor.author","Tromba, Giuliana"],["dc.contributor.author","Alves, Frauke"],["dc.contributor.author","Dullin, Christian"],["dc.date.accessioned","2018-10-10T11:58:28Z"],["dc.date.available","2018-10-10T11:58:28Z"],["dc.date.issued","2017-11-01"],["dc.description.abstract","Chronic asthma patients experience difficulties even years after the inciting allergen. Although studies in small animal asthma models have enormously advanced progress in uncovering the mechanisms of inception and development of the disease, little is known about the processes involved in the persistence of asthma symptoms in the absence of allergen exposure. Long-term asthma mouse models have so far been scarce or not been able to reproduce the findings in patients. Here we used a common ovalbumin-induced acute allergic airway inflammation mouse model to study lung function and remodeling after a 4-mo recovery period. We show by X-ray-based lung function measurements that the recovered mice continue to show impaired lung function by displaying significant air trapping compared with controls. High-resolution synchrotron phase-contrast computed tomography of structural alterations and diaphragm motion analysis suggest that these changes in pulmonary function are the result of a pronounced loss in lung elasticity. Histology of lung sections confirmed that this is most likely caused by a decrease in elastic fibers, indicating that remodeling can develop or persist independent of acute inflammation and is closely related to a loss in lung function. Our findings demonstrate that this X-ray-based imaging platform has the potential to comprehensively and noninvasively unravel long-term effects in preclinical mouse models of allergic airway inflammation and thus benefits our understanding of chronic asthma."],["dc.identifier.doi","10.1152/ajplung.00136.2017"],["dc.identifier.gro","631972"],["dc.identifier.pmid","28775094"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/15962"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation.eissn","1522-1504"],["dc.title","X-ray-based lung function measurement reveals persistent loss of lung tissue elasticity in mice recovered from allergic airway inflammation"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","732"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Molecular Imaging & Biology"],["dc.bibliographiccitation.lastpage","741"],["dc.bibliographiccitation.volume","20"],["dc.contributor.author","Albers, J."],["dc.contributor.author","Pacilé, S."],["dc.contributor.author","Markus, M. A."],["dc.contributor.author","Wiart, M."],["dc.contributor.author","Vande Velde, G."],["dc.contributor.author","Tromba, G."],["dc.contributor.author","Dullin, C."],["dc.date.accessioned","2020-12-10T14:11:58Z"],["dc.date.available","2020-12-10T14:11:58Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1007/s11307-018-1246-3"],["dc.identifier.eissn","1860-2002"],["dc.identifier.issn","1536-1632"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/71263"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","X-ray-Based 3D Virtual Histology—Adding the Next Dimension to Histological Analysis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]